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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3-Bromo-2-fluorophenol Manufacturer/High quality/Best price/In stock

Cas:156682-53-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Phenol,3-bromo-2-fluoro- 156682-53-0

Cas:156682-53-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 3-Bromo-2-fluoro-phenol CAS: 156682-53-0 MF: C6H4BrFO MW: 191 EINECS: Product Categories: Mol File: 156682-53-0.mol 3-Bromo-2-fluoro-phenol Structure 3-Bromo-2-fluoro-phenol Chemical Properties Boiling point

3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Phenol,3-bromo-2-fluoro-

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Phenol,3-bromo-2-fluoro-

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

3-Bromo-2-fluoro-phenol Basic information Product Name: 3-Bromo-2-fluoro-phenol Synonyms: 3-Bromo-2-fluoro-phenol;3-Bromo-2-fluorophenol98% CAS: 156682-53-0 MF: C6H4BrFO MW: 190.9977632 EINECS: Product Categories: Mol File: 156682-53-0.mol

TIANFU-CHEM 3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceutical an

3-Bromo-2-fluorophenol Manufacturer/High quality/Best price/In stock CAS NO.156682-53-0

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:Dark pink crystallize Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-Bromo-2-Fluorophenol cas no. 156682-53-0 98%

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Grams, Kilograms Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

3-Bromo-2-fluorophenol cas 156682-53-0Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3-Bromo-2-fluorophenol cas 156682-53-0

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Ansciep Chemical Co.,Ltd.

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

156682-53-0

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Asure Biochem CO.,LTD.

*stable and better quality products*efficient and meticulous servicesAppearance:Powder Storage:Store in dry, cool and ventilated place Package:10G/bottle 1kg/tin 5kg/tin 25kg/carton Application:1. Chemical raw materials 2. Used as an analytical reage

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:250mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

3-Bromo-2-Fluoro-Phenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3-bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Other

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

3-Bromo-2-fluorophenol 156682-53-0

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shenzhen Foris Technology Co. LTD

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

3-Bromo-2-fluorophenol 156682-53-0

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-Bromo-2-fluoro-phenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Bide Pharmatech Ltd

Our mission is to provide high-quality and innovative products to our customers. By offering a broad range of products, custom synthesis and personalized services, Bide can help scientists speeding up their research in the chemical and pharmaceutical

3-Bromo-2-fluorophenol

Cas:156682-53-0

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

1-bromo-2,3-difluorobenzene
38573-88-5

1-bromo-2,3-difluorobenzene

A

3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

B

2-bromo-6-fluorophenol
2040-89-3

2-bromo-6-fluorophenol

Conditions
ConditionsYield
Stage #1: 1-bromo-2,3-difluorobenzene With potassium trimethylsilonate In diethylene glycol dimethyl ether at 120℃; for 5h; Inert atmosphere;
Stage #2: With hydrogenchloride In diethylene glycol dimethyl ether; water at 20℃; Inert atmosphere;
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

benzyl bromide
100-39-0

benzyl bromide

1-(benzyloxy)-3-bromo-2-fluorobenzene
295376-29-3

1-(benzyloxy)-3-bromo-2-fluorobenzene

Conditions
ConditionsYield
With potassium carbonate In acetone for 4h; Reflux;97%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

6-(benzyloxy)-4-chloro-7-methoxyquinazoline
286371-65-1

6-(benzyloxy)-4-chloro-7-methoxyquinazoline

6-benzyloxy-4-(3-bromo-2-fluorophenoxy)-7-methoxyquinazoline

6-benzyloxy-4-(3-bromo-2-fluorophenoxy)-7-methoxyquinazoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 90℃; for 1h;96%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

isopropyl bromide
75-26-3

isopropyl bromide

1-bromo-2-fluoro-3-isopropoxybenzene
1160293-59-3

1-bromo-2-fluoro-3-isopropoxybenzene

Conditions
ConditionsYield
With potassium carbonate In acetone at 60℃; for 14h; Inert atmosphere;92%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

cyclohexylmethyl alcohol
100-49-2

cyclohexylmethyl alcohol

1-bromo-3-(cyclohexylmethoxy)-2-fluorobenzene

1-bromo-3-(cyclohexylmethoxy)-2-fluorobenzene

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 16h;83%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

