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Sinoway Industrial Co., Ltd.

Sinoway’s advantages: Fast Delivery, Good Quality and reasonable price Professional Manufacturer, 27 years in pharmaceutical industry SGS audit supplier Appearance:A WHITE TO OFF-WHITE CRYSTALLINE POWDER Storage:room tempera

High purity Nevirapine 129618-40-2

Cas:129618-40-2

Min.Order:1 Kilogram

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white powder Storage:-20°C Freezer Package:100g/

Good quality Nevirapine CAS 129618-40-2 supplied by manufacturer

Cas:129618-40-2

Min.Order:100 Gram

FOB Price: $5.0 / 8.0

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Nevirapine

Cas:129618-40-2

Min.Order:1

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Nevirapine manufacturer with low price

Cas:129618-40-2

Min.Order:1 Gram

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Nevirapine 129618-40-2 GMP Manufacturer

Cas:129618-40-2

Min.Order:1 Gram

FOB Price: $0.1

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Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Nevirapine manufacturer CAS NO.129618-40-2 Appearance:whilt powder Storage:cool and dryer Package:durm Application:API Transportation:API Port:shanghai

Nevirapine CAS:129618-40-2

Cas:129618-40-2

Min.Order:1 Metric Ton

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Nevirapine

Cas:129618-40-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nevirapine

Cas:129618-40-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

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Henan Tianfu Chemical Co., Ltd.

Nevirapine Basic information Product Name: Nevirapine Synonyms: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZ

TIANFU-CHEM Nevirapine 129618-40-2

Cas:129618-40-2

Min.Order:1 Kilogram

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

Anti-HIV Virus/Anti-AIDS API Nevirapine 129618-40-2

Cas:129618-40-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 129618-40-2 with best quality

Cas:129618-40-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Nevirapine/ LIDE PHARMA- Factory supply / Best price

Cas:129618-40-2

Min.Order:0

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

API Manufacturer Nevirapine Manufacturer 129618-40-2 For Anti-viral

Cas:129618-40-2

Min.Order:10 Gram

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Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: Nevirapine Structure: Formula: C15H14N4O Molecular Weight : 266.3 Synonyms: 6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE,11-CYCLOPROPYL-5,11-DIHYD

Factory Supply Nevirapine

Cas:129618-40-2

Min.Order:1 Kilogram

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Nevirapine 129618-40-2

Cas:129618-40-2

Min.Order:1 Kilogram

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Nevirapine 99%

Cas:129618-40-2

Min.Order:1 Kilogram

FOB Price: $186.0 / 210.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Nevirapine CAS:129618-40-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Nevirapine CAS:129618-40-2

Cas:129618-40-2

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Nevirapine

Cas:129618-40-2

Min.Order:1 Kilogram

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Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Top quality Nevirapine with reasonable price and fast delivery on hot selling !!

Cas:129618-40-2

Min.Order:10 Gram

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Nevirapine

Cas:129618-40-2

Min.Order:0

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Nevirapine

Cas:129618-40-2

Min.Order:1 Kilogram

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Nevirapine 129618-40-2

Cas:129618-40-2

Min.Order:1 Gram

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Nevirapine

Cas:129618-40-2

Min.Order:0 Metric Ton

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NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

Nevirapine

Cas:129618-40-2

Min.Order:1 Milligram

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Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Nevirapine

Cas:129618-40-2

Min.Order:0

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Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Nevirapine CAS 129618-40-2

Cas:129618-40-2

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

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Wuhan Xinhao Biotechnology Co., Ltd.

