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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

3,4-Methylenedioxy-beta-nitrostyrene CAS 1485-00-3

Cas:1485-00-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3

Cas:1485-00-3

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1,3-Benzodioxole,5-(2-nitroethenyl)-

Cas:1485-00-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanxi Ankesi Biotechnology Co., Ltd

Our Advantage 1. Rich experience We specialize in this filed for many years, our APIs exported to all over the world and and we established long friendly relations of cooperation with our clients. 2. Great quality,purity and favorable Good qual

3,4-Methylenedioxy-beta-nitrostyrene CAS 1485-00-3 AKS

Cas:1485-00-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1,3-Benzodioxole,5-(2-nitroethenyl)-

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality moderate price & quick delivery Appearance:yellow powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used to make other c

3,4-Methylenedioxy-b-nitrostyrene

Cas:1485-00-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providing h

Factory Supply 3,4-Methylenedioxy-b-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Other

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

MNS(3,4-Methylenedioxy-β-nitrostyrene,MDBN);3,4-Methylenedioxy-β-nitrostyrene

Cas:1485-00-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

3,4-Methylenedioxy-b-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

3,4-Methylenedioxy-β-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

3,4-Methylenedioxy-beta-nitrostyrene cas 1485-00-3Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

3,4-Methylenedioxy-beta-nitrostyrene cas 1485-00-3

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Other

inquiry

BOC Sciences

BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. Package:

MNS

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Other

inquiry

Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

HWRK Chem

in store Package:500g Application:Organic Chemicals

3,4-Methylenedioxy- -nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

HENAN SUNLAKE ENTERPRISE CORPORATION

Our Services 1.Certificate Of Analysis (COA) 2.Material Safety Data Sheet (MSDS) 3.Route of synthesis (ROS) 4.Method of Aanlysis (MOA) 5.Nuclear Magnetic Resonance (NMR) 6.Packing pictures and loading video before loading 7.Free Sampl

3,4-Methylenedioxy-beta-nitrostyrene 1485-00-3 C9H7NO4

Cas:1485-00-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Wuhan Sun-shine Bio-technology Corporation Limited

Wuhan Sun-shine Bio-technology Corporation Limited is specializing in the anticancer, antitumor,heart head blood-vessel,pharmaceutical intermediates,fine Chemicals production and customization. Company has strong ability of research and development

MNSwith factory price

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Extraordinary Pharmatech co.,LTD

Changzhou Extraordinary Pharmatech co., LTD. As a leading chemical manufacturer and supplier in China.DAS authentication is passed.We can provide the popular precursor chemicals, we have our own strong R & D team, have our own laboratories and fa

3,4-METHYLENEDIOXY-BETA-NITROSTYRENE (MNS)

Cas:1485-00-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

suzhou BetterBioChem Co., Ltd.

Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Chemical Technology Co.,LTD

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.2. Quality assurance: we have a first-class testing equipment and testi

3,4-Methylenedioxy-beta-nitrostyrene

Cas:1485-00-3

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Share Chemical Co., Ltd

At Share Chemical Company, we scrupulously abide by our policy of “Excellent Quality at a Reasonable Price”. We strive to satisfy all of our customers by providing the finest quality products supported by the finest in customer servi

3,4-Methylenedioxy-^b-nitrostyrene

Cas:1485-00-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Synthetic route

piperonal
120-57-0

piperonal

nitromethane
75-52-5

nitromethane

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

Conditions
ConditionsYield
With sodium acetate; methylamine In methanol; ethanol for 2h; Henry Nitro Aldol Condensation;91%
With aluminum oxide; potassium carbonate for 0.0666667h; microwave irradiation;90%
With ethylenediamine functionalized magnetic Fe3O4 supported on SiO2 nanoparticles; air at 80℃; for 4h;89%
1,3-benzodioxol-5-ylmethyl amine
2620-50-0

