Company information: Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big custo
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists
Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------
Cas:131929-60-7
Min.Order:1 Gram
FOB Price: $100.0 / 500.0
Type:Trading Company
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
Cas:131929-60-7
Min.Order:1 Gram
Negotiable
Type:Manufacturers
inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:veterinary medicine raw
Cas:131929-60-7
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryXi’an Quanao Biotech Co., Ltd. with 18 years experience in plant extract filed. Product grade: Medicine, Health care product, Cosmetics, Food, Beverage, Feed. Hot selling market: Europe, North America, South America, Middle East, Asia Pacifi
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $39.0 / 49.0
Type:Manufacturers
inquiryhigh quality Appearance:white or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Spinosad CAS:131929-60-7 Synonyms Spinosyn A; 2-{(6-Deoxy-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy}-13-{{5-(dimethylamino)tetr ahydro-6-methyl-2H-pyran-2-yl}oxy}-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-t etradecahydr
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryDayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Lab/Research institutions
inquiryHebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car
Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:131929-60-7
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:131929-60-7
Min.Order:10 Kilogram
Negotiable
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $7.0 / 9.0
Type:Trading Company
inquiryProduct Name: Spinosyn D Synonyms: spinosad CAS: 131929-60-7 MF: C41H65NO10 MW: 731.956 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25
Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $20.0 / 40.0
Type:Trading Company
inquiryproduct Name: SPINOSAD Molecular Weight: 731.96 Density: 1.16 g/cm3 Boiling Point: 801.5 °C at 760 mmHg Melting Point: 84 C to 99.5 C Flash Point: 438.5 °C Refractive index: 1.54 Solubility: Water = 89.4 ppm (Spinosyn A) 0.495
Cas:131929-60-7
Min.Order:1 Kilogram
FOB Price: $10.0
Type:Lab/Research institutions
inquiryAbout us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.
SPINOSAD CAS:131929-60-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:131929-60-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:131929-60-7
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:131929-60-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers
Cas:131929-60-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Cas:131929-60-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryHangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting Spinosyn A cas: 131929-60-7, Please contact us by email freely. We are leading exporter in China. If you really need this cargo, ple
Cas:131929-60-7
Min.Order:1 Metric Ton
Negotiable
Type:Other
inquiryAppearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Sea/Air/Courie
Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments Pharmaceutical acti
Cas:131929-60-7
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:131929-60-7
Min.Order:100 Milligram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:131929-60-7
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:131929-60-7
Min.Order:10 Gram
FOB Price: $100.0
Type:Lab/Research institutions
inquirySPINOSAD Basic information Product Name: SPINOSAD Synonyms: SPINOSAD;(2r-(2r*,3as*,5ar*,5bs*,9s*,13s*(2r*,5s*,6r*),14r*,16as*,16br*))-ethyl;)oxy)-13-((5-dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-14-m;1h-as-indaceno(3,2-d)oxacyc
Cas:131929-60-7
Min.Order:1 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiry(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-9-ethyl-13-hydroxy-14-methyl-2-(((2R,3R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,3a,5b,6,9,10,11,12,13,14,16a,16b-dodecahydro-1H-as-indaceno[3,2-d][1]oxacyclododecine-7,15(2H,5aH)-dione
