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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1g/foil bag Application:medicine raw material Transportation:by courie

Manufacturer high quality Larotrectinib Cas 1223403-58-4 with good price

Cas:1223403-58-4

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Larotrectinib CAS No.:1223403-58-4 Name: Larotrectinib Synonyms: (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide; ARRY 470; LOXO 101

High purity Larotrectinib CAS No.:1223403-58-4

Cas:1223403-58-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Hubei DiBo chemical co., LTD

Products Name Larotrectinib LOXO 101 CAS No. 1223403-58-4 Molecular Formula: C21H22F2N6O2 Synonyms ARRY-470; Larotrectinib Molecular Weight : 428.4351864 Packaging Specification: 25kg/drum Hubei DiBo Chemical Co., Ltd. was foun

Larotrectinib LOXO 101/Cas:1223403-58-4 /99% High purity

Cas:1223403-58-4

Min.Order:1 Metric Ton

FOB Price: $3.0 / 5.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Loxo-101 Larotrectinib CAS 1223403-58-4

Cas:1223403-58-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1223403-58-4 with competitive price

Cas:1223403-58-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

LOXO-101

Cas:1223403-58-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

Loxo-101

Cas:1223403-58-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

LOXO-101/ LIDE PHARMA- Factory supply / Best price

Cas:1223403-58-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

LOXO-101 Chemical Properties density 1.55±0.1 g/cm3(Predicted) storage temp. RT solubility Soluble in DMSO (up to 5 mg/ml). form solid pka 8.41±0.40(Predicted) color Yellow Stability: Stable for 1 year from dat

LOXO-101

Cas:1223403-58-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

LOXO-101 CAS:1223403-58-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

LOXO-101 CAS:1223403-58-4

Cas:1223403-58-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

LOXO-101 Larotrectinib

Cas:1223403-58-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:1223403-58-4

Cas:1223403-58-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

LOXO-101 Larotrectinib 1223403-58-4

Cas:1223403-58-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

LOXO-101

Cas:1223403-58-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Larotrectinib CAS No.:1223403-58-4

Cas:1223403-58-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

LOXO-101

Cas:1223403-58-4

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

LOXO-101

Cas:1223403-58-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

LOXO-101 (ARRY-470)

Cas:1223403-58-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: LOXO-101(CAS:1223403-58-4) CAS No.:1223403-58-4 Molecule Formula:C21H22F2N6O2 Molecule Weight:428.44 Purity: 98.0% Package: 25kg/drum Description:Yellow powder Manufacture Standards:Enterprise Standard

High Quality LOXO-101(CAS:1223403-58-4)

Cas:1223403-58-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

LOXO-101

Cas:1223403-58-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

LOXO-101

Cas:1223403-58-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

LOXO-101

Cas:1223403-58-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

LOXO-101

Cas:1223403-58-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Nanjing Fred Technology Co.,Ltd.

LOXO-101 is one of the most competitive products in our company. We can supply it with good quality and best price. Appearance:powder Storage:RT Package:According to the demand of customer Application:API Port:shanghai

LOXO-101

Cas:1223403-58-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

LOXO-101

Cas:1223403-58-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

JINING XINHE CHEMICAL CO., LTD

Advantage 1: The product passed the professional production process and quality inspection, the purity is 99% +. 2: Highly qualified engineers to provide technical documents and service. 3: We could provide sample for your test. 4: High qualit

LOXO-101 1223403-58-4

Cas:1223403-58-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Larotrectinib Cas no.1223403-58-4 98%

Cas:1223403-58-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

LOXO-101

Cas:1223403-58-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api

Larotrectinib

Cas:1223403-58-4

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:to formulate preparations Transportation:by courier, air or sea Port:At any port fro

LOXO-101 cas no. 1223403-58-4 API

Cas:1223403-58-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-amine
1223404-88-3

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-amine

3-hydroxypyrrolidine
100243-39-8

3-hydroxypyrrolidine

1,1'-carbonyldiimidazole
530-62-1

1,1'-carbonyldiimidazole

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Stage #1: 5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine; 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 2h;
Stage #2: 3-hydroxypyrrolidine In dichloromethane for 0.0833333h;
91%
phenyl (5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3,3a-dihydropyrazolo[1,5-a]pyrimidin-3-yl)carbamate

phenyl (5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3,3a-dihydropyrazolo[1,5-a]pyrimidin-3-yl)carbamate

3-hydroxypyrrolidine
100243-39-8

3-hydroxypyrrolidine

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 75℃; for 6h;91%
(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine
1218935-59-1

(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine

(S)-N-(5-chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-chloropyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethanol at 30℃;85%
3-nitro-5-chloropyrazole[1,5-a]pyrimidine