1,3-benzodioxol-5-ylmethyl amine

nitromethane
75-52-5

nitromethane

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

Conditions
ConditionsYield
With 4-(4-fluorophenyl)naphthalene-1,2-dione; oxygen at 80℃; for 12h;53%
sodium compound of nitromethyl-<3.4-methylenedioxy-phenyl>-carbinol

sodium compound of nitromethyl-<3.4-methylenedioxy-phenyl>-carbinol

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

Conditions
ConditionsYield
With acetic acid; zinc(II) chloride
benzene-1,2-diol
120-80-9

benzene-1,2-diol

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / dimethyl sulfoxide / 95 - 120 °C
2: trichlorophosphate
3: sodium acetate; methylamine / ethanol; methanol / 2 h
View Scheme
Methylenedioxybenzene
274-09-9

Methylenedioxybenzene

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate
2: sodium acetate; methylamine / ethanol; methanol / 2 h
View Scheme
piperonal
120-57-0

piperonal

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

Conditions
ConditionsYield
With ammonium acetate; acetic acid at 100℃;
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

3,4-methylenedioxyphenylethylamine
1484-85-1

3,4-methylenedioxyphenylethylamine

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 20 - 70℃; for 4h;100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 4h;95%
With diisobutylaluminium hydride In 1,4-dioxane at 60℃; for 3h;82%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

cyclohexanone
108-94-1

cyclohexanone

(S)-2-((R)-1-(benzo[d][1,3]dioxol-6-yl)-2-nitroethyl)cyclohexanone

(S)-2-((R)-1-(benzo[d][1,3]dioxol-6-yl)-2-nitroethyl)cyclohexanone

Conditions
ConditionsYield
Stage #1: cyclohexanone With (S)-1-(2,3,4,6-tetra-O-acetyl)glucosyl-3-(pyrrolidin-2-ylmethyl)-thiourea trifluoroacetate; triethylamine at 20℃; for 0.333333h;
Stage #2: 5-(2-nitrovinyl)benzo[1,3]dioxole With butyric acid at -15℃; for 52h; Michael condensation;
99%
Stage #1: cyclohexanone With C2HF3O2*C17H19N2O2PS; triethylamine at 25℃; for 0.5h;
Stage #2: With benzoic acid for 0.25h;
Stage #3: 5-(2-nitrovinyl)benzo[1,3]dioxole at -30℃; for 40h; Michael addition; optical yield given as %ee; enantioselective reaction;
95%
With C12H21N4O2(1+)*Cl(1-); triethylamine In methanol at 20℃; for 36h; Michael Addition; enantioselective reaction;95%
1-methylindole
603-76-9

1-methylindole

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1-methyl-1H-indole

3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1-methyl-1H-indole

3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1-methyl-1H-indole

3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1-methyl-1H-indole

Conditions
ConditionsYield
With 1-((1S,2S)-2-aminocyclohexyl)-3-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)thiourea; zinc trifluoromethanesulfonate In toluene at 35℃; for 3h; Friedel-Crafts Alkylation; Inert atmosphere; enantioselective reaction;A 99%
B n/a
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

1,3,5-tris(benzo[d][1,3]dioxol-5-yl)benzene

1,3,5-tris(benzo[d][1,3]dioxol-5-yl)benzene

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 0.2h; Sealed tube;98%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

C21H25O6P

C21H25O6P

C25H22NO7P

C25H22NO7P

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; C41H50N4O2P2 In toluene at 40℃; for 24h; stereoselective reaction;98%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

butyraldehyde
123-72-8

butyraldehyde

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-ethyl-4-nitrobutanal

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-ethyl-4-nitrobutanal

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With 4-methyl-morpholine; C25H31F6N5O2S*C2HF3O2; benzoic acid In dichloromethane at -10℃; for 0.166667h; Michael Addition; Inert atmosphere;
Stage #2: butyraldehyde In dichloromethane at -10 - 20℃; Inert atmosphere; enantioselective reaction;
97%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

3-(3-chlorophenyl)propanal
136415-83-3

3-(3-chlorophenyl)propanal

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-(3-chlorobenzyl)-4-nitrobutanal

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-(3-chlorobenzyl)-4-nitrobutanal

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With 4-methyl-morpholine; C25H31F6N5O2S*C2HF3O2; benzoic acid In dichloromethane at -10℃; for 0.166667h; Michael Addition; Inert atmosphere;
Stage #2: 3-(3-chlorophenyl)propanal In dichloromethane at -10 - 20℃; Inert atmosphere; enantioselective reaction;
97%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