1. We can provide customers with "one-stop"packaging service,from research,development,production,export and so on 2. Powerful R&D strength let our technology in a leading level,forever,in turn,to provide customers with better service .

nevirapine High quality 129618-40-2 CAS NO.129618-40-2

Cas:129618-40-2

Min.Order:100 Gram

FOB Price: $10.0 / 100.0

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Nevirapine

Cas:129618-40-2

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystal powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:used for treating HIV and AIDS, stoppin

Nevirapine

Cas:129618-40-2

Min.Order:1 Gram

Negotiable

Type:Trading Company

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TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Nevirapine

Cas:129618-40-2

Min.Order:10 Gram

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Synthetic route

N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide
133627-47-1

N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
With diethylene glycol dimethyl ether; sodium hydride at 100 - 125℃; for 2.5h; Inert atmosphere;96%
Stage #1: N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide With potassium tert-butylate In diethylene glycol dimethyl ether at 100 - 110℃; for 1.5h;
Stage #2: With acetic acid In diethylene glycol dimethyl ether at 5 - 10℃; pH=6.0 - 7.0; Product distribution / selectivity;
83.39%
Stage #1: N-(2-chloro-4-methyl-3-pyridinyl)-2-(cyclopropylamino)-3-pyridinecarboxamide With potassium tert-butylate In toluene at 100 - 110℃; for 3 - 3.5h;
Stage #2: With sulfuric acid In water; toluene at 5 - 10℃; pH=1 - 7.0; Product distribution / selectivity;
79.96%
methyl 2-(cyclopropylamino)nicotinate

methyl 2-(cyclopropylamino)nicotinate

3-Amino-2-chloro-4-methylpyridine
133627-45-9

3-Amino-2-chloro-4-methylpyridine

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
With sodium hydride In diethylene glycol dimethyl ether at 65 - 165℃; Flow reactor; Green chemistry;96%
Multi-step reaction with 2 steps
1.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
1.2: 2 h / 55 - 65 °C / Inert atmosphere
2.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
1.2: 2 h / 60 °C
2.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
2-(Cyclopropylamino)-N-(2-methoxy-4-methyl-3-pyridinyl)-3-pyridinecarboxamide
162709-30-0

2-(Cyclopropylamino)-N-(2-methoxy-4-methyl-3-pyridinyl)-3-pyridinecarboxamide

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
With pyridine; sodium hexamethyldisilazane at 90℃; for 6h;91%
2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide
133627-46-0

2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide

Cyclopropylamine
765-30-0

Cyclopropylamine

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Stage #1: 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide; Cyclopropylamine With triethylamine In toluene at 130℃; for 10h; Autoclave;
Stage #2: With sodium amide In diethylene glycol dimethyl ether at 15 - 110℃; for 2h; Temperature; Time; Reagent/catalyst; Autoclave;
86%
Stage #1: 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide; Cyclopropylamine With calcium oxide In diethylene glycol dimethyl ether at 135 - 145℃;
Stage #2: With sodium hydride at 140℃; for 0.5 - 1h;
Stage #3: With water; acetic acid; ethyl acetate at 0 - 10℃; for 1 - 2h;
2-chloro-11-cyclopropyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one
135575-99-4

2-chloro-11-cyclopropyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In diethylene glycol dimethyl ether at 100℃; under 2585.7 Torr; for 12h; Yield given;
2-Chloronicotinoyl chloride
49609-84-9

2-Chloronicotinoyl chloride

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h
2: 94 percent / 4 h / 140 °C
3: 67 percent / 80percent NaH / bis-(2-methoxy-ethyl) ether / 1.5 h / 185 °C
View Scheme
Multi-step reaction with 3 steps
1: 65.5 percent / pyridine / cyclohexane; dioxane / 48 h / Ambient temperature
2: 83 percent / xylene / 18 h / 110 °C
3: 67 percent / NaH / various solvent(s) / 1.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: pyridine / acetonitrile / 20 - 45 °C
2: calcium oxide / xylene / 140 °C
3: sodium hydrogen sulfate; copper(l) iodide; sulfuric acid; potassium tert-butylate / diethylene glycol dimethyl ether / 115 °C
View Scheme
2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 99 percent / thionyl chloride / 1 h / Heating
2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h
3: 94 percent / 4 h / 140 °C
4: 67 percent / 80percent NaH / bis-(2-methoxy-ethyl) ether / 1.5 h / 185 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 - 65 °C
2: 5 h / 60 - 65 °C
3: 5%-palladium/activated carbon; hydrogen / ethanol; toluene / 6 h / 30 - 35 °C / 1500.15 - 2250.23 Torr / Autoclave
4: benzenesulfonic acid / 6 h / 90 - 95 °C
View Scheme
2-chloro-3-nitro-4-methylpyridine
23056-39-5

