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inquiryTIANFUCHEM-- 143388-64-1--High purity NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI) in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryNaratriptan Hydrochloride CAS:143388-64-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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inquiryOur company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:Beige solid Storage:Storage in a dry, v
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I
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inquiryName Naratriptan hydrochloride Synonyms N-Methyl-3-(1-methylpiperidin-4-yl)-1H-indole-5-ethanesulfonamide hydrochloride Molecular Structure
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier
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inquirywith high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:to formulate preparations Transportation:by courier, air or sea Port:At any port fro
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquirynaratriptan
naratriptan hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol at 0 - 30℃; for 1h; pH=1.0 - 1.5; Product distribution / selectivity; | 93.4% |
With hydrogenchloride In methanol; water at 0 - 10℃; | 84% |
With hydrogenchloride In methanol; ethanol at 5 - 25℃; pH=1.0; | 71.7% |
With hydrogenchloride In isopropyl alcohol; acetone at 5 - 10℃; pH=1; |
N-methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethenesulphonamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
In hydrogenchloride; methanesulfonic acid; water | 88% |
With hydrogenchloride In water; ethyl acetate; N,N-dimethyl-formamide | |
With hydrogenchloride In water; ethyl acetate; N,N-dimethyl-formamide |
N-methyl-2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Stage #1: N-methyl-2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide With hydrogen; acetic acid; platinum(IV) oxide In methanol at 50 - 60℃; under 3677.86 Torr; Stage #2: With hydrogenchloride In ethanol; isopropyl alcohol for 1h; Product distribution / selectivity; Reflux; | 85% |
Multi-step reaction with 2 steps 1.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 1.2: 10 °C / pH 7.5 - 8.5 2.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
(E)-N-Methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethene sulphonamide, hydrochloride
naratriptan hydrochloride
Conditions | Yield |
---|---|
In methanol; water; ethyl acetate; N,N-dimethyl-formamide | 71.2% |
naratriptan hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water for 12h; pH=2; Product distribution / selectivity; Heating / reflux; |
N-methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethenesulphonamide
pyrographite
naratriptan hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate; N,N-dimethyl-formamide | |
With hydrogenchloride In ethyl acetate; N,N-dimethyl-formamide |
2-(4-amino-phenyl)ethanesulfonic acid methylamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C 2.1: dichloromethane / 1.5 h / 25 °C 3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 3.2: 25 °C 4.1: potassium hydroxide; ethanol / 15 - 25 °C 5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 5.2: 0.5 h / 25 °C 6.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 6.2: 10 - 15 °C / pH 8 7.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 7.2: 10 °C / pH 7.5 - 8.5 8.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 7 steps 1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C 2.1: dichloromethane / 1.5 h / 25 °C 3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 3.2: 25 °C 4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere 4.2: 0.5 h / 25 °C 5.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 5.2: 10 - 15 °C / pH 8 6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 6.2: 10 °C / pH 7.5 - 8.5 7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 8 steps 1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C 2.1: methanol / 25 - 30 °C 2.2: 4 h / 25 - 30 °C 3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 3.2: 25 °C 4.1: potassium hydroxide; ethanol / 15 - 25 °C 5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 6.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 7.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C 8.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 9 steps 1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C 2.1: methanol / 25 - 30 °C 2.2: 4 h / 25 - 30 °C 3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 3.2: 25 °C 4.1: potassium hydroxide; ethanol / 15 - 25 °C 5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 6.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 7.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 7.2: 25 - 30 °C 7.3: 10 - 15 °C 8.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 8.2: 10 °C / pH 7.5 - 8.5 9.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
N-Methyl-1H-indole-5-ethanesulphonamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 1.2: 10 - 15 °C / pH 8 2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 2.2: 10 °C / pH 7.5 - 8.5 3.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
N-[2-iodo-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 1.2: 25 °C 2.1: potassium hydroxide; ethanol / 15 - 25 °C 3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 3.2: 0.5 h / 25 °C 4.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 4.2: 10 - 15 °C / pH 8 5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 5.2: 10 °C / pH 7.5 - 8.5 6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 5 steps 1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 1.2: 25 °C 2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere 2.2: 0.5 h / 25 °C 3.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 3.2: 10 - 15 °C / pH 8 4.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 4.2: 10 °C / pH 7.5 - 8.5 5.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
