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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethyl 5-amino-1-benzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high purity Appearance:Yellow powder Storage:cold storage Package:meet the demand of customer Application:Biomedical reagents Transportation:by sea or by air Port:Shanghai, Qingdao

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Cas:174775-48-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Shanghai SE Pharm Co., Ltd

1. made in GMP plant, commerially 2. Normal Stock: 500kgs 3. Audit accepted. Related documents are available to offer and audited by many clients, such as Lupin, MSN, Dr reddy etc 4. Chromatographic Purity (HPLC): not less than 99.0% 5. Chi

Ethyl 5-amino-1-benzofuran-2-carboxylate(174775-48-5)

Cas:174775-48-5

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-Amino-2-benzofurancarboxylic acid ethyl ester

Cas:174775-48-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc. We are specialized in chemical synthesis, process development of pharmaceu

Ethyl 5-Aminobenzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Cas:174775-48-5

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 174775-48-5 with fast shipping

Cas:174775-48-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Benzofurancarboxylicacid, 5-amino-, ethyl ester 174775-48-5

Cas:174775-48-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE CAS:174775-48-5

Cas:174775-48-5

Min.Order:1 Kilogram

FOB Price: $59.0 / 64.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE CAS:174775-48-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qu

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE CAS:174775-48-5

Cas:174775-48-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Benzofurancarboxylicacid, 5-amino-, ethyl ester

Cas:174775-48-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-Benzofurancarboxylicacid, 5-amino-, ethyl ester

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Ethyl 5-Aminobenzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Cas:174775-48-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Ethyl 5-Amino-1- Benzofuran-2-Carboxylate

Cas:174775-48-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Brown Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:25kg/drum;200kg/drum as per your request Application:Ethyl 5-amino-1-benzofuran-2-carbo

2-Benzofurancarboxylicacid, 5-amino-, ethyl ester

Cas:174775-48-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Basic information Product Name: ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE Synonyms: ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE;2-Benzofurancarboxylicacid,5-amino-,ethylester(9CI);Ethyl 5-aminobenzo[b]furan-2-carboxyla

Tianfu Chem ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Cas:174775-48-5

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Cas:174775-48-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Ethyl 5-Aminobenzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

5-Amino-2-(ethoxycarbonyl)-1-benzofuran

Cas:174775-48-5

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl 5-amino-1-benzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Ethyl 5-amino-1-benzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Ethyl-5-amino-1-benzofuran-2-carboxylate cas no. 174775-48-5 98%

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Ethyl 5-aMino-1-benzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Ethyl 5-amino-1-benzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:as intermediates Transportation:by courier, air or sea Port:At any port from China

Ethyl 5-aminobenzofuran-2-carboxylate 174775-48-5 with best price

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

Ethyl 5-Aminobenzofuran-2-Carboxylate

Cas:174775-48-5

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

ETHYL 5-AMINOBENZOFURAN-2-CARBOXYLATE

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Koning Pharmchem Co., Ltd.

KONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li

Ethyl 5-amino-1-benzofuran-2-carboxylate

Cas:174775-48-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

ethyl 5-nitrobenzo[d]furan-2-carboxylate
69604-00-8

ethyl 5-nitrobenzo[d]furan-2-carboxylate

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 33 - 38℃; under 3000.3 - 3750.38 Torr;100%
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 33 - 38℃; under 3000.3 - 3750.38 Torr;100%
With hydrogen In ethyl acetate; N,N-dimethyl-formamide under 760.051 Torr; for 4h; Heating; Flow reactor; Green chemistry;99%
salicylaldehyde
90-02-8

salicylaldehyde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
With hydrogen In ethanol at 20℃; for 6h;91%
Multi-step reaction with 3 steps
1: nitric acid / acetic acid
2: sodium carbonate / 1-methyl-pyrrolidin-2-one
3: hydrogen
View Scheme
5-Nitrosalicylaldehyde
97-51-8

5-Nitrosalicylaldehyde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 85 - 90 °C / Inert atmosphere
2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 33 - 38 °C / 3000.3 - 3750.38 Torr
View Scheme
Multi-step reaction with 2 steps
1: sodium carbonate / 1-methyl-pyrrolidin-2-one
2: hydrogen
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 30 - 90 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 33 - 38 °C / 3000.3 - 3750.38 Torr
View Scheme
6-nitrocoumarin
2725-81-7

