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Hangzhou Huarong Pharm Co., Ltd.

1. DMF is available. Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, d

Abemaciclib

Cas:1231929-97-7

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

1231929-97-7/Abemaciclib

Cas:1231929-97-7

Min.Order:1 Gram

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Yangzhou Qinyuan Pharmatech Co.,Ltd

Cas no. 1231929-97-7 Abemaciclib Abemaciclib Intermediates Our products are high quality, good price, quick delivery time and we supply all customers best service in the long-term cooperation as below: 1.Established manufacturer. 2.Professional t

Abemaciclib

Cas:1231929-97-7

Min.Order:100 Gram

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Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceutica

LY2835219;Bemaciclib; Abemaciclib / LIDE PHARMA --Factory supply/ Best price

Cas:1231929-97-7

Min.Order:1 Gram

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Abemaciclib Cas 1231929-97-7 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to pale yellow powder Storage:N/A Package:10g,100g,1kg/foil bag Appl

High quality Abemaciclib Cas 1231929-97-7 with favorable price

Cas:1231929-97-7

Min.Order:10 Gram

FOB Price: $40.0 / 45.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

Abemaciclib CAS No.:1231929-97-7 Name: Abemaciclib Synonyms: N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyr

High purity Abemaciclib CAS No.:1231929-97-7

Cas:1231929-97-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

LY2835219

Cas:1231929-97-7

Min.Order:1 Kilogram

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Type:Manufacturers

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Abemaciclib

Cas:1231929-97-7

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:LY2835219 The alias:Abemaciclib CAS NO:1231929-97-7 Molecular formula:C27H32F2N8 Molecular weight:506.59 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without

LY2835219/CAS:1231929-97-7/Raw material supply

Cas:1231929-97-7

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Abemaciclib Powder CAS 1231929-97-7

Cas:1231929-97-7

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 1231929-97-7 with best quality

Cas:1231929-97-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High purity Abemaciclib CAS 1231929-97-7

Cas:1231929-97-7

Min.Order:10 Kilogram

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Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

LY2835219 1231929-97-7

Cas:1231929-97-7

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Abemaciclib CAS:1231929-97-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat

Abemaciclib CAS:1231929-97-7

Cas:1231929-97-7

Min.Order:1 Gram

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Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

LY2835219

Cas:1231929-97-7

Min.Order:1 Kilogram

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Lonwin Chemical Group Limited

Abemaciclib CAS: 1231929-97-7 Specification Items Specification Appearance White to pale yellow powder Assay ≥99% Molecular Formula

Factory supply Abemaciclib

Cas:1231929-97-7

Min.Order:1 Kilogram

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Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

LY2835219

Cas:1231929-97-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government 2. Specialized in the fine chemicals and pharmaceuticals 3. A leading manufacturer and trader of

Supply Abemaciclib high quality Hot sale 99.0% Abemaciclib price market

Cas:1231929-97-7

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Abemaciclib 1231929-97-7

Cas:1231929-97-7

Min.Order:1 Gram

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Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

LY2835219

Cas:1231929-97-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

Abemaciclib

Cas:1231929-97-7

Min.Order:0

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Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

high quality Abemaciclib

Cas:1231929-97-7

Min.Order:1 Gram

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

LY2835219

Cas:1231929-97-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat

LY 2835219 (free base)

Cas:1231929-97-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Abemaciclib

Cas:1231929-97-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

High purity Abemaciclib CAS 1231929-97-7

Cas:1231929-97-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: Bamaciclib CAS No.:1231929-97-7 Molecule Formula:C27H32F2N8 Molecule Weight:506.59 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SP

Best Quality Bamaciclib with good supplier

Cas:1231929-97-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Abemaciclib, >=98%

Cas:1231929-97-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate

N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Stage #1: N-[5-(4-ethylpiperazine-1-yl-methyl)pyridine-2-yl]guanidine nitrate With sulfuric acid; sodium methylate In methanol; N,N-dimethyl-formamide at 30 - 35℃; for 2h;
Stage #2: 6-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole at 80 - 85℃; for 7h;
90.8%
With sodium hydroxide In butan-1-ol at 90 - 100℃; Inert atmosphere;73.1%
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
1180132-17-5

