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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-(Trifluoromethyl)Nicotinic Acid supplier in China

Cas:158063-66-2

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 4-(Trifluoromethyl)nicotinic acid CAS No.

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

4-(Trifluoromethyl)nicotinic acid Basic information Product Name: 4-(Trifluoromethyl)nicotinic acid Synonyms: BUTTPARK 43\57-42;4-(TRIFLUOROMETHYL)NICOTINIC ACID;4-

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-(Trifluoromethyl)Nicotinic Acid

Cas:158063-66-2

Min.Order:1

Negotiable

Type:Other

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-(Trifluoromethyl)-nicotinic acid

Cas:158063-66-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 158063-66-2 with best quality

Cas:158063-66-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: 4-(Trifluoromethyl)nicotinic acid Synonyms: 4-(TrifluoroMethyl)-3-Pyridinecarboxylic Acid;3-Pyridinecarboxylic acid, 4-(trifluoromethyl)-;4-(Trifluoromethyl)pyridine-3-carboxy

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

4-(Trifluoromethyl)nicotinic acid 158063-66-2

Cas:158063-66-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 4-(Trifluoromethyl)nicotinic acid CAS: 158063-66-2 MF: C7H4F3NO2 MW: 191.11 EINECS: 623-902-1 Mol File: 158063-66-2.mol 4-(Trifluoromethyl)nicotinic acid Structure 4-(Trifluoromethyl)nicotinic acid Chemical Propertie

4-(Trifluoromethyl)-3-pyridinecarboxylic acid

Cas:158063-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-(Trifluoromethyl)nicotinic acid CAS:158063-66-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

4-(Trifluoromethyl)nicotinic acid CAS:158063-66-2

Cas:158063-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

4-(Trifluoromethyl)nicotinic acid CAS: 158063-66-2 Specification Product Name 4-(Trifluoromethyl)nicotinic acid CAS No. 158063-66-2 Appearance solid

Factory supply 4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-(Trifluoromethyl)Nicotinic Acid

Cas:158063-66-2

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We have s

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Kilogram

FOB Price: $25.0 / 35.0

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-(Trifluoromethyl)Nicotinic Acid

Cas:158063-66-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

4-(Trifluoromethyl)nicotinic acid CAS NO.158063-66-2

Cas:158063-66-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung, LG, Merck, Thermo Fisher Scientific and so o

158063-66-2 4-(Trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-4-(trifluoromethyl)pyridine

Cas:158063-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-(Trifluoromethyl)nicotinicacid

Cas:158063-66-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-(Trifluoromethyl)nicotinic acid

Cas:158063-66-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-trifluoromethyl-3-pyridinecarboxamide
158062-71-6

4-trifluoromethyl-3-pyridinecarboxamide

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 100℃; for 4h; Concentration;99.1%
Stage #1: 4-trifluoromethyl-3-pyridinecarboxamide With hydrogenchloride; water for 5h; Heating / reflux;
Stage #2: With sodium carbonate In water pH=3;
89.7%
With sodium hydroxide at 100℃; for 5h;
4-(trifluoromethyl)nicotinonitrile
13600-43-6

4-(trifluoromethyl)nicotinonitrile

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 100℃; Temperature;98.3%
With sodium hydroxide In ethanol at 80℃; for 10h; Temperature; Inert atmosphere;90.1%
Stage #1: 4-(trifluoromethyl)nicotinonitrile With potassium hydroxide; water In water; ethylene glycol at 200℃; for 4h;
Stage #2: With hydrogenchloride In water; ethylene glycol at 20℃;
84%
With sulfuric acid In water at 110℃; for 12h;
2-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid
590371-81-6

2-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With ammonium formate; 10% palladium on active carbon In methanol at 25℃; for 0.25h;89%
N-(2-methoxycarbonylvinyl)-4,4,4-trifluoro-3-one-1-butenamine

N-(2-methoxycarbonylvinyl)-4,4,4-trifluoro-3-one-1-butenamine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Stage #1: N-(2-methoxycarbonylvinyl)-4,4,4-trifluoro-3-oxo-1-butenamine With sodium methylate In methanol at 20 - 65℃; for 7h; Inert atmosphere;
Stage #2: With water at 20℃; for 12h;
86.2%
Stage #1: N-(2-methoxycarbonylvinyl)-4,4,4-trifluoro-3-oxo-1-butenamine With sodium methylate In methanol for 6.5h; Reflux;
Stage #2: With water; sodium hydroxide In methanol at 50℃; Time;
75%
With sodium methylate In methanol at 20℃; for 6.5h; Time; Reflux;
4-trifluoromethylpyridine
3796-24-5