A
spinosyn A
Conditions | Yield |
---|---|
With silver trifluoromethanesulfonate In dichloromethane for 3h; Yield given. Yields of byproduct given; |
methyl 4-formylbutanoate
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 16 steps 1: (-)-(1S,2R)-N,N-dibutylnorephedrine / hexane; toluene / 72 h / 0 °C 2: 84 percent / 2,6-lutidine / CH2Cl2 / 2 h / Ambient temperature 3: 94 percent / DIBAL-H / CH2Cl2; toluene / 0.5 h / -78 °C 4: 1.) Bu2BOTf, Et3N / 1.) CH2Cl2, from 0 to 5 deg C, 20 min, 2.) CH2Cl2, from -78 to 0 deg C, 3 h 5: 1.41 g / DMAP / CH2Cl2 / 144 h / Ambient temperature 6: 30percent aq. H2O2, LiOH / H2O; tetrahydrofuran; dimethylformamide / 0 °C 7: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature 8: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 9: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 10: Jones reagent / acetone / 1.5 h / 0 °C 11: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 12: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 13: 63 percent / methanolic K2CO3 / 48 h / Heating 14: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 15: 91 percent / 49percent aq. HF / acetonitrile / 24 h 16: AgOTf3 / CH2Cl2 / 3 h View Scheme |
D-forosamine
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) diethyl azodicarboxylate, PPh3 / 1.) THF, -50 deg C, 10 min, 2.) THF, from -50 to 20 deg C, 3 h 2: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(S)-5-Hydroxy-heptanoic acid methyl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1: 84 percent / 2,6-lutidine / CH2Cl2 / 2 h / Ambient temperature 2: 94 percent / DIBAL-H / CH2Cl2; toluene / 0.5 h / -78 °C 3: 1.) Bu2BOTf, Et3N / 1.) CH2Cl2, from 0 to 5 deg C, 20 min, 2.) CH2Cl2, from -78 to 0 deg C, 3 h 4: 1.41 g / DMAP / CH2Cl2 / 144 h / Ambient temperature 5: 30percent aq. H2O2, LiOH / H2O; tetrahydrofuran; dimethylformamide / 0 °C 6: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature 7: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 8: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 9: Jones reagent / acetone / 1.5 h / 0 °C 10: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 11: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 12: 63 percent / methanolic K2CO3 / 48 h / Heating 13: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 14: 91 percent / 49percent aq. HF / acetonitrile / 24 h 15: AgOTf3 / CH2Cl2 / 3 h View Scheme |
13,14β-Dihydro A83543A aglycon 9α,17α-bis-O-(TBDMS) ether
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 19 steps 1: t-BuOOH, Triton B / methanol; H2O; tetrahydrofuran / 120 h / Ambient temperature 2: diethyl ether / 0 °C 3: 87 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 4: 85 percent / NaIO4 / tetrahydrofuran; H2O / Ambient temperature 5: 1.) KHMDS / 1.) THF, toluene, a) -78 deg C, 15 min, b) RT, 1.5 h, 2.) THF, toluene, from 0 to 20 deg C, 2 h 6: 1.) MCPBA, NaHCO3, 2.) TBAF, 3.) NaIO4 7: 90 percent / pyridine, DMAP 8: MeOH / 168 h / Heating 9: camphorsulfonic acid / CH2Cl2 / 24 h 10: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 11: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 12: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 13: Jones reagent / acetone / 1.5 h / 0 °C 14: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 15: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 16: 63 percent / methanolic K2CO3 / 48 h / Heating 17: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 18: 91 percent / 49percent aq. HF / acetonitrile / 24 h 19: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(S)-5-(tert-butyldimethylsiloxy)heptanal
