Products

Refine

Country

Business Type

Certificate

Display

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Pizotifen Manufacturer/High quality/Best price/In stock

Cas:15574-96-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Pizotyline (base and/or unspecified salts)

Cas:15574-96-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Pizotifen

Cas:15574-96-6

Min.Order:1 Gram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Manufacturer Supply High Quality CAS 15574-96-6 Pizotifen

Cas:15574-96-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 15574-96-6 with fast shipping

Cas:15574-96-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Pizotifen Synonyms: Sandomigran CAS:15574-96-6 MF: C19H21NS Appearance: white powder Storage:Store in cool and dry place, away from sun light. Package: 25kgs/drum Application:APIs Transportation:By sea or by air Port:Qingdao port

Pizotifen

Cas:15574-96-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White or light pink crystalline powder Storage:Store in sea

99% Pharmaceutical Raw Materials Pizotifen CAS 15574-96-6

Cas:15574-96-6

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Piperidine,4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl- 15574-96-6

Cas:15574-96-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA

15574-96-6 cas 99% Ready stock Pizotifen

Cas:15574-96-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

98% Pizotifen Powder CAS :15574-96-6

Cas:15574-96-6

Min.Order:1 Kilogram

FOB Price: $3865.0 / 3940.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Pizotifen CAS:15574-96-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Pizotifen CAS:15574-96-6

Cas:15574-96-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Piperidine,4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-

Cas:15574-96-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Pizotifen

Cas:15574-96-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan BJM Pharm Inc.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad to create a bett

Manufacturer Supply High Quality CAS 15574-96-6 Pizotifen

Cas:15574-96-6

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Piperidine,4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-

Cas:15574-96-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white powder Storage:Store in a cool,dry place and keep away from direct strong light Package:packaged in foil bags or tins Application:Use only for laboratory research Transportation:Sea,Air,DHL/TNT/FEdex/UPS/EMS Por

Pizotifen

Cas:15574-96-6

Min.Order:10 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

Factory Supply Pizotifen CAS 15574-96-6 with Good Quality

Cas:15574-96-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 7.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

Pizotifen

Cas:15574-96-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Pizotifen

Cas:15574-96-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Pizotifen

Cas:15574-96-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Piperidine,4-(9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methyl-

Cas:15574-96-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High Quality Pizotifen

Cas:15574-96-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

supplier in China Appearance:White to Off-White Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Serotonin antagonist structurally relat

Pizotifen

Cas:15574-96-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

Pizotifen

Cas:15574-96-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Pizotifen

Cas:15574-96-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Buy Pizotifen

Cas:15574-96-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Pizotifen

Cas:15574-96-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Pizotifen(CAS:15574-96-6) CAS No.:15574-96-6 Molecule Formula:C19H21NS Molecule Weight:295.44 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

Best Quality Pizotifen(CAS:15574-96-6)

Cas:15574-96-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Pizotifen

Cas:15574-96-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Synthetic route

pizotifen
15574-96-6

pizotifen

4-(2-bromo-9,10-dihydro-1-thiabenzo[f]-azulen-4-ylidene)-1-methylpiperidine
1176736-68-7

4-(2-bromo-9,10-dihydro-1-thiabenzo[f]-azulen-4-ylidene)-1-methylpiperidine

Conditions
ConditionsYield
With bromine In chloroform at 0 - 20℃; for 2h;91%
With bromine In chloroform at 0 - 20℃; for 2h;91%
pizotifen
15574-96-6

pizotifen

C19H20(2)HNS

C19H20(2)HNS

Conditions
ConditionsYield
With water-d2; silver In dimethyl sulfoxide at 40℃; for 12h;75%
chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

pizotifen
15574-96-6

pizotifen

4-(9,10-dihydro-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-piperidine-1-carboxylic acid ethyl ester
23455-54-1

4-(9,10-dihydro-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-piperidine-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In toluene at 60℃; Reflux;9%
pizotifen
15574-96-6

pizotifen

Ethyl 4-(2-bromo-9,10-dihydro-1-thia-benzo[f]azulen-4-ylidene)piperidine-1-carboxylate
1176739-91-5

Ethyl 4-(2-bromo-9,10-dihydro-1-thia-benzo[f]azulen-4-ylidene)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: triethylamine / toluene / 60 °C / Reflux
2: bromine / chloroform / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: toluene / 6 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: toluene / 6 h / Reflux
View Scheme
pizotifen
15574-96-6

pizotifen

3-[4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl]-propionic acid
1176739-46-0

3-[4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl]-propionic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: bromine / chloroform / 2 h / 20 °C
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
View Scheme
pizotifen
15574-96-6

pizotifen

ethyl 4-(2-formyl-9,10-dihydro-1-thia-benzo[f]azulen-4-ylidene)piperidine-1-carboxylate

ethyl 4-(2-formyl-9,10-dihydro-1-thia-benzo[f]azulen-4-ylidene)piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl)acrylic acid
1176738-35-4