4-trifluoromethylpyridine

carbon dioxide
124-38-9

carbon dioxide

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran at -75℃; for 2h;84%
carbon dioxide
124-38-9

carbon dioxide

3-iodo-4-(trifluoromethyl)pyridine
625115-02-8

3-iodo-4-(trifluoromethyl)pyridine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -75℃; for 0.0333333h;81%
N-2-methoxycarbonylvinyl 4,4,4-trifluoro-3-oxo-1-butenylamine

N-2-methoxycarbonylvinyl 4,4,4-trifluoro-3-oxo-1-butenylamine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; diethyl ether; water77%
dimethyl (methoxymethylene)malonate
22398-14-7

dimethyl (methoxymethylene)malonate

4-amino-1,1,1-trifluoro-3-butene-2-one
120417-45-0

4-amino-1,1,1-trifluoro-3-butene-2-one

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Stage #1: 4-amino-1,1,1-trifluoro-3-butene-2-one With sodium hydride In 1-methyl-pyrrolidin-2-one at 0 - 10℃; for 1h;
Stage #2: dimethyl (methoxymethylene)malonate In 1-methyl-pyrrolidin-2-one; methanol at 65℃; for 7h;
Stage #3: With hydrogenchloride In 1-methyl-pyrrolidin-2-one; methanol; water for 9h; Reagent/catalyst; Solvent; Temperature; Reflux;
49%
3-methoxy-2-propenenitrile
60838-50-8

3-methoxy-2-propenenitrile

4-amino-1,1,1-trifluoro-3-butene-2-one
120417-45-0

4-amino-1,1,1-trifluoro-3-butene-2-one

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Stage #1: 3-methoxy-2-propenenitrile; 4-amino-1,1,1-trifluoro-3-butene-2-one With sodium hydride In tetrahydrofuran at 0 - 20℃; for 3.33333h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
Stage #3: With hydrogenchloride; sodium hydroxide; water; sodium methylate more than 3 stages;
45.3%
4-trifluoromethylpyridine
3796-24-5

4-trifluoromethylpyridine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79 percent / 2,2,6,6-tetramethylpiperidine; butyllithium; iodine / tetrahydrofuran; hexane / 2 h / -75 °C
2: 81 percent / butyllithium / tetrahydrofuran; hexane / 0.03 h / -75 °C
View Scheme
2-chloro-4-trifluoromethyl pyridine
81565-18-6

2-chloro-4-trifluoromethyl pyridine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C
2: 89 percent / ammonium formate / palladium (10 percent on charcoal) / methanol / 0.25 h / 25 °C
View Scheme
2,6-dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile
13600-42-5

2,6-dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium hydroxide; water / 8 h / 20 °C
2: hydrogen; triethylamine; 5%-palladium/activated carbon / methanol / Reflux
View Scheme
Multi-step reaction with 2 steps
1: triethylamine; hydrogen; palladium on activated carbon / tetrahydrofuran / 4 h
2: sodium hydroxide / ethanol / 10 h / 80 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: sodium bromide; sulfuric acid
2: sodium carbonate; 5%-palladium/activated carbon; hydrogen / methanol / 6 h
3: sodium hydroxide / 5 h / 100 °C
View Scheme
2,6-dichloro-4-trifluoromethylnicotinic acid
503437-19-2

2,6-dichloro-4-trifluoromethylnicotinic acid

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen; triethylamine In methanol Reagent/catalyst; Reflux;
2,6-dihydroxy-3-cyano-4-trifluoromethylpyridine N-methylmorpholine

2,6-dihydroxy-3-cyano-4-trifluoromethylpyridine N-methylmorpholine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trichlorophosphate / 18 h / 130 °C / Inert atmosphere
2: triethylamine; hydrogen; palladium on activated carbon / tetrahydrofuran / 4 h
3: sodium hydroxide / ethanol / 10 h / 80 °C / Inert atmosphere
View Scheme
2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine
3335-46-4