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1: 1.) Bu2BOTf, Et3N / 1.) CH2Cl2, from 0 to 5 deg C, 20 min, 2.) CH2Cl2, from -78 to 0 deg C, 3 h 2: 1.41 g / DMAP / CH2Cl2 / 144 h / Ambient temperature 3: 30percent aq. H2O2, LiOH / H2O; tetrahydrofuran; dimethylformamide / 0 °C 4: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature 5: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 6: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 7: Jones reagent / acetone / 1.5 h / 0 °C 8: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 9: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 10: 63 percent / methanolic K2CO3 / 48 h / Heating 11: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 12: 91 percent / 49percent aq. HF / acetonitrile / 24 h 13: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(S)-5-(tert-Butyl-dimethyl-silanyloxy)-heptanoic acid methyl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1: 94 percent / DIBAL-H / CH2Cl2; toluene / 0.5 h / -78 °C 2: 1.) Bu2BOTf, Et3N / 1.) CH2Cl2, from 0 to 5 deg C, 20 min, 2.) CH2Cl2, from -78 to 0 deg C, 3 h 3: 1.41 g / DMAP / CH2Cl2 / 144 h / Ambient temperature 4: 30percent aq. H2O2, LiOH / H2O; tetrahydrofuran; dimethylformamide / 0 °C 5: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature 6: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 7: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 8: Jones reagent / acetone / 1.5 h / 0 °C 9: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 10: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 11: 63 percent / methanolic K2CO3 / 48 h / Heating 12: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 13: 91 percent / 49percent aq. HF / acetonitrile / 24 h 14: AgOTf3 / CH2Cl2 / 3 h View Scheme |
Formic acid 2-((3S,3aR,5aS,7R,8aR,8bS)-7-hydroxy-2-oxo-1,2,3,3a,5a,6,7,8,8a,8b-decahydro-as-indacen-3-yl)-ethyl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1: 90 percent / pyridine, DMAP 2: MeOH / 168 h / Heating 3: camphorsulfonic acid / CH2Cl2 / 24 h 4: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 5: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 6: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 7: Jones reagent / acetone / 1.5 h / 0 °C 8: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 9: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 10: 63 percent / methanolic K2CO3 / 48 h / Heating 11: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 12: 91 percent / 49percent aq. HF / acetonitrile / 24 h 13: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(2R,3aS,5aR,5bS,10aS,10bR)-2-(tert-Butyl-dimethyl-silanyloxy)-2,3,3a,5a,5b,6,7,9,9a,10,10a,10b-dodecahydro-1H-8-oxa-cyclopenta[a]fluoren-9-ol
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 15 steps 1: 1.) KHMDS / 1.) THF, toluene, a) -78 deg C, 15 min, b) RT, 1.5 h, 2.) THF, toluene, from 0 to 20 deg C, 2 h 2: 1.) MCPBA, NaHCO3, 2.) TBAF, 3.) NaIO4 3: 90 percent / pyridine, DMAP 4: MeOH / 168 h / Heating 5: camphorsulfonic acid / CH2Cl2 / 24 h 6: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 7: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 8: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 9: Jones reagent / acetone / 1.5 h / 0 °C 10: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 11: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 12: 63 percent / methanolic K2CO3 / 48 h / Heating 13: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 14: 91 percent / 49percent aq. HF / acetonitrile / 24 h 15: AgOTf3 / CH2Cl2 / 3 h View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: camphorsulfonic acid / CH2Cl2 / 24 h 2: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 3: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 4: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 5: Jones reagent / acetone / 1.5 h / 0 °C 6: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 7: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 8: 63 percent / methanolic K2CO3 / 48 h / Heating 9: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 10: 91 percent / 49percent aq. HF / acetonitrile / 24 h 11: AgOTf3 / CH2Cl2 / 3 h View Scheme |