3-nitro-5-chloropyrazole[1,5-a]pyrimidine

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ammonium chloride; iron / ethanol; water / Inert atmosphere; Reflux
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 10 °C
3: ethanol / 25 °C
4: N-ethyl-N,N-diisopropylamine / ethanol / 30 °C
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / tetrahydrofuran / 5 h / 50 °C
2: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 °C
4: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
5-chloropyrazolo[1,5-a]pyrimidin-3-amine

5-chloropyrazolo[1,5-a]pyrimidin-3-amine

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 10 °C
2: ethanol / 25 °C
3: N-ethyl-N,N-diisopropylamine / ethanol / 30 °C
View Scheme
(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine
1218935-59-1

(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / tetrahydrofuran / 5 h / 50 °C
2: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
3: triethylamine / tetrahydrofuran / 1 h / 0 °C
4: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
C15H21F2NO3

C15H21F2NO3

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine; p-toluenesulfonyl chloride / tetrahydrofuran / 12 h / 35 °C
1.2: 1 h
2.1: triethylamine / tetrahydrofuran / 5 h / 50 °C
3.1: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
5.1: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
4H,5H-pyrazolo[1,5-a]pyrimidine-5-one
29274-22-4

4H,5H-pyrazolo[1,5-a]pyrimidine-5-one

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: phosphorus trichloride / 6 h / 80 °C
2: nitric acid; sulfuric acid / 2 h / 0 - 5 °C
3: triethylamine / tetrahydrofuran / 5 h / 50 °C
4: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
5: triethylamine / tetrahydrofuran / 1 h / 0 °C
6: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
5-chloropyrazolo[1,5-a]pyrimidine
29274-24-6

5-chloropyrazolo[1,5-a]pyrimidine

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: nitric acid; sulfuric acid / 2 h / 0 - 5 °C
2: triethylamine / tetrahydrofuran / 5 h / 50 °C
3: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
4: triethylamine / tetrahydrofuran / 1 h / 0 °C
5: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine
1223404-90-7

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
2: triethylamine / tetrahydrofuran / 1 h / 0 °C
3: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-amine
1223404-88-3

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-amine

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 1 h / 0 °C
2: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
(2,5-difluorophenyl)magnesium bromide
899819-34-2

(2,5-difluorophenyl)magnesium bromide

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 8 h / 0 - 10 °C
2.1: C25H30ClN2O2RuS; sodium formate / water; isopropyl alcohol / 12 h / 20 °C / Inert atmosphere
3.1: triethylamine; p-toluenesulfonyl chloride / tetrahydrofuran / 12 h / 35 °C
3.2: 1 h
4.1: triethylamine / tetrahydrofuran / 5 h / 50 °C
5.1: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
6.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
7.1: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
Multi-step reaction with 8 steps
1: tetrahydrofuran / 8 h / 0 - 10 °C
2: hydrogenchloride / tetrahydrofuran; water / 2 h / 50 °C
3: sodium formate; C25H30N2O2RuS(1+)*C32H12BF24(1-) / water; isopropyl alcohol / 12 h / 20 °C
4: hydrogenchloride / tetrahydrofuran; water / 2 h
5: triethylamine / tetrahydrofuran / 5 h / 50 °C
6: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
7: triethylamine / tetrahydrofuran / 1 h / 0 °C
8: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
(4-(2,5-difluorophenyl)-4-oxobutyl)carbamic acid tert-butyl ester

(4-(2,5-difluorophenyl)-4-oxobutyl)carbamic acid tert-butyl ester

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: C25H30ClN2O2RuS; sodium formate / water; isopropyl alcohol / 12 h / 20 °C / Inert atmosphere
2.1: triethylamine; p-toluenesulfonyl chloride / tetrahydrofuran / 12 h / 35 °C
2.2: 1 h
3.1: triethylamine / tetrahydrofuran / 5 h / 50 °C
4.1: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
5.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
6.1: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
Multi-step reaction with 7 steps
1: hydrogenchloride / tetrahydrofuran; water / 2 h / 50 °C
2: sodium formate; C25H30N2O2RuS(1+)*C32H12BF24(1-) / water; isopropyl alcohol / 12 h / 20 °C
3: hydrogenchloride / tetrahydrofuran; water / 2 h
4: triethylamine / tetrahydrofuran / 5 h / 50 °C
5: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
6: triethylamine / tetrahydrofuran / 1 h / 0 °C
7: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole
1443623-92-4

2-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium formate; C25H30N2O2RuS(1+)*C32H12BF24(1-) / water; isopropyl alcohol / 12 h / 20 °C
2: hydrogenchloride / tetrahydrofuran; water / 2 h
3: triethylamine / tetrahydrofuran / 5 h / 50 °C
4: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
5: triethylamine / tetrahydrofuran / 1 h / 0 °C
6: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate
1218935-58-0

