Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

Safinamide

Cas:133865-89-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Analysis tests Standard Results Appearance White to off-white powder White powder Melting point

High purity Safinamide with high quality and best price cas:133865-89-1

Cas:133865-89-1

Min.Order:1 Kilogram

FOB Price: $2200.0 / 2800.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:1kg/foil bag;25kg/drum Application:medicine raw material Transportatio

Manufacturer high quality Safinamide Cas 133865-89-1 with good price

Cas:133865-89-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply N2-{4-[(3-Fluorbenzyl)oxy]benzyl}-L-alaninamid

Cas:133865-89-1

Min.Order:1

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Safinamide manufacturer with low price

Cas:133865-89-1

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Safinamide 133865-89-1 GMP Manufacturer

Cas:133865-89-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

v Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing ne

Safinamide

Cas:133865-89-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Safinamide

Cas:133865-89-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Safinamide The alias:FCE 26743; Safinamide; N~2~-{4-[(3-fluorobenzyl)oxy]benzyl}-L-alaninamide CAS NO: 133865-89-1 Molecular formula:C17H19FN2O2 Molecular weight:302.3434 Product Quality 12 years of chemical raw materials Mature operatio

Safinamide/CAS:133865-89-1/Manufacturer

Cas:133865-89-1

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production Cyromazine、lead diacetate trihydrate /Lead acetate trihydrateC、 2-phenylacetamide 、 4-Aminophenyl-1-phenethylpiperidine 、Citric acid monohydrate 、 Citric acid/c

133865-89-1 Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-

Cas:133865-89-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

We are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare

Safinamide

Cas:133865-89-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM Safinamide

Cas:133865-89-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 133865-89-1 with competitive price

Cas:133865-89-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Safinamide CAS:133865-89-1

Cas:133865-89-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)- 133865-89-1

Cas:133865-89-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Safinamide CAS:133865-89-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

Safinamide CAS:133865-89-1

Cas:133865-89-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-

Cas:133865-89-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Propanamide,2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-

Cas:133865-89-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em

Safinamide Chemical CAS 133865-89-1

Cas:133865-89-1

Min.Order:1 Gram

FOB Price: $400.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

SAFINAMIDE:(S)-(+)-2-[4-(3-FLUOROBENZYLOXY)BENZYLAMINO]PROPANAMIDE METHANSULFONATE

Cas:133865-89-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Safinamide 133865-89-1

Cas:133865-89-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Safinamide CAS NO.133865-89-1

Cas:133865-89-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(S)-2-[4-(3-FLUOROBENZYLOXY)BENZYLAMINO]PROPA NAMIDE

Cas:133865-89-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Safinamide

Cas:133865-89-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Safinamide

Cas:133865-89-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

SAFINAMIDEAppearance:Contact me Storage:Store in cool and dry palce. Keep away from strong light ,high temperature. Package:according to customers' requirements Application:Used for pharmaceutical intermediates Transportation:By air(EMS or EUB or Fed

SAFINAMIDE

Cas:133865-89-1

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Siwei Development Group Ltd.

Product name: Safinamide CAS No.:133865-89-1 Molecule Formula:C17H19FN2O2 Molecule Weight:302.34 Purity: 99.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TEST

High Quality Safinamide on stock

Cas:133865-89-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Safinamide USP/EP/BP

Cas:133865-89-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd

Safinamide

Cas:133865-89-1

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Best OfferSafinamide

Cas:133865-89-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(S)-2-[4-(3-fluorobenzyloxy)benzylideneamino]propanamide
1000370-31-9

(S)-2-[4-(3-fluorobenzyloxy)benzylideneamino]propanamide

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
With potassium borohydride In methanol96%
With hydrogen; 5 % platinum on carbon In methanol at 35℃; under 3750.38 Torr; for 1h; Product distribution / selectivity;94.8%
With sodium tetrahydroborate In methanol at 2 - 5℃; for 2.33333h; Product distribution / selectivity;89.2%
With palladium 10% on activated carbon; hydrogen In methanol at 35℃; for 5h;87.7%
L-alanine amide
7324-05-2

