Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:123654-26-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:123654-26-2
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inquiry4-Amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid, CAS No.:123654-26-2 Name: 4-Amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid Synonym
Cas:123654-26-2
Min.Order:1 Kilogram
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Type:Other
inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Cas:123654-26-2
Min.Order:1 Kilogram
FOB Price: $5.0 / 10.0
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:123654-26-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:123654-26-2
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:123654-26-2
Min.Order:1 Kilogram
FOB Price: $139.0 / 210.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:123654-26-2
Min.Order:10 Kilogram
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Type:Trading Company
inquiryAppearance:light brown powder Storage:R.T Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Any port in China
Cas:123654-26-2
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
Cas:123654-26-2
Min.Order:1 Kilogram
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inquiry1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ
Cas:123654-26-2
Min.Order:1 Gram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Superiority We can customize and synthesize products that other suppliers may not be able to provide. 1. best service, high quality and reasonable way for his produccts from many recent effective packing way.best s
Cas:123654-26-2
Min.Order:100 Kilogram
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Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present
Cas:123654-26-2
Min.Order:1 Gram
FOB Price: $123.0
Type:Trading Company
inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Pharmaceutical Transportation:Common products:Sea/Air/Courier Dangerous Chem:Sea/Air Port:
Cas:123654-26-2
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:123654-26-2
Min.Order:0 Metric Ton
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:123654-26-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:123654-26-2
Min.Order:4 Kilogram
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Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:123654-26-2
Min.Order:0
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inquiryWe are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov
Cas:123654-26-2
Min.Order:100 Gram
FOB Price: $100.0 / 2000.0
Type:Lab/Research institutions
inquiryTianfu Chemical, built in 2009, is a professional supplier for API materials in China. With 10 years development, we have bulit our own factory and lab to produce a certain of products. And we have established stable business relationship
Cas:123654-26-2
Min.Order:1 Kilogram
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inquiryProduct name: 4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid CAS No.:123654-26-2 Molecule Formula:C9H8ClNO3 Molecule Weight:213.61 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
Cas:123654-26-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:123654-26-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
Cas:123654-26-2
Min.Order:1 Milligram
Negotiable
Type:Trading Company
inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:123654-26-2
Min.Order:1 Kilogram
FOB Price: $18.0 / 20.0
Type:Trading Company
inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
Cas:123654-26-2
Min.Order:0
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Type:Trading Company
inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:123654-26-2
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & CommercialHisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, special chemicals and OLED
Cas:123654-26-2
Min.Order:0
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Type:Trading Company
inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:123654-26-2
Min.Order:1 Metric Ton
FOB Price: $7.0 / 8.0
Type:Trading Company
inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
Cas:123654-26-2
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water at 100℃; for 3h; | 97% |
Multi-step reaction with 2 steps 1: sulfuric acid / 8 h / 10 °C / Reflux 2: water; sodium hydroxide / methanol / 2 h / Reflux View Scheme |
4-acetamido-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid methyl ester
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol for 2h; Heating; | 90.3% |
With 1-methoxy-2-propanol; water; sodium hydroxide at 90℃; for 8h; | 89.8% |
With water; sodium hydroxide for 5h; Reagent/catalyst; | 89% |
Multi-step reaction with 3 steps 1: water; sodium hydroxide / methanol / 2.17 h / 25 - 55 °C 2: sulfuric acid / 8 h / 10 °C / Reflux 3: water; sodium hydroxide / methanol / 2 h / Reflux View Scheme |