5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine

6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-33-8

6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene at 98 - 100℃; Inert atmosphere;82.85%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
With formic acid; trimethyl orthoformate In acetonitrile at 80℃; for 16h; Reagent/catalyst; Leukardt-Wallach Amination; Sealed tube;74%
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
1180132-17-5

5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-42-9

6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
With potassium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; bis(dibenzylideneacetone)-palladium(0) In tert-Amyl alcohol at 100℃; for 19h;57.3%
With caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 2h; Product distribution / selectivity; Inert atmosphere;
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; for 2h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;22.11 g
4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole
1231930-37-2

4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-benzo[d]imidazole

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane / 80 °C / Inert atmosphere
1.2: 5.5 h / 80 °C / Inert atmosphere
2.1: palladium dichloride; potassium carbonate / tert-Amyl alcohol / 18 h / 100 °C / Inert atmosphere
3.1: trimethyl orthoformate; formic acid / acetonitrile / 16 h / 80 °C / Sealed tube
View Scheme
Multi-step reaction with 2 steps
1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere
2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
N-isopropylacetamide
1118-69-0

N-isopropylacetamide

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine; trichlorophosphate / toluene / 3 h / Reflux
2: potassium tert-butylate; N-Methylformamide / 70 - 75 °C / Large scale
3: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere
4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere
5: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate; triethylamine / toluene / 10 °C / Reflux
2: potassium hydroxide / toluene; dimethyl sulfoxide / 30 °C / Reflux
3: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 98 - 100 °C / Inert atmosphere
View Scheme
N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine
1231930-29-2

N-(4-bromo-2,6-difluorophenyl)-N'-isopropylacetamidine

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium tert-butylate; N-Methylformamide / 70 - 75 °C / Large scale
2: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere
3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere
4: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
1231930-33-8

6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere
2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere
3: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 - 30 °C / Large scale
2: ammonia / methanol / 40 - 75 °C
3: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
6-bromonicotinaldehyde
149806-06-4

6-bromonicotinaldehyde

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tris(acetoxy)borohydride / dichloromethane / 12 h / 20 - 30 °C / Large scale
2: ammonia / methanol / 40 - 75 °C
3: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine
1231930-25-8

1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ammonia / methanol / 40 - 75 °C
2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
4-bromo-2,6-difluoroaniline
67567-26-4

4-bromo-2,6-difluoroaniline

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine; trichlorophosphate / toluene / 3 h / Reflux
2: potassium tert-butylate; N-Methylformamide / 70 - 75 °C / Large scale
3: tricyclohexylphosphine; potassium acetate; palladium diacetate / dimethyl sulfoxide / 1 h / 90 °C / Inert atmosphere
4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; 1,2-dimethoxyethane / 1 h / 80 - 84 °C / Inert atmosphere
5: caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: trichlorophosphate; triethylamine / toluene / 10 °C / Reflux
2: potassium hydroxide / toluene; dimethyl sulfoxide / 30 °C / Reflux
3: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 98 - 100 °C / Inert atmosphere
View Scheme
1-(4-amino-3,5-difluorophenyl)-2-fluoroethanone

1-(4-amino-3,5-difluorophenyl)-2-fluoroethanone

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: phosphorus trichloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 105 °C / Inert atmosphere
2: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere
3: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere
4: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: N,N-dimethyl-formamide / 140 - 150 °C / Inert atmosphere
2: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere
3: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C
4: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
2,6-difluoroaniline
5509-65-9

2,6-difluoroaniline

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: trifluorormethanesulfonic acid / dichloromethane / 50 °C
2: phosphorus trichloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 105 °C / Inert atmosphere
3: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere
4: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere
5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: trifluorormethanesulfonic acid / dichloromethane / 50 °C
2: N,N-dimethyl-formamide / 140 - 150 °C / Inert atmosphere
3: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere
4: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C
5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
1-(4-amino-2,6-difluorophenyl)-3-N,N-dimethylammonium-2-fluoro-2-acrylketone

