As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryProduct Name: 3-(2-(7-CHLOROQUINOLINE-2-YL)-(E)-VINYL)BENZALDEHYDE CAS: 120578-03-2 MF: C18H12ClNO MW: 293.75 EINECS: 421-800-1 Mol File: 120578-03-2.mol 3-(2-(7-CHLOROQUINOLINE-2-YL)-(E)-VINYL)BENZALDEHYDE Structure 3-(2-(7-CHLOR
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inquiry3-(2-(7-CHLOROQUINOLINE-2-YL)-(E)-VINYL)BENZALDEHYDE CAS:120578-03-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, speciali
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryhigh purity Application:Pharmaceutical Intermediate
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inquiryLower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryEnterprise standard Application:Pharma Intermediate
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiryTIANFUCHEM--120578-03-2---C18H12ClNO Application:TIANFUCHEM--120578-03-2---C18H12ClNO
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inquiryWe are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white crystalline powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use
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inquiry2-methyl-7-chloroquinoline
Isophthalaldehyde
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
Conditions | Yield |
---|---|
With lanthanum pentafluorobenzoate In toluene at 120℃; for 24h; | 97% |
With tert-butylammonium hexafluorophosphate(V); calcium(II) trifluoromethanesulfonate In neat (no solvent) at 130℃; Green chemistry; | 93% |
With acetic anhydride In toluene at 100 - 105℃; for 12 - 15h; | 75.15% |
2-methyl-7-chloroquinoline
Isophthalaldehyde
A
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
B
C28H18Cl2N2
Conditions | Yield |
---|---|
With acetic acid at 100℃; Product distribution / selectivity; | A 65.45% B 7.75% |
With acetic anhydride In xylene for 7h; Heating; Yield given; | |
With acetic anhydride In xylene for 7h; Heating; Yields of byproduct given; |
2-((S)-3-Acetoxy-1-bromo-3-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propyl)-benzoic acid methyl ester
A
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
B
trans-3-[2-(7-chloroquinolin-2-yl)ethenyl]benzyl alcohol
C
3-[(E)-2-(7-chloro-2-quinolyl)vinyl]benzoic acid
D
2-((S)-1-Bromo-3-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-hydroxy-propyl)-benzoic acid
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran; methanol at 23℃; for 24h; |
methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / Et3N, 4-DMAP / CH2Cl2 / 0.25 h 2: 69 percent / NBS, (BzO)2 / CCl4 / 3 h / Heating 3: 1 N LiOH / tetrahydrofuran; methanol / 24 h / 23 °C View Scheme |
2-((S)-3-Acetoxy-3-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-propyl)-benzoic acid methyl ester
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 69 percent / NBS, (BzO)2 / CCl4 / 3 h / Heating 2: 1 N LiOH / tetrahydrofuran; methanol / 24 h / 23 °C View Scheme |
2-methyl-7-chloroquinoline
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
Conditions | Yield |
---|---|
In Isophthalaldehyde |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
ethylene glycol
2-<3-<2-(7-chloro-2-quinolinyl)-(E)-ethenyl>phenyl>-1,3-dioxolane
Conditions | Yield |
---|---|
In toluene Heating; | 98% |
vinyl magnesium bromide
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
A
trans-3-[2-(7-chloroquinolin-2-yl)ethenyl]benzyl alcohol
B
(E)-3-<2-(7-chloro-2-quinolinyl)ethenyl>-α-ethenylphenylmethanol
Conditions | Yield |
---|---|
In tetrahydrofuran; toluene at 0 - 5℃; for 1h; Yields of byproduct given; | A n/a B 92% |
vinylmagnesium chloride
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
(E)-3-<2-(7-chloro-2-quinolinyl)ethenyl>-α-ethenylphenylmethanol
Conditions | Yield |
---|---|
In tetrahydrofuran; ethylbenzene at -15℃; | 91% |
Stage #1: vinylmagnesium chloride; (E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde In tetrahydrofuran; toluene at 0 - 10℃; for 1.5h; Stage #2: With ammonium acetate; water In tetrahydrofuran; toluene for 1h; |