2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 6 h / 125 °C
2: sodium bromide; sulfuric acid
3: sodium carbonate; 5%-palladium/activated carbon; hydrogen / methanol / 6 h
4: sodium hydroxide / 5 h / 100 °C
View Scheme
2-aminoacetonitrile hydrochloride
6011-14-9

2-aminoacetonitrile hydrochloride

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

flonicamide

flonicamide

Conditions
ConditionsYield
Stage #1: 4-(trifluoromethyl)nicotinic acid With thionyl chloride In toluene at 0 - 120℃; for 2.5h; Inert atmosphere;
Stage #2: 2-aminoacetonitrile hydrochloride With triethylamine In tetrahydrofuran; toluene at 0 - 25℃; for 10h; Inert atmosphere;
93.4%
With phosgene; triethylamine In toluene at -10 - 5℃; for 4h; Reagent/catalyst; Solvent; Temperature;91.6%
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

N-methoxy-N-methyl-4-(trifluoromethyl)nicotinamide
323180-94-5

N-methoxy-N-methyl-4-(trifluoromethyl)nicotinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; for 5h; Inert atmosphere;93%
With HATU; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 5h; Inert atmosphere;
cyanomethylamine sulfate
151-63-3

cyanomethylamine sulfate

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

flonicamide

flonicamide

Conditions
ConditionsYield
With triethylamine In 1,2-dichloro-ethane at 0 - 35℃; for 4h; Solvent;90.4%
With thionyl chloride; triethylamine; N-methyl-acetamide In tetrahydrofuran; benzene
4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

4-(trifluoromethyl)pyridine-3-carbonyl chloride
104326-73-0

4-(trifluoromethyl)pyridine-3-carbonyl chloride

Conditions
ConditionsYield
With thionyl chloride; N,N-dimethyl-formamide In benzene for 3h; Heating / reflux;90.1%
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h;
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 1h; Product distribution / selectivity;
4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

6-nitro-4-trifluoromethyl-3-picolinic acid

6-nitro-4-trifluoromethyl-3-picolinic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid at 0 - 20℃;89.8%
1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

tert-butyl 4-(4-(trifluoromethyl)nicotinoyl)piperazine-1-carboxylate

tert-butyl 4-(4-(trifluoromethyl)nicotinoyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 20h;83.9%
C23H21N3O2S
1261276-98-5

C23H21N3O2S

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

C30H23F3N4O3S
1261275-82-4

C30H23F3N4O3S

Conditions
ConditionsYield
Stage #1: 4-(trifluoromethyl)nicotinic acid With oxalyl dichloride; N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: C23H21N3O2S With pyridine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
82%
C17H22F3NO3

C17H22F3NO3

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

C24H24F6N2O4

C24H24F6N2O4

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 23℃;82%
C18H22F3NO3
1000894-58-5

C18H22F3NO3

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

C25H24F6N2O4

C25H24F6N2O4

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane; N,N-dimethyl-formamide at 20℃; for 18h;75%
2-aminoacetonitrile hydrochloride
6011-14-9

2-aminoacetonitrile hydrochloride

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

N-cyanomethyl-N,N-bis(4-trifluoromethylnicotinoyl)amine

N-cyanomethyl-N,N-bis(4-trifluoromethylnicotinoyl)amine

Conditions
ConditionsYield
Stage #1: 2-aminoacetonitrile hydrochloride With triethylamine In 5,5-dimethyl-1,3-cyclohexadiene at 43℃; for 0.333333h;
Stage #2: 4-(trifluoromethyl)nicotinic acid With oxalyl dichloride In 5,5-dimethyl-1,3-cyclohexadiene at -20 - 105℃; for 0.7h; Temperature;
73.7%
3-hydroxypiperazine
6859-99-0

3-hydroxypiperazine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

C12H13F3N2O2
1000894-22-3

C12H13F3N2O2

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 0 - 20℃; for 20h;70%
N,N-diethylhydrazine
616-40-0

N,N-diethylhydrazine

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

N',N'-diethyl-4-(trifluoromethyl)nicotinohydrazide

N',N'-diethyl-4-(trifluoromethyl)nicotinohydrazide

Conditions
ConditionsYield
Stage #1: 4-(trifluoromethyl)nicotinic acid With triethylamine In dichloromethane at 20℃; for 0.0833333h;
Stage #2: N,N-diethylhydrazine With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
64%
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