2-chloro-3-nitro-4-methylpyridine

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 98 percent / SnCl2 * 2 H2O, conc. HCl / diethyl ether / 0.33 h / Ambient temperature
2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h
3: 94 percent / 4 h / 140 °C
4: 67 percent / 80percent NaH / bis-(2-methoxy-ethyl) ether / 1.5 h / 185 °C
View Scheme
Multi-step reaction with 4 steps
1: 75 percent / H2 / 5percent Rh/C / ethanol / 3 h / 2585.7 Torr
2: 65.5 percent / pyridine / cyclohexane; dioxane / 48 h / Ambient temperature
3: 83 percent / xylene / 18 h / 110 °C
4: 67 percent / NaH / various solvent(s) / 1.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: 5 h / 60 - 65 °C
2: 5%-palladium/activated carbon; hydrogen / ethanol; toluene / 6 h / 30 - 35 °C / 1500.15 - 2250.23 Torr / Autoclave
3: benzenesulfonic acid / 6 h / 90 - 95 °C
View Scheme
3-Amino-2-chloro-4-methylpyridine
133627-45-9

3-Amino-2-chloro-4-methylpyridine

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h
2: 94 percent / 4 h / 140 °C
3: 67 percent / 80percent NaH / bis-(2-methoxy-ethyl) ether / 1.5 h / 185 °C
View Scheme
Multi-step reaction with 3 steps
1: 65.5 percent / pyridine / cyclohexane; dioxane / 48 h / Ambient temperature
2: 83 percent / xylene / 18 h / 110 °C
3: 67 percent / NaH / various solvent(s) / 1.5 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: pyridine / acetonitrile / 20 - 45 °C
2: calcium oxide / xylene / 140 °C
3: sodium hydrogen sulfate; copper(l) iodide; sulfuric acid; potassium tert-butylate / diethylene glycol dimethyl ether / 115 °C
View Scheme
2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide
133627-46-0

2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / 4 h / 140 °C
2: 67 percent / 80percent NaH / bis-(2-methoxy-ethyl) ether / 1.5 h / 185 °C
View Scheme
Multi-step reaction with 2 steps
1: 83 percent / xylene / 18 h / 110 °C
2: 67 percent / NaH / various solvent(s) / 1.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: calcium oxide / xylene / 140 °C
2: sodium hydrogen sulfate; copper(l) iodide; sulfuric acid; potassium tert-butylate / diethylene glycol dimethyl ether / 115 °C
View Scheme
tert-butyl methyl ether
1634-04-4

tert-butyl methyl ether

2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide
133627-46-0

2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide

Cyclopropylamine
765-30-0

Cyclopropylamine

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
In ethanol; diethylene glycol dimethyl ether; cyclohexane; water; acetic acid
In diglyme (diethylene glycol-dimethylether); ethanol; diethylene glycol dimethyl ether; cyclohexane; water; acetic acid
Reaxys ID: 19829874

Reaxys ID: 19829874

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
With strong base
2-chloro-4-methyl-3-pyridinecarbonitrile
65169-38-2

2-chloro-4-methyl-3-pyridinecarbonitrile

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sulfuric acid / 1.25 h / 40 - 105 °C
1.2: 70 - 75 °C
2.1: sodium hydroxide; bromine / toluene; water / 0 - 60 °C
3.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
3.2: 2 h / 55 - 65 °C / Inert atmosphere
4.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid / water / 8.25 h / 40 - 105 °C
2: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C
3: sodium hydride / diethylene glycol dimethyl ether / 65 - 165 °C / Flow reactor; Green chemistry
View Scheme
Multi-step reaction with 4 steps
1.1: sulfuric acid / water / 8.25 h / 40 - 105 °C
2.1: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C
3.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
3.2: 2 h / 60 °C
4.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
2-chloro-4-methyl-3-pyridinecarboxamide
152362-01-1

