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inquiryAnalysis tests Standard Results Appearance White to off-white powder White powder Melting point
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inquiryUnique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine raw material Transportatio
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inquiryv Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing ne
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Name:Safinamide The alias:FCE 26743; Safinamide; N~2~-{4-[(3-fluorobenzyl)oxy]benzyl}-L-alaninamide CAS NO: 133865-89-1 Molecular formula:C17H19FN2O2 Molecular weight:302.3434 Product Quality 12 years of chemical raw materials Mature operatio
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inquiryHebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c
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inquirySafinamide CAS:133865-89-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquirySAFINAMIDEAppearance:Contact me Storage:Store in cool and dry palce. Keep away from strong light ,high temperature. Package:according to customers' requirements Application:Used for pharmaceutical intermediates Transportation:By air(EMS or EUB or Fed
Product name: Safinamide CAS No.:133865-89-1 Molecule Formula:C17H19FN2O2 Molecule Weight:302.34 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TEST
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
(S)-2-[4-(3-fluorobenzyloxy)benzylideneamino]propanamide
safinamide
Conditions | Yield |
---|---|
With potassium borohydride In methanol | 96% |
With hydrogen; 5 % platinum on carbon In methanol at 35℃; under 3750.38 Torr; for 1h; Product distribution / selectivity; | 94.8% |
With sodium tetrahydroborate In methanol at 2 - 5℃; for 2.33333h; Product distribution / selectivity; | 89.2% |
With palladium 10% on activated carbon; hydrogen In methanol at 35℃; for 5h; | 87.7% |
Conditions | Yield |
---|---|
Stage #1: L-alanine amide; 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 20 - 25℃; for 1h; Stage #2: With hydrogen; 5 % platinum on carbon In methanol at 20 - 35℃; under 750.075 - 3750.38 Torr; for 5h; Product distribution / selectivity; | 92% |
Stage #1: L-alanine amide; 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol for 1.5h; Stage #2: With sodium tetrahydroborate In methanol for 1h; Cooling with ice; | 88.4% |
With sodium cyanoborohydride In methanol at 40℃; for 0.666667h; Temperature; | 81.9% |
4-(3-fluoro-benzyloxy)-benzaldehyde
(S)-alaninamide hydrochloride
safinamide
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 30℃; for 0.166667h; Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 20℃; for 3.5h; Stage #3: With sodium tetrahydroborate In methanol at 5℃; for 2h; Product distribution / selectivity; | 90% |
Stage #1: 4-(3-fluoro-benzyloxy)-benzaldehyde; (S)-alaninamide hydrochloride With triethylamine In methanol at 20 - 25℃; for 1h; Stage #2: With hydrogen; 5 % platinum on carbon In methanol at 20 - 35℃; under 750.075 - 3750.38 Torr; for 5h; Product distribution / selectivity; | 90% |
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 30℃; for 0.166667h; Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 30℃; for 3.5h; Stage #3: With sodium hydroxide; sodium tetrahydroborate In methanol; water at 5℃; for 2h; Product distribution / selectivity; | 88.5% |
safinamide
Conditions | Yield |
---|---|
With potassium carbonate; thiophenol In N,N-dimethyl-formamide at 20℃; | 86% |
With potassium carbonate; thiophenol In N,N-dimethyl-formamide for 6h; | 86% |
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
3-fluoro-benzenemethanol
4-(triisopropylsilyloxy)benzaldehyde
safinamide
Conditions | Yield |
---|---|
Multistep reaction.; |
4-(3-fluoro-benzyloxy)-benzaldehyde
2-aminopropanamide hydrochloride
A
safinamide
B
FCE 28073
Conditions | Yield |
---|---|
Stage #1: 4-(3-fluoro-benzyloxy)-benzaldehyde; 2-aminopropanamide hydrochloride With triethylamine In methanol at 25℃; for 10.1667h; Stage #2: With sodium hydroxide; sodium tetrahydroborate In methanol; water at 5 - 10℃; for 1h; Product distribution / selectivity; |
4-(3-fluoro-benzyloxy)-benzaldehyde
(S)-alaninamide hydrochloride
A
safinamide
B
FCE 28073
Conditions | Yield |
---|---|
Stage #1: (S)-alaninamide hydrochloride With sodium methylate In methanol; ethanol at 17 - 23℃; for 1.25h; Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 20℃; for 20.5h; Stage #3: With sodium tetrahydroborate In methanol at 3 - 10℃; for 2h; Product distribution / selectivity; |
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 72 h / 70 °C 2.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C 3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 3.2: 16 h / 0 - 20 °C 4.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / acetonitrile / 72 h / 70 °C 2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7 3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 3.2: 16 h / 20 °C 4.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h View Scheme |
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C 2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 2.2: 16 h / 0 - 20 °C 3.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7 2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 2.2: 16 h / 20 °C 3.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h View Scheme |
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C 2.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 1.2: 16 h / 20 °C 2.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h View Scheme |
3-fluoro-benzenemethanol