(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / tetrahydrofuran; water / 2 h
2: triethylamine / tetrahydrofuran / 5 h / 50 °C
3: acetic acid; hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 2.5 h / 20 °C / 7600.51 Torr
4: triethylamine / tetrahydrofuran / 1 h / 0 °C
5: triethylamine / tetrahydrofuran / 6 h / 75 °C
View Scheme
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
1223405-08-0

(S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate

Conditions
ConditionsYield
With sulfuric acid In methanol at 20℃; for 0.5h; Solvent; Concentration; Temperature; Inert atmosphere;98.43%
With sulfuric acid In methanol at 20℃; for 0.5h;94%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogensulfate

(S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogensulfate

Conditions
ConditionsYield
With sulfuric acid In methanol at 20℃; for 0.5h; Solvent; Temperature; Time;98.43%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

C28H28F2N6O4S

C28H28F2N6O4S

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;94.6%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

methyl trifluoromethanesulfonate
333-27-7

methyl trifluoromethanesulfonate

C22H24F2N6O2

C22H24F2N6O2

Conditions
ConditionsYield
Stage #1: (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide With potassium tert-butylate In tetrahydrofuran for 0.0666667h; Inert atmosphere;
Stage #2: methyl trifluoromethanesulfonate In tetrahydrofuran at 60℃; for 2h; Inert atmosphere;
92.3%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

[1H]-methyl trifluoromethanesulfonate

[1H]-methyl trifluoromethanesulfonate

C22H23(3)HF2N6O2

C22H23(3)HF2N6O2

Conditions
ConditionsYield
Stage #1: (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide With potassium tert-butylate In tetrahydrofuran for 0.0666667h; Inert atmosphere;
Stage #2: [1H]-methyl trifluoromethanesulfonate In tetrahydrofuran at 60℃; Inert atmosphere;
92.3%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidine-1-yl)pyrazolo [1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrochloride

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidine-1-yl)pyrazolo [1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; tert-butyl methyl ether; water at 50℃;89%
With hydrogenchloride In ethanol; tert-butyl methyl ether at 50℃; for 4h; Inert atmosphere;89%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrobromide

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In ethanol; tert-butyl methyl ether; water at 50℃; Reflux;85%
With hydrogen bromide In ethanol; tert-butyl methyl ether; water at 50℃; Inert atmosphere;85%
2,2-difluoro-2-(fluorosulfonyl)acetic acid
1717-59-5

2,2-difluoro-2-(fluorosulfonyl)acetic acid

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

C22H22F4N6O2

C22H22F4N6O2

Conditions
ConditionsYield
With copper(l) iodide In acetonitrile at 50℃; for 1.25h; Inert atmosphere;82.3%
methanesulfonic acid
75-75-2

methanesulfonic acid

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide methanesulfonate

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide methanesulfonate

Conditions
ConditionsYield
In ethanol; tert-butyl methyl ether at 50℃; Reflux;78%
In ethyl acetate at 20 - 50℃; for 48h;
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide methanesulfonate

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide methanesulfonate

Conditions
ConditionsYield
With methanesulfonic acid In ethanol; tert-butyl methyl ether at 50℃; Inert atmosphere;78%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

2-fluoroethyl tosylate
383-50-6

2-fluoroethyl tosylate

C23H25F3N6O2

C23H25F3N6O2

Conditions
ConditionsYield
Stage #1: (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide With potassium carbonate In ethanol at 20℃; for 0.25h;
Stage #2: 2-fluoroethyl tosylate In ethanol at 70℃; for 18h;
46%
fluoromethyl-d2 4-methylbenzenesulfonate
1180485-67-9

fluoromethyl-d2 4-methylbenzenesulfonate

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

C22H21(2)H2F2(18)FN6O2

C22H21(2)H2F2(18)FN6O2

Conditions
ConditionsYield
Stage #1: (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide With potassium tert-butylate In acetonitrile at 20℃; for 0.25h; Inert atmosphere;
Stage #2: fluoromethyl-d2 4-methylbenzenesulfonate In acetonitrile at 20℃; for 2.91667h; Inert atmosphere;
Stage #3: With tetrabutyl ammonium fluoride In acetonitrile at 20℃; for 18h; Inert atmosphere;
29.2%
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-A]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidincarboxamide hydrochloride

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-A]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidincarboxamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 5 - 15℃; for 5h; Temperature;
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(1S,4R)-(+)-camphorsulfonic acid

(1S,4R)-(+)-camphorsulfonic acid

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Conditions
ConditionsYield
In ethanol; tert-butyl methyl ether Reflux;
(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide
1223403-58-4

(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidi n-3-yl]-3-hydroxypyrrolidine-1-carboxamide

(1S)-10-camphorsulfonic acid
3144-16-9

(1S)-10-camphorsulfonic acid

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate

Conditions
ConditionsYield
In ethanol; tert-butyl methyl ether Reflux; Inert atmosphere;

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