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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Naratriptan

Cas:121679-13-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Naratriptan CAS 121679-13-8

Cas:121679-13-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 121679-13-8 with competitive price

Cas:121679-13-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)- 121679-13-8

Cas:121679-13-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Naratriptan CAS:121679-13-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Naratriptan CAS:121679-13-8

Cas:121679-13-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Naratriptan

Cas:121679-13-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

Naratriptan

Cas:121679-13-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Naratriptan CAS 121679-13-8 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control sys

Naratriptan CAS 121679-13-8

Cas:121679-13-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

NARATRIPTAN

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Miheng Trading Co., Ltd.

Naratriptan CAS 121679-13-8 Our advantage 1.Top quality: Using high quality material and establishing a strict quality control system,assigning specific persons in charge of each part of production,from raw material purchase to assembly. 2

Naratriptan CAS 121679-13-8

Cas:121679-13-8

Min.Order:1 Kilogram

FOB Price: $50.0 / 100.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Naratriptan

Cas:121679-13-8

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:Used as Pharmaceutical Intermediates Transporta

1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-

Cas:121679-13-8

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

121679-13-8 1H-Indole-5-ethanesulfonamide,N-methyl-3-(1-methyl-4-piperidinyl)-

Cas:121679-13-8

Min.Order:1 Metric Ton

FOB Price: $5000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Naratriptan

Cas:121679-13-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Top Purity Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Trading Company

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Naratriptan

Cas:121679-13-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Naratriptan

Cas:121679-13-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Naratriptan

Cas:121679-13-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Other

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Naratriptan

Cas:121679-13-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

high purity, manufacturer Application:Intermediate

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Naratriptan

Cas:121679-13-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

N-methyl-2-[1-benzyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
894351-87-2

N-methyl-2-[1-benzyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
With ammonia; sodium In tetrahydrofuran for 0.166667h;84%
Stage #1: N-methyl-2-[1-benzyl-3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide With hydrogen; acetic acid; palladium 10% on activated carbon at 25℃; under 724.026 Torr;
Stage #2: With ammonia In water at 10℃; pH=7.5 - 8.5;
2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide
639008-15-4

2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
With sodium In tetrahydrofuran; ammonia at -78℃; for 0.75h;80%
N-methyl-2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide
121679-20-7

N-methyl-2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In ethanol at 25 - 35℃; Product distribution / selectivity;73.3%
With hydrogen; palladium 10% on activated carbon In ethanol; N,N-dimethyl-formamide at 25 - 35℃; under 2206.72 Torr; for 2h; Product distribution / selectivity;72.7%
With 5% Pd(II)/C(eggshell); hydrogen; acetic acid In methanol; water at 25 - 35℃; under 6840.46 - 7600.51 Torr; Reactivity; Reagent/catalyst; Solvent; Time;64%
1-benzyl-1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-piperidinium bromide

1-benzyl-1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-piperidinium bromide

A

naratriptan
121679-13-8

naratriptan

B

2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide
220392-03-0

2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

Conditions
ConditionsYield
With lithium triamylborohydride In tetrahydrofuran for 26h; dequaternisation; Heating;A n/a
B 44%
1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-1-(1-phenyl-ethyl)piperidinium bromide

1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-1-(1-phenyl-ethyl)piperidinium bromide

A

naratriptan
121679-13-8

naratriptan

B

2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide
220392-08-5

2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran at 60℃; for 22h; dequaternisation; Title compound not separated from byproducts;
2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide
894351-85-0

2-(1-benzyl-1H-indol-5-yl)ethanesulfonic acid methylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 75 percent / trifluoroacetic acid; acetic acid / 1 h / 100 °C
2: 74 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 4 h / 20 °C / 3750.3 Torr
3: 84 percent / Na; liquid NH3 / tetrahydrofuran / 0.17 h
View Scheme
Multi-step reaction with 3 steps
1.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
2.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
2.2: 25 - 30 °C
2.3: 10 - 15 °C
3.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
3.2: 10 °C / pH 7.5 - 8.5
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
2: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
View Scheme
2-(1-benzyl-1H-indol-5-yl)ethenesulfonic acid methylamide
894351-84-9

2-(1-benzyl-1H-indol-5-yl)ethenesulfonic acid methylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 84 percent / H2 / 10 percent Pd/C / methanol / 2 h / 20 °C / 3750.3 Torr
2: 75 percent / trifluoroacetic acid; acetic acid / 1 h / 100 °C
3: 74 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 4 h / 20 °C / 3750.3 Torr
4: 84 percent / Na; liquid NH3 / tetrahydrofuran / 0.17 h
View Scheme
2-[1-benzyl-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide
894351-86-1

