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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1H-Indazol-5-ol Manufacturer/High quality/Best price/In stock

Cas:15579-15-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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ANQING CHICO PHARMACEUTICAL CO.,LTD.

High quality. Factory supply. In stock. Best price.1.Quick response within 24 hours;2.Best quality in your requirement;?3.We pay more attention on delivery time, and usually ship on time;4.Under the premise of safety and effectiveness, we can produce

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Hydroxyindazole

Cas:15579-15-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 15579-15-4 with best quality

Cas:15579-15-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: 1H-Indazol-5-ol Synonyms: 5-HYDROXY (1H)INDAZOLE;1H-INDAZOL-5-OL;5-hydroxyindazole;5-Hydroxy-1H-indazole;5-Hydroxy-1H-indazole, 97+%;5-Hydroxy-1H-indazole 97% CAS: 15579-

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Qingdao Beluga Import and Export Co., LTD

1H-Indazol-5-ol CAS: 15579-15-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermed

1H-Indazol-5-ol CAS: 15579-15-4

Cas:15579-15-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Gram

FOB Price: $65.0

Type:Trading Company

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and als

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-hydroxy-1h-indazole

Cas:15579-15-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Trading Company

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Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:100 Gram

Negotiable

Type:Manufacturers

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

5-Hydroxy-1H-indazole

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

1h-indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Cas no.15579-15-4 98% 1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Other

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Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

1H-Indazol-5-ol CAS 15579-15-4

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

5-Hydroxyindazole

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high qualityAppearance:white crystalline powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

3-(2-methoxyethyl)piperidine(SALTDATA: HCl)

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Hazard Codes Xi,Xn Risk Statements 22-41 Safety Statements 26-39 Hazard Note Irritant Appearance:off-white Storage:stored in a cool, dry and ventilated place Package:as per buyer's request Application:Organic Chemicals Transportatio

15579-15-4 1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:1 Metric Ton

FOB Price: $5000.0

Type:Lab/Research institutions

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

1H-Indazol-5-ol

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

5-Hydroxy-1H-indazole

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

15579-15-4 CAS No.15579-15-4

Cas:15579-15-4

Min.Order:0

Negotiable

Type:Trading Company

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Synthetic route

5-methoxy-1H-indazole
94444-96-9

5-methoxy-1H-indazole

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

Conditions
ConditionsYield
With boron tribromide In dichloromethane at 20℃; for 10h;71%
1H-indazol-5-ylamine
19335-11-6

1H-indazol-5-ylamine

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

Conditions
ConditionsYield
With sulfuric acid at 170 - 180℃;
With sulfuric acid at 200 - 205℃; unter Druck;
Stage #1: 1H-indazol-5-ylamine With sulfuric acid In water at 180℃; for 15h;
Stage #2: With sodium hydroxide In water pH=> 10;
N,O-diacetyl-5-hydroxy-1H-indazole
36174-07-9

N,O-diacetyl-5-hydroxy-1H-indazole

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

Conditions
ConditionsYield
With hydrogenchloride In methanol at 80℃; for 5h;7.99 g
4-amino-3-methylphenol
2835-99-6

4-amino-3-methylphenol

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium acetate; isoamyl nitrite / CHCl3 / 18 h / 80 °C
2: 7.99 g / HCl / methanol / 5 h / 80 °C
View Scheme
5-nitroindazole
5401-94-5

5-nitroindazole

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel / Hydrogenation
2: aqueous H2SO4 / 170 - 180 °C
View Scheme
isopentyl nitrate
543-87-3

isopentyl nitrate

4-amino-3-methylphenol
2835-99-6

4-amino-3-methylphenol

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

Conditions
ConditionsYield
With potassium acetate; acetic anhydride In hydrochloric acid-methanol; water; chlorobenzene
2-methyl-4-methoxyaniline
102-50-1

2-methyl-4-methoxyaniline

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; sodium nitrite / water / 20 °C
2: boron tribromide / dichloromethane / 10 h / 20 °C
View Scheme
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

5-(tert-butyl-dimethyl-silanyloxy)-1H-indazole
1254473-74-9

5-(tert-butyl-dimethyl-silanyloxy)-1H-indazole

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 18℃; for 3.5h;100%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 18℃; for 3.5h;100%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 18h;99%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

ethyl bromoacetate
105-36-2

ethyl bromoacetate

1H-indazol-5-yloxyacetic acid
30226-16-5

1H-indazol-5-yloxyacetic acid

Conditions
ConditionsYield
Stage #1: 5-hydroxy-1H-indazole; ethyl bromoacetate With potassium carbonate In acetone for 16h; Inert atmosphere; Reflux;
Stage #2: With sodium hydroxide In methanol at 20℃; for 3h; Inert atmosphere;
99%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

