Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Description Product website: http://www.finerchem.com Product Name 2-Chloro-3-amino-4-picoline CAS No. 133627-45-9 Appearan
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inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica
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inquiryAppearance & Physical State: off white crystals Density: 1.26 g/cm3 Melting Point: 61-64ºC Boiling Point: 283.3ºC at 760 mmHg Flash Point: 125.2ºC Refractive Inde
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inquiry3-Amino-2-chloro-4-methylpyridine CAS:133627-45-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryProduct Name: 3-Amino-2-chloro-4-methylpyridine Synonyms: 2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE;2-CHLORO-4-METHYLPYRIDIN-3-AMINE;2-CHLORO-3-AMINO-4-PICOLINE;2-CHLORO-3-AMINO-4-METHYLPYRIDINE;3-AMINO-2-CHLORO-4-METHYLPYRIDINE;3-AMINO-2-CHLORO-4-PIC
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inquiryProduct name: 2-Chloro-3-Amino-4-Methyl Pyridine CAS No.:133627-45-9 Molecule Formula:C6H7ClN2 Molecule Weight:142.59 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard
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inquiry2-chloro-3-nitro-4-methylpyridine
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With hydrogenchloride; tin(ll) chloride In diethyl ether for 0.333333h; Ambient temperature; | 98% |
Stage #1: 2-chloro-3-nitro-4-methylpyridine With iron; acetic acid at 70 - 80℃; Stage #2: With sodium carbonate In water pH=8.0 - 8.5; Product distribution / selectivity; | 90.79% |
Stage #1: 2-chloro-3-nitro-4-methylpyridine With hydrogenchloride In methanol; water at 65℃; Stage #2: With iron In methanol; water at 65℃; Product distribution / selectivity; | 90.1% |
2-chloro-4-methyl-3-pyridinecarboxamide
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With sodium hypobromide; bromine; sodium hydroxide In water at 65 - 75℃; for 4h; Hofmann Rearrangement; | 98% |
With bromine; sodium hydroxide In water at 0 - 20℃; for 2h; | 97% |
With bromine; sodium hydroxide In water; toluene at 0 - 60℃; | 96.9% |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Stage #1: 4-methylpiperidin-3-one With hydrogenchloride; dihydrogen peroxide In chloroform; water at 30 - 40℃; for 5h; Green chemistry; Stage #2: With ammonium hydroxide at 40 - 45℃; for 3h; Solvent; Reagent/catalyst; Green chemistry; | 93.3% |
3-amino-4-methylpyridine
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With hydrogenchloride; dihydrogen peroxide at 20℃; for 0.5h; | 89% |
With hydrogenchloride; chlorine In water at 20℃; for 0.416667h; | 84% |
Stage #1: 3-amino-4-methylpyridine With hydrogenchloride In water at 40℃; Cooling with ice; Stage #2: With dihydrogen peroxide for 2h; | 83.2% |
3-nitro-4-methylpyridine
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / H2 / 5 percent Pd/C / methanol / 5 h / 20 °C / 3750.3 Torr 2: 89 percent / conc. aq. HCl; 35 percent aq. H2O2 / 0.5 h / 20 °C View Scheme |
2-chloro-4-methylnicotinoylchloride
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: NH3(g) / toluene / below 30 deg C 2: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme |
ethyl 2-chloro-4-methyl-3-pyridinecarboxylate
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 90 percent / NaOH / methanol; H2O / 75 °C 2: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 3: NH3(g) / toluene / below 30 deg C 4: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme |
2-chloro-4-methyl-3-pyridinecarboxylic acid
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 2: NH3(g) / toluene / below 30 deg C 3: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme |
ethyl 2-chloro-2-cyano-3-methyl-5-oxopentanoate