3-(4-piperidin-4-ylidene-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl)acrylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: piperidine; hydrogenchloride / pyridine / Reflux
4.1: potassium hydroxide / isopropyl alcohol / 24 h / Reflux
4.2: pH 7 / Cooling
View Scheme
pizotifen
15574-96-6

pizotifen

ethyl 4-[2-(2-ethoxycarbonylvinyl)-9,10-dihydro-1-thiabenzo[f]azulen-4-ylidene]piperidine-1-carboxylate
1176739-93-7

ethyl 4-[2-(2-ethoxycarbonylvinyl)-9,10-dihydro-1-thiabenzo[f]azulen-4-ylidene]piperidine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / toluene / 60 °C / Reflux
2: bromine / chloroform / 2 h / 20 °C
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: toluene / 6 h / Reflux
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: toluene / 6 h / Reflux
3: triethylamine / tri-ortho-toluoylphosphine; palladium diacetate / water; argon; N,N-dimethyl-formamide / 80 °C / Inert atmosphere
View Scheme
pizotifen
15574-96-6

pizotifen

ethyl 3-[4-(1-tert-butoxy-carbonylpiperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]-propionate
1176739-94-8

ethyl 3-[4-(1-tert-butoxy-carbonylpiperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]-propionate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 6 h / Reflux
5.1: acetonitrile / 20 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: triethylamine / toluene / 60 °C / Reflux
2: bromine / chloroform / 2 h / 20 °C
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4: hydrogen bromide / acetic acid / 6 h / Reflux
5: acetonitrile / 20 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: toluene / 6 h / Reflux
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4: hydrogen bromide / acetic acid / 6 h / Reflux
5: acetonitrile / 20 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine / tri-ortho-toluoylphosphine; palladium diacetate / water; argon; N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
View Scheme
pizotifen
15574-96-6

pizotifen

3-[4-(1-tert-butoxycarbonylpiperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]propionic acid
1262518-43-3

3-[4-(1-tert-butoxycarbonylpiperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]propionic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 6 h / Reflux
5.1: acetonitrile / 20 h / 20 °C
6.1: sodium hydroxide; water / ethanol / 20 h
View Scheme
Multi-step reaction with 6 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: piperidine; hydrogenchloride / pyridine / Reflux
4.1: potassium hydroxide / isopropyl alcohol / 8 h / Reflux
4.2: 4 h / 60 °C
5.1: hydrogen bromide / acetic acid / 2 h / 20 - 100 °C
6.1: sodium hydroxide / isopropyl alcohol; water / 20 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: triethylamine / toluene / 60 °C / Reflux
2: bromine / chloroform / 2 h / 20 °C
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4: hydrogen bromide / acetic acid / 6 h / Reflux
5: acetonitrile / 20 h / 20 °C
6: sodium hydroxide; water / ethanol / 20 h
View Scheme
Multi-step reaction with 6 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: toluene / 6 h / Reflux
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4: hydrogen bromide / acetic acid / 6 h / Reflux
5: acetonitrile / 20 h / 20 °C
6: sodium hydroxide; water / ethanol / 20 h
View Scheme
pizotifen
15574-96-6

pizotifen

3-[4-(1-ethoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]acrylic acid
1262518-41-1

3-[4-(1-ethoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]acrylic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: piperidine; hydrogenchloride / pyridine / Reflux
View Scheme
pizotifen
15574-96-6

pizotifen

3-[4-(1-tert-butoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]acrylic acid
1262518-42-2

3-[4-(1-tert-butoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]acrylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: piperidine; hydrogenchloride / pyridine / Reflux
4.1: potassium hydroxide / isopropyl alcohol / 8 h / Reflux
4.2: 4 h / 60 °C
View Scheme
pizotifen
15574-96-6

pizotifen

ethyl 3-[4-(piperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]-propionate

ethyl 3-[4-(piperidin-4-ylidene)-4H-1-thiabenzo[f]azulen-2-yl]-propionate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 6 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: triethylamine / toluene / 60 °C / Reflux
2: bromine / chloroform / 2 h / 20 °C
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4: hydrogen bromide / acetic acid / 6 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: toluene / 6 h / Reflux
3: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4: hydrogen bromide / acetic acid / 6 h / Reflux
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid methanesulfonate
1262518-47-7

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid methanesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 40 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: bromine / chloroform / 2 h / 20 °C
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 40 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 40 h / 20 °C
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid nitrate
1262518-51-3

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid nitrate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: nitric acid / water / 1 h / Cooling
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: bromine / chloroform / 2 h / 20 °C
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: nitric acid / water / 1 h / Cooling
View Scheme
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: nitric acid / water / 1 h / Cooling
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-4H-1-thiabenzon[f]azulen-2-yl)propionic propionic acid hydrochloride
1262518-49-9

3-(4-piperidin-4-ylidene-4H-1-thiabenzon[f]azulen-2-yl)propionic propionic acid hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: water / 0.5 h / 80 - 90 °C
5.2: 0.5 h / 10 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: bromine / chloroform / 2 h / 20 °C
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: water / 0.5 h / 80 - 90 °C
5.2: 0.5 h / 10 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: water / 0.5 h / 80 - 90 °C
5.2: 0.5 h / 10 - 90 °C
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid hydrobromide

