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Cas no. 1231929-97-7 Abemaciclib Abemaciclib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional t
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inquiryAbemaciclib CAS No.:1231929-97-7 Name: Abemaciclib Synonyms: N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyr
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inquiryName:LY2835219 The alias:Abemaciclib CAS NO:1231929-97-7 Molecular formula:C27H32F2N8 Molecular weight:506.59 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without
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Abemaciclib CAS: 1231929-97-7 Specification Items Specification Appearance White to pale yellow powder Assay ≥99% Molecular Formula
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inquiryN-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Stage #1: N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate With sulfuric acid; sodium methylate In methanol; N,N-dimethyl-formamide at 30 - 35℃; for 2h; Stage #2: 6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole at 80 - 85℃; for 7h; | 90.8% |
With sodium hydroxide In butan-1-ol at 90 - 100℃; Inert atmosphere; | 73.1% |
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene at 98 - 100℃; Inert atmosphere; | 82.85% |
4-ethylpiperazine
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
With formic acid; trimethyl orthoformate In acetonitrile at 80℃; for 16h; Reagent/catalyst; Leukardt-Wallach Amination; Sealed tube; | 74% |
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
With potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In tert-Amyl alcohol at 100℃; for 19h; | 57.3% |
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 2h; Product distribution / selectivity; Inert atmosphere; | |
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 2h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 22.11 g |
4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 80 °C / Inert atmosphere 1.2: 5.5 h / 80 °C / Inert atmosphere 2.1: palladium dichloride; potassium carbonate / tert-Amyl alcohol / 18 h / 100 °C / Inert atmosphere 3.1: trimethyl orthoformate; formic acid / acetonitrile / 16 h / 80 °C / Sealed tube View Scheme | |
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere 2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme |
N-isopropylacetamide
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine; trichlorophosphate / toluene / 3 h / Reflux 2: potassium tert-butylate; N-Methylformamide / 70 - 75 °C / Large scale 3: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere 4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere 5: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate; triethylamine / toluene / 10 °C / Reflux 2: potassium hydroxide / toluene; dimethyl sulfoxide / 30 °C / Reflux 3: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 98 - 100 °C / Inert atmosphere View Scheme |
N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: potassium tert-butylate; N-Methylformamide / 70 - 75 °C / Large scale 2: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere 3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere 4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme |
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere 2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere 3: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme |
4-ethylpiperazine
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 - 30 °C / Large scale 2: ammonia / methanol / 40 - 75 °C 3: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme |
6-bromonicotinaldehyde
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 - 30 °C / Large scale 2: ammonia / methanol / 40 - 75 °C 3: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme |
1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ammonia / methanol / 40 - 75 °C 2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme |
4-bromo-2,6-difluoroaniline
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine; trichlorophosphate / toluene / 3 h / Reflux 2: potassium tert-butylate; N-Methylformamide / 70 - 75 °C / Large scale 3: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere 4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere 5: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: trichlorophosphate; triethylamine / toluene / 10 °C / Reflux 2: potassium hydroxide / toluene; dimethyl sulfoxide / 30 °C / Reflux 3: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 98 - 100 °C / Inert atmosphere View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: phosphorus trichloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 105 °C / Inert atmosphere 2: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere 3: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere 4: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide / 140 - 150 °C / Inert atmosphere 2: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere 3: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C 4: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
2,6-difluoroaniline
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: trifluorormethanesulfonic acid / dichloromethane / 50 °C 2: phosphorus trichloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 105 °C / Inert atmosphere 3: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere 4: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere 5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: trifluorormethanesulfonic acid / dichloromethane / 50 °C 2: N,N-dimethyl-formamide / 140 - 150 °C / Inert atmosphere 3: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere 4: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C 5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere 2: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C 3: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C 2: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere 2: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere 3: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere 2: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: nitric acid / ethanol; water / 0 - 80 °C / Inert atmosphere 2: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
1-(4-amino-3,5-difluorophenyl)ethan-1-one
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: Selectfluor / methanol / 48 h 2: phosphorus trichloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 105 °C / Inert atmosphere 3: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere 4: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere 5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1: Selectfluor / methanol / 48 h 2: N,N-dimethyl-formamide / 140 - 150 °C / Inert atmosphere 3: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere 4: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C 5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium hydroxide / toluene; dimethyl sulfoxide / 30 °C / Reflux 2: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 98 - 100 °C / Inert atmosphere View Scheme |
3,5-difluoro-4-nitro-benzonitrile
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 - 65 °C / Autoclave 2.1: hydrogen / N,N-dimethyl-formamide / 9 h / 50 - 95 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere 3.1: tetrahydrofuran / 5 h / 30 - 35 °C 4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 95 - 100 °C 5.1: sulfuric acid; sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 30 - 35 °C 5.2: 7 h / 80 - 85 °C View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrogen / N,N-dimethyl-formamide / 9 h / 50 - 95 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere 2.1: tetrahydrofuran / 5 h / 30 - 35 °C 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 95 - 100 °C 4.1: sulfuric acid; sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 30 - 35 °C 4.2: 7 h / 80 - 85 °C View Scheme |
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: tetrahydrofuran / 5 h / 30 - 35 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 95 - 100 °C 3.1: sulfuric acid; sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 30 - 35 °C 3.2: 7 h / 80 - 85 °C View Scheme |
methanesulfonic acid
N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
Conditions | Yield |
---|---|
In methanol; dichloromethane for 1h; | |
In methanol; dichloromethane for 1h; | 20.4 g |
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