6,7-dibenzyloxy-4-chloroquinazoline

6,7-dibenzyloxy-4-chloroquinazoline

6,7-dibenzyloxy-4-(3-bromo-2-fluorophenoxy)quinazoline

6,7-dibenzyloxy-4-(3-bromo-2-fluorophenoxy)quinazoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 1h;82%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

benzyl (3S)-3-((4-(2-fluoro-3-pyridyl)pyrimidin-2-yl)amino)piperidine-1-carboxylate

benzyl (3S)-3-((4-(2-fluoro-3-pyridyl)pyrimidin-2-yl)amino)piperidine-1-carboxylate

benzyl (3S)-3-((4-(2-(3-bromo-2-fluoro-phenoxy)-3-pyridyl)pyrimidin-2-yl)amino)piperidine-1-carboxylate

benzyl (3S)-3-((4-(2-(3-bromo-2-fluoro-phenoxy)-3-pyridyl)pyrimidin-2-yl)amino)piperidine-1-carboxylate

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 110℃; for 1h;76.8%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

diphenyliodonium tetrafluoroborate

diphenyliodonium tetrafluoroborate

1-bromo-2-fluoro-3-phenoxybenzene

1-bromo-2-fluoro-3-phenoxybenzene

Conditions
ConditionsYield
Stage #1: 3-bromo-2-fluoro-phenol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.25h;
Stage #2: diphenyliodonium tetrafluoroborate In tetrahydrofuran at 40℃; for 1h;
76%
Stage #1: 3-bromo-2-fluoro-phenol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.25h;
Stage #2: diphenyliodonium tetrafluoroborate In tetrahydrofuran at 40℃; for 1h;
76%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

bis(3-fluorophenyl)iodonium tetrafluoroborate
1426251-76-4

bis(3-fluorophenyl)iodonium tetrafluoroborate

1-bromo-2-fluoro-3-(3-fluorophenoxy)benzene

1-bromo-2-fluoro-3-(3-fluorophenoxy)benzene

Conditions
ConditionsYield
Stage #1: 3-bromo-2-fluoro-phenol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.25h;
Stage #2: bis(3-fluorophenyl)iodonium tetrafluoroborate In tetrahydrofuran at 40℃; for 1h;
71%
Stage #1: 3-bromo-2-fluoro-phenol With potassium tert-butylate In tetrahydrofuran at 0℃; for 0.25h;
Stage #2: bis(3-fluorophenyl)iodonium tetrafluoroborate In tetrahydrofuran at 40℃; for 1h;
71%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

2-methyl-3-bromo-1-propene
1458-98-6

2-methyl-3-bromo-1-propene

C10H10BrFO

C10H10BrFO

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 18h; Inert atmosphere; Reflux;70%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

sodium chlorodifluoroacetate
1895-39-2

sodium chlorodifluoroacetate

1-bromo-3-(difluoromethoxy)-2-fluorobenzene
1242249-28-0

1-bromo-3-(difluoromethoxy)-2-fluorobenzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 2h;47%
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 2h;
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 4h;
4-bromotetrahydro-2H-pyran
25637-16-5

4-bromotetrahydro-2H-pyran

3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

C11H12BrFO2

C11H12BrFO2

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 80℃; for 18h;31.24%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

(3-(aminocarbonyl)phenyl)boronic acid

(3-(aminocarbonyl)phenyl)boronic acid

3-(2-fluoro-3-hydroxy-phenyl)benzamide

3-(2-fluoro-3-hydroxy-phenyl)benzamide

Conditions
ConditionsYield
With potassium phosphate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride In 1,4-dioxane; ethanol at 100℃; for 1h; Inert atmosphere; Microwave irradiation; Sealed tube;29%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

phenylboronic acid
98-80-6

phenylboronic acid

1-bromo-2-fluoro-3-phenoxybenzene

1-bromo-2-fluoro-3-phenoxybenzene

Conditions
ConditionsYield
With copper diacetate; triethylamine In dichloromethane at 20℃; Molecular sieve;4%
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

1-bromo-hexane
111-25-1

1-bromo-hexane

A

6-bromo-2-hexyloxyfluorobenzene
176317-01-4

6-bromo-2-hexyloxyfluorobenzene

B

2-Hexyloxy-1,6,7,8-tetrafluorophenanthrene

2-Hexyloxy-1,6,7,8-tetrafluorophenanthrene

Conditions
ConditionsYield
With hydrogenchloride; potassium carbonate In water; acetone
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

2-(3-(difluoromethoxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
1313426-18-4

2-(3-(difluoromethoxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C
2: potassium acetate / 1,4-dioxane / 2 h / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 100 °C
2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 3 h / 110 °C
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

4-[2-(benzyloxy)-6-bromophenoxymethyl]pyridine
1372147-59-5

4-[2-(benzyloxy)-6-bromophenoxymethyl]pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]pyridinium bromide
1372147-65-3

1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]pyridinium bromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine
1372147-73-3

