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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethyl 2-fluoroacetoacetate Manufacturer/High quality/Best price/In stock

Cas:1522-41-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl 2-fluoro-3-oxobutanoate

Cas:1522-41-4

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Ethyl 2-fluoro-3-oxobutanoate

Cas:1522-41-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company

TIANFU-CHEM - ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 1522-41-4 with best quality

Cas:1522-41-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Butanoic acid,2-fluoro-3-oxo-, ethyl ester

Cas:1522-41-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Butanoic acid,2-fluoro-3-oxo-, ethyl ester

Cas:1522-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 2-fluoroacetoacetate

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Poly[4-Vinylpyridinium Poly(Hydrogen Fluoride)] CAS No.:1522-41-4 Molecule Formula:C6H9FO3 Molecule Weight:148.13 Purity: 98% Package: 25kg/drum Description:White to light yellow powder Manufacture Standards:Enterprise Standard

High Quality Poly[4-Vinylpyridinium Poly(Hydrogen Fluoride)] in stock

Cas:1522-41-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...)

ETHYL 2-FLUOROACETOACETATECAS NO.: 1522-41-4

Cas:1522-41-4

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1522-41-4 CAS NO.1522-41-4

Cas:1522-41-4

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl 2-fluoroacetoacetate

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Ethyl 2-fluoroacetoacetate

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-Fluoroacetoacetic Acid Ethyl Ester cas no. 1522-41-4 98%

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Ethyl 2-fluoroacetoacetate

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is

1522-41-4 supplier in China

Cas:1522-41-4

Min.Order:100 Gram

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec ETHYL 2-FLUOROACETOACETATE 25g

Cas:1522-41-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Ethyl 2-Fluoroacetoacetate

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Butanoic acid,2-fluoro-3-oxo-, ethyl ester

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

ETHYL 2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

1522-41-4

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Ethyl 2-fluoroacetoacetate cas 1522-41-4Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Ethyl 2-fluoroacetoacetate cas 1522-41-4

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low priceAppearance:Clear colorless liquid Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

ETHYL2-FLUOROACETOACETATE

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

1522-41-4 Application:intermediate

ethyl 2-fluoro-3-oxobutanoate

Cas:1522-41-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl acetoacetate
141-97-9

ethyl acetoacetate

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With N-fluorobis<(trifluoromethyl)sulfonyl>imide In dichloromethane; water at 22℃; for 8h;86%
With N-fluorobis<(trifluoromethyl)sulfonyl>imide In dichloromethane; water at 22℃; for 8h;86%
With trifluoroamine oxide; tetra(n-butyl)ammonium hydroxide In acetonitrile at 20℃; for 12h;85%
acetyl hypofluorite
78948-09-1

acetyl hypofluorite

sodium ethyl acetylacetate enolate
1007476-32-5

sodium ethyl acetylacetate enolate

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
In tetrahydrofuran; trichlorofluoromethane at -75℃; for 0.0166667h;81%
ethyl acetoacetate
141-97-9

ethyl acetoacetate

A

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

B

2,2-difluoro-3-oxobutyric acid ethyl ester
2266-48-0

2,2-difluoro-3-oxobutyric acid ethyl ester

C

ethyl 2,4-difluoro-3-oxobutanoate
363-77-9

ethyl 2,4-difluoro-3-oxobutanoate

Conditions
ConditionsYield
With fluorine In formic acid at 10 - 15℃;A 80%
B 1%
C 10%
With fluorine In formic acid at 10 - 15℃; for 2h; Yield given. Yields of byproduct given;
perfluorobutanesulfonic acid
375-73-5

perfluorobutanesulfonic acid

ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With hydrogen fluoride at -10 - 20℃; Temperature; Inert atmosphere;68.51%
ethyl 3-trimethylsiloxy-2-butenoate
13257-83-5

ethyl 3-trimethylsiloxy-2-butenoate

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With fluorine In trichlorofluoromethane at -78℃;48%
ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

acetyl chloride
75-36-5

acetyl chloride

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With diethyl ether; sodium hydride
ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

acetyl chloride
75-36-5

acetyl chloride

formic acid ethyl ester
109-94-4

formic acid ethyl ester

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
(i) NaOEt, (ii) /BRN= 605303/; Multistep reaction;
2-chloro-1,2,2-trifluoroethyl methyl ketone
684-05-9