L-alanine amide

4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2

4-(3-fluoro-benzyloxy)-benzaldehyde

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Stage #1: L-alanine amide; 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 20 - 25℃; for 1h;
Stage #2: With hydrogen; 5 % platinum on carbon In methanol at 20 - 35℃; under 750.075 - 3750.38 Torr; for 5h; Product distribution / selectivity;
92%
Stage #1: L-alanine amide; 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol for 1.5h;
Stage #2: With sodium tetrahydroborate In methanol for 1h; Cooling with ice;
88.4%
With sodium cyanoborohydride In methanol at 40℃; for 0.666667h; Temperature;81.9%
4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2

4-(3-fluoro-benzyloxy)-benzaldehyde

(S)-alaninamide hydrochloride
33208-99-0

(S)-alaninamide hydrochloride

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 30℃; for 0.166667h;
Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 20℃; for 3.5h;
Stage #3: With sodium tetrahydroborate In methanol at 5℃; for 2h; Product distribution / selectivity;
90%
Stage #1: 4-(3-fluoro-benzyloxy)-benzaldehyde; (S)-alaninamide hydrochloride With triethylamine In methanol at 20 - 25℃; for 1h;
Stage #2: With hydrogen; 5 % platinum on carbon In methanol at 20 - 35℃; under 750.075 - 3750.38 Torr; for 5h; Product distribution / selectivity;
90%
Stage #1: (S)-alaninamide hydrochloride With triethylamine In methanol at 30℃; for 0.166667h;
Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 30℃; for 3.5h;
Stage #3: With sodium hydroxide; sodium tetrahydroborate In methanol; water at 5℃; for 2h; Product distribution / selectivity;
88.5%
(S)-2-(N-(4-((3-fluorobenzyl)oxy)benzyl)-2-nitrophenylsulfonamido)propanamide

(S)-2-(N-(4-((3-fluorobenzyl)oxy)benzyl)-2-nitrophenylsulfonamido)propanamide

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
With potassium carbonate; thiophenol In N,N-dimethyl-formamide at 20℃;86%
With potassium carbonate; thiophenol In N,N-dimethyl-formamide for 6h;86%
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine
35661-39-3

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

3-fluoro-benzenemethanol
456-47-3

3-fluoro-benzenemethanol

4-(triisopropylsilyloxy)benzaldehyde
211617-68-4

4-(triisopropylsilyloxy)benzaldehyde

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multistep reaction.;
4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2

4-(3-fluoro-benzyloxy)-benzaldehyde

2-aminopropanamide hydrochloride
80222-96-4

2-aminopropanamide hydrochloride

A

safinamide
133865-89-1

safinamide

B

FCE 28073
174756-44-6

FCE 28073

Conditions
ConditionsYield
Stage #1: 4-(3-fluoro-benzyloxy)-benzaldehyde; 2-aminopropanamide hydrochloride With triethylamine In methanol at 25℃; for 10.1667h;
Stage #2: With sodium hydroxide; sodium tetrahydroborate In methanol; water at 5 - 10℃; for 1h; Product distribution / selectivity;
4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2

4-(3-fluoro-benzyloxy)-benzaldehyde

(S)-alaninamide hydrochloride
33208-99-0

(S)-alaninamide hydrochloride

A

safinamide
133865-89-1

safinamide

B

FCE 28073
174756-44-6

FCE 28073

Conditions
ConditionsYield
Stage #1: (S)-alaninamide hydrochloride With sodium methylate In methanol; ethanol at 17 - 23℃; for 1.25h;
Stage #2: 4-(3-fluoro-benzyloxy)-benzaldehyde In methanol at 20℃; for 20.5h;
Stage #3: With sodium tetrahydroborate In methanol at 3 - 10℃; for 2h; Product distribution / selectivity;
1-fluoro-3-((4-(iodomethyl)phenoxy)methyl)benzene

1-fluoro-3-((4-(iodomethyl)phenoxy)methyl)benzene

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 72 h / 70 °C
2.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C
3.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
3.2: 16 h / 0 - 20 °C
4.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 72 h / 70 °C
2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7
3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
3.2: 16 h / 20 °C
4.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h
View Scheme
N-{4-[(3-fluorobenzyl)oxy]benzyl}-N-[(1S)-2-hydroxy-1-methylethyl]-2-nitrobenzenesulfonamide