2-chloro-4-methyl-3-pyridinecarboxamide

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide; bromine / toluene; water / 0 - 60 °C
2.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
2.2: 2 h / 55 - 65 °C / Inert atmosphere
3.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C
2.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
2.2: 2 h / 60 °C
3.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
2-chloro-3-pyridinecarbonitrile
6602-54-6

2-chloro-3-pyridinecarbonitrile

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / water; isopropyl alcohol / 140 °C / 517.16 - 3102.97 Torr / Inert atmosphere
2.1: water; potassium hydroxide / isopropyl alcohol / 12 h / 80 °C
3.1: thionyl chloride / toluene / 0.58 h / 20 - 50 °C / Inert atmosphere
3.2: 40 - 50 °C
4.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
4.2: 2 h / 55 - 65 °C / Inert atmosphere
5.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / water; isopropyl alcohol / 6 h / 140 °C / 517.16 - 3102.97 Torr / Inert atmosphere
2.1: potassium hydroxide / 12 h / 20 - 40 °C
3.1: thionyl chloride / toluene / 0.5 h / 20 - 50 °C / Inert atmosphere
3.2: 2 h / 50 °C / Inert atmosphere
4.1: sodium hydride / diethylene glycol dimethyl ether / 65 - 165 °C / Flow reactor; Green chemistry
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / water; isopropyl alcohol / 6 h / 140 °C / 517.16 - 3102.97 Torr / Inert atmosphere
2.1: potassium hydroxide / 12 h / 20 - 40 °C
3.1: thionyl chloride / toluene / 0.5 h / 20 - 50 °C / Inert atmosphere
3.2: 2 h / 50 °C / Inert atmosphere
4.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
4.2: 2 h / 60 °C
5.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
2-(cyclopropylamino)pyridine-3-carboxylic acid
639807-18-4

2-(cyclopropylamino)pyridine-3-carboxylic acid

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 0.58 h / 20 - 50 °C / Inert atmosphere
1.2: 40 - 50 °C
2.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
2.2: 2 h / 55 - 65 °C / Inert atmosphere
3.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: thionyl chloride / toluene / 0.5 h / 20 - 50 °C / Inert atmosphere
1.2: 2 h / 50 °C / Inert atmosphere
2.1: sodium hydride / diethylene glycol dimethyl ether / 65 - 165 °C / Flow reactor; Green chemistry
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene / 0.5 h / 20 - 50 °C / Inert atmosphere
1.2: 2 h / 50 °C / Inert atmosphere
2.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
2.2: 2 h / 60 °C
3.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
Multi-step reaction with 3 steps
1: 5 h / 60 - 65 °C
2: 5%-palladium/activated carbon; hydrogen / ethanol; toluene / 6 h / 30 - 35 °C / 1500.15 - 2250.23 Torr / Autoclave
3: benzenesulfonic acid / 6 h / 90 - 95 °C
View Scheme
2-cyclopropylaminonicotinonitrile
52583-90-1

2-cyclopropylaminonicotinonitrile

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: water; potassium hydroxide / isopropyl alcohol / 12 h / 80 °C
2.1: thionyl chloride / toluene / 0.58 h / 20 - 50 °C / Inert atmosphere
2.2: 40 - 50 °C
3.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
3.2: 2 h / 55 - 65 °C / Inert atmosphere
4.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / 12 h / 20 - 40 °C
2.1: thionyl chloride / toluene / 0.5 h / 20 - 50 °C / Inert atmosphere
2.2: 2 h / 50 °C / Inert atmosphere
3.1: sodium hydride / diethylene glycol dimethyl ether / 65 - 165 °C / Flow reactor; Green chemistry
View Scheme
Multi-step reaction with 4 steps
1.1: potassium hydroxide / 12 h / 20 - 40 °C
2.1: thionyl chloride / toluene / 0.5 h / 20 - 50 °C / Inert atmosphere
2.2: 2 h / 50 °C / Inert atmosphere
3.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
3.2: 2 h / 60 °C
4.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
2-(4-(dimethylamino)but-3-en-2-ylidene)malononitrile
71493-72-6