2,2-Dimethyl-propionic acid (2R,3aS,5aR,6S,8aS,8bR)-6-(2-formyloxy-ethyl)-7-oxo-1,2,3,3a,5a,6,7,8,8a,8b-decahydro-as-indacen-2-yl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: MeOH / 168 h / Heating 2: camphorsulfonic acid / CH2Cl2 / 24 h 3: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 4: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 5: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 6: Jones reagent / acetone / 1.5 h / 0 °C 7: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 8: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 9: 63 percent / methanolic K2CO3 / 48 h / Heating 10: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 11: 91 percent / 49percent aq. HF / acetonitrile / 24 h 12: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(R)-3-[(2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2-methyl-nonanoyl]-4-isopropyl-oxazolidin-2-one
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 1.41 g / DMAP / CH2Cl2 / 144 h / Ambient temperature 2: 30percent aq. H2O2, LiOH / H2O; tetrahydrofuran; dimethylformamide / 0 °C 3: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature 4: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 5: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 6: Jones reagent / acetone / 1.5 h / 0 °C 7: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 8: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 9: 63 percent / methanolic K2CO3 / 48 h / Heating 10: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 11: 91 percent / 49percent aq. HF / acetonitrile / 24 h 12: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(S)-1-[(3S,3aR,5aS,7R,8aR,8bS)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(2-hydroxy-ethyl)-1,2,3,3a,5a,6,7,8,8a,8b-decahydro-as-indacen-2-yl]-2-methyl-nonane-1,2,7-triol
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 16 steps 1: 85 percent / NaIO4 / tetrahydrofuran; H2O / Ambient temperature 2: 1.) KHMDS / 1.) THF, toluene, a) -78 deg C, 15 min, b) RT, 1.5 h, 2.) THF, toluene, from 0 to 20 deg C, 2 h 3: 1.) MCPBA, NaHCO3, 2.) TBAF, 3.) NaIO4 4: 90 percent / pyridine, DMAP 5: MeOH / 168 h / Heating 6: camphorsulfonic acid / CH2Cl2 / 24 h 7: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 8: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 9: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 10: Jones reagent / acetone / 1.5 h / 0 °C 11: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 12: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 13: 63 percent / methanolic K2CO3 / 48 h / Heating 14: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 15: 91 percent / 49percent aq. HF / acetonitrile / 24 h 16: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoic acid
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature 2: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 3: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 4: Jones reagent / acetone / 1.5 h / 0 °C 5: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 6: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 7: 63 percent / methanolic K2CO3 / 48 h / Heating 8: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 9: 91 percent / 49percent aq. HF / acetonitrile / 24 h 10: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(2R,3S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl chloride
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 2: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 3: Jones reagent / acetone / 1.5 h / 0 °C 4: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 5: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 6: 63 percent / methanolic K2CO3 / 48 h / Heating 7: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 8: 91 percent / 49percent aq. HF / acetonitrile / 24 h 9: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(3S,3aR,5aS,7R,8aR,8bS)-7-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(tert-butyl-dimethyl-silanyloxy)-meth-(E)-ylidene]-1,2,3,3a,5a,6,7,8,8a,8b-decahydro-as-indacene