2-chloro-1,2,2-trifluoroethyl methyl ketone

ethanol
64-17-5

ethanol

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With hydrogenchloride; sodium 1.) 2 h, r.t.; 2.) 15 h, r.t.; Yield given. Multistep reaction;
ethyl bromofluoroacetate
401-55-8

ethyl bromofluoroacetate

acetic anhydride
108-24-7

acetic anhydride

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
Yield given. Multistep reaction;
ethyl acetoacetate
141-97-9

ethyl acetoacetate

A

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

B

2,2-difluoro-3-oxobutyric acid ethyl ester
2266-48-0

2,2-difluoro-3-oxobutyric acid ethyl ester

Conditions
ConditionsYield
With 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; zinc(II) chloride In 1,2-dichloro-ethane at 60℃; for 24h;A 69 % Spectr.
B 12 % Spectr.
With 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate; zinc(II) chloride In 1,2-dichloro-ethane at 60℃; for 12h;A 32 % Spectr.
B 64 % Spectr.
With 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate; cyclopentadienyl titanium(IV) trichloride In acetonitrile at 20℃;
Tributyl-(1-ethoxycarbonyl-1-fluoro-2-oxo-propyl)-phosphonium; chloride

Tributyl-(1-ethoxycarbonyl-1-fluoro-2-oxo-propyl)-phosphonium; chloride

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water for 6h; Ambient temperature; Yield given;
Chlorotrifluoroethylene
79-38-9

Chlorotrifluoroethylene

ethyl acetate
141-78-6

ethyl acetate

A

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

B

1,1,2,4,5,5-Hexafluoro-3-methyl-penta-1,4-dien-3-ol
108400-48-2

1,1,2,4,5,5-Hexafluoro-3-methyl-penta-1,4-dien-3-ol

Conditions
ConditionsYield
With sec.-butyllithium 1.) isopentane, ether, -60 deg C, 15 min, 2.) ether, -50 deg C, 40 min; Yield given. Multistep reaction. Yields of byproduct given;
4,4,4-Triethoxy-3-fluoro-butan-2-one

4,4,4-Triethoxy-3-fluoro-butan-2-one

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With hydrogen cation
(+-)-chloro-fluoro-acetic acid ethyl ester

(+-)-chloro-fluoro-acetic acid ethyl ester

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With diethyl ether; magnesium; ethyl acetate
diethyl ether
60-29-7

diethyl ether

ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

sodium hydride

sodium hydride

A

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

B

2-acetyl-2-fluoro-3-oxo-butyric acid ethyl ester

2-acetyl-2-fluoro-3-oxo-butyric acid ethyl ester

Conditions
ConditionsYield
anschliessendes Behandeln mit Acetylchlorid;
ethyl 2-chloro-3-oxo-butyrate
609-15-4

ethyl 2-chloro-3-oxo-butyrate

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

Conditions
ConditionsYield
With hydrogen fluoride; triethylamine In acetonitrile
[bis(acetoxy)iodo]benzene
3240-34-4

[bis(acetoxy)iodo]benzene

ethyl acetoacetate
141-97-9

ethyl acetoacetate

A

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

B

2,2-difluoro-3-oxobutyric acid ethyl ester
2266-48-0

2,2-difluoro-3-oxobutyric acid ethyl ester

C

2-acetoxy-acetoacetic acid ethyl ester
18632-42-3

2-acetoxy-acetoacetic acid ethyl ester

Conditions
ConditionsYield
With triethylamine tris(hydrogen fluoride) In acetonitrile at 75℃; for 20h; Temperature; Inert atmosphere;
With triethylamine tris(hydrogen fluoride) In acetonitrile at 75℃; for 20h; Inert atmosphere;
formaldehyd
50-00-0

formaldehyd

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

diethylamine
109-89-7

diethylamine

ethyl-2-((diethylamino)methyl)-2-fluoro-3-oxobutanoate

ethyl-2-((diethylamino)methyl)-2-fluoro-3-oxobutanoate

Conditions
ConditionsYield
Stage #1: formaldehyd; diethylamine In dichloromethane at 20℃; for 2h;
Stage #2: ethyl-2-fluoroacetoacetate With sodium hydride In dichloromethane for 16h; Mannich Aminomethylation;
100%
cyclohexenone
930-68-7

cyclohexenone

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

ethyl α-acetyl-α-fluoro-3-oxocyclohexaneacetate
88100-70-3

ethyl α-acetyl-α-fluoro-3-oxocyclohexaneacetate

Conditions
ConditionsYield
With potassium fluoride In sulfolane for 24h;99%
4-penten-3-one
1629-58-9