N-{4-[(3-fluorobenzyl)oxy]benzyl}-N-[(1S)-2-hydroxy-1-methylethyl]-2-nitrobenzenesulfonamide

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C
2.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2.2: 16 h / 0 - 20 °C
3.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7
2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2.2: 16 h / 20 °C
3.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h
View Scheme
(S)-2-(N-(4-((3-fluorobenzyl)oxy)benzyl)-2-nitrophenylsulfonamido)propanoic acid

(S)-2-(N-(4-((3-fluorobenzyl)oxy)benzyl)-2-nitrophenylsulfonamido)propanoic acid

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 16 h / 0 - 20 °C
2.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 16 h / 20 °C
2.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h
View Scheme
3-fluoro-benzenemethanol
456-47-3

3-fluoro-benzenemethanol

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness
2.1: potassium carbonate / acetonitrile / 6 h / 70 °C
3.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness
4.1: potassium carbonate / acetonitrile / 72 h / 70 °C
5.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C
6.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
6.2: 16 h / 0 - 20 °C
7.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness
2.1: potassium carbonate / acetonitrile / 6 h / 70 °C
3.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness
4.1: potassium carbonate / acetonitrile / 72 h / 70 °C
5.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7
6.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
6.2: 16 h / 20 °C
7.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h
View Scheme
1-fluoro-3-(iodomethyl)benzene
28490-56-4

1-fluoro-3-(iodomethyl)benzene

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 6 h / 70 °C
2.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness
3.1: potassium carbonate / acetonitrile / 72 h / 70 °C
4.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C
5.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
5.2: 16 h / 0 - 20 °C
6.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetonitrile / 6 h / 70 °C
2.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness
3.1: potassium carbonate / acetonitrile / 72 h / 70 °C
4.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7
5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
5.2: 16 h / 20 °C
6.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h
View Scheme
(4-((3-fluorobenzyl)oxy)phenyl)methanol
690969-16-5

(4-((3-fluorobenzyl)oxy)phenyl)methanol

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: iodine; triphenylphosphine; 1H-imidazole / dichloromethane / 1.17 h / 0 - 20 °C / Darkness
2.1: potassium carbonate / acetonitrile / 72 h / 70 °C
3.1: sodium hypochlorite; sodium chlorite; 2,2,6,6-tetramethyl-piperidine-N-oxyl / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C
4.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.2: 16 h / 0 - 20 °C
5.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 1.17 h / 0 °C / Darkness
2.1: potassium carbonate / acetonitrile / 72 h / 70 °C
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium chlorite / acetonitrile; aq. phosphate buffer; water / 4 h / 35 °C / pH 6.7
4.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
4.2: 16 h / 20 °C
5.1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 6 h
View Scheme
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / ethanol / 0.5 h / 20 °C
1.2: 4 h / Reflux
2.1: triethylamine / methanol / 0.5 h / 20 °C
2.2: 2 h / 20 °C
3.1: potassium borohydride / methanol
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate; potassium iodide / ethanol / 0.25 h
1.2: 6 h / Reflux
2.1: triethylamine / methanol / 1.2 h / 20 °C / Molecular sieve
3.1: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 35 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / ethanol / 6.75 h / Heating / reflux
2.1: methanol / 1 h / 20 - 25 °C
2.2: 5 h / 20 - 35 °C / 750.08 - 3750.38 Torr
View Scheme
m-fluorobenzyl chloride
456-42-8

m-fluorobenzyl chloride

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / ethanol / 0.5 h / 20 °C
1.2: 4 h / Reflux
2.1: triethylamine / methanol / 0.5 h / 20 °C
2.2: 2 h / 20 °C
3.1: potassium borohydride / methanol
View Scheme
Multi-step reaction with 3 steps
1.1: potassium carbonate; potassium iodide / ethanol / 0.25 h
1.2: 6 h / Reflux
2.1: triethylamine / methanol / 1.2 h / 20 °C / Molecular sieve
3.1: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 35 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / ethanol / 6.75 h / Heating / reflux
2.1: methanol / 1 h / 20 - 25 °C
2.2: 5 h / 20 - 35 °C / 750.08 - 3750.38 Torr
View Scheme
4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2

