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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Atrasentan CAS 173937-91-2

Cas:173937-91-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Atrasentan

Cas:173937-91-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

atrasentan

Cas:173937-91-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

Atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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BOC Sciences

GMP factory Packing with pallet as buyer's special request Best service after shipment with e-mail Cargos together with container sales seervice available Api, inhibitor, and fine chemicals for more

Atrasentan cas 173937-91-2

Cas:173937-91-2

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Antimex Chemical Limied

factory?direct?sale Application:healing drugs

Atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Atrasentan CAS No.173937-91-2

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Trading Company

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:25kg,50kg,180kg,200kg,250kg,1000kg,customization Application:Pharma;Industry;Agricultural;chemical reaserch Tran

atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

(2R,3R,4S)-4-(1,3-BENZODIOXOL-5-YL)-1-[2-(DIBUTYLAMINO)-2-OXOETHYL]-2-(METHOXYPHENYL)PYRROLIDINE-3-CARBOXYLIC ACIDCASAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transp

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Other

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Trading Company

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

Atrasentan

Cas:173937-91-2

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Sun-shine Bio-technology Corporation Limited

Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization. Company has strong ability of research and development

Atrasentan (ABT-627)with factory price

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

atrasentan

Cas:173937-91-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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MENGNA

This chemical is called Atrasentan, and its systematic name is (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid. With the molecular formula of C29H38N2O6, its molecular weight is 5

Atrasentan

Cas:173937-91-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Jinan Great Chemical Co.,Ltd.

Molecular Formula C29H38N2O6 Molecular Weight 510.62 CAS Registry Number 173937-91-2 AtrasentanSynonyms(2R,3R,4S)-4-(1,3-Benz…

Atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan MoonZY Biological Technology Co.,Ltd

instock with good quality and wholesale price Storage:Keep in a cool & dry place Package:Packing material and QTY as your request Application:Pharma;Industry;other application Transportation:Express or as your request Port:Any port of China

Atrasentan,173937-91-2

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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coolpharm Ltd

Known for its best quality and competitve price, this chemicals we offered is widely appreciated by our customers.Appearance:yellow to white solid Storage:keep sealed and keep from direct light Package:According client's requirements Application:Phar

ATRASENTAN

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai Haoyuan Chemexpress Co., Ltd.

Atrasentan

Cas:173937-91-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

2-[(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(4-methoxy-phenyl)-pyrrolidin-1-yl]-N,N-dibutyl-acetamide

2-[(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(4-methoxy-phenyl)-pyrrolidin-1-yl]-N,N-dibutyl-acetamide

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
With lithium hydroxide; dihydrogen peroxide In tetrahydrofuran for 0.5h;78%
5-((E)-2-nitroethenyl)-1,3-benzodioxole
1485-00-3, 22568-48-5

5-((E)-2-nitroethenyl)-1,3-benzodioxole

palladium

palladium

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 78 percent / DBU / tetrahydrofuran; propan-2-ol / 4 h / Ambient temperature
2: 12.34 g / H2 / Raney nickel / ethanol / 3040 Torr
3: 1.) sodium cyanoborohydride, 2.) bromocresol green, conc. HCl / 1.) THF, EtOH, 2.) THF, EtOH, 20 min
4: 2.775 g / C2H5ONa / ethanol / Heating
5: 91 percent / CH2Cl2 / 1 h / Ambient temperature
6: 95 percent / NaOH
7: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
8: 4 N aq. HCl / dioxane
9: iPr2NEt / acetonitrile
10: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
Multi-step reaction with 9 steps
1: 78 percent / DBU / tetrahydrofuran; propan-2-ol / 4 h / Ambient temperature
2: 12.34 g / H2 / Raney nickel / ethanol / 3040 Torr
3: 1.) sodium cyanoborohydride, 2.) bromocresol green, conc. HCl / 1.) THF, EtOH, 2.) THF, EtOH, 20 min
4: 91 percent / CH2Cl2 / 1 h / Ambient temperature
5: 95 percent / NaOH
6: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
7: 4 N aq. HCl / dioxane
8: iPr2NEt / acetonitrile
9: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
N,N-dibutylbromoacetamide
40124-27-4