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 17 percent / PCl3, HCl(g) / dimethylformamide / 1.) 85 deg C; 2.) 90 deg C 2: 90 percent / NaOH / methanol; H2O / 75 °C 3: SOCl2 / toluene / 1.) 70 deg C, 1 h; 2.) reflux, 4 h 4: NH3(g) / toluene / below 30 deg C 5: 93 percent / NaOH, Br2 / H2O / 1.) 5 deg C; 2.) 75 deg C, 90 min View Scheme |
2-chloro-3-nitro-4-methylpyridine
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With sodium hydroxide; acetic acid In hydrogenchloride; water |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: sulfuric acid / ethanol / 3.67 h / 20 - 50 °C 2.1: trichlorophosphate / 2 h / 35 °C / Reflux 3.1: sulfuric acid / 4 h / 50 - 105 °C 3.2: 1.5 h / 60 - 65 °C 3.3: pH 7 / Cooling with ice 4.1: sodium hypochlorite; sodium hydroxide / methanol; water / 4 h / 10 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: sulfuric acid / ethanol / 1.17 h / 25 - 50 °C 2.1: trichlorophosphate / 2.25 h / 35 °C / Reflux 2.2: 50 - 110 °C 3.1: sodium hydroxide; sodium hypochlorite / ethanol; water / 4.17 h / 10 - 60 °C View Scheme |
2-hydroxy-4-methylpyridine-3-carbonitrile
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trichlorophosphate / 2 h / 35 °C / Reflux 2.1: sulfuric acid / 4 h / 50 - 105 °C 2.2: 1.5 h / 60 - 65 °C 2.3: pH 7 / Cooling with ice 3.1: sodium hypochlorite; sodium hydroxide / methanol; water / 4 h / 10 - 60 °C View Scheme |
2-chloro-4-methyl-3-pyridinecarbonitrile
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: sulfuric acid / 4 h / 50 - 105 °C 1.2: 1.5 h / 60 - 65 °C 1.3: pH 7 / Cooling with ice 2.1: sodium hypochlorite; sodium hydroxide / methanol; water / 4 h / 10 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sulfuric acid / 1.25 h / 40 - 105 °C 1.2: 70 - 75 °C 2.1: sodium hydroxide; bromine / toluene; water / 0 - 60 °C View Scheme | |
Multi-step reaction with 2 steps 1: sulfuric acid / water / 8.25 h / 40 - 105 °C 2: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C View Scheme |
2-amino-4-methyl-3-nitropyridine
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium nitrite; sulfuric acid / water 2: trichlorophosphate / 110 °C 3: tin(II) chloride dihdyrate; hydrogenchloride / 55 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium nitrite; sulfuric acid / 4 h / 20 °C 2: trichlorophosphate / 4 h / 110 °C 3: tin(II) chloride dihdyrate; hydrogenchloride / 1 h / 50 °C View Scheme |
2-hydroxy-4-methyl-3-nitropyridine
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: trichlorophosphate / 110 °C 2: tin(II) chloride dihdyrate; hydrogenchloride / 55 °C View Scheme | |
Multi-step reaction with 2 steps 1: trichlorophosphate / 4 h / 110 °C 2: tin(II) chloride dihdyrate; hydrogenchloride / 1 h / 50 °C View Scheme |
2-(4-(dimethylamino)but-3-en-2-ylidene)malononitrile
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / 2 h / 50 - 55 °C 2.1: sulfuric acid / 1.25 h / 40 - 105 °C 2.2: 70 - 75 °C 3.1: sodium hydroxide; bromine / toluene; water / 0 - 60 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / toluene / 20 - 55 °C 2: sulfuric acid / water / 8.25 h / 40 - 105 °C 3: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C View Scheme |
isopropylidenemalonodinitrile
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethylamine; acetic anhydride / toluene / 2 h / 5 - 20 °C / Inert atmosphere 2.1: hydrogenchloride / 2 h / 50 - 55 °C 3.1: sulfuric acid / 1.25 h / 40 - 105 °C 3.2: 70 - 75 °C 4.1: sodium hydroxide; bromine / toluene; water / 0 - 60 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: acetic anhydride / toluene / 5 - 10 °C / Inert atmosphere 1.2: 2 h / 5 - 20 °C / Inert atmosphere 2.1: hydrogenchloride / toluene / 20 - 55 °C 3.1: sulfuric acid / water / 8.25 h / 40 - 105 °C 4.1: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C View Scheme |