2-(4-(dimethylamino)but-3-en-2-ylidene)malononitrile

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: hydrogenchloride / 2 h / 50 - 55 °C
2.1: sulfuric acid / 1.25 h / 40 - 105 °C
2.2: 70 - 75 °C
3.1: sodium hydroxide; bromine / toluene; water / 0 - 60 °C
4.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
4.2: 2 h / 55 - 65 °C / Inert atmosphere
5.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / toluene / 20 - 55 °C
2: sulfuric acid / water / 8.25 h / 40 - 105 °C
3: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C
4: sodium hydride / diethylene glycol dimethyl ether / 65 - 165 °C / Flow reactor; Green chemistry
View Scheme
Multi-step reaction with 5 steps
1.1: hydrogenchloride / toluene / 20 - 55 °C
2.1: sulfuric acid / water / 8.25 h / 40 - 105 °C
3.1: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C
4.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
4.2: 2 h / 60 °C
5.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
isopropylidenemalonodinitrile
13166-10-4

isopropylidenemalonodinitrile

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine; acetic anhydride / toluene / 2 h / 5 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / 2 h / 50 - 55 °C
3.1: sulfuric acid / 1.25 h / 40 - 105 °C
3.2: 70 - 75 °C
4.1: sodium hydroxide; bromine / toluene; water / 0 - 60 °C
5.1: sodium hydride / 3.5 h / 30 - 60 °C / Inert atmosphere
5.2: 2 h / 55 - 65 °C / Inert atmosphere
6.1: sodium hydride; diethylene glycol dimethyl ether / 2.5 h / 100 - 125 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: acetic anhydride / toluene / 5 - 10 °C / Inert atmosphere
1.2: 2 h / 5 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / toluene / 20 - 55 °C
3.1: sulfuric acid / water / 8.25 h / 40 - 105 °C
4.1: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C
5.1: sodium hydride / diethylene glycol dimethyl ether / 65 - 165 °C / Flow reactor; Green chemistry
View Scheme
Multi-step reaction with 6 steps
1.1: acetic anhydride / toluene / 5 - 10 °C / Inert atmosphere
1.2: 2 h / 5 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / toluene / 20 - 55 °C
3.1: sulfuric acid / water / 8.25 h / 40 - 105 °C
4.1: sodium hydroxide; bromine / water / 2 h / 0 - 20 °C
5.1: sodium hydride / diethylene glycol dimethyl ether / 0.5 h / 20 °C
5.2: 2 h / 60 °C
6.1: sodium hydride / diethylene glycol dimethyl ether / 4 h / 105 - 117 °C / Green chemistry
View Scheme
3-amino-4-methylpyridine
3430-27-1

3-amino-4-methylpyridine

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrogenchloride; dihydrogen peroxide / water / 20 °C
1.2: pH 8
2.1: pyridine / acetonitrile / 20 - 45 °C
3.1: calcium oxide / xylene / 140 °C
4.1: sodium hydrogen sulfate; copper(l) iodide; sulfuric acid; potassium tert-butylate / diethylene glycol dimethyl ether / 115 °C
View Scheme
C8H12BrNO5

C8H12BrNO5

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ammonium hydroxide / 5 h / 40 - 45 °C
2: trichlorophosphate / 1,2-dichloro-ethane / 8 h / 70 - 75 °C
3: 5 h / 60 - 65 °C
4: 5%-palladium/activated carbon; hydrogen / ethanol; toluene / 6 h / 30 - 35 °C / 1500.15 - 2250.23 Torr / Autoclave
5: benzenesulfonic acid / 6 h / 90 - 95 °C
View Scheme
C15H16N4O2

