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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Naratriptan hydrochloride Manufacturer/High quality/Best price/In stock

Cas:143388-64-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Naratriptan Hydrochloride 143388-64-1 GMP Manufacturer

Cas:143388-64-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Naratriptan monohydrochloride

Cas:143388-64-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 143388-64-1--High purity NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI) in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China

TIANFUCHEM-- 143388-64-1--High purity NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI) in stock

Cas:143388-64-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Naratriptan Hydrochloride

Cas:143388-64-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 143388-64-1 with competitive price

Cas:143388-64-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Naratriptan hydrochloride/ LIDE PHARMA- Factory supply / Best price

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

Naratriptan Hydrochloride CAS:143388-64-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

Naratriptan Hydrochloride CAS:143388-64-1

Cas:143388-64-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-, hydrochloride (1:1)

Cas:143388-64-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-, hydrochloride (1:1)

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Naratriptan HCl

Cas:143388-64-1

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Naratriptan hydrochloride

Cas:143388-64-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Naratriptan hydrochloride 143388-64-1

Cas:143388-64-1

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-, hydrochloride (1:1)

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Naratriptan hydrochloride Manufacturer

Cas:143388-64-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Naratriptan Hydrochloride

Cas:143388-64-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Naratriptanhydrochloride

Cas:143388-64-1

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:Beige solid Storage:Storage in a dry, v

Naratriptan hydrochloride 98% CAS NO.143388-64-1

Cas:143388-64-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

143388-64-1 CAS NO.143388-64-1

Cas:143388-64-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Naratriptan hydrochloride

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Name Naratriptan hydrochloride Synonyms N-Methyl-3-(1-methylpiperidin-4-yl)-1H-indole-5-ethanesulfonamide hydrochloride Molecular Structure

NARATRIPTAN HYDROCHLORIDE

Cas:143388-64-1

Min.Order:100 Gram

Negotiable

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Naratriptan Hydrochloride cas no. 143388-64-1 98%

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

NARATRIPTAN HYDROCHLORIDE (125 MG)F0C36099%8MG/MG(AI)

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Naratryptan hydrochloride

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:to formulate preparations Transportation:by courier, air or sea Port:At any port fro

Naratriptan Hydrochloride 143388-64-1 API

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Naratriptan Hydrochloride (125 mg)

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

NARATRIPTAN HYDROCHLORIDE (125 MG)F0C3600.998MG/MG(AI)

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-, hydrochloride (1:1)

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Naratriptan hydrochloride CAS No.143388-64-1

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as primary a

Naratriptan Hydrochloride - Labeled d3

Cas:143388-64-1

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

naratriptan
121679-13-8

naratriptan

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 0 - 30℃; for 1h; pH=1.0 - 1.5; Product distribution / selectivity;93.4%
With hydrogenchloride In methanol; water at 0 - 10℃;84%
With hydrogenchloride In methanol; ethanol at 5 - 25℃; pH=1.0;71.7%
With hydrogenchloride In isopropyl alcohol; acetone at 5 - 10℃; pH=1;
palladium oxide on charcoal

palladium oxide on charcoal

N-methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethenesulphonamide
166306-28-1

N-methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethenesulphonamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
In hydrogenchloride; methanesulfonic acid; water88%
With hydrogenchloride In water; ethyl acetate; N,N-dimethyl-formamide
With hydrogenchloride In water; ethyl acetate; N,N-dimethyl-formamide
N-methyl-2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide
121679-20-7

N-methyl-2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Stage #1: N-methyl-2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide With hydrogen; acetic acid; platinum(IV) oxide In methanol at 50 - 60℃; under 3677.86 Torr;
Stage #2: With hydrogenchloride In ethanol; isopropyl alcohol for 1h; Product distribution / selectivity; Reflux;
85%
Multi-step reaction with 2 steps
1.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
1.2: 10 °C / pH 7.5 - 8.5
2.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
palladium oxide on charcoal

palladium oxide on charcoal

(E)-N-Methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethene sulphonamide, hydrochloride
166306-29-2

(E)-N-Methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethene sulphonamide, hydrochloride

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
In methanol; water; ethyl acetate; N,N-dimethyl-formamide71.2%
C18H24N3O4S(1-)*Na(1+)

C18H24N3O4S(1-)*Na(1+)