4-penten-3-one

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

2-Acetyl-2-fluoro-5-oxo-heptanoic acid ethyl ester
88100-63-4

2-Acetyl-2-fluoro-5-oxo-heptanoic acid ethyl ester

Conditions
ConditionsYield
With potassium fluoride In sulfolane for 1h;99%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

methyl vinyl ketone
78-94-4

methyl vinyl ketone

ethyl 2-fluoro-2-acetyl-5-oxohexanoate
88100-62-3

ethyl 2-fluoro-2-acetyl-5-oxohexanoate

Conditions
ConditionsYield
With potassium fluoride In sulfolane for 10h;99%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

C10H10FNO2
681260-31-1

C10H10FNO2

C16H19F2NO5
1166839-29-7

C16H19F2NO5

Conditions
ConditionsYield
With 2,6-di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole In dichloromethane at -50℃; for 24h; Mannich reaction; optical yield given as %de; diastereoselective reaction;99%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

acetoxy-benzyloxycarbonylamino-acetic acid ethyl ester
62183-04-4

acetoxy-benzyloxycarbonylamino-acetic acid ethyl ester

C18H22FNO7

C18H22FNO7

Conditions
ConditionsYield
With C8H20N2*CHF3O3S In chloroform at 60℃; for 48h; Mannich Aminomethylation; stereoselective reaction;99%
3-acetoxycyclopent-1-ene
20657-21-0

3-acetoxycyclopent-1-ene

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

C11H15FO3
946007-52-9

C11H15FO3

Conditions
ConditionsYield
With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); N-ethyl-N,N-diisopropylamine; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 0℃; for 1.16667h; Product distribution / selectivity;98%
With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); Tri-n-octylamine; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 0℃; for 1.16667h; Product distribution / selectivity;92%
With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); triethylamine; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 0℃; for 1.16667h; Product distribution / selectivity;90%
With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); tetrahexylammonium bromide; sodium hydride; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 0℃; for 1.16667h; Product distribution / selectivity;87%
With trans-1,2-(1S,2S)-1,2-diaminocyclohexane-N,N’-bis(2’-diphenylphosphinobenzoyl); sodium hydride; bis(η3-allyl-μ-chloropalladium(II)) In dichloromethane at 0℃; for 1.16667h; Product distribution / selectivity;65%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

1,3-di(m-bromophenyl)allyl acetate

1,3-di(m-bromophenyl)allyl acetate

(E)-3,5-bis(3-chlorophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

(E)-3,5-bis(3-chlorophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

Conditions
ConditionsYield
Stage #1: 1,3-di(m-bromophenyl)allyl acetate With bis(η3-allyl-μ-chloropalladium(II)); (R)-N-tert-butylsulfinyl-2-hydroxybenzamide In tetrahydrofuran; 1,4-dioxane at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: ethyl-2-fluoroacetoacetate With potassium phosphate In tetrahydrofuran; 1,4-dioxane at 20℃; Reagent/catalyst; Solvent;
98%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

(E)-1,3-bis(3-chlorophenyl)-2-propen-1-yl acetate
1292309-64-8

(E)-1,3-bis(3-chlorophenyl)-2-propen-1-yl acetate

(E)-3,5-bis(3-chlorophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

(E)-3,5-bis(3-chlorophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

Conditions
ConditionsYield
Stage #1: (E)-1,3-bis(3-chlorophenyl)-2-propen-1-yl acetate With bis(η3-allyl-μ-chloropalladium(II)); (R)-N-tert-butylsulfinyl-2-hydroxybenzamide In tetrahydrofuran; 1,4-dioxane at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: ethyl-2-fluoroacetoacetate With potassium phosphate In tetrahydrofuran; 1,4-dioxane at 20℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Schlenk technique;
98%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

rac-(E)-1,3-bis(4-bromophenyl)-2-propen-1-yl acetate

rac-(E)-1,3-bis(4-bromophenyl)-2-propen-1-yl acetate

(E)-3,5-bis(4-bromophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

(E)-3,5-bis(4-bromophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

Conditions
ConditionsYield
Stage #1: rac-(E)-1,3-bis(4-bromophenyl)-2-propen-1-yl acetate With bis(η3-allyl-μ-chloropalladium(II)); (R)-N-tert-butylsulfinyl-2-hydroxybenzamide In tetrahydrofuran; 1,4-dioxane at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: ethyl-2-fluoroacetoacetate With potassium phosphate In tetrahydrofuran; 1,4-dioxane at 20℃; Inert atmosphere; Schlenk technique;
98%
pyrrolidine
123-75-1