4-bromo-1H-indazol-5-ol

4-bromo-1H-indazol-5-ol

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrahydrofuran at 20℃; for 14h;91%
With N-Bromosuccinimide In tetrahydrofuran at 25℃; for 12h;90%
(R)-tert-butyl 4-(3-(methylsulfonyloxy)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate
1351167-84-4

(R)-tert-butyl 4-(3-(methylsulfonyloxy)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

(S)-tert-butyl 4-(3-(1H-indazol-5-yloxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate
1351168-51-8

(S)-tert-butyl 4-(3-(1H-indazol-5-yloxy)-2-oxopyrrolidin-1-yl)piperidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 130℃;90%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

1H-indazol-5-ol

1H-indazol-5-ol

4-bromo-1H-indazol-5-ol

4-bromo-1H-indazol-5-ol

Conditions
ConditionsYield
With N-Bromosuccinimide In tetrahydrofuran at 0℃; for 2.5h;89%
2,6-Dichloropyrimidine
3934-20-1

2,6-Dichloropyrimidine

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

5-((2-chloropyrimidin-4-yl)oxy)-1H-indazole
1595291-23-8

5-((2-chloropyrimidin-4-yl)oxy)-1H-indazole

Conditions
ConditionsYield
With triethylamine In ethanol at 80℃;87%
With triethylamine In ethanol at 80℃;87%
With triethylamine In ethanol at 80℃;
With triethylamine In ethanol at 80℃;
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

4-chloro-1H-indazol-5-ol
478834-25-2

4-chloro-1H-indazol-5-ol

Conditions
ConditionsYield
With N-chloro-succinimide In tetrahydrofuran at 20 - 50℃; for 8h;86%
4-methylphenyl(mesityl)iodonium trifluoromethanesulfonate

4-methylphenyl(mesityl)iodonium trifluoromethanesulfonate

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

2-(p-tolyl)-2H-indazol-5-ol

2-(p-tolyl)-2H-indazol-5-ol

Conditions
ConditionsYield
With copper(l) chloride In tetrahydrofuran at 50℃; for 12h; Inert atmosphere; Sealed tube; regioselective reaction;82%
Ethyl N-phenylformimidate
6780-49-0

Ethyl N-phenylformimidate

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

4-phenyliminomethyl-1H-indazol-5-ol

4-phenyliminomethyl-1H-indazol-5-ol

Conditions
ConditionsYield
at 175℃; for 2h;76%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

C19H22F3IO2

C19H22F3IO2

acetyl chloride
75-36-5

acetyl chloride

C17H13ClN2O4

C17H13ClN2O4

Conditions
ConditionsYield
Stage #1: 5-hydroxy-1H-indazole; C19H22F3IO2 With copper(l) chloride In tetrahydrofuran at 80℃; for 12h; Inert atmosphere;
Stage #2: acetyl chloride With triethylamine In tetrahydrofuran at 20℃; for 4h;
Stage #3: With N-chloro-succinimide In tetrahydrofuran at 20℃; for 4h;
75.2%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

3-Iodobenzoic acid
618-51-9

3-Iodobenzoic acid

3-(5-hydroxy-1H-indazo-1-yl)benzoic acid

3-(5-hydroxy-1H-indazo-1-yl)benzoic acid

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; tert-butyl XPhos In 2-methyltetrahydrofuran at 70℃; for 1h; Inert atmosphere;75%
C16H16F3IO4S

C16H16F3IO4S

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

acetyl chloride
75-36-5

acetyl chloride

C17H13ClN2O4

C17H13ClN2O4

Conditions
ConditionsYield
Stage #1: C16H16F3IO4S; 5-hydroxy-1H-indazole With copper(l) chloride In tetrahydrofuran at 80℃; for 12h; Inert atmosphere; Sealed tube;
Stage #2: acetyl chloride With triethylamine at 20℃; for 4h; Inert atmosphere; Sealed tube;
Stage #3: With N-chloro-succinimide at 20℃; for 4h; Inert atmosphere; Sealed tube;
75%
2-((2-bromoethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

2-((2-bromoethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

5-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)-1H-indazole
1430211-17-8

5-(2-((5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)thio)ethoxy)-1H-indazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide; acetonitrile at 70℃; for 5h; Temperature; Inert atmosphere;74%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

5-Hydroxy-2H-indazole adenine dinucleotide

5-Hydroxy-2H-indazole adenine dinucleotide

Conditions
ConditionsYield
Porcine Brain NADase(EC 3.2.2.5) In water; dimethyl sulfoxide for 15h; Tris-HCl;73%
1-Chloro-4-fluorobenzene
352-33-0