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness 2.1: potassium carbonate / acetonitrile / 6 h / 70 °C 3.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness 4.1: potassium carbonate / acetonitrile / 72 h / 70 °C 5.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C 6.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 6.2: 16 h / 0 - 20 °C 7.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness 2.1: potassium carbonate / acetonitrile / 6 h / 70 °C 3.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness 4.1: potassium carbonate / acetonitrile / 72 h / 70 °C 5.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7 6.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 6.2: 16 h / 20 °C 7.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h View Scheme |
1-fluoro-3-(iodomethyl)benzene
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium carbonate / acetonitrile / 6 h / 70 °C 2.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness 3.1: potassium carbonate / acetonitrile / 72 h / 70 °C 4.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C 5.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 5.2: 16 h / 0 - 20 °C 6.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: potassium carbonate / acetonitrile / 6 h / 70 °C 2.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness 3.1: potassium carbonate / acetonitrile / 72 h / 70 °C 4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7 5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 5.2: 16 h / 20 °C 6.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h View Scheme |
(4-((3-fluorobenzyl)oxy)phenyl)methanol
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness 2.1: potassium carbonate / acetonitrile / 72 h / 70 °C 3.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C 4.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 4.2: 16 h / 0 - 20 °C 5.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness 2.1: potassium carbonate / acetonitrile / 72 h / 70 °C 3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7 4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere 4.2: 16 h / 20 °C 5.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h View Scheme |
4-hydroxy-benzaldehyde
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / ethanol / 0.5 h / 20 °C 1.2: 4 h / Reflux 2.1: triethylamine / methanol / 0.5 h / 20 °C 2.2: 2 h / 20 °C 3.1: potassium borohydride / methanol View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate; potassium iodide / ethanol / 0.25 h 1.2: 6 h / Reflux 2.1: triethylamine / methanol / 1.2 h / 20 °C / Molecular sieve 3.1: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 35 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide / ethanol / 6.75 h / Heating / reflux 2.1: methanol / 1 h / 20 - 25 °C 2.2: 5 h / 20 - 35 °C / 750.08 - 3750.38 Torr View Scheme |
m-fluorobenzyl chloride
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium carbonate / ethanol / 0.5 h / 20 °C 1.2: 4 h / Reflux 2.1: triethylamine / methanol / 0.5 h / 20 °C 2.2: 2 h / 20 °C 3.1: potassium borohydride / methanol View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium carbonate; potassium iodide / ethanol / 0.25 h 1.2: 6 h / Reflux 2.1: triethylamine / methanol / 1.2 h / 20 °C / Molecular sieve 3.1: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 35 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide / ethanol / 6.75 h / Heating / reflux 2.1: methanol / 1 h / 20 - 25 °C 2.2: 5 h / 20 - 35 °C / 750.08 - 3750.38 Torr View Scheme |
4-(3-fluoro-benzyloxy)-benzaldehyde
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / methanol / 0.5 h / 20 °C 1.2: 2 h / 20 °C 2.1: potassium borohydride / methanol View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / methanol / 1.2 h / 20 °C / Molecular sieve 2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 35 °C View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / methanol / 1 h / 20 °C 2: hydrogen / 5 % platinum on carbon / methanol / 1 h / 35 °C / 3750.38 Torr View Scheme |
4-hydroxy-benzoic acid
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: sodium hydroxide / 13.25 h / 30 °C / Reflux 1.2: 8 h / 0 °C / pH 1 2.1: benzene / 0.33 h / Reflux 2.2: 2.5 h / Reflux 3.1: tin(ll) chloride / 30 °C / Reflux 4.1: hydrogen; palladium on activated charcoal; potassium borohydride 5.1: sodium carbonate; potassium iodide View Scheme |
4-methoxybenzoic acid
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: benzene / 0.33 h / Reflux 1.2: 2.5 h / Reflux 2.1: tin(ll) chloride / 30 °C / Reflux 3.1: hydrogen; palladium on activated charcoal; potassium borohydride 4.1: sodium carbonate; potassium iodide View Scheme |
4-methoxy-benzoyl chloride
safinamide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: tin(ll) chloride / 30 °C / Reflux 2: hydrogen; palladium on activated charcoal; potassium borohydride 3: sodium carbonate; potassium iodide View Scheme |
Conditions | Yield |
---|---|
With sodium carbonate; potassium iodide | 8.23 g |
4-(3-fluoro-benzyloxy)-benzaldehyde
safinamide
Conditions | Yield |
---|---|
Stage #1: 4-(3-fluoro-benzyloxy)-benzaldehyde; (S)-2-aminopropane carboxamide hydrochloride With sodium cyanoborohydride In methanol at 45 - 55℃; for 6h; Stage #2: With potassium carbonate In dichloromethane; water at 20 - 50℃; for 0.5h; | 9.6 g |
Conditions | Yield |
---|---|
In Isopropyl acetate at 50℃; for 1.5h; Solvent; | 99.33% |
In ethyl acetate; N,N-dimethyl-formamide | 97.5% |
In ethyl acetate at 20 - 55℃; for 1h; | 95% |
safinamide
Conditions | Yield |
---|---|
With hydrogen bromide In water; ethyl acetate at 50 - 60℃; for 1h; Concentration; Inert atmosphere; | 70.5% |
Conditions | Yield |
---|---|
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; C27H35N3*C4H10O2*NiCl2; trifluoroacetic acid In acetonitrile at 25℃; for 16h; Irradiation; chemoselective reaction; | 51% |
safinamide
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 50 - 60℃; for 2h; Inert atmosphere; | 28.9 g |
safinamide
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water at 20 - 60℃; for 672h; |
Conditions | Yield |
---|---|
In ethyl acetate at 45 - 85℃; for 0.5h; | 11.4 g |
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