2-(4-benzylamino-3-iodophenyl)ethanesulfonic acid methylamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 1.2: 25 °C 2.1: potassium hydroxide; ethanol / 15 - 25 °C 3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 4.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 5.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 5.2: 25 - 30 °C 5.3: 10 - 15 °C 6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 6.2: 10 °C / pH 7.5 - 8.5 7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 6 steps 1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 1.2: 25 °C 2.1: potassium hydroxide; ethanol / 15 - 25 °C 3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 4.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 5.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C 6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
N-[4-(2-{methylsulfamoyl}ethyl)-2-{2-(trimethylsilanyl)ethynyl}phenyl]acetamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium hydroxide; ethanol / 15 - 25 °C 2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 2.2: 0.5 h / 25 °C 3.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 3.2: 10 - 15 °C / pH 8 4.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 4.2: 10 °C / pH 7.5 - 8.5 5.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere 1.2: 0.5 h / 25 °C 2.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 2.2: 10 - 15 °C / pH 8 3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 3.2: 10 °C / pH 7.5 - 8.5 4.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: potassium hydroxide; ethanol / 15 - 25 °C 2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 3.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 4.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 4.2: 25 - 30 °C 4.3: 10 - 15 °C 5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 5.2: 10 °C / pH 7.5 - 8.5 6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 5 steps 1: potassium hydroxide; ethanol / 15 - 25 °C 2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 3: potassium hydroxide / methanol / 8 h / 60 - 65 °C 4: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C 5: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 1.2: 0.5 h / 25 °C 2.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 2.2: 10 - 15 °C / pH 8 3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 3.2: 10 °C / pH 7.5 - 8.5 4.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
2-(4-benzylamino-3-ethynylphenyl)ethanesulfonic acid methylamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 2.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 3.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 3.2: 25 - 30 °C 3.3: 10 - 15 °C 4.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 4.2: 10 °C / pH 7.5 - 8.5 5.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 4 steps 1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 2: potassium hydroxide / methanol / 8 h / 60 - 65 °C 3: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C 4: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 2.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 2.2: 25 - 30 °C 2.3: 10 - 15 °C 3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 3.2: 10 °C / pH 7.5 - 8.5 4.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 3 steps 1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 2: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C 3: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
2-[1-benzyl-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 1.2: 25 - 30 °C 1.3: 10 - 15 °C 2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 2.2: 10 °C / pH 7.5 - 8.5 3.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
N-methyl-2-[1-benzyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 1.2: 10 °C / pH 7.5 - 8.5 2.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
2-(4-amino-3-iodo-phenyl)ethanesulfonic acid methylamide
naratriptan hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: dichloromethane / 1.5 h / 25 °C 2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 2.2: 25 °C 3.1: potassium hydroxide; ethanol / 15 - 25 °C 4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 4.2: 0.5 h / 25 °C 5.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 5.2: 10 - 15 °C / pH 8 6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 6.2: 10 °C / pH 7.5 - 8.5 7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 6 steps 1.1: dichloromethane / 1.5 h / 25 °C 2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 2.2: 25 °C 3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere 3.2: 0.5 h / 25 °C 4.1: trifluoroacetic acid / ethanol / 25 °C / Reflux 4.2: 10 - 15 °C / pH 8 5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr 5.2: 10 °C / pH 7.5 - 8.5 6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 7 steps 1.1: methanol / 25 - 30 °C 1.2: 4 h / 25 - 30 °C 2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 2.2: 25 °C 3.1: potassium hydroxide; ethanol / 15 - 25 °C 4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 5.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 6.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C 7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme | |
Multi-step reaction with 8 steps 1.1: methanol / 25 - 30 °C 1.2: 4 h / 25 - 30 °C 2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C 2.2: 25 °C 3.1: potassium hydroxide; ethanol / 15 - 25 °C 4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C 5.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C 6.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C 6.2: 25 - 30 °C 6.3: 10 - 15 °C 7.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr 7.2: 10 °C / pH 7.5 - 8.5 8.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1 View Scheme |
naratriptan hydrochloride
Conditions | Yield |
---|---|
With sodium periodate In methanol at 20℃; for 68.5h; | 76% |
naratriptan hydrochloride
Conditions | Yield |
---|---|
With 2-((-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)cyclohexyl)carbamoyl)-3,4,5,6-tetrachlorobenzoic acid; trifluoroacetic acid In methanol; dichloromethane; water at 20℃; for 24h; | 49% |
naratriptan hydrochloride
Conditions | Yield |
---|---|
With water; iodine; sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 20h; chemoselective reaction; | 24% |
naratriptan hydrochloride
naratriptan
Conditions | Yield |
---|---|
With sodium hydroxide In water |
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