2-[1-benzyl-3-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 4 h / 20 °C / 3750.3 Torr
2: 84 percent / Na; liquid NH3 / tetrahydrofuran / 0.17 h
View Scheme
With triethylsilane; ethanol; hydrogen; palladium 10% on activated carbon In ethanol at 25 - 30℃;
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
1.2: 25 - 30 °C
1.3: 10 - 15 °C
2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
2.2: 10 °C / pH 7.5 - 8.5
View Scheme
N-benzylindoline-5-carboxaldehyde
63263-84-3

N-benzylindoline-5-carboxaldehyde

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 75 percent / DDQ / CH2Cl2 / 3 h / 0 °C
2.1: t-BuOK / tetrahydrofuran / 1 h / -78 °C
2.2: 73 percent / tetrahydrofuran / -78 - 0 °C
3.1: 84 percent / H2 / 10 percent Pd/C / methanol / 2 h / 20 °C / 3750.3 Torr
4.1: 75 percent / trifluoroacetic acid; acetic acid / 1 h / 100 °C
5.1: 74 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 4 h / 20 °C / 3750.3 Torr
6.1: 84 percent / Na; liquid NH3 / tetrahydrofuran / 0.17 h
View Scheme
1-benzyl-1H-indole-5-carbaldehyde
63263-88-7

1-benzyl-1H-indole-5-carbaldehyde

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: t-BuOK / tetrahydrofuran / 1 h / -78 °C
1.2: 73 percent / tetrahydrofuran / -78 - 0 °C
2.1: 84 percent / H2 / 10 percent Pd/C / methanol / 2 h / 20 °C / 3750.3 Torr
3.1: 75 percent / trifluoroacetic acid; acetic acid / 1 h / 100 °C
4.1: 74 percent / H2 / 10 percent Pd/C / tetrahydrofuran / 4 h / 20 °C / 3750.3 Torr
5.1: 84 percent / Na; liquid NH3 / tetrahydrofuran / 0.17 h
View Scheme
1-Methyl-4-piperidone
1445-73-4

1-Methyl-4-piperidone

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / KOH / methanol / 8 h / Heating
2: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
3: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
trans-2-(p-nitrophenyl)ethenesulfonyl chloride
52148-00-2

trans-2-(p-nitrophenyl)ethenesulfonyl chloride

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C
2: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
3: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
4: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
5: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
6: 84 percent / KOH / methanol / 2 h / 20 °C
7: 83 percent / KOH / methanol / 8 h / Heating
8: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
9: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1: 86 percent / t-BuOK / tetrahydrofuran / 4.5 h / -78 °C
2: 82 percent / triethylamine; methanesulfonyl chloride / CHCl3 / 25.25 h / 0 - 5 °C
3: 0.7 g / NaI*2H2O / acetone / 6 h / Heating
4: 64 percent / dimethylformamide; SOCl2 / benzene / 5 h / Heating
5: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C
6: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
7: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
8: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
9: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
10: 84 percent / KOH / methanol / 2 h / 20 °C
11: 83 percent / KOH / methanol / 8 h / Heating
12: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
13: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
Multi-step reaction with 10 steps
1: 100 percent / n-BuLi / tetrahydrofuran; hexane / 4.5 h / -78 °C
2: 85 percent / triethylamine; methanesulfonyl chloride / CH2Cl2 / 24.17 h / 0 - 5 °C
3: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
4: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
5: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
6: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
7: 84 percent / KOH / methanol / 2 h / 20 °C
8: 83 percent / KOH / methanol / 8 h / Heating
9: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
10: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-(4-nitrophenyl)ethenesulfonic acid isopropyl ester

2-(4-nitrophenyl)ethenesulfonic acid isopropyl ester

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 0.7 g / NaI*2H2O / acetone / 6 h / Heating
2: 64 percent / dimethylformamide; SOCl2 / benzene / 5 h / Heating
3: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C
4: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
5: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
6: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
7: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
8: 84 percent / KOH / methanol / 2 h / 20 °C
9: 83 percent / KOH / methanol / 8 h / Heating
10: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
11: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester
639008-17-6

2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid isopropyl ester

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 82 percent / triethylamine; methanesulfonyl chloride / CHCl3 / 25.25 h / 0 - 5 °C
2: 0.7 g / NaI*2H2O / acetone / 6 h / Heating
3: 64 percent / dimethylformamide; SOCl2 / benzene / 5 h / Heating
4: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C
5: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
6: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
7: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
8: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
9: 84 percent / KOH / methanol / 2 h / 20 °C
10: 83 percent / KOH / methanol / 8 h / Heating
11: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
12: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-(4-nitrophenyl)ethenesulfonic acid benzylmethylamide
639008-01-8

2-(4-nitrophenyl)ethenesulfonic acid benzylmethylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
2: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
3: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
4: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
5: 84 percent / KOH / methanol / 2 h / 20 °C
6: 83 percent / KOH / methanol / 8 h / Heating
7: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
8: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-(4-aminophenyl)ethanesulfonic acid benzylmethylamide
639008-03-0