3-(4-methoxyphenyl)propional
20401-88-1

3-(4-methoxyphenyl)propional

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-(4-methoxybenzyl)-4-nitrobutanal

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-(4-methoxybenzyl)-4-nitrobutanal

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With 4-methyl-morpholine; C25H31F6N5O2S*C2HF3O2; benzoic acid In dichloromethane at -10℃; for 0.166667h; Michael Addition; Inert atmosphere;
Stage #2: 3-(4-methoxyphenyl)propional In dichloromethane at -10 - 20℃; Inert atmosphere; enantioselective reaction;
97%
prop-2-ene-1-thiol
870-23-5

prop-2-ene-1-thiol

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

2-(allylthio)-2-(3,4-(methylenedioxy)phenyl)-1-nitroethane
128869-28-3

2-(allylthio)-2-(3,4-(methylenedioxy)phenyl)-1-nitroethane

Conditions
ConditionsYield
With piperidine In diethyl ether96%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

butyraldehyde
123-72-8

butyraldehyde

(2R,3S)-3-(benzo[d][1,3]dioxol-5-yl)-2-ethyl-4-nitrobutyraldehyde
1241905-72-5

(2R,3S)-3-(benzo[d][1,3]dioxol-5-yl)-2-ethyl-4-nitrobutyraldehyde

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With benzoic acid; <(S)-2'-hydroxymethylpyrrolidinyl-N'-carboxy>-(S)-proline In dichloromethane at -20℃; for 0.333333h; Michael addition;
Stage #2: butyraldehyde In dichloromethane at -20℃; for 60h; Michael addition; optical yield given as %ee; enantioselective reaction;
96%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

isovaleraldehyde
590-86-3

isovaleraldehyde

A

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-isopropyl-4-nitrobutanal

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-isopropyl-4-nitrobutanal

B

C14H17NO5

C14H17NO5

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With 4-methyl-morpholine; C25H31F6N5O2S*C2HF3O2; benzoic acid In dichloromethane at -10℃; for 0.166667h; Michael Addition; Inert atmosphere;
Stage #2: isovaleraldehyde In dichloromethane at -10 - 20℃; Inert atmosphere; enantioselective reaction;
A 96%
B n/a
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

4-Methoxycarbonyl-buten-(3)-yl-(1)-malonsaeurediaethylester
17171-26-5

4-Methoxycarbonyl-buten-(3)-yl-(1)-malonsaeurediaethylester

A

diethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-(2-methoxy-2-oxoethyl)-3-nitrocyclohexane-1,1-dicarboxylate

diethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-(2-methoxy-2-oxoethyl)-3-nitrocyclohexane-1,1-dicarboxylate

B

(2R,3R,4S)-diethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-(2-methoxy-2-oxoethyl)-3-nitrocyclohexane-1,1-dicarboxylate
1408234-32-1

(2R,3R,4S)-diethyl 2-(benzo[d][1,3]dioxol-5-yl)-4-(2-methoxy-2-oxoethyl)-3-nitrocyclohexane-1,1-dicarboxylate

Conditions
ConditionsYield
With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methyl)thiourea In toluene at 20℃; for 360h; Overall yield = 95 %; Overall yield = 88.4 mg; stereoselective reaction;A n/a
B 95%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

methyl 1-acetyl-3-oxoindoline-2-carboxylate
143466-17-5

methyl 1-acetyl-3-oxoindoline-2-carboxylate

(S)-methyl 1-acetyl-2-((S)-1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-3-oxoindoline-2-carboxylate
1415352-26-9

(S)-methyl 1-acetyl-2-((S)-1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-3-oxoindoline-2-carboxylate

Conditions
ConditionsYield
With C30H29F6N3OS In dichloromethane at 0℃; for 24h; Reagent/catalyst; Solvent; Time; Michael Addition; enantioselective reaction;95%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

dimethyl (prop-2-yn-1-yl)malonate
95124-07-5

dimethyl (prop-2-yn-1-yl)malonate

dimethyl 2-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-2-(prop-2-yn-1-yl)malonate

dimethyl 2-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-2-(prop-2-yn-1-yl)malonate

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -78℃; for 4h; Inert atmosphere;95%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