N,N-dibutylbromoacetamide

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iPr2NEt / acetonitrile
2: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
dibutylamine
111-92-2

dibutylamine

(+-)-2-chloro-1-<6-methoxy-8-nitro-<4>quinolyl>-ethanol

(+-)-2-chloro-1-<6-methoxy-8-nitro-<4>quinolyl>-ethanol

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / 1,2-dichloro-ethane / 0.83 h / -20 - 20 °C
2: iPr2NEt / acetonitrile
3: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
Ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4.5-dihydro-3H-pyrrole-3-carboxylate
173864-46-5

Ethyl 2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)-4.5-dihydro-3H-pyrrole-3-carboxylate

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: 1.) sodium cyanoborohydride, 2.) bromocresol green, conc. HCl / 1.) THF, EtOH, 2.) THF, EtOH, 20 min
2: 2.775 g / C2H5ONa / ethanol / Heating
3: 91 percent / CH2Cl2 / 1 h / Ambient temperature
4: 95 percent / NaOH
5: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
6: 4 N aq. HCl / dioxane
7: iPr2NEt / acetonitrile
8: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
Multi-step reaction with 7 steps
1: 1.) sodium cyanoborohydride, 2.) bromocresol green, conc. HCl / 1.) THF, EtOH, 2.) THF, EtOH, 20 min
2: 91 percent / CH2Cl2 / 1 h / Ambient temperature
3: 95 percent / NaOH
4: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
5: 4 N aq. HCl / dioxane
6: iPr2NEt / acetonitrile
7: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
Ethyl 2-(4-methoxybenzoyl)-3-(3,4-methylenedioxy-phenyl)-4-nitro-butanoate
173864-45-4

Ethyl 2-(4-methoxybenzoyl)-3-(3,4-methylenedioxy-phenyl)-4-nitro-butanoate

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 12.34 g / H2 / Raney nickel / ethanol / 3040 Torr
2: 1.) sodium cyanoborohydride, 2.) bromocresol green, conc. HCl / 1.) THF, EtOH, 2.) THF, EtOH, 20 min
3: 2.775 g / C2H5ONa / ethanol / Heating
4: 91 percent / CH2Cl2 / 1 h / Ambient temperature
5: 95 percent / NaOH
6: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
7: 4 N aq. HCl / dioxane
8: iPr2NEt / acetonitrile
9: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
Multi-step reaction with 8 steps
1: 12.34 g / H2 / Raney nickel / ethanol / 3040 Torr
2: 1.) sodium cyanoborohydride, 2.) bromocresol green, conc. HCl / 1.) THF, EtOH, 2.) THF, EtOH, 20 min
3: 91 percent / CH2Cl2 / 1 h / Ambient temperature
4: 95 percent / NaOH
5: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
6: 4 N aq. HCl / dioxane
7: iPr2NEt / acetonitrile
8: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
ethyl 4-(1,3-benzodioxol-5-yl)-N-tert-butoxycarbonyl-2-(4-methoxyphenyl)pyrrolidine-3-carboxylate

ethyl 4-(1,3-benzodioxol-5-yl)-N-tert-butoxycarbonyl-2-(4-methoxyphenyl)pyrrolidine-3-carboxylate

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 95 percent / NaOH
2: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
3: 4 N aq. HCl / dioxane
4: iPr2NEt / acetonitrile
5: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(4-methoxy-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

(2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(4-methoxy-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 4 N aq. HCl / dioxane
2: iPr2NEt / acetonitrile
3: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
(2R,3S,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

(2R,3S,4S)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-phenyl)-pyrrolidine-3-carboxylic acid ethyl ester