methyl 4-acetamido-2-hydroxybenzoate
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: 95.5 percent / K2CO3, tetra-n-butylammonium chloride / acetonitrile / 22 h / Heating 2: 94.9 percent / N-methylpyrrolidone / 1.5 h / Heating 3: OsO4 / diethyl ether; H2O / 0.17 h / 20 - 25 °C 4: NaIO4 / diethyl ether; H2O / 12 h / 20 - 25 °C 5: NaBH4 / methanol / 2 h / 20 - 25 °C 6: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C 7: NCS / dimethylformamide / 3 h / 70 °C 8: 90.3 percent / 4N NaOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: sulfuryl dichloride / ethyl acetate / 2 h / -5 - 0 °C 2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C 3.1: potassium carbonate / N,N-dimethyl acetamide / 0.5 h / 20 °C 3.2: 5 h / 50 °C 4.1: zinc / N,N-dimethyl acetamide / 22 h / 20 - 50 °C / Inert atmosphere 4.2: 0.5 h / 70 °C / Inert atmosphere 5.1: sodium hydroxide; 1-methoxy-2-propanol; water / 8 h / 90 °C View Scheme |
methyl 2-allyloxy-4-acetylaminobenzoate
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 94.9 percent / N-methylpyrrolidone / 1.5 h / Heating 2: OsO4 / diethyl ether; H2O / 0.17 h / 20 - 25 °C 3: NaIO4 / diethyl ether; H2O / 12 h / 20 - 25 °C 4: NaBH4 / methanol / 2 h / 20 - 25 °C 5: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C 6: NCS / dimethylformamide / 3 h / 70 °C 7: 90.3 percent / 4N NaOH / methanol / 2 h / Heating View Scheme |
methyl 2-hydroxy-3-allyl-4-acetaminobenzoate
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: OsO4 / diethyl ether; H2O / 0.17 h / 20 - 25 °C 2: NaIO4 / diethyl ether; H2O / 12 h / 20 - 25 °C 3: NaBH4 / methanol / 2 h / 20 - 25 °C 4: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C 5: NCS / dimethylformamide / 3 h / 70 °C 6: 90.3 percent / 4N NaOH / methanol / 2 h / Heating View Scheme |
4-(acetylamino)-2-hydroxy-3-(2-oxoethyl)benzoic acid methyl ester
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: NaBH4 / methanol / 2 h / 20 - 25 °C 2: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C 3: NCS / dimethylformamide / 3 h / 70 °C 4: 90.3 percent / 4N NaOH / methanol / 2 h / Heating View Scheme |
methyl 4-acetylamino-2-hydroxy-3-(2-hydroxyethyl)benzoate
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C 2: NCS / dimethylformamide / 3 h / 70 °C 3: 90.3 percent / 4N NaOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: triphenylphosphine / tetrahydrofuran / 0.25 h / 25 - 30 °C 1.2: 1 h / 10 - 30 °C 2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.17 h / 25 - 75 °C 3.1: water; sodium hydroxide / methanol / 2.17 h / 25 - 55 °C 4.1: sulfuric acid / 8 h / 10 °C / Reflux 5.1: water; sodium hydroxide / methanol / 2 h / Reflux View Scheme |
methyl 4-acetylamino-2,3-dihydrobenzo[b]furan-7-carboxylate
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NCS / dimethylformamide / 3 h / 70 °C 2: 90.3 percent / 4N NaOH / methanol / 2 h / Heating View Scheme | |
Multi-step reaction with 4 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.17 h / 25 - 75 °C 2: water; sodium hydroxide / methanol / 2.17 h / 25 - 55 °C 3: sulfuric acid / 8 h / 10 °C / Reflux 4: water; sodium hydroxide / methanol / 2 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 65 °C 2: water; sodium hydroxide / 5 h View Scheme |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: NaIO4 / diethyl ether; H2O / 12 h / 20 - 25 °C 2: NaBH4 / methanol / 2 h / 20 - 25 °C 3: 86.7 percent / diethyl azodicarboxylate, Ph3P / tetrahydrofuran / 1 h / 20 - 25 °C 4: NCS / dimethylformamide / 3 h / 70 °C 5: 90.3 percent / 4N NaOH / methanol / 2 h / Heating View Scheme |
carbon dioxide
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With n-butyllithium In tetrahydrofuran; hexane; water | 1.1 parts (32.2%) |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide In methanol for 2h; Reflux; |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / N,N-dimethyl acetamide / 0.5 h / 20 °C 1.2: 5 h / 50 °C 2.1: zinc / N,N-dimethyl acetamide / 22 h / 20 - 50 °C / Inert atmosphere 2.2: 0.5 h / 70 °C / Inert atmosphere 3.1: sodium hydroxide; 1-methoxy-2-propanol; water / 8 h / 90 °C View Scheme |
methyl 4-aminosalicylate
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: acetic acid / 1 h / 40 °C 2.1: sulfuryl dichloride / ethyl acetate / 2 h / -5 - 0 °C 3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C 4.1: potassium carbonate / N,N-dimethyl acetamide / 0.5 h / 20 °C 4.2: 5 h / 50 °C 5.1: zinc / N,N-dimethyl acetamide / 22 h / 20 - 50 °C / Inert atmosphere 5.2: 0.5 h / 70 °C / Inert atmosphere 6.1: sodium hydroxide; 1-methoxy-2-propanol; water / 8 h / 90 °C View Scheme |
4-Aminosalicylic acid
