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inquiryProduct name Diethyl 2-(1-cyano-3-methylbutyl)malonate Synonyms 2-Ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester CAS No. 186038-82-4 EINECS No.
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inquirywe are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Orga
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryDIETHYL (1-CYANO-3-METHYLBUTYL)MALONATE CAS:186038-82-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high
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inquiry1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:186038-82-4
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inquiryProduct name: Diethyl-2-(1-Cyano-3-Methylbutyl)malonate CAS No.:186038-82-4 Molecule Formula:C13H21NO4 Molecule Weight:255.31 Purity: 98.0% Package: 25kg/drum Description:White to off-white powder Manufacture Standards:Enterprise Stan
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inquiryOur Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an
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inquiryProduct Name: DIETHYL (1-CYANO-3-METHYLBUTYL)MALONATE Synonyms: DIETHYL (1-CYANO-3-METHYLBUTYL)MALONATE;1-cyano-3-Methylbutyl-Propanedioic acid diethyl ester;2-Ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester;Ethyl 2-Carboxyethyl-3-Cyan
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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Cas:186038-82-4
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inquiryR & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates
Cas:186038-82-4
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inquiryJ&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
Cas:186038-82-4
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inquiry1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.
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inquirybest seller Application:API
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inquiryAnsciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali
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inquiry186038-82-4 DIETHYL (1-CYANO-3-METHYLBUTYL)MALONATE Application:186038-82-4 DIETHYL (1-CYANO-3-METHYLBUTYL)MALONATE
Cas:186038-82-4
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inquiry(R)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: (R)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With ethanol; sodium ethanolate at 80℃; for 20h; Stage #2: With acetic acid In ethanol at 20℃; | 100% |
With sodium ethanolate In toluene | |
With sodium ethanolate In ethanol; toluene at 80℃; |
diethyl 2-(3-methylbutylidene)malonate
sodium cyanide
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
In ethanol at 25 - 35℃; for 2 - 3h; | 97.97% |
diethyl 2-(3-methylbutylidene)malonate
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With acetic acid In ethanol; water at 30℃; for 0.5h; | 87.6% |
In ethanol at 25 - 42℃; Product distribution / selectivity; | |
With water; N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-D-lysine In dichloromethane at 20℃; Product distribution / selectivity; |
trimethylsilyl cyanide
diethyl 2-(3-methylbutylidene)malonate
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In ethanol at 20℃; for 12h; |
sodium cyanide
diethyl 2-(3-methylbutylidene)malonate
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With water; N-benzylcinchonidinum chloride In toluene at 20℃; |
hydrogen cyanide
diethyl 2-(3-methylbutylidene)malonate
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
In ethanol at 20℃; for 4h; Michael Addition; |
isovaleraldehyde
diethyl malonate
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetic acid; di-n-propylamine / cyclohexane / 8 h / 75 °C 2: ethanol / 4 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: tetrabutylammomium bromide; di-n-propylamine; acetic acid / hexane / 4 h / Reflux 1.2: 20 °C 2.1: acetic acid / ethanol; water / 0.5 h / 30 °C View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
(R,S)-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With water; sodium chloride In dimethyl sulfoxide at 25 - 145℃; for 10 - 12h; | 94% |
With sodium chloride In water; dimethyl sulfoxide at 140℃; for 9h; | 87.1% |
With lithium chloride In water; dimethyl sulfoxide at 140℃; for 1h; Temperature; |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
B
(R)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With water; Lipolase at 30℃; for 24h; pH=7.2; Potassium phosphate buffer; Stage #2: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; | |
Stage #1: 2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With water; Pseudomonas sp. lipase at 30℃; for 24h; pH=7.2; Potassium phosphate buffer; Stage #2: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; | |
Stage #1: 2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With water; pig liver esterase at 30℃; for 24h; pH=7.2; Potassium phosphate buffer; Stage #2: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
B
(R)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With potassium hydroxide; sodium hydroxide; water; Lipolase for 24h; pH=8.0; potassium phosphate buffer; | |
With potassium hydroxide; water; Lipolase for 20 - 25h; pH=7.0; calcium acetate buffer; |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
B