2-(4-aminophenyl)ethanesulfonic acid benzylmethylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
2: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
3: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
4: 84 percent / KOH / methanol / 2 h / 20 °C
5: 83 percent / KOH / methanol / 8 h / Heating
6: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
7: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
N-benzyl-2-(1H-indole-5-yl)-N-methylethane-1-sulfonamide
639008-13-2

N-benzyl-2-(1H-indole-5-yl)-N-methylethane-1-sulfonamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 83 percent / KOH / methanol / 8 h / Heating
2: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
3: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid benzylmethylamide
639008-16-5

2-hydroxy-2-(4-nitrophenyl)ethanesulfonic acid benzylmethylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 85 percent / triethylamine; methanesulfonyl chloride / CH2Cl2 / 24.17 h / 0 - 5 °C
2: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
3: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
4: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
5: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
6: 84 percent / KOH / methanol / 2 h / 20 °C
7: 83 percent / KOH / methanol / 8 h / Heating
8: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
9: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-[4-(2,2-dimethoxyethylamino)phenyl]ethanesulfonic acid benzylmethylamide
639008-08-5

2-[4-(2,2-dimethoxyethylamino)phenyl]ethanesulfonic acid benzylmethylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
2: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
3: 84 percent / KOH / methanol / 2 h / 20 °C
4: 83 percent / KOH / methanol / 8 h / Heating
5: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
6: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-[1-(2,2,2-trifluoroacetyl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide
639008-12-1

2-[1-(2,2,2-trifluoroacetyl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 84 percent / KOH / methanol / 2 h / 20 °C
2: 83 percent / KOH / methanol / 8 h / Heating
3: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
4: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide
639008-14-3

2-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]ethanesulfonic acid benzylmethylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
2: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide
639008-10-9

N-{4-[2-(benzylmethylsulfamoyl)ethyl]phenyl}-N-(2,2-dimethoxyethyl)-2,2,2-trifluoroacetamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
2: 84 percent / KOH / methanol / 2 h / 20 °C
3: 83 percent / KOH / methanol / 8 h / Heating
4: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
5: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
sodium 2-(4-nitrophenyl)ethenesulfonate

sodium 2-(4-nitrophenyl)ethenesulfonate

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 64 percent / dimethylformamide; SOCl2 / benzene / 5 h / Heating
2: 54 percent / triethylamine / benzene / 5 h / 0 - 20 °C
3: 88 percent / H2 / Pd/C / dioxane / 24 h / 20 °C / 750.06 Torr
4: 84 percent / H2 / Pd/C / ethanol / 8 h / 20 °C
5: 87 percent / triethylamine / CH2Cl2 / 19 h / 0 - 20 °C
6: 51 percent / TiCl4 / chlorobenzene / 0.28 h / 100 - 110 °C
7: 84 percent / KOH / methanol / 2 h / 20 °C
8: 83 percent / KOH / methanol / 8 h / Heating
9: 85 percent / H2 / Pd/C / methanol / 6 h / 20 °C / 3750.3 Torr
10: 80 percent / Na / liquid ammonia; tetrahydrofuran / 0.75 h / -78 °C
View Scheme
4-hydrazino-N-methyl-benzenethanesulphonamide

4-hydrazino-N-methyl-benzenethanesulphonamide

1-methyl-4 (formylmethyl)piperidine
10333-64-9

1-methyl-4 (formylmethyl)piperidine

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
With hydrogenchloride; polyphosphate ester; sodium carbonate In chloroform; water
2-(4-amino-phenyl)ethanesulfonic acid methylamide
98623-16-6

2-(4-amino-phenyl)ethanesulfonic acid methylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: dichloromethane / 1.5 h / 25 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium hydroxide; ethanol / 15 - 25 °C
5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
5.2: 0.5 h / 25 °C
6.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
6.2: 10 - 15 °C / pH 8
7.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
7.2: 10 °C / pH 7.5 - 8.5
View Scheme
Multi-step reaction with 6 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: dichloromethane / 1.5 h / 25 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere
4.2: 0.5 h / 25 °C
5.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
5.2: 10 - 15 °C / pH 8
6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
6.2: 10 °C / pH 7.5 - 8.5
View Scheme
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: methanol / 25 - 30 °C
2.2: 4 h / 25 - 30 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium hydroxide; ethanol / 15 - 25 °C
5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
6.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
7.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sodium hydrogencarbonate; iodine / dichloromethane / 25 - 30 °C
2.1: methanol / 25 - 30 °C
2.2: 4 h / 25 - 30 °C
3.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
3.2: 25 °C
4.1: potassium hydroxide; ethanol / 15 - 25 °C
5.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
6.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
7.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
7.2: 25 - 30 °C
7.3: 10 - 15 °C
8.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
8.2: 10 °C / pH 7.5 - 8.5
View Scheme
N-Methyl-1H-indole-5-ethanesulphonamide
98623-50-8