1-Chloro-4-fluorobenzene

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

1-(4-fluorophenyl)-1H-indazol-5-ol
1034156-20-1

1-(4-fluorophenyl)-1H-indazol-5-ol

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; tert-butyl XPhos In 2-methyltetrahydrofuran at 73℃; for 15h; Industrial scale;72%
piperidine
110-89-4

piperidine

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

4-(thiazol-2-yl)-benzaldehyde
198904-53-9

4-(thiazol-2-yl)-benzaldehyde

4-(piperidin-1-yl(4-(thiazol-2-yl)phenyl)methyl)-1H-indazol-5-ol

4-(piperidin-1-yl(4-(thiazol-2-yl)phenyl)methyl)-1H-indazol-5-ol

Conditions
ConditionsYield
In toluene at 100℃;70%
piperidine
110-89-4

piperidine

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

4-((4-nitrophenyl)(piperidin-1-yl)methyl)-1H-indazol-5-ol

4-((4-nitrophenyl)(piperidin-1-yl)methyl)-1H-indazol-5-ol

Conditions
ConditionsYield
In ethanol at 120℃; for 0.75h; Microwave irradiation;67%
piperidine
110-89-4

piperidine

4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

4-(piperidin-1-yl(4-(trifluoromethyl)phenyl)methyl)-1H-indazol-5-ol

4-(piperidin-1-yl(4-(trifluoromethyl)phenyl)methyl)-1H-indazol-5-ol

Conditions
ConditionsYield
In ethanol at 120℃; for 0.75h; Microwave irradiation;65%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

tert-butyl (3S)-3-(4-chloropyrido[3,2-d]pyrimidin-6-yl)oxypyrrolidine-1-carboxylate

tert-butyl (3S)-3-(4-chloropyrido[3,2-d]pyrimidin-6-yl)oxypyrrolidine-1-carboxylate

(S)-tert-butyl 3-((4-((1H-indazol-5-yl)oxy)pyrido[3,2-d]pyrimidin-6-yl)oxy)pyrrolidine-1-carboxylate

(S)-tert-butyl 3-((4-((1H-indazol-5-yl)oxy)pyrido[3,2-d]pyrimidin-6-yl)oxy)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 12h; Inert atmosphere;63%
piperidine
110-89-4

piperidine

1-(4’-formylphenyl)pyrrole
23351-05-5

1-(4’-formylphenyl)pyrrole

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

4-((4-(1H-pyrrol-1-yl)phenyl)(piperidin-1-yl)methyl)-1H-indazol-5-ol

4-((4-(1H-pyrrol-1-yl)phenyl)(piperidin-1-yl)methyl)-1H-indazol-5-ol

Conditions
ConditionsYield
In toluene at 100℃;62%
2-iodo-propane
75-30-9

2-iodo-propane

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

5-isopropoxy-1H-indazole

5-isopropoxy-1H-indazole

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 72h;59.3%
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 26h;
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

rac-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-ol

rac-1-(tetrahydro-pyran-2-yl)-1H-indazol-5-ol

Conditions
ConditionsYield
With methanesulfonic acid In tetrahydrofuran; dichloromethane at 20℃; for 72h; Inert atmosphere;54%
With methanesulfonic acid In tetrahydrofuran; dichloromethane at 20℃;
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

methyl iodide
74-88-4

methyl iodide

5-methoxy-1-methyl-1H-indazole
756839-44-8

5-methoxy-1-methyl-1H-indazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 18h;54%
2-thiophenethanol
5402-55-1

2-thiophenethanol

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

5-(2-(thiophen-2-yl)ethoxy)-1H-indazole
1338795-77-9

5-(2-(thiophen-2-yl)ethoxy)-1H-indazole

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0℃; for 4h;52%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0℃; for 4h; Inert atmosphere;52%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

1-bromomethyl-3-nitrobenzene
3958-57-4

1-bromomethyl-3-nitrobenzene

C14H11N3O3

C14H11N3O3

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 5h;52%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine
936850-02-1

6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

trifluoroacetic acid
76-05-1

trifluoroacetic acid

2-((1H-indazol-5-yl)oxy)-6-chloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine trifluoroacetic acid

2-((1H-indazol-5-yl)oxy)-6-chloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine trifluoroacetic acid

Conditions
ConditionsYield
Stage #1: 6-chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine; 5-hydroxy-1H-indazole With potassium tert-butylate In tert-butyl alcohol at 50℃;
Stage #2: trifluoroacetic acid
52%
Tetrahydro-pyran-4-ol
2081-44-9

Tetrahydro-pyran-4-ol

5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

5-(tetrahydro-2H-pyran-4-yloxy)-1H-indazole

5-(tetrahydro-2H-pyran-4-yloxy)-1H-indazole

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran; toluene at 0 - 20℃;47%
5-hydroxy-1H-indazole
15579-15-4

5-hydroxy-1H-indazole

benzyl bromide
100-39-0

benzyl bromide

5-(benzyloxy)-1H-indazole
78299-75-9

5-(benzyloxy)-1H-indazole

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;46%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃;46%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 40℃; for 2h;38%

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