pyrrolidine

formaldehyd
50-00-0

formaldehyd

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

ethyl-2-(pyrrolidin-1-methyl)-2-fluoro-3-oxobutanoate

ethyl-2-(pyrrolidin-1-methyl)-2-fluoro-3-oxobutanoate

Conditions
ConditionsYield
Stage #1: pyrrolidine; formaldehyd In dichloromethane at 20℃; for 2h;
Stage #2: ethyl-2-fluoroacetoacetate In dichloromethane for 16h; Mannich Aminomethylation;
98%
formaldehyd
50-00-0

formaldehyd

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

ethyl-2-((benzylmethylamino)methyl)-2-fluoro-3-oxobutanoate

ethyl-2-((benzylmethylamino)methyl)-2-fluoro-3-oxobutanoate

Conditions
ConditionsYield
Stage #1: formaldehyd; benzyl-methyl-amine In dichloromethane at 20℃; for 2h;
Stage #2: ethyl-2-fluoroacetoacetate With sodium hydride In dichloromethane for 16h; Mannich Aminomethylation;
98%
piperidine
110-89-4

piperidine

formaldehyd
50-00-0

formaldehyd

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

ethyl-2-(piperidin-1-methyl)-2-fluoro-3-oxobutanoate

ethyl-2-(piperidin-1-methyl)-2-fluoro-3-oxobutanoate

Conditions
ConditionsYield
Stage #1: piperidine; formaldehyd In dichloromethane at 20℃; for 2h;
Stage #2: ethyl-2-fluoroacetoacetate In dichloromethane for 16h; Mannich Aminomethylation;
98%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

rac-(E)-1,3-bis(4-chlorophenyl)-2-propen-1-yl acetate

rac-(E)-1,3-bis(4-chlorophenyl)-2-propen-1-yl acetate

(E)-3,5-bis(4-chlorophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

(E)-3,5-bis(4-chlorophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

Conditions
ConditionsYield
Stage #1: rac-(E)-1,3-bis(4-chlorophenyl)-2-propen-1-yl acetate With bis(η3-allyl-μ-chloropalladium(II)); (R)-N-tert-butylsulfinyl-2-hydroxybenzamide In tetrahydrofuran; 1,4-dioxane at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: ethyl-2-fluoroacetoacetate With potassium phosphate In tetrahydrofuran; 1,4-dioxane at 20℃; Inert atmosphere; Schlenk technique;
97%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

2-methoxyresorcinol
29267-67-2

2-methoxyresorcinol

3-fluoro-7-hydroxy-8-methoxy-4-methyl-2H-1-benzopyran-2-one
1211944-06-7

3-fluoro-7-hydroxy-8-methoxy-4-methyl-2H-1-benzopyran-2-one

Conditions
ConditionsYield
With perchloric acid at 20℃; Pechmann condensation;96%
In 1,4-dioxane at 20℃; Pechmann Condensation; Acidic conditions;
tert-Butyl N-hydroxycarbamate
36016-38-3

tert-Butyl N-hydroxycarbamate

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

C11H18FNO6

C11H18FNO6

Conditions
ConditionsYield
With copper(II) acetate hydrate; 2-ethyl-1,3-oxazoline; copper(l) chloride In isopropyl alcohol at 20℃; regioselective reaction;96%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

4-bromo-β-nitrostyrene
3156-37-4

4-bromo-β-nitrostyrene

(2S,3R)-ethyl 2-acetyl-3-(4-bromophenyl)-2-fluoro-4-nitrobutanoate

(2S,3R)-ethyl 2-acetyl-3-(4-bromophenyl)-2-fluoro-4-nitrobutanoate

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; (S)-N1-(2-adamantyl)-3,3-dimethylbutane-1,2-diamine; 4-nitro-benzoic acid In dichloromethane at 20℃; Michael Addition; enantioselective reaction;96%
formaldehyd
50-00-0

formaldehyd

ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

diisopropylamine
108-18-9

diisopropylamine

ethyl-2-((diisopropylamino)methyl)-2-fluoro-3-oxobutanoate

ethyl-2-((diisopropylamino)methyl)-2-fluoro-3-oxobutanoate

Conditions
ConditionsYield
Stage #1: formaldehyd; diisopropylamine In dichloromethane at 20℃; for 2h;
Stage #2: ethyl-2-fluoroacetoacetate With sodium hydride In dichloromethane for 16h; Mannich Aminomethylation;
95%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

trans-4'-(trifluoromethyl)chalcone
32120-33-5

trans-4'-(trifluoromethyl)chalcone

3-phenyl-5-(4-trifluoromethylphenyl)-phenol

3-phenyl-5-(4-trifluoromethylphenyl)-phenol

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 120℃; for 4h;94%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