N-Methyl-1H-indole-5-ethanesulphonamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
1.2: 10 - 15 °C / pH 8
2.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
2.2: 10 °C / pH 7.5 - 8.5
View Scheme
N-[2-iodo-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide
1268265-90-2

N-[2-iodo-4-(2-(methylsulfamoyl)ethyl)phenyl]acetamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium hydroxide; ethanol / 15 - 25 °C
3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
3.2: 0.5 h / 25 °C
4.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
4.2: 10 - 15 °C / pH 8
5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
5.2: 10 °C / pH 7.5 - 8.5
View Scheme
Multi-step reaction with 4 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 25 - 85 °C / Inert atmosphere
2.2: 0.5 h / 25 °C
3.1: trifluoroacetic acid / ethanol / 25 °C / Reflux
3.2: 10 - 15 °C / pH 8
4.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 1448.05 - 2172.08 Torr
4.2: 10 °C / pH 7.5 - 8.5
View Scheme
2-(4-benzylamino-3-iodophenyl)ethanesulfonic acid methylamide
1268265-93-5

2-(4-benzylamino-3-iodophenyl)ethanesulfonic acid methylamide

naratriptan
121679-13-8

naratriptan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium hydroxide; ethanol / 15 - 25 °C
3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
4.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
5.1: trifluoroacetic acid / dichloromethane / 0.17 h / 25 °C
5.2: 25 - 30 °C
5.3: 10 - 15 °C
6.1: hydrogen; acetic acid / palladium 10% on activated carbon / 25 °C / 724.03 Torr
6.2: 10 °C / pH 7.5 - 8.5
View Scheme
Multi-step reaction with 5 steps
1.1: copper(l) iodide; lithium chloride / N,N-dimethyl-formamide / 0.5 h / 25 °C
1.2: 25 °C
2.1: potassium hydroxide; ethanol / 15 - 25 °C
3.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 80 - 85 °C
4.1: potassium hydroxide / methanol / 8 h / 60 - 65 °C
5.1: hydrogen; ethanol; triethylsilane / palladium 10% on activated carbon / ethanol / 25 - 30 °C
View Scheme
(1-bromoethyl)benzne
585-71-7, 38661-81-3

(1-bromoethyl)benzne

naratriptan
121679-13-8

naratriptan

1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-1-(1-phenyl-ethyl)piperidinium bromide

1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-1-(1-phenyl-ethyl)piperidinium bromide

Conditions
ConditionsYield
In acetone at 50℃; for 260h; quaternisation;100%
benzyl bromide
100-39-0

benzyl bromide

naratriptan
121679-13-8

naratriptan

1-benzyl-1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-piperidinium bromide

1-benzyl-1-methyl-4-[5-(2-methylsulfamoyl-ethyl)-1H-indol-3-yl]-piperidinium bromide

Conditions
ConditionsYield
In acetone quaternisation;99%
[13C2H3] methyl iodide
20710-47-8

[13C2H3] methyl iodide

naratriptan
121679-13-8

naratriptan

C17(13)CH25(2)H3N3O2S(1+)*I(1-)

C17(13)CH25(2)H3N3O2S(1+)*I(1-)

Conditions
ConditionsYield
In acetone at 20℃; for 18h; quaternisation;95%
naratriptan
121679-13-8

naratriptan

naratriptan hydrochloride
143388-64-1

naratriptan hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 0 - 30℃; for 1h; pH=1.0 - 1.5; Product distribution / selectivity;93.4%
With hydrogenchloride In methanol; water at 0 - 10℃;84%
With hydrogenchloride In methanol; ethanol at 5 - 25℃; pH=1.0;71.7%
With hydrogenchloride In isopropyl alcohol; acetone at 5 - 10℃; pH=1;
naratriptan
121679-13-8

naratriptan

2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide
220392-08-5

2-{3-[1-(1-phenyl-ethyl)-piperidin-4-yl]-1H-indol-5-yl}-ethanesulfonic acid methylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / acetone / 260 h / 50 °C
2: lithium tri-sec-butylborohydride / tetrahydrofuran / 22 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1: 100 percent / acetone / 260 h / 50 °C
2: lithium trisecbutylborohydride / tetrahydrofuran / 70 h / Heating
View Scheme
naratriptan
121679-13-8

naratriptan

2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide
220392-03-0

2-[3-(1-benzyl-piperidin-4-yl)-1H-indol-5-yl]-ethanesulfonic acid methylamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / acetone
2: 44 percent / lithium trisamylborohydride / tetrahydrofuran / 26 h / Heating
View Scheme

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