C8H6F3NO
955997-27-0

C8H6F3NO

Conditions
ConditionsYield
With PyBOP; triethylamine In tetrahydrofuran at 20℃; for 18h;62%
Stage #1: 4-(trifluoromethyl)nicotinic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃; for 0.166667h;
Stage #2: cycl-isopropylidene malonate In tetrahydrofuran at 20℃;
Stage #3: With hydrogenchloride In tetrahydrofuran; water for 18h; Heating / reflux;
62%
cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

methyl 4-trifluoromethylpyridine-3-carboxylate
175204-82-7

methyl 4-trifluoromethylpyridine-3-carboxylate

Conditions
ConditionsYield
Stage #1: cycl-isopropylidene malonate; 4-(trifluoromethyl)nicotinic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran at 20℃;
Stage #2: With hydrogenchloride; water In tetrahydrofuran for 18h;
Stage #3: In tetrahydrofuran; water
62%
5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

5-(4-aminophenyl)-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

5-[4-[[4-(trifluoromethyl)pyridin-3-yl]carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

5-[4-[[4-(trifluoromethyl)pyridin-3-yl]carbonylamino]phenyl]-1H-naphtho[1,2-b][1,4]diazepine-2,4(3H,5H)-dione

Conditions
ConditionsYield
With pyridine Heating;60%
4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

methyl iodide
74-88-4

methyl iodide

methyl 4-trifluoromethylpyridine-3-carboxylate
175204-82-7

methyl 4-trifluoromethylpyridine-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 12h;56.1%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 12h;56.1%
1,7,11-trideacetyl-pyripyropene A

1,7,11-trideacetyl-pyripyropene A

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

1,7,11-tri-deacetyl-1,7,11-tri-O-(4-trifluoromethyl-3-pyridylcarbonyl)pyripyropene A
1351304-15-8

1,7,11-tri-deacetyl-1,7,11-tri-O-(4-trifluoromethyl-3-pyridylcarbonyl)pyripyropene A

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 68h;56%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 17.5h;36 mg
serinol
534-03-2

serinol

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

N-(4-trifluoromethylnicotinoyl)serinol
506433-31-4

N-(4-trifluoromethylnicotinoyl)serinol

Conditions
ConditionsYield
Stage #1: 4-(trifluoromethyl)nicotinic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 40 - 50℃; for 6h;
Stage #2: serinol In tetrahydrofuran at 50 - 60℃; for 4h;
55.3%
2-amino-1-(4-chlorophenyl)-3-methylbutan-1-one hydrochloride
1407542-08-8

2-amino-1-(4-chlorophenyl)-3-methylbutan-1-one hydrochloride

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-4-(trifluoromethyl)nicotinamide

N-(1-(4-chlorophenyl)-3-methyl-1-oxobutan-2-yl)-4-(trifluoromethyl)nicotinamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 30℃; for 16h;51%
4-(4,5-dimethyl-6-(4-(methylamino)piperidin-1-yl)pyridazin-3-yl)benzonitrile
1227070-29-2

4-(4,5-dimethyl-6-(4-(methylamino)piperidin-1-yl)pyridazin-3-yl)benzonitrile

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

N-(1-(6-(4-cyanophenyl)-4,5-dimethylpyridazin-3-yl)piperidin-4-yl)-N-methyl-4-(trifluoromethyl)nicotinamide hydrochloride
1227070-13-4

N-(1-(6-(4-cyanophenyl)-4,5-dimethylpyridazin-3-yl)piperidin-4-yl)-N-methyl-4-(trifluoromethyl)nicotinamide hydrochloride

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane for 72h;49%
1,7,11-tri-deacetyl-1,11-di-O-propionylpyripyropene A
915971-55-0

1,7,11-tri-deacetyl-1,11-di-O-propionylpyripyropene A

4-(trifluoromethyl)nicotinic acid
158063-66-2

4-(trifluoromethyl)nicotinic acid

1,7,11-tri-deacetyl-1,11-di-O-propionyl-7-O-(4-trifluoromethyl-3-pyridylcarbonyl)pyripyropene A
915971-76-5

1,7,11-tri-deacetyl-1,11-di-O-propionyl-7-O-(4-trifluoromethyl-3-pyridylcarbonyl)pyripyropene A

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 4.5h;49%

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