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water for 12h; pH=2; Product distribution / selectivity; Heating / reflux;
palladium oxide on charcoal

palladium oxide on charcoal

N-methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethenesulphonamide
166306-28-1

N-methyl-2-[3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indol-5-yl]ethenesulphonamide

pyrographite
7440-44-0

pyrographite

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate; N,N-dimethyl-formamide
With hydrogenchloride In ethyl acetate; N,N-dimethyl-formamide
2-(4-amino-phenyl)ethanesulfonic acid methylamide
98623-16-6

2-(4-amino-phenyl)ethanesulfonic acid methylamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: dichloromethane / 1.5 h / 25 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium hydroxide; ethanol / 15 - 25 °C
5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
5.2: 0.5 h / 25 °C
6.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
6.2: 10 - 15 °C / pH 8
7.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
7.2: 10 °C / pH 7.5 - 8.5
8.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: dichloromethane / 1.5 h / 25 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere
4.2: 0.5 h / 25 °C
5.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
5.2: 10 - 15 °C / pH 8
6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
6.2: 10 °C / pH 7.5 - 8.5
7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: methanol / 25 - 30 °C
2.2: 4 h / 25 - 30 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium hydroxide; ethanol / 15 - 25 °C
5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
6.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
7.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
8.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 9 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: methanol / 25 - 30 °C
2.2: 4 h / 25 - 30 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium hydroxide; ethanol / 15 - 25 °C
5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
6.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
7.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
7.2: 25 - 30 °C
7.3: 10 - 15 °C
8.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
8.2: 10 °C / pH 7.5 - 8.5
9.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
N-Methyl-1H-indole-5-ethanesulphonamide
98623-50-8

N-Methyl-1H-indole-5-ethanesulphonamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
1.2: 10 - 15 °C / pH 8
2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
2.2: 10 °C / pH 7.5 - 8.5
3.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
N-[2-iodo-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide
1268265-90-2

N-[2-iodo-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium hydroxide; ethanol / 15 - 25 °C
3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
3.2: 0.5 h / 25 °C
4.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
4.2: 10 - 15 °C / pH 8
5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
5.2: 10 °C / pH 7.5 - 8.5
6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 5 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere
2.2: 0.5 h / 25 °C
3.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
3.2: 10 - 15 °C / pH 8
4.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
4.2: 10 °C / pH 7.5 - 8.5
5.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
2-(4-benzylamino-3-iodophenyl)ethanesulfonic acid methylamide
1268265-93-5

2-(4-benzylamino-3-iodophenyl)ethanesulfonic acid methylamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium hydroxide; ethanol / 15 - 25 °C
3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
4.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
5.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
5.2: 25 - 30 °C
5.3: 10 - 15 °C
6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
6.2: 10 °C / pH 7.5 - 8.5
7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 6 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium hydroxide; ethanol / 15 - 25 °C
3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
4.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
5.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
N-[4-(2-{methylsulfamoyl}ethyl)-2-{2-(trimethylsilanyl)ethynyl}phenyl]acetamide
1268265-95-7

N-[4-(2-{methylsulfamoyl}ethyl)-2-{2-(trimethylsilanyl)ethynyl}phenyl]acetamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium hydroxide; ethanol / 15 - 25 °C
2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
2.2: 0.5 h / 25 °C
3.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
3.2: 10 - 15 °C / pH 8
4.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
4.2: 10 °C / pH 7.5 - 8.5
5.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere
1.2: 0.5 h / 25 °C
2.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
2.2: 10 - 15 °C / pH 8
3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
3.2: 10 °C / pH 7.5 - 8.5
4.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide
1268265-97-9

2-(4-benzylamino-3-trimethylsilanylethynyl-phenyl)ethanesulfonic acid methylamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium hydroxide; ethanol / 15 - 25 °C
2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
3.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
4.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
4.2: 25 - 30 °C
4.3: 10 - 15 °C
5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
5.2: 10 °C / pH 7.5 - 8.5
6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 5 steps
1: potassium hydroxide; ethanol / 15 - 25 °C
2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
3: potassium hydroxide / methanol / 8 h / 60 - 65 °C
4: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
5: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide
1268265-99-1