(R)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With sodium hydroxide; water; calcium acetate; Lipolase for 20 - 25h; pH=7.0; | |
With lipase Enzymatic reaction; |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
A
(3R)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid
B
(S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With water; streptomyces griseus protease at 30℃; for 24h; pH=7.2; Potassium phosphate buffer; Stage #2: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; | |
Stage #1: 2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With water; streptomyces sp. protease at 30℃; for 24h; pH=7.2; Potassium phosphate buffer; Stage #2: With hydrogenchloride In water; ethyl acetate Product distribution / selectivity; |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With ethanol; potassium hydroxide at 75 - 80℃; Stage #2: With water; potassium hydroxide In ethanol at 20℃; for 1h; Stage #3: Raney nickel |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
(S)-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester With calcium acetate hemihydrate; sodium hydroxide In water for 24h; Stage #2: at 85℃; for 3h; Inert atmosphere; | n/a |
Multi-step reaction with 3 steps 1: calcium acetate hemihydrate; sodium hydroxide / water / 24 h 2: Raney nickel water solution / water / 20 h / 2585.81 Torr 3: hydrogenchloride; acetic acid / water / 80 - 110 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide 2: Raney nickel water solution / water / 20 h / 2585.81 Torr 3: hydrogenchloride; acetic acid / water / 80 - 110 °C View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With sodium hydroxide |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
A
(R)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
With calcium acetate hemihydrate; sodium hydroxide In water for 24h; |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: calcium acetate hemihydrate; sodium hydroxide / water / 24 h 2: isopropyl alcohol; tert-butyl methyl ether View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide 2: isopropyl alcohol; tert-butyl methyl ether View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: calcium acetate hemihydrate; sodium hydroxide / water / 24 h 2: Raney nickel water solution / water / 20 h / 2585.81 Torr View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydroxide 2: Raney nickel water solution / water / 20 h / 2585.81 Torr View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
pregabilin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: calcium acetate hemihydrate; sodium hydroxide / water / 24 h 1.2: 3 h / 85 °C / Inert atmosphere 2.1: potassium hydroxide / water; Isopropyl acetate / 1 h / 20 °C 2.2: 5 h View Scheme | |
Multi-step reaction with 4 steps 1.1: calcium acetate hemihydrate; sodium hydroxide / water / 24 h 2.1: Raney nickel water solution / water / 20 h / 2585.81 Torr 3.1: hydrogenchloride; acetic acid / water / 80 - 110 °C 4.1: potassium hydroxide / water; Isopropyl acetate / 1 h / 20 °C 4.2: 5 h View Scheme | |
Multi-step reaction with 4 steps 1.1: sodium hydroxide 2.1: Raney nickel water solution / water / 20 h / 2585.81 Torr 3.1: hydrogenchloride; acetic acid / water / 80 - 110 °C 4.1: potassium hydroxide / water; Isopropyl acetate / 1 h / 20 °C 4.2: 5 h View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
A
(R)-2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
B
(S)-3-cyano-2-ethoxycarbonyl-5-methyl-hexanoic acid ethyl ester
Conditions | Yield |
---|---|
In aq. phosphate buffer pH=7.2; Resolution of racemate; |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
racemic 3-cyano-5-methylhexanoic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: lithium chloride / dimethyl sulfoxide; water / 1 h / 140 °C 2: sodium hydroxide; water / 0.5 h / 20 °C / pH 8 View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
(R,S)-3-iso-butyl-4-aminobutyric acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium chloride / dimethyl sulfoxide; water / 1 h / 140 °C 2: sodium hydroxide; water / 0.5 h / 20 °C / pH 8 3: hydrogen / 18 h / 80 °C / 6750.68 Torr View Scheme | |
Multi-step reaction with 3 steps 1: sodium chloride / water; dimethyl sulfoxide / 9 h / 140 °C 2: potassium hydroxide; dihydrogen peroxide / water; dimethyl sulfoxide / 2 h / 20 °C / Cooling with ice 3: sodium hydroxide / water / 0 - 10 °C View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
A
pregabilin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: lithium chloride / dimethyl sulfoxide; water / 1 h / 140 °C 2: sodium hydroxide; water / 0.5 h / 20 °C / pH 8 3: hydrogen / 18 h / 80 °C / 6750.68 Torr 4: lipase Lipolase 100T / aq. phosphate buffer / 24 h / 30 °C / pH 7.5 View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium chloride / water; dimethyl sulfoxide / 9 h / 140 °C 2: potassium hydroxide; dihydrogen peroxide / water; dimethyl sulfoxide / 2 h / 20 °C / Cooling with ice 3: sodium hydroxide / water / 0 - 10 °C 4: (S)-Mandelic acid / isopropyl alcohol / 0.5 h / 60 °C View Scheme |
2-ethoxycarbonyl-3-cyano-5-methylhexanoic acid ethyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium chloride / water; dimethyl sulfoxide / 9 h / 140 °C 2: potassium hydroxide; dihydrogen peroxide / water; dimethyl sulfoxide / 2 h / 20 °C / Cooling with ice View Scheme |
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