1-(4-amino-2,6-difluorophenyl)-3-N,N-dimethylammonium-2-fluoro-2-acrylketone

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere
2: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C
3: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
N-[2,6-difluoro-4-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)phenyl]-N’-isopropylethanamidine

N-[2,6-difluoro-4-(3-N,N-dimethylamino-2-fluoro-2-acrylketone-1-yl)phenyl]-N’-isopropylethanamidine

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C
2: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
N'-[2,6-difluoro-4-(2-fluoroethanone-1-yl)phenyl]-N-isopropylethanamidine

N'-[2,6-difluoro-4-(2-fluoroethanone-1-yl)phenyl]-N-isopropylethanamidine

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere
2: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere
3: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
6-(2-fluoroethanone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

6-(2-fluoroethanone-1-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzimidazole

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere
2: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine
1180132-17-5

5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nitric acid / ethanol; water / 0 - 80 °C / Inert atmosphere
2: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
1-(4-amino-3,5-difluorophenyl)ethan-1-one
811799-69-6

1-(4-amino-3,5-difluorophenyl)ethan-1-one

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: Selectfluor / methanol / 48 h
2: phosphorus trichloride; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 0 - 105 °C / Inert atmosphere
3: sodium hydride / toluene; mineral oil / 5 - 115 °C / Inert atmosphere
4: 5,5-dimethyl-1,3-cyclohexadiene / 120 - 130 °C / Inert atmosphere
5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1: Selectfluor / methanol / 48 h
2: N,N-dimethyl-formamide / 140 - 150 °C / Inert atmosphere
3: phosphorus trichloride; triethylamine / toluene / 0 - 115 °C / Inert atmosphere
4: potassium tert-butylate / N,N-dimethyl-formamide / 5 - 150 °C
5: sodium hydroxide / butan-1-ol / 90 - 100 °C / Inert atmosphere
View Scheme
N-(4-bromo-2,6-difluorophenyl)-N'-isopropylethanimidamide

N-(4-bromo-2,6-difluorophenyl)-N'-isopropylethanimidamide

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide / toluene; dimethyl sulfoxide / 30 °C / Reflux
2: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate / 98 - 100 °C / Inert atmosphere
View Scheme
3,5-difluoro-4-nitro-benzonitrile
1123172-88-2

3,5-difluoro-4-nitro-benzonitrile

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 - 65 °C / Autoclave
2.1: hydrogen / N,N-dimethyl-formamide / 9 h / 50 - 95 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere
3.1: tetrahydrofuran / 5 h / 30 - 35 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 95 - 100 °C
5.1: sulfuric acid; sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 30 - 35 °C
5.2: 7 h / 80 - 85 °C
View Scheme
3-fluoro-4-nitro-5-isopropylaminobenzonitrile

3-fluoro-4-nitro-5-isopropylaminobenzonitrile

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogen / N,N-dimethyl-formamide / 9 h / 50 - 95 °C / 2250.23 - 3000.3 Torr / Autoclave; Inert atmosphere
2.1: tetrahydrofuran / 5 h / 30 - 35 °C
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 95 - 100 °C
4.1: sulfuric acid; sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 30 - 35 °C
4.2: 7 h / 80 - 85 °C
View Scheme
1-isopropyl-2-methyl-4-fluoro-6-cyano-1H-benzimidazole

1-isopropyl-2-methyl-4-fluoro-6-cyano-1H-benzimidazole

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 5 h / 30 - 35 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 6 h / 95 - 100 °C
3.1: sulfuric acid; sodium methylate / N,N-dimethyl-formamide; methanol / 2 h / 30 - 35 °C
3.2: 7 h / 80 - 85 °C
View Scheme
methanesulfonic acid
75-75-2

methanesulfonic acid

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine
1231929-97-7

N-(5-((4-ethyl-1-piperazinyl)methyl)-2-pyridinyl)-5-fluoro-4-(4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl)-2-pyrimidinamine

[5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)pyrimidin-2-yl]amine methanesulfonate

[5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)pyrimidin-2-yl]amine methanesulfonate

Conditions
ConditionsYield
In methanol; dichloromethane for 1h;
In methanol; dichloromethane for 1h;20.4 g

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