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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate CAS 153559-45-6

Cas:153559-45-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate CAS:153559-45-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate CAS:153559-45-6

Cas:153559-45-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzoic acid,4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]-, methylester

Cas:153559-45-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Benzoic acid,4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]-, methylester

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

METHYL 4-[(5,6,7,8-TETRAHYDRO-3,5,5,8,8-PENTAMETHYL-2- NAPHTHALENYL)CARBONYL]BENZOATE

Cas:153559-45-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoic acid,4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]-, methylester

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

153559-45-6 Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:1 Kilogram

FOB Price: $1000.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Methyl4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

highest purity most favorable priceAppearance:solid or liquid Storage:room temperature under 25℃ Package:drum or bag Application:for pharmaceutical Transportation:by sea and air

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Methyl 4-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalene-2-carbonyl)benzoate

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan kingson pharmaceutical technology co.ltd

MF: C24H30O3 MW: 366.498 Mol File: 852524-20-0.mol density 1.090 Our company,HUNAN KINSON PHARMACEUTICAL TECHNOLOGY CO Limited is a leading t… Package:25kg/drum or as your demand Application:Bexarotene Transportation:FOB Guangzhou or as your dem

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzoic acid,4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]-, methylester

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate cas 153559-45-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air,

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

153559-45-6 Application:intermediate

Benzoic acid, 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]-, methyl ester

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

153559-45-6

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

Methyl4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

4-[oxo-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)methyl]benzoic acid methyl ester

Cas:153559-45-6

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

Xiamen BaiFuchem Co.,Ltd

BaiFuChem is a Professional chemical raw material supplier in China, our main products include Biochemical , Pharma Intermediate and Organic chemical etc. BaiFuChem have wealth of products,experience , expertise and state-of-the-art

Hebei Fulong Import & Export Co., Ltd.

Product name:Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate Synonyms:Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate;BexaroteAppearance:POWDER Storage:Store at RT Package:Alu

Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate

Cas:153559-45-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

Synthetic route

Monomethyl terephthalate
1679-64-7

Monomethyl terephthalate

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
With aluminum (III) chloride; thionyl chloride In dichloromethane at 20℃; for 4h; Temperature; Solvent; Reflux;95.3%
1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

4-Methoxycarbonylbenzoyl chloride
7377-26-6

4-Methoxycarbonylbenzoyl chloride

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
With aluminum (III) chloride Friedel Crafts Acylation;82%
With iron(III) chloride In 1,2-dichloro-ethane at 75℃; for 16h; Friedel-Crafts acylation;81%
With aluminium trichloride In dichloromethane for 0.25h; Heating;72%
2,5-dimethyl-2,5-hexanediol
110-03-2

2,5-dimethyl-2,5-hexanediol

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HCl conc. / 3 h / 20 °C
2: 99 percent / AlCl3 / CH2Cl2 / 20 °C
3: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C
View Scheme
Multi-step reaction with 3 steps
1: 56 percent / HCl gas / ethanol
2: 91 percent / AlCl3 / CH2Cl2 / 1.) RT, 30 min, 2.) reflux, 15 min
3: 72 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water
2: aluminum (III) chloride
3: aluminum (III) chloride
View Scheme
2,5-dichloro-2,5-dimethyl hexane
6223-78-5

2,5-dichloro-2,5-dimethyl hexane

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C
2: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride
2: aluminum (III) chloride
View Scheme
Multi-step reaction with 2 steps
1: aluminum (III) chloride / 1 h / 0 - 20 °C
2: iron(III) chloride / 1,2-dichloro-ethane / 75 °C / Inert atmosphere
View Scheme
1,1,4,4,7-pentamethyl-2-oxo-1,2,3,4-tetrahydronaphthalene
29020-85-7

1,1,4,4,7-pentamethyl-2-oxo-1,2,3,4-tetrahydronaphthalene

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating
2: 79 percent / POCl3, pyridine / 100 °C
3: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
4: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating
View Scheme
2,2,5,5-tetramethyltetrahydro-3-oxofuran
5455-94-7