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: sulfuric acid / 6 h / 0 - 80 °C 2.1: acetic acid / 1 h / 40 °C 3.1: sulfuryl dichloride / ethyl acetate / 2 h / -5 - 0 °C 4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C 5.1: potassium carbonate / N,N-dimethyl acetamide / 0.5 h / 20 °C 5.2: 5 h / 50 °C 6.1: zinc / N,N-dimethyl acetamide / 22 h / 20 - 50 °C / Inert atmosphere 6.2: 0.5 h / 70 °C / Inert atmosphere 7.1: sodium hydroxide; 1-methoxy-2-propanol; water / 8 h / 90 °C View Scheme |
methyl 4-acetylamino-5-chloro-2-hydroxybenzoate
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C 2.1: potassium carbonate / N,N-dimethyl acetamide / 0.5 h / 20 °C 2.2: 5 h / 50 °C 3.1: zinc / N,N-dimethyl acetamide / 22 h / 20 - 50 °C / Inert atmosphere 3.2: 0.5 h / 70 °C / Inert atmosphere 4.1: sodium hydroxide; 1-methoxy-2-propanol; water / 8 h / 90 °C View Scheme |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
In thionyl chloride; chloroform; toluene | 100% |
4-amino-1-(3-methoxypropyl)piperidine
succinic acid
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 1.5h; Stage #2: 4-amino-1-(3-methoxypropyl)piperidine In tetrahydrofuran at 45℃; for 4h; Stage #3: succinic acid In ethanol at 20℃; for 2h; Solvent; Reagent/catalyst; Temperature; | 94% |
methanol
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 20℃; for 2h; Reflux; | 92.9% |
With thionyl chloride at 0℃; Reflux; | 92.9% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 70℃; for 2.5h; Stage #2: With ammonium hydroxide In N,N-dimethyl-formamide at 20 - 70℃; for 20h; | 86% |
4-amino-1-(3-methoxypropyl)piperidine
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
prucalopride
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.416667h; Stage #2: 4-amino-1-(3-methoxypropyl)piperidine In tetrahydrofuran at 45 - 50℃; for 4h; | 85% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 20℃; for 20h; | 61% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
4-amine-1-(3-fluoro)benzylpiperidine
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With triethylamine; isobutyl chloroformate In dichloromethane at 0℃; for 2h; Stage #2: 4-amine-1-(3-fluoro)benzylpiperidine In dichloromethane for 15h; | 58.1% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 4h; | 57% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
4-amino-1-[(4-fluorophenyl)methyl]piperidine
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With triethylamine; isobutyl chloroformate In dichloromethane at 0℃; for 2h; Stage #2: 4-amino-1-[(4-fluorophenyl)methyl]piperidine In dichloromethane for 15h; | 54% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 20h; | 52% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; | 52% |
2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With triethylamine; isobutyl chloroformate In dichloromethane at 0℃; for 1h; Stage #2: 2-(aminomethyl)morpholine-4-carboxylic acid tert-butyl ester In dichloromethane for 29.5h; | 51.9% |
1-(tetrahydro-2H-pyran-4-yl)piperidine-4-amine hydrochloride
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 20℃; for 20h; | 46% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 22h; | 39% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 16h; | 39% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 22h; | 37% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 36% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 12h; | 30% |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With triethylamine; isobutyl chloroformate In dichloromethane at 0℃; for 4h; Stage #2: (4-(3-methoxypropyl)morpholin-2-yl)methylamine hydrochloride In dichloromethane at 20℃; for 19h; | 25% |
1-piperidinoethanol
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) DMF, 40 deg C, 2 h; Multistep reaction; |
1-(2-aminoethyl)piperidine
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) THF, 40 deg C, 2 h; Multistep reaction; |
1-(3-aminopropyl)piperidine
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) THF, 40 deg C, 2 h; Multistep reaction; |
3-piperidinopropan-1-ol
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) DMF, 40 deg C, 2 h; Multistep reaction; |
1-(1-butyl-4-piperidinyl)methanamine
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) THF, 40 deg C, 2 h; Multistep reaction; |
(S)-3-aminoquinuclidine
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) THF, 40 deg C, 2 h; Multistep reaction; |
(R)-3-aminoquinuclinine
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) THF, 40 deg C, 2 h; Multistep reaction; |
N-butyl-4-hydroxymethyl-piperidine
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) DMF, 40 deg C, 2 h; Multistep reaction; |
4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid
(S)-quinuclidin-3-ol
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole 1.) THF, 40 deg C, 1 h, 2.) DMF, 40 deg C, 2 h; Multistep reaction; |
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