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 14 steps 1: 1.) MCPBA, NaHCO3, 2.) TBAF, 3.) NaIO4 2: 90 percent / pyridine, DMAP 3: MeOH / 168 h / Heating 4: camphorsulfonic acid / CH2Cl2 / 24 h 5: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 6: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 7: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 8: Jones reagent / acetone / 1.5 h / 0 °C 9: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 10: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 11: 63 percent / methanolic K2CO3 / 48 h / Heating 12: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 13: 91 percent / 49percent aq. HF / acetonitrile / 24 h 14: AgOTf3 / CH2Cl2 / 3 h View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 18 steps 1: diethyl ether / 0 °C 2: 87 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 3: 85 percent / NaIO4 / tetrahydrofuran; H2O / Ambient temperature 4: 1.) KHMDS / 1.) THF, toluene, a) -78 deg C, 15 min, b) RT, 1.5 h, 2.) THF, toluene, from 0 to 20 deg C, 2 h 5: 1.) MCPBA, NaHCO3, 2.) TBAF, 3.) NaIO4 6: 90 percent / pyridine, DMAP 7: MeOH / 168 h / Heating 8: camphorsulfonic acid / CH2Cl2 / 24 h 9: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 10: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 11: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 12: Jones reagent / acetone / 1.5 h / 0 °C 13: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 14: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 15: 63 percent / methanolic K2CO3 / 48 h / Heating 16: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 17: 91 percent / 49percent aq. HF / acetonitrile / 24 h 18: AgOTf3 / CH2Cl2 / 3 h View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 17 steps 1: 87 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature 2: 85 percent / NaIO4 / tetrahydrofuran; H2O / Ambient temperature 3: 1.) KHMDS / 1.) THF, toluene, a) -78 deg C, 15 min, b) RT, 1.5 h, 2.) THF, toluene, from 0 to 20 deg C, 2 h 4: 1.) MCPBA, NaHCO3, 2.) TBAF, 3.) NaIO4 5: 90 percent / pyridine, DMAP 6: MeOH / 168 h / Heating 7: camphorsulfonic acid / CH2Cl2 / 24 h 8: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 9: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 10: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 11: Jones reagent / acetone / 1.5 h / 0 °C 12: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 13: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 14: 63 percent / methanolic K2CO3 / 48 h / Heating 15: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 16: 91 percent / 49percent aq. HF / acetonitrile / 24 h 17: AgOTf3 / CH2Cl2 / 3 h View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1: 30percent aq. H2O2, LiOH / H2O; tetrahydrofuran; dimethylformamide / 0 °C 2: oxalyl chloride / dimethylformamide; hexane / 0.75 h / Ambient temperature 3: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 4: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 5: Jones reagent / acetone / 1.5 h / 0 °C 6: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 7: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 8: 63 percent / methanolic K2CO3 / 48 h / Heating 9: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 10: 91 percent / 49percent aq. HF / acetonitrile / 24 h 11: AgOTf3 / CH2Cl2 / 3 h View Scheme |
2,2-Dimethyl-propionic acid (2R,3aS,5aR,6S,8aS,8bR)-6-[2-(4-methoxy-benzyloxy)-ethyl]-7-trifluoromethanesulfonyloxy-1,2,3,3a,5a,6,8a,8b-octahydro-as-indacen-2-yl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 2: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 3: Jones reagent / acetone / 1.5 h / 0 °C 4: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 5: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 6: 63 percent / methanolic K2CO3 / 48 h / Heating 7: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 8: 91 percent / 49percent aq. HF / acetonitrile / 24 h 9: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(2R,3S,3aR,5aS,7R,8aR,8bS)-2-[(2R,3S,7S)-3-(tert-butyldiphenylsiloxy)-7-hydroxy-2-methylnonanoyl]-1,2,3,3a,5a,6,7,8,8a,8b-decahydro-7-hydroxy-as-indacene-3-acetic acid κ-lactone