2,2,5,5-tetramethyltetrahydro-3-oxofuran

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 45 percent / AlCl3 / 2 h / 0 - 20 °C
2: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating
3: 79 percent / POCl3, pyridine / 100 °C
4: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
5: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating
View Scheme
toluene
108-88-3

toluene

(+-)-o-toluenesulfinic acid-chloride

(+-)-o-toluenesulfinic acid-chloride

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 45 percent / AlCl3 / 2 h / 0 - 20 °C
2: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating
3: 79 percent / POCl3, pyridine / 100 °C
4: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
5: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating
View Scheme
1,1,4,4,6-pentamethyl-1,4-dihydronaphthalene
167958-79-4

1,1,4,4,6-pentamethyl-1,4-dihydronaphthalene

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
2: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating
View Scheme
1,1,4,4,7-pentamethyl-2-hydroxy-1,2,3,4-tetrahydronaphthalene
167958-78-3

1,1,4,4,7-pentamethyl-2-hydroxy-1,2,3,4-tetrahydronaphthalene

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79 percent / POCl3, pyridine / 100 °C
2: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h
3: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating
View Scheme
2,5-dichloro-2,5-dimethyl hexane
6223-78-5

2,5-dichloro-2,5-dimethyl hexane

petroleum ether

petroleum ether

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / AlCl3 / CH2Cl2 / 1.) RT, 30 min, 2.) reflux, 15 min
2: 72 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating
View Scheme
Monomethyl terephthalate
1679-64-7

Monomethyl terephthalate

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene
6683-48-3

1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene

A

C38H46O2
1349659-51-3

C38H46O2

B

4-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl]benzoic acid
153559-46-7

4-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl]benzoic acid

C

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Stage #1: Monomethyl terephthalate; 1,1,4,4,6-pentamethyl-1,2,3,4-tetrahydronaphthalene With aluminum (III) chloride In dichloromethane at -10 - 44℃; Inert atmosphere; Reflux;
Stage #2: With hydrogenchloride; water In dichloromethane; water at 15 - 20℃;
toluene
108-88-3

toluene

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride / 1 h / 0 - 20 °C
2: iron(III) chloride / 1,2-dichloro-ethane / 75 °C / Inert atmosphere
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

4-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl]benzoic acid
153559-46-7

4-[(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl]benzoic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol for 2h; Heating;100%
With potassium hydroxide In methanol; water at 60℃; for 1h;89%
Stage #1: methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate With water; potassium hydroxide In methanol for 1h; Reflux;
Stage #2: With hydrogenchloride In methanol; water at 20℃;
88%
Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

methyl 4-<1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl>benzoate
153559-48-9

methyl 4-<1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl>benzoate

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With potassium hexamethylsilazane In tetrahydrofuran at -30 - 0℃; for 0.5h; Inert atmosphere;
Stage #2: methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate In tetrahydrofuran at -30 - 0℃; for 1h;
69%
Stage #1: Methyltriphenylphosphonium bromide With sodium amide In tetrahydrofuran Inert atmosphere;
Stage #2: methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate In tetrahydrofuran for 1h; Wittig reaction; Inert atmosphere;
66%
With sodium amide In tetrahydrofuran Wittig Reaction;66%
cyclopropyltriphenylphosphonium bromide
14114-05-7

cyclopropyltriphenylphosphonium bromide

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

4-[cyclopropylidene-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid methyl ester

4-[cyclopropylidene-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid methyl ester

Conditions
ConditionsYield
With Tris(3,6-dioxaheptyl)amine; potassium hexamethylsilazane In toluene Substitution; Heating;69%
dimethyl zinc(II)
544-97-8

dimethyl zinc(II)

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

methyl 4-<1-methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethyl>benzoate

methyl 4-<1-methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethyl>benzoate

Conditions
ConditionsYield
With titanium tetrachloride 1.) CH2Cl2, -30 deg C, 30 min, 2.) CH2Cl2, 30 min; Yield given. Multistep reaction;
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

cis-4-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl>benzoic acid oxime

cis-4-<(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)carbonyl>benzoic acid oxime

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / aq. NaOH / methanol / 2 h / Heating
2: 1.98 g / aq. NH2OH / acetic acid / 1 h / Heating
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

4-[[(E)-Hydroxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid

4-[[(E)-Hydroxyimino]-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-methyl]-benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / aq. NaOH / methanol / 2 h / Heating
2: aq. NH2OH / acetic acid / 1 h / Heating
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