C15H16N4O2

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
With benzenesulfonic acid at 90 - 95℃; for 6h; Reagent/catalyst;12.6 g
C8H12ClNO5

C8H12ClNO5

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: ammonium hydroxide / 5 h / 50 - 55 °C
2: trichlorophosphate / 1,2-dichloro-ethane / 8 h / 70 - 75 °C
3: 5 h / 60 - 65 °C
4: 5%-palladium/activated carbon; hydrogen / ethanol; toluene / 6 h / 30 - 35 °C / 1500.15 - 2250.23 Torr / Autoclave
5: benzenesulfonic acid / 6 h / 90 - 95 °C
View Scheme
4-Methyl-3-nitro-2-pyridone
21901-18-8

4-Methyl-3-nitro-2-pyridone

Nevirapine
129618-40-2

Nevirapine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trichlorophosphate / 1,2-dichloro-ethane / 8 h / 70 - 75 °C
2: 5 h / 60 - 65 °C
3: 5%-palladium/activated carbon; hydrogen / ethanol; toluene / 6 h / 30 - 35 °C / 1500.15 - 2250.23 Torr / Autoclave
4: benzenesulfonic acid / 6 h / 90 - 95 °C
View Scheme
silver(I) acetate
563-63-3

silver(I) acetate

Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-4-methyl-6-oxo-6,11-dihydro-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-2-yl acetate
1350539-29-5

11-cyclopropyl-4-methyl-6-oxo-6,11-dihydro-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-2-yl acetate

Conditions
ConditionsYield
With iodine In dichloromethane at 104℃; for 0.0833333h;100%
formaldehyd
50-00-0

formaldehyd

1-(4-Nitrophenyl)piperazine
6269-89-2

1-(4-Nitrophenyl)piperazine

Nevirapine
129618-40-2

Nevirapine

5-cyclopropyl-9-methyl-10-[4-(4-nitro-phenyl)-piperazin-1-ylmethyl]-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

5-cyclopropyl-9-methyl-10-[4-(4-nitro-phenyl)-piperazin-1-ylmethyl]-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;92%
formaldehyd
50-00-0

formaldehyd

4-phenyl-1-piperazine
92-54-6

4-phenyl-1-piperazine

Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-4-methyl-5-[(4-phenylpiperazin-1-yl)methyl]-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

11-cyclopropyl-4-methyl-5-[(4-phenylpiperazin-1-yl)methyl]-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;91%
formaldehyd
50-00-0

formaldehyd

4-(4-chlorophenyl) piperazine
38212-33-8

4-(4-chlorophenyl) piperazine

Nevirapine
129618-40-2

Nevirapine

5-{[4-(4-chlorophenyl)piperazin-1-yl]methyl}-11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

5-{[4-(4-chlorophenyl)piperazin-1-yl]methyl}-11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;89%
formaldehyd
50-00-0

formaldehyd

1-(4-methoxyphenyl)piperazine
38212-30-5

1-(4-methoxyphenyl)piperazine

Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-5-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

11-cyclopropyl-5-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;86%
formaldehyd
50-00-0

formaldehyd

1-phenylmethylpiperazine
2759-28-6

1-phenylmethylpiperazine

Nevirapine
129618-40-2

Nevirapine

5-[(4-benzylpiperazin-1-yl)methyl]-11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

5-[(4-benzylpiperazin-1-yl)methyl]-11-cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;83%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

formaldehyd
50-00-0

formaldehyd

Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-4-methyl-5-[4-methylpiperazin-1-yl]methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

11-cyclopropyl-4-methyl-5-[4-methylpiperazin-1-yl]methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;80%
Nevirapine
129618-40-2