6-nitrocoumarin

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: bromine / chloroform / 0 - 20 °C
2.1: 1 h / Reflux
2.2: 8 h / Reflux
3.1: hydrogen; 5%-palladium/activated carbon / ethanol / 3 h / 10 - 30 °C / 2250.23 - 3750.38 Torr
View Scheme
Multi-step reaction with 4 steps
1: bromine / chloroform / 0 - 20 °C
2: 1 h / Reflux
3: triethylamine / ethanol / 8 h / Reflux
4: hydrogen; 5%-palladium/activated carbon / ethanol / 3 h / 10 - 30 °C / 2250.23 - 3750.38 Torr
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / ethanol; water / 4 h / Reflux
2: copper dichloride; caesium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C
3: sulfuric acid / 2 h / Reflux
4: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 30 °C / 3000.3 - 3750.38 Torr
View Scheme
3,4-dibromo-6-nitrochroman-2-one

3,4-dibromo-6-nitrochroman-2-one

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 1 h / Reflux
1.2: 8 h / Reflux
2.1: hydrogen; 5%-palladium/activated carbon / ethanol / 3 h / 10 - 30 °C / 2250.23 - 3750.38 Torr
View Scheme
Multi-step reaction with 3 steps
1: 1 h / Reflux
2: triethylamine / ethanol / 8 h / Reflux
3: hydrogen; 5%-palladium/activated carbon / ethanol / 3 h / 10 - 30 °C / 2250.23 - 3750.38 Torr
View Scheme
3-(2-hydroxy-5-nitrophenyl)acrylic acid
50396-49-1

3-(2-hydroxy-5-nitrophenyl)acrylic acid

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: copper dichloride; caesium carbonate / N,N-dimethyl-formamide / 5 h / 100 °C
2: sulfuric acid / 2 h / Reflux
3: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 30 °C / 3000.3 - 3750.38 Torr
View Scheme
5-nitrobenzofuran-2-carboxylic acid
10242-12-3

5-nitrobenzofuran-2-carboxylic acid

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / 2 h / Reflux
2: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 30 °C / 3000.3 - 3750.38 Torr
View Scheme
C17H27NO3Si2

C17H27NO3Si2

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

Conditions
ConditionsYield
With hydrogenchloride In chloroform; water for 1h;63.3 mg
(2S,3S)-1-(tert-butoxycarbonyl)-3-(2-methylphenyl)pyrrolidine-2-carboxylic acid

(2S,3S)-1-(tert-butoxycarbonyl)-3-(2-methylphenyl)pyrrolidine-2-carboxylic acid

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

tert-butyl (2S,3S)-2-{[2-(ethoxycarbonyl)-1-benzofuran-5-yl]carbamoyl}-3-(2-methylphenyl)pyrrolidine-1-carboxylate

tert-butyl (2S,3S)-2-{[2-(ethoxycarbonyl)-1-benzofuran-5-yl]carbamoyl}-3-(2-methylphenyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
Stage #1: (2S,3S)-1-(tert-butoxycarbonyl)-3-(2-methylphenyl)pyrrolidine-2-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: ethyl 5-amino-1-benzofuran-2-carboxylate In N,N-dimethyl-formamide at 20 - 70℃; for 5h;
99%
ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

C11H9(2)H2NO3

C11H9(2)H2NO3

Conditions
ConditionsYield
With C40H51ClIrN3; potassium carbonate; deuterium In dichloromethane at 50℃; under 760.051 Torr; for 12h; Sealed tube; Inert atmosphere; regioselective reaction;96%
4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid
77716-11-1

4-[(tert-butoxycarbonyl)amino]-1-methyl-1H-pyrrole-2-carboxylic acid

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

C22H25N3O6

C22H25N3O6

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide90%
4-hydroxy[1]benzopyran-2-one
1076-38-6

4-hydroxy[1]benzopyran-2-one

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 13-(4-bromophenyl)-12-oxo-6,13-dihydro-12H-chromeno[4,3-b]furo[3,2-f]quinoline-2-carboxylate

ethyl 13-(4-bromophenyl)-12-oxo-6,13-dihydro-12H-chromeno[4,3-b]furo[3,2-f]quinoline-2-carboxylate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 6h;90%
ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

C10H8N2O3
1418125-60-6

C10H8N2O3

Conditions
ConditionsYield
With sodium methylate at 20℃; for 6h;86%
1,3-cyclopentadione
3859-41-4

1,3-cyclopentadione

2,6-dichlorobenzaldehyde
83-38-5

2,6-dichlorobenzaldehyde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 10-(2,6-dichlorophenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f]quinoline-2-carboxylate

ethyl 10-(2,6-dichlorophenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f]quinoline-2-carboxylate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 8h;86%
4-hydroxy[1]benzopyran-2-one
1076-38-6