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 2: 91 percent / 49percent aq. HF / acetonitrile / 24 h 3: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(3S,3aR,5aS,7R,8aR,8bS)-2-[(2R,3S,7S)-3-(tert-butyldiphenylsiloxy)-7-hydroxy-2-methylnonanoyl]-3,3a,5a,6,7,8,8a,8b-octahydro-7-hydroxy-as-indacene-3-acetic acid κ-lactone pivalate
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 63 percent / methanolic K2CO3 / 48 h / Heating 2: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 3: 91 percent / 49percent aq. HF / acetonitrile / 24 h 4: AgOTf3 / CH2Cl2 / 3 h View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 2: 63 percent / methanolic K2CO3 / 48 h / Heating 3: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 4: 91 percent / 49percent aq. HF / acetonitrile / 24 h 5: AgOTf3 / CH2Cl2 / 3 h View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: Jones reagent / acetone / 1.5 h / 0 °C 2: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 3: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 4: 63 percent / methanolic K2CO3 / 48 h / Heating 5: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 6: 91 percent / 49percent aq. HF / acetonitrile / 24 h 7: AgOTf3 / CH2Cl2 / 3 h View Scheme |
2,2-Dimethyl-propionic acid (2R,3aS,5aR,6S,8aS,8bR)-7-[(2R,3S,7S)-7-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl]-6-carboxymethyl-1,2,3,3a,5a,6,8a,8b-octahydro-as-indacen-2-yl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 2: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 3: 63 percent / methanolic K2CO3 / 48 h / Heating 4: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 5: 91 percent / 49percent aq. HF / acetonitrile / 24 h 6: AgOTf3 / CH2Cl2 / 3 h View Scheme |
(3S,3aR,5aS,7S,8aR,8bS)-2-[(2R,3S,7S)-3-(tert-butyldiphenylsiloxy)-7-hydroxy-2-methylnonanoyl]-7-[(6-deoxy-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-3,3a,5a,6,7,8,8a,8b-octahydro-as-indacene-3-acetic acid κ-lactone
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / 49percent aq. HF / acetonitrile / 24 h 2: AgOTf3 / CH2Cl2 / 3 h View Scheme |
2,2-Dimethyl-propionic acid (2R,3aS,5aR,6S,8aS,8bR)-7-[(2R,3S,7S)-7-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-nonanoyl]-6-[2-(4-methoxy-benzyloxy)-ethyl]-1,2,3,3a,5a,6,8a,8b-octahydro-as-indacen-2-yl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 2: Jones reagent / acetone / 1.5 h / 0 °C 3: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 4: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 5: 63 percent / methanolic K2CO3 / 48 h / Heating 6: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 7: 91 percent / 49percent aq. HF / acetonitrile / 24 h 8: AgOTf3 / CH2Cl2 / 3 h View Scheme |
2,2-Dimethyl-propionic acid (2R,3aS,5aR,6S,8aS,8bR)-6-[2-(4-methoxy-benzyloxy)-ethyl]-7-oxo-1,2,3,3a,5a,6,7,8,8a,8b-decahydro-as-indacen-2-yl ester
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 10 steps 1: 1.) KHMDS / 1.) toluene, THF, -78 deg C, 30 min, 2.) toluene, THF, from -78 deg C to RT, 4 h 2: 1.) Me3SnSnMe3, (Ph3P)4Pd, LiCl, 2.) Pd2(dba)3*CHCl3, (i-Pr)2NEt / 1.) THF, 60 deg C, 2 d, 2.) benzene, RT, 6 h 3: DDQ, phosphate buffer / CH2Cl2 / 2 h / 0 °C 4: Jones reagent / acetone / 1.5 h / 0 °C 5: aq. AcOH / tetrahydrofuran / 24 h / 0 - 20 °C 6: 2,4,6-trichlorobenzoyl chlorie, DMAP, Et3N / benzene 7: 63 percent / methanolic K2CO3 / 48 h / Heating 8: 85 percent / trityl perchlorate / toluene / 3.17 h / 0 - 20 °C 9: 91 percent / 49percent aq. HF / acetonitrile / 24 h 10: AgOTf3 / CH2Cl2 / 3 h View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1.1: Tetrabutylammoniumsalz der Diphenylphosphinsaeure; copper(I) thiophene-2-carboxylate; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere; Schlenk technique 2.1: tributylphosphine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 3.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C 4.1: manganese(IV) oxide / dichloromethane / 5 h / 20 °C 5.1: (2R,5R)-(+)-2-tert-butyl-3-methyl-5-benzyl-4-imidazolidinone; trifluoroacetic acid / water; acetonitrile / 72 h / -20 °C 6.