Nevirapine

6-chloro-11-cyclopropyl-4-methyl-11H-dipyrido[3,2-b:2',3'-e][1,4]diazepine

6-chloro-11-cyclopropyl-4-methyl-11H-dipyrido[3,2-b:2',3'-e][1,4]diazepine

Conditions
ConditionsYield
With N,N-dimethyl-aniline; trichlorophosphate at 110℃; for 8h;80%
In toluene
formaldehyd
50-00-0

formaldehyd

Nevirapine
129618-40-2

Nevirapine

1-(4-Fluorophenyl)piperazine
2252-63-3

1-(4-Fluorophenyl)piperazine

5-cyclopropyl-10-[4-(4-fluoro-phenyl)-piperazin-1-ylmethyl]-9-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

5-cyclopropyl-10-[4-(4-fluoro-phenyl)-piperazin-1-ylmethyl]-9-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;78%
triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane
745783-97-5

triethyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-4-methyl-9-(triethylsilyl)-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

11-cyclopropyl-4-methyl-9-(triethylsilyl)-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Conditions
ConditionsYield
With 1,2-dimethoxyethane; potassium hexamethylsilazane for 3h; Inert atmosphere; regioselective reaction;74%
formaldehyd
50-00-0

formaldehyd

Nevirapine
129618-40-2

Nevirapine

N-(m-chlorophenyl)piperazine
6640-24-0

N-(m-chlorophenyl)piperazine

10-[4-(3-chloro-phenyl)-piperazin-1-ylmethyl]-5-cyclopropyl-9-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

10-[4-(3-chloro-phenyl)-piperazin-1-ylmethyl]-5-cyclopropyl-9-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;69%
piperazine
110-85-0

piperazine

formaldehyd
50-00-0

formaldehyd

Nevirapine
129618-40-2

Nevirapine

5-cyclopropyl-9-methyl-10-piperazin-1-ylmethyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

5-cyclopropyl-9-methyl-10-piperazin-1-ylmethyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions
ConditionsYield
In ethanol Mannich reaction; Irradiation; microwave;68%
Nevirapine
129618-40-2

Nevirapine

d8-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one
1051418-86-0

d8-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one

Conditions
ConditionsYield
With water-d2; sodium formate; palladium 10% on activated carbon In 1,4-dioxane at 200℃; for 48h;58%
Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one
133627-24-4

11-cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one

Conditions
ConditionsYield
With oxygen; lithium diisopropyl amide In tetrahydrofuran Ambient temperature;31%
With MoO5*pyridine*HMPA; lithium diisopropyl amide Product distribution; multistep reaction; influence of base;
With MoO5*pyridine*HMPA; lithium diisopropyl amide 1.) THF, hexane, below -40 deg C, 5 min, 2.) -30 to -40 deg C, 75 min; Yield given. Multistep reaction;
With MoO5*pyridine*HMPA; lithium diisopropyl amide 1.) THF, hexane, -30 deg C, 5 min, 2.) THF, hexane, -30 deg C, 1.5 h; Yield given. Multistep reaction;
Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-5,11-dihydro-4-methyl-3-nitro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
284686-16-4

11-cyclopropyl-5,11-dihydro-4-methyl-3-nitro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Conditions
ConditionsYield
With nitronium tetrafluoborate; 4 A molecular sieve In acetonitrile at 0℃; for 20h; Nitration;20%
Nevirapine
129618-40-2

Nevirapine

A

5-Cyclopropyl-9-methyl-4-oxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

5-Cyclopropyl-9-methyl-4-oxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

B

5-Cyclopropyl-9-methyl-6-oxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

5-Cyclopropyl-9-methyl-6-oxy-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

C

11-cyclopropyl-5,11-dihydro-4-methyl-8-hydroxy-1,10-dioxy-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepin-6-one

11-cyclopropyl-5,11-dihydro-4-methyl-8-hydroxy-1,10-dioxy-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepin-6-one

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid at 95℃; for 18h;A 0.9%
B 17%
C 9%
Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-7-iodo-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one
1227201-82-2