1-benzyl-4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

benzyl 4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine-1-carboxylate
1372147-81-3

benzyl 4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C
5.1: potassium hydrogencarbonate / dichloromethane / 24 h / 0 - 20 °C
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

ethyl 4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine-1-carboxylate
1372147-83-5

ethyl 4-[2-(benzyloxy)-6-bromophenoxymethyl]-1,2,3,6-tetrahydropyridine-1-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C
5.1: potassium hydrogencarbonate / 1,2-dichloro-ethane / 2 h / Reflux
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

benzyl 7-(benzyloxy)-2',3'-dihydro-1'H,2H-spiro[1-benzofuran-3,4'-pyridine]-1'-carboxylate
1372147-92-6

benzyl 7-(benzyloxy)-2',3'-dihydro-1'H,2H-spiro[1-benzofuran-3,4'-pyridine]-1'-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C
5.1: potassium hydrogencarbonate / dichloromethane / 24 h / 0 - 20 °C
6.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); silver carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 140 °C / Inert atmosphere
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

ethyl 7-(benzyloxy)-2',3'-dihydro-1'H,2H-spiro[1-benzofuran-3,4'-pyridine]-1'-carboxylate
1372147-94-8

ethyl 7-(benzyloxy)-2',3'-dihydro-1'H,2H-spiro[1-benzofuran-3,4'-pyridine]-1'-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C
5.1: potassium hydrogencarbonate / 1,2-dichloro-ethane / 2 h / Reflux
6.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); silver carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 140 °C / Inert atmosphere
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

ethyl 7-hydroxy-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-carboxylate
1372148-02-1

ethyl 7-hydroxy-2H-spiro[1-benzofuran-3,4'-piperidine]-1'-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C
5.1: potassium hydrogencarbonate / 1,2-dichloro-ethane / 2 h / Reflux
6.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); silver carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 140 °C / Inert atmosphere
7.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 18 h / 20 °C / 760.05 Torr
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

2H-spiro[1-benzofuran-3,4'-piperidin]-7-ol hydrochloride
1372148-00-9

2H-spiro[1-benzofuran-3,4'-piperidin]-7-ol hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: potassium carbonate / acetone / 4 h / Reflux
2.1: sodium hydride / 1-methyl-pyrrolidin-2-one; mineral oil / 0.5 h / 60 °C / Cooling with ice
2.2: 2 h / 100 °C
3.1: acetone / 18 h / Reflux
4.1: sodium tetrahydroborate / methanol / 2 h / -5 - 20 °C
5.1: potassium hydrogencarbonate / 1,2-dichloro-ethane / 2 h / Reflux
6.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); silver carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 140 °C / Inert atmosphere
7.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 18 h / 20 °C / 760.05 Torr
8.1: hydrogenchloride; water; acetic acid / 18 h / Reflux
View Scheme
tetrahydrofurfuryl bromide
1192-30-9

tetrahydrofurfuryl bromide

3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

2-(3-bromo-2-fluoro-phenoxymethyl)-tetrahydrofuran
1398923-65-3

2-(3-bromo-2-fluoro-phenoxymethyl)-tetrahydrofuran

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 130℃; for 2h; Inert atmosphere;
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

cis-7-[3-(1,1-dioxo-1-thiomorpholin-4-ylmethyl)-cyclobutyl]-5-[2-fluoro-3-(tetrahydro-furan-2-ylmethoxy)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

cis-7-[3-(1,1-dioxo-1-thiomorpholin-4-ylmethyl)-cyclobutyl]-5-[2-fluoro-3-(tetrahydro-furan-2-ylmethoxy)-phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 130 °C / Inert atmosphere
2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere
3: potassium phosphate; sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1.5 h / 100 °C / Inert atmosphere; sealed tube
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

2-(4-amino-5-{2-fluoro-3-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-phenyl}-pyrrolo[2,3-d]pyrimidin-7-yl)-5-oxa-7-aza-spiro[3.4]octan-6-one

2-(4-amino-5-{2-fluoro-3-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-phenyl}-pyrrolo[2,3-d]pyrimidin-7-yl)-5-oxa-7-aza-spiro[3.4]octan-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C
2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere
3: potassium phosphate; sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 1.5 h / 80 °C / Inert atmosphere; sealed tube
View Scheme
3-bromo-2-fluoro-phenol
156682-53-0

3-bromo-2-fluoro-phenol

1-{4-[cis-3-(4-amino-5-{2-fluoro-3-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-phenyl}-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutyl]-piperazin-1-yl}-ethanone

1-{4-[cis-3-(4-amino-5-{2-fluoro-3-[(S)-1-(tetrahydro-furan-2-yl)methoxy]-phenyl}-pyrrolo[2,3-d]pyrimidin-7-yl)-cyclobutyl]-piperazin-1-yl}-ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C
2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere
3: potassium phosphate; sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide; water / 2.5 h / 100 °C / Inert atmosphere; sealed tube
View Scheme

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