methylmagnesium chloride
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
3-(7-Chloroquinol-2-yl-trans-ethenyl)-alpha-methylbenzyl alcohol
Conditions | Yield |
---|---|
Stage #1: methylmagnesium chloride; (E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde In tetrahydrofuran at -10 - 5℃; for 2.75h; Stage #2: With water at 10 - 15℃; for 0.5h; | 89.43% |
In tetrahydrofuran; toluene at -10℃; for 2h; Inert atmosphere; | 78% |
In tetrahydrofuran; toluene at -10℃; for 2h; Inert atmosphere; | 78% |
Stage #1: methylmagnesium chloride; (E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde In toluene at -5℃; for 2h; Stage #2: With water; ammonium chloride In toluene at 5℃; for 2h; Product distribution / selectivity; |
Methyl 3-mercaptopropionate
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
dimethyl 5-<3-<2-(7-chloro-2-quinolinyl)-(E)-ethenyl>phenyl>-4,6-dithianonanedioate
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In dichloromethane at -5 - 0℃; for 2h; | 87% |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
acetone
(E)-4-{3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}but-3-en-2-one
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; water for 3h; | 76.47% |
With sodium hydroxide In tetrahydrofuran; water for 3h; | 76.47% |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
dimethyl sulfoxide
7-chloro-2-[(E)-2-(3-oxiranylphenyl)vinyl]quinoline
Conditions | Yield |
---|---|
With trimethylsulphonium iodide; sodium hydride In tetrahydrofuran; dimethyl sulfoxide for 2h; Inert atmosphere; | 66% |
With trimethylsulphonium iodide; sodium hydride In tetrahydrofuran for 2h; Inert atmosphere; | 66% |
Methyl 3-mercaptopropionate
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
N,N-dimethyl-3-mercaptopropionamide
(+)-methyl 5-(3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoate
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate In chloroform at -8 - 2℃; for 2h; | 49% |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
ethyl bromoacetate
ethyl 3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropanoate
Conditions | Yield |
---|---|
Stage #1: (E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde With zinc In diethyl ether; toluene at 60 - 70℃; for 0.5 - 0.75h; Stage #2: ethyl bromoacetate In diethyl ether; toluene at 60 - 70℃; for 3h; | 46% |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
A
trans-3-[2-(7-chloroquinolin-2-yl)ethenyl]benzyl alcohol
B
(E)-3-<2-(7-chloro-2-quinolinyl)ethenyl>-α-ethenylphenylmethanol
Conditions | Yield |
---|---|
With vinyl magnesium bromide In tetrahydrofuran at 0 - 5℃; for 1h; | A 40% B n/a |
Methyl 3-mercaptopropionate
(R)-(-)-α-methoxyphenylthiolacetic acid
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
A
3-[(R)-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-((R)-2-methoxy-2-phenyl-acetylsulfanyl)-methylsulfanyl]-propionic acid methyl ester
B
3-[(S)-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-((R)-2-methoxy-2-phenyl-acetylsulfanyl)-methylsulfanyl]-propionic acid methyl ester
Conditions | Yield |
---|---|
With 2,6-di-tert-butyl-4-methyl-phenol; boron trifluoride diethyl etherate In 1,2-dichloro-ethane for 24h; Ambient temperature; Yield given. Yields of byproduct given; |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
N,N-dimethyl-3-mercaptopropionamide
1,1,1,3,3,3-hexamethyl-disilazane
3-({3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-trimethylsilanyloxy-methylsulfanyl)-N,N-dimethyl-propionamide
Conditions | Yield |
---|---|
With 1H-imidazole In dichloromethane at 12 - 14℃; for 24h; |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
-1-<2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>phenyl>ethanone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h 4: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h View Scheme | |