C8H12O3

C8H12O3

C17H19NO7

C17H19NO7

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With C34H34FeN4O3 In dichloromethane for 0.0833333h; Michael Addition; Inert atmosphere;
Stage #2: C8H12O3 In dichloromethane at 20℃; for 4h; Michael Addition; Inert atmosphere;
94%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

Benzimidazol-2-thiol
134469-07-1

Benzimidazol-2-thiol

3-(benzo[d][1,3]dioxol-5-yl)benzo[4,5]imidazo[2,1-b]thiazole

3-(benzo[d][1,3]dioxol-5-yl)benzo[4,5]imidazo[2,1-b]thiazole

Conditions
ConditionsYield
With copper(II) acetate monohydrate In N,N-dimethyl-formamide at 80℃; for 8h;94%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

4-(benzo[d][1,3]dioxol-5-yl)-1H-1,2,3-triazole
369363-79-1

4-(benzo[d][1,3]dioxol-5-yl)-1H-1,2,3-triazole

Conditions
ConditionsYield
With sodium azide In water Heating; Green chemistry; regioselective reaction;94%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

2-ethoxycarbonyl-1-cyclopentanone
611-10-9

2-ethoxycarbonyl-1-cyclopentanone

ethyl (S)-1-((S)-1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-2-oxocyclopentane-1-carboxylate

ethyl (S)-1-((S)-1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-2-oxocyclopentane-1-carboxylate

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With C50H43CuF3N4O5S In tetrahydrofuran at -20℃; for 0.0833333h; Inert atmosphere;
Stage #2: 2-ethoxycarbonyl-1-cyclopentanone In tetrahydrofuran at -20℃; for 72h; Inert atmosphere; stereoselective reaction;
94%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-benzyl-4-nitrobutanal

(2S,3R)-3-(benzo[d][1,3]dioxol-5-yl)-2-benzyl-4-nitrobutanal

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With 4-methyl-morpholine; C25H31F6N5O2S*C2HF3O2; benzoic acid In dichloromethane at -10℃; for 0.166667h; Michael Addition; Inert atmosphere;
Stage #2: 3-phenyl-propionaldehyde In dichloromethane at -10 - 20℃; Inert atmosphere; enantioselective reaction;
94%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

acetone
67-64-1

acetone

(S)-4-(benzo[d][1,3]dioxol-5-yl)-5-nitropentan-2-one
1093846-34-4

(S)-4-(benzo[d][1,3]dioxol-5-yl)-5-nitropentan-2-one

Conditions
ConditionsYield
With (1R,2R)-(-)-N-diphenylthiophosphorylcyclohexane-1,2-diamine; phenol In toluene at 0℃; for 108h; Michael addition; optical yield given as %ee; enantioselective reaction;93%
With N-((1R,2R)-2-amino-1,2-diphenylethyl)-P,P-diphenylphosphinothioic amide In toluene at 20℃; for 36h; asymmetric Michael addition; optical yield given as %ee; enantioselective reaction;90%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

5-(1,2-dicyanoethyl)-1,3-benzodioxole

5-(1,2-dicyanoethyl)-1,3-benzodioxole

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran; acetonitrile at 20℃; for 2h; Michael Addition; Inert atmosphere;93%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

1-methyl-5-nitro-1H-indole-2,3-dione
3484-32-0

1-methyl-5-nitro-1H-indole-2,3-dione

L-proline
147-85-3

L-proline

1-methyl-1',5-dinitro-2'-(3,4-methylenedioxyphenyl)-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2-one

1-methyl-1',5-dinitro-2'-(3,4-methylenedioxyphenyl)-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2-one

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole; 1-methyl-5-nitro-1H-indole-2,3-dione With 1,2-propylene cyclic carbonate In water at 90℃; for 0.25h;
Stage #2: L-proline With carbon dioxide In water at 90℃; for 1h; regioselective reaction;
92%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

acetylacetone
123-54-6

acetylacetone

C14H15NO6
1639342-48-5

C14H15NO6

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole With C34H34FeN4O3 In dichloromethane for 0.0833333h; Michael Addition; Inert atmosphere;
Stage #2: acetylacetone In dichloromethane at 20℃; for 5h; Michael Addition; Inert atmosphere;
91%
With 3-((3,5-bis(trifluoromethyl)benzyl)amino)-4-(((1S)-(6-methoxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione In dichloromethane at 20℃; for 24h; Michael Addition;
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