N-[2-ethynyl-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
1.2: 0.5 h / 25 °C
2.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
2.2: 10 - 15 °C / pH 8
3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
3.2: 10 °C / pH 7.5 - 8.5
4.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
2-(4-benzylamino-3-ethynylphenyl)ethanesulfonic acid methylamide
1268266-01-8

2-(4-benzylamino-3-ethynylphenyl)ethanesulfonic acid methylamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
2.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
3.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
3.2: 25 - 30 °C
3.3: 10 - 15 °C
4.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
4.2: 10 °C / pH 7.5 - 8.5
5.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 4 steps
1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
2: potassium hydroxide / methanol / 8 h / 60 - 65 °C
3: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
4: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide
894351-85-0

2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
2.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
2.2: 25 - 30 °C
2.3: 10 - 15 °C
3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
3.2: 10 °C / pH 7.5 - 8.5
4.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 3 steps
1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
2: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
3: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
2-[1-benzyl-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide
894351-86-1

2-[1-benzyl-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
1.2: 25 - 30 °C
1.3: 10 - 15 °C
2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
2.2: 10 °C / pH 7.5 - 8.5
3.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
N-methyl-2-[1-benzyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
894351-87-2

N-methyl-2-[1-benzyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
1.2: 10 °C / pH 7.5 - 8.5
2.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
2-(4-amino-3-iodo-phenyl)ethanesulfonic acid methylamide
1200070-42-3

2-(4-amino-3-iodo-phenyl)ethanesulfonic acid methylamide

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: dichloromethane / 1.5 h / 25 °C
2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
2.2: 25 °C
3.1: potassium hydroxide; ethanol / 15 - 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
4.2: 0.5 h / 25 °C
5.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
5.2: 10 - 15 °C / pH 8
6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
6.2: 10 °C / pH 7.5 - 8.5
7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 6 steps
1.1: dichloromethane / 1.5 h / 25 °C
2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
2.2: 25 °C
3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere
3.2: 0.5 h / 25 °C
4.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
4.2: 10 - 15 °C / pH 8
5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
5.2: 10 °C / pH 7.5 - 8.5
6.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 7 steps
1.1: methanol / 25 - 30 °C
1.2: 4 h / 25 - 30 °C
2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
2.2: 25 °C
3.1: potassium hydroxide; ethanol / 15 - 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
5.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
6.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
7.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
Multi-step reaction with 8 steps
1.1: methanol / 25 - 30 °C
1.2: 4 h / 25 - 30 °C
2.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
2.2: 25 °C
3.1: potassium hydroxide; ethanol / 15 - 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
5.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
6.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
6.2: 25 - 30 °C
6.3: 10 - 15 °C
7.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
7.2: 10 °C / pH 7.5 - 8.5
8.1: hydrogenchloride / isopropyl alcohol; acetone / 5 - 10 °C / pH 1
View Scheme
naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

2-[4-formylamino-3-(1-methylpiperidine-4-carbonyl)phenyl]ethanesulphonic acid methylamide

2-[4-formylamino-3-(1-methylpiperidine-4-carbonyl)phenyl]ethanesulphonic acid methylamide

Conditions
ConditionsYield
With sodium periodate In methanol at 20℃; for 68.5h;76%
1-((4-azido)phenylthio)pyrrolidine-2,5-dione

1-((4-azido)phenylthio)pyrrolidine-2,5-dione

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

2-(2-(4-azidophenyl)thio-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)-N-methylethanesulfonamide

2-(2-(4-azidophenyl)thio-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)-N-methylethanesulfonamide

Conditions
ConditionsYield
With 2-((-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)cyclohexyl)carbamoyl)-3,4,5,6-tetrachlorobenzoic acid; trifluoroacetic acid In methanol; dichloromethane; water at 20℃; for 24h;49%
naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

1-methyl-5'-(2-(N-methylsulfamoyl)ethyl)-2'-oxo-1-azaspiro[bicyclo[2.2.1]heptane-7,3'-indolin]-1-ium iodide

1-methyl-5'-(2-(N-methylsulfamoyl)ethyl)-2'-oxo-1-azaspiro[bicyclo[2.2.1]heptane-7,3'-indolin]-1-ium iodide

Conditions
ConditionsYield
With water; iodine; sodium hydrogencarbonate In tetrahydrofuran at 20℃; for 20h; chemoselective reaction;24%
naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
With sodium hydroxide In water

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