Multi-step reaction with 4 steps 1: vinylmagnesium bromide / tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h 4: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: vinylmagnesium bromide / tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h 4: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h 5: Et3N / toluene / 1 h / -5 °C View Scheme | |
Multi-step reaction with 5 steps 1: vinylmagnesium bromide / tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h 4: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h 5: Et3N / toluene / 1 h / -5 °C View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h 4: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h 5: Et3N / toluene / 1 h / -5 °C 6: 1) BuLi / 1) THF, hexane, -75 to 10 deg C, 1 h, 2) toluene, 20 deg C, 2 h View Scheme | |
Multi-step reaction with 6 steps 1: vinylmagnesium bromide / tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h 4: 1) lithium hexamethyldisilazide / 1) THF, 2) toluene, 0 deg C, 1 h 5: Et3N / toluene / 1 h / -5 °C 6: 1) BuLi / 1) THF, hexane, -75 to 10 deg C, 1 h, 2) toluene, 20 deg C, 2 h View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
-2-<3-<3-<2-(7-chloro-2-quinolinyl)ethenyl>phenyl>-3-hydroxypropyl>benzoic acid methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h View Scheme | |
Multi-step reaction with 3 steps 1: vinylmagnesium bromide / tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (+)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h View Scheme | |
Multi-step reaction with 3 steps 1: vinylmagnesium bromide / tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (+)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
trans-3-<2-(7-chloro-2-quinolinyl)cyclopropyl>benzaldehyde
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 98 percent / toluene / Heating 2: 1.) n-BuLi / 1.) THF, from -10 deg C to 21 deg C, 2 h, 2.) THF, 0 deg C, overnight 3: 97 percent / tetrahydrofuran; acetic acid; H2O / 2 h / Heating View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
trans-2-<3-<2-(7-chloro-2-quinolinyl)cyclopropyl>phenyl>-1,3-dioxolane
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 98 percent / toluene / Heating 2: 1.) n-BuLi / 1.) THF, from -10 deg C to 21 deg C, 2 h, 2.) THF, 0 deg C, overnight View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
trans-5-<3-<2-(7-chloro-2-quinolinyl)cyclopropyl>phenyl>-4,6-dithianonanedioic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 98 percent / toluene / Heating 2: 1.) n-BuLi / 1.) THF, from -10 deg C to 21 deg C, 2 h, 2.) THF, 0 deg C, overnight 3: 97 percent / tetrahydrofuran; acetic acid; H2O / 2 h / Heating 4: 71 percent / p-TsOH / toluene / 4.5 h / Heating View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
(E)-5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 49 percent / BF3*Et2O / CHCl3 / 2 h / -8 - 2 °C 2: 88 percent / 1.00 N aq. LiOH / tetrahydrofuran / 4.5 h / -3 - 2 °C View Scheme | |
Multi-step reaction with 3 steps 1: imidazole / CH2Cl2 / 24 h / 12 - 14 °C 2: 61 percent / BF3*Et2O / CH2Cl2 / 16 h / -50 °C 3: 88 percent / 1.00 N aq. LiOH / tetrahydrofuran / 4.5 h / -3 - 2 °C View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
(+)-methyl 5-(3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: imidazole / CH2Cl2 / 24 h / 12 - 14 °C 2: 61 percent / BF3*Et2O / CH2Cl2 / 16 h / -50 °C View Scheme |
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
3-[{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-N,N-dimethyl-propionamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: imidazole / CH2Cl2 / 24 h / 12 - 14 °C 2: BF3*Et2O / CH2Cl2 / 16 h / -50 °C View Scheme |
(2S,3S)-3-mercapto-2-methylbutanoic acid
(E)-3-[2-(7-chloro-2-quinolinyl)ethenyl]benzaldehyde
(2S,3S,2'S,3'S)-3,3'-[({3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]phenyl}methylene)bis(thio)]bis(2-methylbutanoic acid)
Conditions | Yield |
---|---|
With trifluoroacetic acid at 20℃; for 0.25h; |
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