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C 6.2: 2 h / -78 °C 6.3: 20 h / -78 - 20 °C 7.1: silver(I) triflimide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); N-iodo-succinimide / acetone; water / 5 h / -15 - 20 °C 8.1: palladium diacetate; tetraethylammonium chloride; trifuran-2-yl-phosphane / toluene / 6 h / 90 °C / 2280.15 Torr / Molecular sieve 9.1: pyridine; hydrogen fluoride / tetrahydrofuran / 0 - 20 °C 10.1: dichloromethane / 1 h / 20 °C / Molecular sieve 10.2: 24 h / -30 °C 11.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 5 h / 0 °C / pH 7 12.1: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); silver trifluoromethanesulfonate / chlorobenzene / 25 h / 20 - 50 °C / Molecular sieve View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 11 steps 1.1: tributylphosphine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / dichloromethane / 2 h / -78 °C 3.1: manganese(IV) oxide / dichloromethane / 5 h / 20 °C 4.1: (2R,5R)-(+)-2-tert-butyl-3-methyl-5-benzyl-4-imidazolidinone; trifluoroacetic acid / water; acetonitrile / 72 h / -20 °C 5.1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C 5.2: 2 h / -78 °C 5.3: 20 h / -78 - 20 °C 6.1: silver(I) triflimide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); N-iodo-succinimide / acetone; water / 5 h / -15 - 20 °C 7.1: palladium diacetate; tetraethylammonium chloride; trifuran-2-yl-phosphane / toluene / 6 h / 90 °C / 2280.15 Torr / Molecular sieve 8.1: pyridine; hydrogen fluoride / tetrahydrofuran / 0 - 20 °C 9.1: dichloromethane / 1 h / 20 °C / Molecular sieve 9.2: 24 h / -30 °C 10.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 5 h / 0 °C / pH 7 11.1: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); silver trifluoromethanesulfonate / chlorobenzene / 25 h / 20 - 50 °C / Molecular sieve View Scheme |
spinosyn A
Conditions | Yield |
---|---|
With N-Bromosuccinimide; sulfuric acid; water In dimethyl sulfoxide at 0℃; for 0.5h; | 97.1% |
spinosyn A
5,6-dihydrospinosyn A
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 48h; | 93% |
With palladium 10% on activated carbon; hydrogen In methanol at 20℃; for 48h; | 93% |
spinosyn A
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-9-ethyl-13-hydroxy-14-methyl-2-(((2R,3R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,3a,5b,6,9,10,11,12,13,14,16a,16b-dodecahydro-1H-as-indaceno[3,2-d][1]oxacyclododecine-7,15(2H,5aH)-dione
Conditions | Yield |
---|---|
With sulfuric acid In water at 80 - 90℃; for 24h; | 90% |
With sulfuric acid In water at 80℃; for 2h; Hydrolysis; | 89% |
With sulfuric acid | 89% |
With sulfuric acid In dichloromethane at 80℃; | |
With sulfuric acid at 80℃; |
spinosyn A
A
D-forosamine
B
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-9-ethyl-13-hydroxy-14-methyl-2-(((2R,3R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,3a,5b,6,9,10,11,12,13,14,16a,16b-dodecahydro-1H-as-indaceno[3,2-d][1]oxacyclododecine-7,15(2H,5aH)-dione
Conditions | Yield |
---|---|
With sulfuric acid; water at 80℃; for 2h; | A n/a B 89% |
spinosyn A
Conditions | Yield |
---|---|
With N-Bromosuccinimide; sulfuric acid In water; dimethyl sulfoxide at 0℃; for 0.166667h; | 86% |
spinosyn A
N-demethyl-spinosyn A
Conditions | Yield |
---|---|
With iodine; sodium acetate In methanol; water for 12h; Reflux; | 81% |
With iodine; sodium acetate In methanol; water for 12h; Reflux; | 81% |
spinosyn A
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 3h; | 78% |
spinosyn A
(1aR,1bR,3S,4aS,4bR,7R,8S,12S,15aS,15bR,15cS)-8-(((2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12-ethyl-7-methyl-3-(((2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,3,4,4a,7,8,9,10,11,12,15,15a,15b,15c-tetradecahydra-1aH-oxireno[2’,3':4,5]-as-indaceno[3,2-d][1] oxacyclododecine-6,14(1bH,4bH)-dione
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 2.5h; | 76% |
spinosyn A
4''-ketospinosyn A
Conditions | Yield |
---|---|
With pyridine; 1-chloromethyl-4-fluorotriethylenediamine tetrafluoroborate In acetonitrile at 0℃; for 1h; | 63% |
spinosyn A