picoline
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride; potassium bromide / 1 h / 20 °C / Inert atmosphere 1.2: 27 h / 120 °C / Inert atmosphere 2.1: copper(II) sulfate; ammonia / methanol / 8 h / 160 °C / 3800.26 Torr / Autoclave 3.1: hydrogenchloride / water / 40 °C / Cooling with ice 3.2: 2 h View Scheme |
3-methyltetrahydro-2-furanone
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 5 h / 40 - 45 °C / Green chemistry 1.2: 4 h / 20 - 25 °C / Green chemistry 1.3: 4 h / 30 - 35 °C / 1500.15 - 2250.23 Torr / Autoclave; Green chemistry 2.1: hydrogenchloride; dihydrogen peroxide / chloroform; water / 5 h / 30 - 40 °C / Green chemistry 2.2: 3 h / 40 - 45 °C / Green chemistry View Scheme |
3-Amino-2-chloro-4-methylpyridine
Nevirapine
Conditions | Yield |
---|---|
With sodium hydride In diethylene glycol dimethyl ether at 65 - 165℃; Flow reactor; Green chemistry; | 96% |
Multi-step reaction with 2 steps 1.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere 1.2: 2 h / 55 - 65 °C / Inert atmosphere 2.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C 1.2: 2 h / 60 °C 2.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry View Scheme |
3-Amino-2-chloro-4-methylpyridine
2-chloro-3-amino-4-methyl-6-bromopyridine
Conditions | Yield |
---|---|
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In dichloromethane at 0 - 20℃; for 1.66667h; Product distribution / selectivity; | 94% |
3-Amino-2-chloro-4-methylpyridine
N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide
Conditions | Yield |
---|---|
Stage #1: 3-Amino-2-chloro-4-methylpyridine With sodium hydride In diethylene glycol dimethyl ether at 20℃; for 0.5h; Stage #2: methyl 2-(cyclopropylamino)nicotinate In diethylene glycol dimethyl ether at 60℃; for 2h; Reagent/catalyst; | 94% |
2-Chloronicotinoyl chloride
3-Amino-2-chloro-4-methylpyridine
2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide
Conditions | Yield |
---|---|
In dichloromethane 1.) -78 deg C, 1 h, 2.) RT, 23 h; | 87% |
With pyridine In 1,4-dioxane; cyclohexane for 48h; Ambient temperature; | 65.5% |
With potassium carbonate In ethyl acetate at 75 - 80℃; for 14h; Product distribution / selectivity; |
ethyl 2-cyano-3,3-di(methylsulfanyl)acrylate
3-Amino-2-chloro-4-methylpyridine
(E)-ethyl 3-(2-chloro-4-methylpyridin-3-yl-amino)-2-cyano-3-methylthioacrylate
Conditions | Yield |
---|---|
With sodium hydride In tetrahydrofuran; N,N-dimethyl-formamide at 50℃; for 0.5h; microwave irradiation; | 85.2% |
With sodium hydride In N,N-dimethyl-formamide; toluene at 40 - 45℃; for 1h; | 73.5% |
3-Amino-2-chloro-4-methylpyridine
Cyclopropylamine
N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide
Conditions | Yield |
---|---|
In toluene at 125 - 130℃; under 775.743 Torr; for 21h; | 79.64% |
methanol
3-Amino-2-chloro-4-methylpyridine
2-methoxy-3-amino-4-methylpyridine
Conditions | Yield |
---|---|
With copper(l) iodide; sodium at 110℃; for 14h; Autoclave; | 78.7% |
With copper(l) iodide; sodium at 110℃; for 14h; Autoclave; | 78.7% |
3-Amino-2-chloro-4-methylpyridine
4,5-dichloro-1,2,3-dithiazolium chloride
(Z)-2-chloro-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)-4-methylpyridin-3-amine
Conditions | Yield |
---|---|
Stage #1: 3-Amino-2-chloro-4-methylpyridine; 4,5-dichloro-1,2,3-dithiazolium chloride In dichloromethane at 20℃; for 1h; Stage #2: With 2,6-dimethylpyridine In dichloromethane at 20℃; for 2h; | 60% |
Stage #1: 3-Amino-2-chloro-4-methylpyridine; 4,5-dichloro-1,2,3-dithiazolium chloride In dichloromethane for 1h; Stage #2: With pyridine for 2h; | 42% |
3-Amino-2-chloro-4-methylpyridine
2-chloro-3-iodo-4-methyl-pyridine
Conditions | Yield |
---|---|
Stage #1: 3-Amino-2-chloro-4-methylpyridine With hydrogenchloride; sodium nitrite In water at 0℃; Stage #2: With potassium iodide In water at 0 - 20℃; | 58% |