4-hydroxy[1]benzopyran-2-one

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 13-(4-chlorophenyl)-12-oxo-6,13-dihydro-12H-chromeno[4,3-b]furo[3,2-f]quinoline-2-carboxylate

ethyl 13-(4-chlorophenyl)-12-oxo-6,13-dihydro-12H-chromeno[4,3-b]furo[3,2-f]quinoline-2-carboxylate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 6h;85%
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

5-(piperazin-1-yl)benzofuran-2-carboxylic acid ethyl ester

5-(piperazin-1-yl)benzofuran-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
With sodium carbonate In isopropyl alcohol at 50 - 60℃; for 4h;85%
With sodium carbonate In ethanol at 50 - 60℃; for 4h;83.1%
1,3-cyclopentadione
3859-41-4

1,3-cyclopentadione

3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 10-(3,4-dimethoxyphenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f]quinoline-2-carboxylate

ethyl 10-(3,4-dimethoxyphenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f]quinoline-2-carboxylate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 10h;84%
tetrafluoroboric acid

tetrafluoroboric acid

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

2‐(ethoxycarbonyl)‐1‐benzofuran‐5‐diazonium tetrafluoroborate
1618107-87-1

2‐(ethoxycarbonyl)‐1‐benzofuran‐5‐diazonium tetrafluoroborate

Conditions
ConditionsYield
Stage #1: tetrafluoroboric acid; ethyl 5-amino-1-benzofuran-2-carboxylate In ethanol; water at 20℃; for 0.0333333h;
Stage #2: With tert.-butylnitrite In ethanol; water at 0 - 20℃; for 1.25h;
83%
ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

C17H23NO5

C17H23NO5

Conditions
ConditionsYield
With 3,4,5-trifluorophenylboronic acid In toluene at 60℃; for 24h; regioselective reaction;83%
1,3-cyclopentadione
3859-41-4

1,3-cyclopentadione

2,4-dichlorobenzaldeyhde
874-42-0

2,4-dichlorobenzaldeyhde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 10-(2,4-dichlorophenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f]quinoline-2-carboxylate

ethyl 10-(2,4-dichlorophenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f]quinoline-2-carboxylate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 8h;82%
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate dihydrochloride

ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate dihydrochloride

Conditions
ConditionsYield
Stage #1: bis-(2-chloroethyl)amine hydrochloride; ethyl 5-amino-1-benzofuran-2-carboxylate With tetrabutylammomium bromide; potassium carbonate In o-xylene at 135 - 140℃; for 32h;
Stage #2: With hydrogenchloride In dichloromethane; water
81.3%
Stage #1: bis-(2-chloroethyl)amine hydrochloride; ethyl 5-amino-1-benzofuran-2-carboxylate With tetrabutylammomium bromide; potassium carbonate In o-xylene at 20 - 140℃; for 32h;
Stage #2: With hydrogenchloride In dichloromethane; water
81.3%
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate hydrobromide
1469427-45-9

ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate hydrobromide

Conditions
ConditionsYield
Stage #1: bis-(2-chloroethyl)amine hydrochloride; ethyl 5-amino-1-benzofuran-2-carboxylate With tetrabutylammomium bromide; potassium carbonate In o-xylene at 135 - 140℃; for 32h;
Stage #2: With hydrogen bromide In dichloromethane; water
81.3%
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate hydrobromide

ethyl 5-(1-piperazinyl)benzofuran-2-carboxylate hydrobromide

Conditions
ConditionsYield
Stage #1: bis-(2-chloroethyl)amine hydrochloride; ethyl 5-amino-1-benzofuran-2-carboxylate With tetrabutylammomium bromide; potassium carbonate In o-xylene at 20 - 140℃; for 32h;
Stage #2: With hydrogen bromide In dichloromethane; water
81.3%
1,3-cyclopentadione
3859-41-4

1,3-cyclopentadione

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 10-(4-chlorophenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f] quinoline-2-carboxylate

ethyl 10-(4-chlorophenyl)-9-oxo-7,8,9,10-tetrahydro-6H-cyclopenta[b]furo[3,2-f] quinoline-2-carboxylate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 8h;79%
Phenyl-vinyl-glykolsaeure
1626-05-7

Phenyl-vinyl-glykolsaeure

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

C21H17NO4

C21H17NO4

Conditions
ConditionsYield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene In acetonitrile at 25℃; for 12h;73%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-(methylsulfonamido)benzofuran-2-carboxylate

ethyl 5-(methylsulfonamido)benzofuran-2-carboxylate

Conditions
ConditionsYield
With pyridine at 0 - 20℃; for 3h;72%
tetrahydroxydiboron
13675-18-8

tetrahydroxydiboron

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

2-(ethoxycarbonyl)benzofuran-5-ylboronic acid
1618107-90-6

2-(ethoxycarbonyl)benzofuran-5-ylboronic acid

Conditions
ConditionsYield
Stage #1: ethyl 5-amino-1-benzofuran-2-carboxylate With hydrogenchloride; sodium nitrite In water at 0℃; for 0.25h;
Stage #2: tetrahydroxydiboron With sodium acetate In water at 20℃; for 0.333333h;
70.5%
acetic acid
64-19-7

acetic acid

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-acetamidobenzofuran-2-carboxylate

ethyl 5-acetamidobenzofuran-2-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 15h;66%
Langlois reagent
2926-29-6