Conditions | Yield |
---|---|
With sodium tetrahydroborate In ethanol for 1h; | 57% |
spinosyn A
Conditions | Yield |
---|---|
Stage #1: spinosyn A With mercury(II) trifluoroacetate In tetrahydrofuran; water at 23℃; for 0.5h; Stage #2: With sodium hydroxide; sodium tetrahydroborate Further stages.; | 30.4% |
spinosyn A
(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-9-ethyl-2,13-dihydroxy-14-methyl-3,3a,5b,6,9,10,11,12,13,14,16a,16b-dodecahydro-1H-as-indaceno[3,2-d][1]oxacyclododecine-7,15(2H,5aH)-dione
Conditions | Yield |
---|---|
With sulfuric acid In ethanol for 4.5h; Heating; Yield given; | |
Multi-step reaction with 2 steps 1: 89 percent / 1 N H2SO4 / H2O / 2 h / 80 °C 2: 66 percent / H2SO4 / methanol / 3 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: water; sulfuric acid / 2 h / 80 °C 2: water; sulfuric acid / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid 2: sulfuric acid / methanol / Reflux View Scheme |
spinosyn A
A
(1aR,1bR,3S,4aS,4bR,7R,8S,12S,15aS,15bR,15cS)-8-(((2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-12-ethyl-7-methyl-3-(((2R,3R,4R,5S,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,3,4,4a,7,8,9,10,11,12,15,15a,15b,15c-tetradecahydra-1aH-oxireno[2’,3':4,5]-as-indaceno[3,2-d][1] oxacyclododecine-6,14(1bH,4bH)-dione
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 23℃; | |
With 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 6h; | A 120 mg B 20 mg |
spinosyn A
(4''S)-4''-desdimethylamino-4''-hydroxyspinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 63 percent / pyridine; 1-chloromethyl-4-fluorotriethylenediamine tetrafluoroborate / acetonitrile / 1 h / 0 °C 2: 99 percent / Li(t-BuO)3AlH / diethyl ether; dioxane / 0.17 h / 0 °C View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 90 percent / aq. H2SO4 / H2O / 24 h / 80 - 90 °C 2: 36 percent / PPTS; BF3*OEt2 / 1,2-dichloro-ethane 3: 42 percent / aq. NH4OAc; Zn / tetrahydrofuran; methanol / 3.5 h / 20 °C View Scheme |
spinosyn A
C39H61NO10
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 63 percent / pyridine; 1-chloromethyl-4-fluorotriethylenediamine tetrafluoroborate / acetonitrile / 1 h / 0 °C 2: 99 percent / Li(t-BuO)3AlH / diethyl ether; dioxane / 0.17 h / 0 °C 3: 91 percent / pyridine; DIPEA / CH2Cl2 / 1 h / 0 °C 4: 39 percent / NaN3 / dimethylformamide / 1 h / 120 °C 5: SnCl2*2H2O / methanol / 20 h / 20 °C View Scheme |
spinosyn A
(4''R)-4''-desdimethylamino-4''-(azido)spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 63 percent / pyridine; 1-chloromethyl-4-fluorotriethylenediamine tetrafluoroborate / acetonitrile / 1 h / 0 °C 2: 99 percent / Li(t-BuO)3AlH / diethyl ether; dioxane / 0.17 h / 0 °C 3: 91 percent / pyridine; DIPEA / CH2Cl2 / 1 h / 0 °C 4: 39 percent / NaN3 / dimethylformamide / 1 h / 120 °C View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 63 percent / pyridine; 1-chloromethyl-4-fluorotriethylenediamine tetrafluoroborate / acetonitrile / 1 h / 0 °C 2: 99 percent / Li(t-BuO)3AlH / diethyl ether; dioxane / 0.17 h / 0 °C 3: 91 percent / pyridine; DIPEA / CH2Cl2 / 1 h / 0 °C 4: 39 percent / NaN3 / dimethylformamide / 1 h / 120 °C 5: SnCl2*2H2O / methanol / 20 h / 20 °C 6: 7.0 mg / acetonitrile / 2 h / Heating View Scheme |
spinosyn A
(4''S)-4''-desdimethylamino-4''-(methanesulfonyloxy)spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 63 percent / pyridine; 1-chloromethyl-4-fluorotriethylenediamine tetrafluoroborate / acetonitrile / 1 h / 0 °C 2: 99 percent / Li(t-BuO)3AlH / diethyl ether; dioxane / 0.17 h / 0 °C 3: 91 percent / pyridine; DIPEA / CH2Cl2 / 1 h / 0 °C View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / aq. H2SO4 / H2O / 24 h / 80 - 90 °C 2: 36 percent / PPTS; BF3*OEt2 / 1,2-dichloro-ethane View Scheme |
spinosyn A
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 86 percent / conc. H2SO4; NBS / dimethylsulfoxide; H2O / 0.17 h / 0 °C 2: 96 percent / NaH / tetrahydrofuran / 0.5 h View Scheme |
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View