Stage #1: 3-Amino-2-chloro-4-methylpyridine With hydrogenchloride; sodium nitrite In water at 0℃; Stage #2: With potassium iodide In water at 0 - 20℃; | 47% |
Stage #1: 3-Amino-2-chloro-4-methylpyridine With hydrogenchloride; sodium nitrite In water at 0℃; for 1h; Stage #2: With potassium iodide In water at 0 - 20℃; for 12h; |
2-Picolinic acid
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 70℃; for 15h; | 55% |
2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamido)acetic acid
3-Amino-2-chloro-4-methylpyridine
3-bromo-N-(2-((2-chloro-4-methylpyridin-3-yl)amino)-2-oxoethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
Conditions | Yield |
---|---|
With triethylamine; trichlorophosphate In acetonitrile for 2h; Reflux; | 52.6% |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With selenium; sodium tetrahydroborate; toluene-4-sulfonic acid at 50℃; for 20h; Inert atmosphere; | 51% |
3-Amino-2-chloro-4-methylpyridine
7-chloro-1H-pyrazolo<3,4-c>pyridine
Conditions | Yield |
---|---|
With potassium acetate; sodium nitrite In water; ethyl acetate | 46% |
Multi-step reaction with 2 steps 1: 2.1 g / toluene / 2 h / 100 °C 2: 1.) phosphorus pentaoxide, potassium acetate, nitrosyl chloride, 2.) sodium carbonate / 1.) acetic acid, 2.) benzene, reflux View Scheme | |
Multi-step reaction with 4 steps 1: 2.1 g / toluene / 2 h / 100 °C 2: 1.) phosphorus pentaoxide, potassium acetate, nitrosyl chloride, 2.) sodium carbonate / 1.) acetic acid, 2.) benzene, reflux 3: 67 percent / phosphorus pentasulphide / pyridine / 4.5 h / Heating 4: 71 percent / chlorine, conc. hydrochloric acid / 0.33 h View Scheme |
6-chloropicolinic acid
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 70℃; for 15h; | 46% |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
With trimethylaluminum In dichloromethane at 50℃; for 12h; | 40% |
3-Amino-2-chloro-4-methylpyridine
(1-methyl-1H-pyrazol-5-yl)boronic acid
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate In 1,4-dioxane; water at 100℃; for 3h; | 30% |
3-Amino-2-chloro-4-methylpyridine
aniline
4-methyl-N2-phenylpyridine-2,3-diamine
Conditions | Yield |
---|---|
at 180℃; for 1.25h; Microwave irradiation; | 28% |
2-(2,5-dichloro-phenoxy)-nicotinic acid
3-Amino-2-chloro-4-methylpyridine
methyl iodide
N-(2-chloro-4-methylpyridin-3-yl)-2-(2,5-dichlorophenoxy)-N-methylnicotinamide
Conditions | Yield |
---|---|
Stage #1: 2-(2,5-dichloro-phenoxy)-nicotinic acid; 3-Amino-2-chloro-4-methylpyridine With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 18h; Stage #2: methyl iodide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 40℃; for 2h; | 3% |
acetic anhydride
3-Amino-2-chloro-4-methylpyridine
3-acetamido-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
In toluene at 100℃; for 2h; | 2.1 g |
In dichloromethane at 20℃; | |
In dichloromethane at 20℃; for 24h; |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 73.5 percent / sodium hydride / dimethylformamide; toluene / 1 h / 40 - 45 °C 2: 63.8 percent / ethanol / 4 h / 78 - 80 °C View Scheme |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 73.5 percent / sodium hydride / dimethylformamide; toluene / 1 h / 40 - 45 °C 2: 54.7 percent / ethanol / 4 h / 78 - 80 °C View Scheme |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 73.5 percent / sodium hydride / dimethylformamide; toluene / 1 h / 40 - 45 °C 2: 74.5 percent / ethanol / 4 h / 78 - 80 °C View Scheme |
3-Amino-2-chloro-4-methylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 73.5 percent / sodium hydride / dimethylformamide; toluene / 1 h / 40 - 45 °C 2: 55.7 percent / ethanol / 4 h / 78 - 80 °C View Scheme |
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