Langlois reagent

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-isothiocyanatobenzofuran-2-carboxylate

ethyl 5-isothiocyanatobenzofuran-2-carboxylate

Conditions
ConditionsYield
With copper(l) iodide; phosphonic acid diethyl ester In toluene at 110℃; for 16h; Schlenk technique; Green chemistry;61%
triphenyl phosphite
101-02-0

triphenyl phosphite

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-(diphenoxyphosphoryl)benzofuran-2-carboxylate

ethyl 5-(diphenoxyphosphoryl)benzofuran-2-carboxylate

Conditions
ConditionsYield
With tert.-butylnitrite; toluene-4-sulfonic acid In acetonitrile at 0 - 20℃; for 8h;59%
Stage #1: ethyl 5-amino-1-benzofuran-2-carboxylate With tert.-butylnitrite; toluene-4-sulfonic acid In acetonitrile at 0℃; for 8h; Sandmeyer Reaction;
Stage #2: triphenyl phosphite In acetonitrile at 0.25℃; for 8h; Sandmeyer Reaction;
58%
carbon monoxide
201230-82-2

carbon monoxide

cyclobutanone O-(4-(trifluoromethyl)benzoyl) oxime

cyclobutanone O-(4-(trifluoromethyl)benzoyl) oxime

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

C16H16N2O4

C16H16N2O4

Conditions
ConditionsYield
With copper(l) chloride; 4,4',4-tri-tert-butyl-2,2':6',2-terpyridine at 20℃; Irradiation; chemoselective reaction;57%
ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

trifluoromethylsilver

trifluoromethylsilver

ethyl 5-(trifluoromethyl)benzofuran-2-carboxylate
575469-30-6

ethyl 5-(trifluoromethyl)benzofuran-2-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 5-amino-1-benzofuran-2-carboxylate With hydrogenchloride In water at 0℃; for 0.0833333h; Inert atmosphere; Schlenk technique;
Stage #2: With tert.-butylnitrite at 0℃; for 0.25h; Inert atmosphere; Schlenk technique;
Stage #3: trifluoromethylsilver at -78 - 20℃; for 4h; Inert atmosphere; Schlenk technique;
55%
Stage #1: ethyl 5-amino-1-benzofuran-2-carboxylate With hydrogenchloride In water at 0℃; for 0.0833333h; Sandmeyer Reaction; Schlenk technique;
Stage #2: With tert.-butylnitrite In water at -196 - 20℃; Sandmeyer Reaction; Schlenk technique; Inert atmosphere;
Stage #3: trifluoromethylsilver In water at -78 - 20℃; for 5h; Sandmeyer Reaction; Schlenk technique; Inert atmosphere;
55%
Se-(difluoromethyl) 4-methylbenzenesulfonoselenoate

Se-(difluoromethyl) 4-methylbenzenesulfonoselenoate

ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-((difluoromethyl)selanyl)benzofuran-2-carboxylate

ethyl 5-((difluoromethyl)selanyl)benzofuran-2-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 5-amino-1-benzofuran-2-carboxylate With rose bengal; toluene-4-sulfonic acid In dimethyl sulfoxide for 0.0833333h; Sealed tube;
Stage #2: Se-(difluoromethyl) 4-methylbenzenesulfonoselenoate With tert.-butylnitrite In dimethyl sulfoxide at 20℃; for 10h; Irradiation;
51%
ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

ethyl 5-fluoro-1H-benzofuran-2-carboxylate
93849-31-1

ethyl 5-fluoro-1H-benzofuran-2-carboxylate

Conditions
ConditionsYield
With hydrogenchloride; tetrafluoroboric acid; sodium nitrite In water at 0℃; for 1h;45%
ethyl 5-amino-1-benzofuran-2-carboxylate
174775-48-5

ethyl 5-amino-1-benzofuran-2-carboxylate

C11H10(2)HNO3

C11H10(2)HNO3

Conditions
ConditionsYield
With chloro(cycloocta-1,5-diene)(1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene)iridium; deuterium In dichloromethane at 50℃; under 760.051 Torr; for 12h; Reagent/catalyst; Sealed tube; Inert atmosphere; regioselective reaction;45%
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