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: piperidine; hydrogenchloride / pyridine / Reflux
4.1: potassium hydroxide / isopropyl alcohol / 8 h / Reflux
4.2: 4 h / 60 °C
5.1: hydrogen bromide / acetic acid / 2 h / 20 - 100 °C
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid p-toluene sulfonate
1262518-45-5

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid p-toluene sulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: bromine / chloroform / 2 h / 20 °C
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 1 h / 20 °C
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid benzenesulfonate
1262518-46-6

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid benzenesulfonate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 15 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: bromine / chloroform / 2 h / 20 °C
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 15 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: acetone / 15 h / 20 °C
View Scheme
pizotifen
15574-96-6

pizotifen

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid sulfate

3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)-propionic acid sulfate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: trichlorophosphate / 1,2-dichloro-ethane / 1.5 h / 0 - 20 °C
2.2: 37 h / 50 °C
2.3: 1 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C / Inert atmosphere; Cooling
3.2: 2 h / 20 °C
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: sulfuric acid / formic acid / 1 h / Cooling
View Scheme
Multi-step reaction with 5 steps
1.1: triethylamine / toluene / 60 °C / Reflux
2.1: bromine / chloroform / 2 h / 20 °C
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: sulfuric acid / formic acid / 1 h / Cooling
View Scheme
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine; tri-ortho-toluoylphosphine / palladium diacetate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: sulfuric acid / formic acid / 1 h / Cooling
View Scheme
pizotifen
15574-96-6

pizotifen

Ethyl [4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate
1176736-60-9

Ethyl [4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3: water; sodium hydroxide / ethanol / Reflux
4: thionyl chloride / 2.5 h / 0 °C / Reflux
View Scheme
pizotifen
15574-96-6

pizotifen

Ethyl [4-(piperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate
1176737-42-0

Ethyl [4-(piperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3: water; sodium hydroxide / ethanol / Reflux
4: thionyl chloride / 2.5 h / 0 °C / Reflux
5: 1,2-dichloro-ethane / Reflux
6: hydrogen bromide / acetic acid / 5 h / Reflux
View Scheme
pizotifen
15574-96-6

pizotifen

Ethyl 3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)propionate
1176739-95-9

Ethyl 3-(4-piperidin-4-ylidene-4H-1-thiabenzo[f]azulen-2-yl)propionate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: toluene / 6 h / Reflux
3.1: triethylamine / tri-ortho-toluoylphosphine; palladium diacetate / water; argon; N,N-dimethyl-formamide / 80 °C / Inert atmosphere
4.1: hydrogen bromide / acetic acid / 4 h / 120 °C
4.2: 3 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C
View Scheme
pizotifen
15574-96-6

pizotifen

Ethyl [4-(1-ethoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate
1176737-41-9

Ethyl [4-(1-ethoxycarbonylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3: water; sodium hydroxide / ethanol / Reflux
4: thionyl chloride / 2.5 h / 0 °C / Reflux
5: 1,2-dichloro-ethane / Reflux
View Scheme
pizotifen
15574-96-6

pizotifen

2-Cyano-4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene hydrochloride
1176736-56-3

2-Cyano-4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
View Scheme
pizotifen
15574-96-6

pizotifen

[4-(1-Methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylic acid hydrochloride
1176736-62-1

[4-(1-Methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl]carboxylic acid hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3: water; sodium hydroxide / ethanol / Reflux
View Scheme
pizotifen
15574-96-6

pizotifen

Ethyl {4-{1-[4-(4-t-butylphenyl)-4-oxobutyl]piperidin-4-ylidene}-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl}carboxylate
1176737-91-9

Ethyl {4-{1-[4-(4-t-butylphenyl)-4-oxobutyl]piperidin-4-ylidene}-9,10-dihydro-4H-1-thiabenzo[f]azulen-2-yl}carboxylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: bromine / chloroform / 2 h / 0 - 20 °C
2: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3: water; sodium hydroxide / ethanol / Reflux
4: thionyl chloride / 2.5 h / 0 °C / Reflux
5: 1,2-dichloro-ethane / Reflux
6: hydrogen bromide / acetic acid / 5 h / Reflux
7: triethylamine / N,N-dimethyl-formamide / 21 h / 80 °C
View Scheme
pizotifen
15574-96-6

pizotifen

1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride
1176738-87-6

1-Cyclohexyloxycarbonyloxyethyl 4-(1-methylpiperidin-4-ylidene)-9,10-dihydro-4H-1-thiabenzo[f]azulene-2-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: bromine / chloroform / 2 h / 0 - 20 °C
2.1: 1,1'-bis-(diphenylphosphino)ferrocene / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 80 °C / Inert atmosphere
3.1: water; sodium hydroxide / ethanol / Reflux
4.1: triethylamine; potassium iodide / 1,4-dioxane; N,N-dimethyl-formamide / 80 °C
4.2: 1 h
View Scheme
Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View