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 2.775 g / C2H5ONa / ethanol / Heating
2: 91 percent / CH2Cl2 / 1 h / Ambient temperature
3: 95 percent / NaOH
4: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
5: 4 N aq. HCl / dioxane
6: iPr2NEt / acetonitrile
7: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
ethyl c-(1,3-benzodioxol-5-yl)-r-2-(4-methoxyphenyl)pyrrolidine-t-3-carboxylate

ethyl c-(1,3-benzodioxol-5-yl)-r-2-(4-methoxyphenyl)pyrrolidine-t-3-carboxylate

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 91 percent / CH2Cl2 / 1 h / Ambient temperature
2: 95 percent / NaOH
3: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
4: 4 N aq. HCl / dioxane
5: iPr2NEt / acetonitrile
6: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
rac-(2R,3R,4S)-1-(tert-butoxycarbonyl)-4-(benzo[d][1,3]dioxol-6-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid

rac-(2R,3R,4S)-1-(tert-butoxycarbonyl)-4-(benzo[d][1,3]dioxol-6-yl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) Et3N, t-BuCOCl, 2.) n-BuLi
2: 4 N aq. HCl / dioxane
3: iPr2NEt / acetonitrile
4: 78 percent / aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 0.5 h
View Scheme
N,N-dibutylbromoacetamide
40124-27-4

N,N-dibutylbromoacetamide

ethyl (2R,3R,4S)-5-(4-methoxyphenyl)-3-(3,4-(methylenedioxy)phenyl)pyrrolidine-3-carboxylate
178739-03-2

ethyl (2R,3R,4S)-5-(4-methoxyphenyl)-3-(3,4-(methylenedioxy)phenyl)pyrrolidine-3-carboxylate

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile
ethyl (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate, (S)-(+)-mandelate
195708-14-6

ethyl (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate, (S)-(+)-mandelate

N,N-dibutylbromoacetamide
40124-27-4

N,N-dibutylbromoacetamide

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Stage #1: ethyl (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate, (S)-(+)-mandelate With sodium hydrogencarbonate In water; ethyl acetate at 25℃;
Stage #2: N,N-dibutylbromoacetamide With N-ethyl-N,N-diisopropylamine In acetonitrile at 10℃; for 12h;
Stage #3: With hydrogenchloride; sodium hydroxide more than 3 stages;
ethyl (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate, (S)-(+) mandelate
403614-49-3

ethyl (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate, (S)-(+) mandelate

N,N-dibutylbromoacetamide
40124-27-4

N,N-dibutylbromoacetamide

N-ethyl-N,N-diisopropylamine
7087-68-5

N-ethyl-N,N-diisopropylamine

atrasentan
173937-91-2

atrasentan

Conditions
ConditionsYield
Stage #1: ethyl (2R,3R,4S)-(+)-2-(4-methoxyphenyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate, (S)-(+) mandelate With sodium hydrogencarbonate In water; ethyl acetate at 25℃;
Stage #2: N,N-dibutylbromoacetamide; N-ethyl-N,N-diisopropylamine In ethyl acetate; acetonitrile at 110℃; for 16h;
atrasentan
173937-91-2

atrasentan

Atrasentan hydrochloride

Atrasentan hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water; ethyl acetate for 0.25h;
With hydrogenchloride In water; ethyl acetate at 0℃; for 2 - 3h; Product distribution / selectivity;
With hydrogenchloride In ethanol; water; ethyl acetate for 0.25h; Product distribution / selectivity;
With hydrogenchloride In ethyl acetate at 0 - 45℃; for 26.5 - 39.5h;
(S)-Mandelic acid
17199-29-0

(S)-Mandelic acid

atrasentan
173937-91-2

atrasentan

atrasentan (S)-mandelate salt

atrasentan (S)-mandelate salt

Conditions
ConditionsYield
In methanol; water at 50℃;
(S)-Mandelic acid
17199-29-0

(S)-Mandelic acid

atrasentan
173937-91-2

atrasentan

atrasentan (S)-mandelate salt

atrasentan (S)-mandelate salt

Conditions
ConditionsYield
In methanol; water at 40℃; Temperature;
(R)-Mandelic Acid
611-71-2

(R)-Mandelic Acid

atrasentan
173937-91-2

atrasentan

atrasentan R-mandelate salt

atrasentan R-mandelate salt

Conditions
ConditionsYield
In water at 50℃; for 0.25h; Sonication;

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