SR11173

SR11173

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / KN(SiMe3)2; (MeOCH2CH2OCH2CH2)3N / toluene / Heating
2: 83 percent / aq. KOH; aq. citric acid / ethanol
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

bexarotene
153559-49-0

bexarotene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) 0.5 M potassium bis(trimethylsilyl)amide / 1.) C6H6, tluene, RT, 5 min, 2.) C6H6, toluene, RT, 3 h
2: 91 percent / KOH / methanol; H2O / 1 h / 70 °C
View Scheme
Multi-step reaction with 2 steps
1: 1.) NaNH2 / 1.) THF, 1 h, 2.) THF, 30 min
2: 85 percent / aq. 5N KOH / methanol / 0.17 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 1.) NaNH2 / 1.) THF, 15 h, 2.) THF, below 50 deg C, 30 min
2: 93 percent / 5 N aq. KOH / methanol / Heating
View Scheme
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane / toluene / 0.75 h / 25 - 50 °C / Inert atmosphere
1.2: 2 h / 0 - 5 °C / Inert atmosphere
2.1: potassium hydroxide; water / methanol / 8 h / 25 °C / Reflux
2.2: 10 - 25 °C / pH 1 - 2
View Scheme
Multi-step reaction with 2 steps
1: sodium amide / tetrahydrofuran
2: potassium hydroxide; methanol
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

4-[1-methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethyl]benzoic acid

4-[1-methyl-1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethyl]benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) TiCl4 / 1.) CH2Cl2, -30 deg C, 30 min, 2.) CH2Cl2, 30 min
2: 73 percent / 5N aq. KOH / methanol / Heating
View Scheme
Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

A

C25H30O
1349659-53-5

C25H30O

B

C26H32
1349659-55-7

C26H32

C

C39H48O
1349659-56-8

C39H48O

D

C40H50
1349659-57-9

C40H50

E

methyl 4-<1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl>benzoate
153559-48-9

methyl 4-<1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl>benzoate

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With potassium hexamethylsilazane In toluene at 25 - 50℃; for 0.75h; Inert atmosphere;
Stage #2: methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate In toluene at 0 - 5℃; for 2h; Inert atmosphere;
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

4-(1-(3-(difluoromethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

4-(1-(3-(difluoromethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 80 °C
2.1: dimethyl sulfoxide / 2 h / 100 °C
3.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / 20 °C
4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / -30 - 0 °C
4.2: 3 h / -30 - 0 °C
5.1: lithium hydroxide; water / tetrahydrofuran / 8 h / 50 °C
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

methyl 4-[[3-(dibromomethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl]carbonyl]benzoate

methyl 4-[[3-(dibromomethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl]carbonyl]benzoate

Conditions
ConditionsYield
With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 80℃;
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

methyl 4-[(3-formyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]benzoate

methyl 4-[(3-formyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 80 °C
2: dimethyl sulfoxide / 2 h / 100 °C
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

methyl 4-[[3-(difluoromethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl]carbonyl]benzoate

methyl 4-[[3-(difluoromethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl]carbonyl]benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 80 °C
2: dimethyl sulfoxide / 2 h / 100 °C
3: diethylamino-sulfur trifluoride / dichloromethane / 24 h / 20 °C
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

methyl 4-[1-[3-(difluoromethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl]benzoate

methyl 4-[1-[3-(difluoromethyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl]benzoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 80 °C
2.1: dimethyl sulfoxide / 2 h / 100 °C
3.1: diethylamino-sulfur trifluoride / dichloromethane / 24 h / 20 °C
4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.67 h / -30 - 0 °C
4.2: 3 h / -30 - 0 °C
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

methyl 4-<1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl>benzoate

methyl 4-<1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl>benzoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -30 - 0 °C / Inert atmosphere
1.2: 1 h / -30 - 0 °C
2.1: diethylzinc; trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
2.2: 2 h / 0 - 20 °C
View Scheme
methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate
153559-45-6

methyl 4-<(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl>benzoate

LGD1268

LGD1268

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -30 - 0 °C / Inert atmosphere
1.2: 1 h / -30 - 0 °C
2.1: diethylzinc; trifluoroacetic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
2.2: 2 h / 0 - 20 °C
3.1: lithium hydroxide; water / tetrahydrofuran / 24 h / 20 °C
View Scheme

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