4-(3-fluoro-benzyloxy)-benzaldehyde

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / methanol / 0.5 h / 20 °C
1.2: 2 h / 20 °C
2.1: potassium borohydride / methanol
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / methanol / 1.2 h / 20 °C / Molecular sieve
2: hydrogen; palladium 10% on activated carbon / methanol / 5 h / 35 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / methanol / 1 h / 20 °C
2: hydrogen / 5 % platinum on carbon / methanol / 1 h / 35 °C / 3750.38 Torr
View Scheme
4-hydroxy-benzoic acid
99-96-7

4-hydroxy-benzoic acid

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: sodium hydroxide / 13.25 h / 30 °C / Reflux
1.2: 8 h / 0 °C / pH 1
2.1: benzene / 0.33 h / Reflux
2.2: 2.5 h / Reflux
3.1: tin(ll) chloride / 30 °C / Reflux
4.1: hydrogen; palladium on activated charcoal; potassium borohydride
5.1: sodium carbonate; potassium iodide
View Scheme
4-methoxybenzoic acid
100-09-4

4-methoxybenzoic acid

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: benzene / 0.33 h / Reflux
1.2: 2.5 h / Reflux
2.1: tin(ll) chloride / 30 °C / Reflux
3.1: hydrogen; palladium on activated charcoal; potassium borohydride
4.1: sodium carbonate; potassium iodide
View Scheme
4-methoxy-benzoyl chloride
100-07-2

4-methoxy-benzoyl chloride

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tin(ll) chloride / 30 °C / Reflux
2: hydrogen; palladium on activated charcoal; potassium borohydride
3: sodium carbonate; potassium iodide
View Scheme
3-chlorofluorobenzene
625-98-9

3-chlorofluorobenzene

(S)-2-((4-methoxybenzyl)amino)propanamide

(S)-2-((4-methoxybenzyl)amino)propanamide

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
With sodium carbonate; potassium iodide8.23 g
4-(3-fluoro-benzyloxy)-benzaldehyde
66742-57-2

4-(3-fluoro-benzyloxy)-benzaldehyde

(S)-2-aminopropane carboxamide hydrochloride

(S)-2-aminopropane carboxamide hydrochloride

safinamide
133865-89-1

safinamide

Conditions
ConditionsYield
Stage #1: 4-(3-fluoro-benzyloxy)-benzaldehyde; (S)-2-aminopropane carboxamide hydrochloride With sodium cyanoborohydride In methanol at 45 - 55℃; for 6h;
Stage #2: With potassium carbonate In dichloromethane; water at 20 - 50℃; for 0.5h;
9.6 g
methanesulfonic acid
75-75-2

methanesulfonic acid

safinamide
133865-89-1

safinamide

safinamide mesylate

safinamide mesylate

Conditions
ConditionsYield
In Isopropyl acetate at 50℃; for 1.5h; Solvent;99.33%
In ethyl acetate; N,N-dimethyl-formamide97.5%
In ethyl acetate at 20 - 55℃; for 1h;95%
safinamide
133865-89-1

safinamide

safinamide hydrobromide

safinamide hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; ethyl acetate at 50 - 60℃; for 1h; Concentration; Inert atmosphere;70.5%
bis(1-methyl-1-phenylethyl)peroxide
80-43-3

bis(1-methyl-1-phenylethyl)peroxide

safinamide
133865-89-1

safinamide

C18H21FN2O2*C2HF3O2

C18H21FN2O2*C2HF3O2

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; C27H35N3*C4H10O2*NiCl2; trifluoroacetic acid In acetonitrile at 25℃; for 16h; Irradiation; chemoselective reaction;51%
safinamide
133865-89-1

safinamide

safinamide hydrochloride

safinamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 50 - 60℃; for 2h; Inert atmosphere;28.9 g
safinamide
133865-89-1

safinamide

safinamide acid hydrochloride

safinamide acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 20 - 60℃; for 672h;
methanesulfonic acid
75-75-2

methanesulfonic acid

safinamide
133865-89-1

safinamide

safinamide mesylate

safinamide mesylate

Conditions
ConditionsYield
In ethyl acetate at 45 - 85℃; for 0.5h;11.4 g

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View