11-cyclopropyl-7-iodo-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one

Conditions
ConditionsYield
Stage #1: Nevirapine With dilithium magnesium bis(2,2,6,6-tetramethylpiperidin-1-ide) dichloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
10%
oxodiperoxymolybdenum(pyridine)hexamethylphosphoramide

oxodiperoxymolybdenum(pyridine)hexamethylphosphoramide

Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-5,11-dihydro-5-hydroxy-4-methyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepin-6-one
135794-73-9

11-cyclopropyl-5,11-dihydro-5-hydroxy-4-methyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepin-6-one

Conditions
ConditionsYield
In tetrahydrofuran; mineral oil9.5%
sodium 7‐azido‐1,1‐difluoroheptane‐1‐sulfinate

sodium 7‐azido‐1,1‐difluoroheptane‐1‐sulfinate

Nevirapine
129618-40-2

Nevirapine

A

C22H25F2N7O
1450912-75-0

C22H25F2N7O

B

C22H25F2N7O
1450912-76-1

C22H25F2N7O

C

C22H25F2N7O
1450912-74-9

C22H25F2N7O

Conditions
ConditionsYield
With tert.-butylhydroperoxide; trifluoroacetic acid; zinc(II) chloride In water; dimethyl sulfoxide at 50℃; for 11h; Cooling with ice;A 8%
B 9%
C 9%
Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-5,11-dihydro-8-hydroxy-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

11-cyclopropyl-5,11-dihydro-8-hydroxy-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Conditions
ConditionsYield
Stage #1: Nevirapine With dihydrogen peroxide; acetic acid at 95 - 100℃; for 48h; Oxidation;
Stage #2: With hydrogen; palladium on activated charcoal In ethyl acetate under 2068.59 Torr; for 6h; Reduction;
5%
Nevirapine
129618-40-2

Nevirapine

11-cyclopropyl-5,11-dihydro-5-hydroxy-4-methyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepin-6-one
135794-73-9

11-cyclopropyl-5,11-dihydro-5-hydroxy-4-methyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepin-6-one

Conditions
ConditionsYield
With MoO5*pyridine*HMPA; sodium hydride 1.) THF, r.t., 1 h, 2.) 0 deg C to r.t., 2 d; Yield given. Multistep reaction;
Nevirapine
129618-40-2

Nevirapine

phenyldimethylsilyl chloride
768-33-2

phenyldimethylsilyl chloride

A

11-cyclopropyl-5,11-dihydro-4-<(dimethylphenylsilyl)methyl>-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one
141319-44-0

11-cyclopropyl-5,11-dihydro-4-<(dimethylphenylsilyl)methyl>-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one

B

11-cyclopropyl-5,11-dihydro-7-(dimethylphenylsilyl)-4-methyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one
141319-45-1

11-cyclopropyl-5,11-dihydro-7-(dimethylphenylsilyl)-4-methyl-6H-dipyrido<3,2-b:2',3'-e><1,4>diazepine-6-one

Conditions
ConditionsYield
Product distribution; multistep reaction; reaction of nevirapine with phenyldimethylchlorosilane;
Yield given. Multistep reaction. Yields of byproduct given;
Nevirapine
129618-40-2

Nevirapine

methyl iodide
74-88-4

methyl iodide

5-Cyclopropyl-9,10-dimethyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one
133627-19-7

5-Cyclopropyl-9,10-dimethyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions
ConditionsYield
With sodium hydride 1.) DMSO, 2.) DMSO; Multistep reaction;
Stage #1: Nevirapine With sodium hydride In N,N-dimethyl-formamide at 60℃; for 2h;
Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 2h;
Nevirapine
129618-40-2

Nevirapine

2-amino-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one
284686-15-3

2-amino-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 20 percent / 4A molecular sieves; nitronium tetrafluoroborate / acetonitrile / 20 h / 0 °C
2: 86 percent / tin(II) chloride; conc. aq. HCl; acetic acid / 20 °C
View Scheme

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