1-methyl-5-nitro-1H-indole-2,3-dione
3484-32-0

1-methyl-5-nitro-1H-indole-2,3-dione

L-proline
147-85-3

L-proline

5-chloro-1-methyl-1'-nitro-2'-(3,4-methylenedioxyphenyl)-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2-one

5-chloro-1-methyl-1'-nitro-2'-(3,4-methylenedioxyphenyl)-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizin]-2-one

Conditions
ConditionsYield
Stage #1: 5-(2-nitrovinyl)benzo[1,3]dioxole; 1-methyl-5-nitro-1H-indole-2,3-dione With 1,2-propylene cyclic carbonate In water at 90℃; for 0.25h;
Stage #2: L-proline With carbon dioxide In water at 90℃; for 1h; regioselective reaction;
91%
indole
120-72-9

indole

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1H-indole

3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1H-indole

Conditions
ConditionsYield
With iron(III) chloride hexahydrate In neat (no solvent) at 80℃; for 24h; Michael Addition; Green chemistry;90%
With zinc(II) acetate dihydrate In cyclohexane at 80℃; for 18h; Michael addition;83%
With silica gel at 20℃; for 2.5h; Michael addition; Neat (no solvent);82%
With water at 100℃; for 10h; Un-catalyzed Friedel-Crafts alkylation;64%
at 100℃; for 9h; Friedel Crafts alkylation; Neat (no solvent);63%
indole
120-72-9

indole

5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

(S)-3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1H-indole
1092516-33-0

(S)-3-(1-(benzo[d][1,3]dioxol-5-yl)-2-nitroethyl)-1H-indole

Conditions
ConditionsYield
With 2‐(((1S,2R)‐2‐hydroxy‐2,3‐dihydro‐1H‐inden‐1‐yl)carbamothioyl)quinolin‐1‐ium tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate In chloroform at 0℃; for 19h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;90%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

C14H15NO8
1542155-34-9

C14H15NO8

Conditions
ConditionsYield
With Cl(1-)*C32H12BF24(1-)*C6H5N2O2(1-)*C42H48CoN6(3+) In [(2)H6]acetone at 0℃; for 24h;90%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

5-(2-nitroethyl)benzo[1,3]dioxole
21473-47-2

5-(2-nitroethyl)benzo[1,3]dioxole

Conditions
ConditionsYield
With zinc(II) tetrahydroborate In 1,2-dimethoxyethane at 0 - 5℃; for 6h;88%
With zinc(II) tetrahydroborate In 1,2-dimethoxyethane at 0℃; for 6h;88%
With magnesium(II) perchlorate; "grafted NADH model" reagent In acetonitrile; benzene at 80℃; for 120h;72%
5-(2-nitrovinyl)benzo[1,3]dioxole
1485-00-3

5-(2-nitrovinyl)benzo[1,3]dioxole

(E)-4-methyl-N-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide
1195694-52-0

(E)-4-methyl-N-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide

2-((2S,3R,4S)-2-(benzo[d][1,3]dioxol-5-yl)-1,2,3,4-tetrahydro-3-nitro-1-tosylquinolin-4-yl)-1-phenylethanone
1619985-25-9

2-((2S,3R,4S)-2-(benzo[d][1,3]dioxol-5-yl)-1,2,3,4-tetrahydro-3-nitro-1-tosylquinolin-4-yl)-1-phenylethanone

Conditions
ConditionsYield
Stage #1: 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide With 1-(3,5-Bis-trifluoromethyl-phenyl)-3-[(R)-quinolin-4-yl-((2R,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl]-thiourea In toluene at 0℃; for 0.0833333h;
Stage #2: 5-(2-nitrovinyl)benzo[1,3]dioxole In toluene at 0℃; for 36h; Michael Addition; stereoselective reaction;
88%
Stage #1: 4-methyl-N-(2-((E)-3-oxo-3-phenylprop-1-en-1-yl)phenyl)benzenesulfonamide With C28H26F6N4S In toluene at 0℃; for 0.0833333h;
Stage #2: 5-(2-nitrovinyl)benzo[1,3]dioxole In toluene at 0℃; for 36h; stereoselective reaction;
88%

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