(E)‐3‐phenyl‐1‐[3‐(trifluoromethyl)phenyl]prop‐2‐en‐1‐one

(E)‐3‐phenyl‐1‐[3‐(trifluoromethyl)phenyl]prop‐2‐en‐1‐one

ethyl 3-phenyl-5-(3-trifluoromethylphenyl)-phenol-2-carboxylate

ethyl 3-phenyl-5-(3-trifluoromethylphenyl)-phenol-2-carboxylate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 70℃; for 0.5h;94%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

rac-(E)-1,3-bis(3-bromophenyl)-2-propen-1-yl acetate
1445949-58-5

rac-(E)-1,3-bis(3-bromophenyl)-2-propen-1-yl acetate

(E)-3,5-bis(3-bromophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

(E)-3,5-bis(3-bromophenyl)-2-acetyl-2-fluoro-4-pentenoate ethyl ester

Conditions
ConditionsYield
Stage #1: rac-(E)-1,3-bis(3-bromophenyl)-2-propen-1-yl acetate With bis(η3-allyl-μ-chloropalladium(II)); (R)-N-tert-butylsulfinyl-2-hydroxybenzamide In tetrahydrofuran; 1,4-dioxane at 20℃; for 0.5h; Inert atmosphere; Schlenk technique;
Stage #2: ethyl-2-fluoroacetoacetate With potassium phosphate In tetrahydrofuran; 1,4-dioxane at 20℃; Inert atmosphere; Schlenk technique;
94%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

benzalacetophenone
94-41-7

benzalacetophenone

1-Fluor-6-oxo-2,4-diphenyl-cyclohexen-(4)-carbonsaeure-(1)-aethylester
1995-49-9

1-Fluor-6-oxo-2,4-diphenyl-cyclohexen-(4)-carbonsaeure-(1)-aethylester

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 20℃; for 24h;93%
With N-benzyl-trimethylammonium hydroxide; triethylamine In ethanol
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

1-iodo-2-phenylethyne
932-88-7

1-iodo-2-phenylethyne

(E)-ethyl 2-ethanoyl-2-fluoro-4-iodo-3-phenylbut-3-enoate
1016893-08-5

(E)-ethyl 2-ethanoyl-2-fluoro-4-iodo-3-phenylbut-3-enoate

Conditions
ConditionsYield
With indium(III) tris[bis(trifluoromethanesulfonyl)amide] In toluene at 70℃; for 16h; Darkness; regioselective reaction;93%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

4-fluorochalcone
1608-51-1

4-fluorochalcone

4-fluoro-[1,1':3',1''-terphenyl]-5'-ol
1316191-13-5

4-fluoro-[1,1':3',1''-terphenyl]-5'-ol

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 120℃; for 4h;93%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

(E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one
2960-55-6

(E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one

4-nitro-[1,1':3',1"-terphenyl]-5'-phenol
98124-35-7

4-nitro-[1,1':3',1"-terphenyl]-5'-phenol

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 120℃; for 4h;93%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

trans-4'-(trifluoromethyl)chalcone
32120-33-5

trans-4'-(trifluoromethyl)chalcone

ethyl 3-phenyl-5-(4-trifluoromethylphenyl)-phenol-2-carboxylate

ethyl 3-phenyl-5-(4-trifluoromethylphenyl)-phenol-2-carboxylate

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 70℃; for 0.5h;93%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

(E)-1-Phenyl-3-pyrid-3-yl-propenon
20890-14-6

(E)-1-Phenyl-3-pyrid-3-yl-propenon

3-phenyl-5-(3-pyridyl)-phenol

3-phenyl-5-(3-pyridyl)-phenol

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 120℃; for 4h;93%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

(Z)-2-fluoro-1-phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one
126912-60-5

(Z)-2-fluoro-1-phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

3-(4-trifluoromethylphenyl)-4-fluoro-5-phenylphenol

3-(4-trifluoromethylphenyl)-4-fluoro-5-phenylphenol

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 120℃; for 4h;93%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

(Z)-2-fluoro-1-phenyl-3-(pyridin-2-yl)prop-2-en-1-one

(Z)-2-fluoro-1-phenyl-3-(pyridin-2-yl)prop-2-en-1-one

3-(2-pyridyl)-4-fluoro-5-phenylphenol

3-(2-pyridyl)-4-fluoro-5-phenylphenol

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 120℃; for 4h;93%
ethyl-2-fluoroacetoacetate
1522-41-4

ethyl-2-fluoroacetoacetate

4-chloro-[1,1':3',1''-terphenyl]-5'-ol
115752-51-7

4-chloro-[1,1':3',1''-terphenyl]-5'-ol

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 120℃; for 4h;93%

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