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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

1-Methyl-1H-pyrazol-3-amine Manufacturer/High quality/Best price/In stock

Cas:1904-31-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-amino-1-Methylpyrazole supplier in China

Cas:1904-31-0

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-amino-1-Methylpyrazole

Cas:1904-31-0

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3-Amino-1-methylpyrazole

Cas:1904-31-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

1-Methyl-1H-pyrazol-3-amine 1904-31-0

Cas:1904-31-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 1904-31-0 with fast shipping

Cas:1904-31-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-Methyl-1H-pyrazol-3-amine 1904-31-0

Cas:1904-31-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 1-Methyl-1H-pyrazol-3-amine CAS: 1904-31-0 MF: C4H7N3 MW: 97.12 EINECS: Triazoles;Pyrazole Mol File: 1904-31-0.mol 1-Methyl-1H-pyrazol-3-amine Structure 1-Methyl-1H-pyrazol-3-amine Chemical Properties Boiling point

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-amino-1-Methylpyrazole

Cas:1904-31-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 1-Methyl-1H-pyrazol-3-aMine(1904-31-0)

Cas:1904-31-0

Min.Order:100 Gram

Negotiable

Type:Other

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Siwei Development Group Ltd.

Product name: 3-Amino-1-Methylpyrazole CAS No.: 1904-31-0 Molecule Formula:C4H7N3 Molecule Weight:97.12 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING IT

Lower Price 3-Amino-1-Methylpyrazole

Cas:1904-31-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3-Amino-1-methylpyrazole

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

3-Amino-1-methyl-pyrazole

Cas:1904-31-0

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

1-methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

1-Methyl-1H-pyrazol-3-amine cas no. 1904-31-0 98%

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

3-Amino-1-Methylpyrazole

Cas:1904-31-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. located in Lingang industrial areas, our plant covers an area of 6000 square meters.ZeErRui dedicated to the development, production and marketing of chemicals. We have earned ourselves a good reputation at home

3-amino-1-Methylpyrazole china manufacture

Cas:1904-31-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

1-Methyl-1H-pyrazol-3-yl-aMine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3-amino-1-Methylpyrazole

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Xi`an Eastling Biotech Co., Ltd.

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou

1-Methyl-1H-pyrazol-3-amine

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

3-Amino-1-methylpyrazole

Cas:1904-31-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-methyl-3-nitro-1H-pyrazole
54210-32-1

1-methyl-3-nitro-1H-pyrazole

A

1,1'-dimethyl-3-azoxypyrazole
132038-69-8

1,1'-dimethyl-3-azoxypyrazole

B

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

Conditions
ConditionsYield
With hydrazine hydrate; nickel In ethanol Heating;A 54%
B 7.1 g
4-iodo-1-methyl-3-nitro-1H-pyrazole
75092-34-1

4-iodo-1-methyl-3-nitro-1H-pyrazole

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride In water at 30℃; for 2h; Reduction;51%
N-(1-methyl-3-pyrazolyl)-acetoacetamide
91027-92-8

N-(1-methyl-3-pyrazolyl)-acetoacetamide

A

2,4-dimethyl-2H-pyrazolo<3,4-b>pyridin-6(7H)-one
73810-75-0

2,4-dimethyl-2H-pyrazolo<3,4-b>pyridin-6(7H)-one

B

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 3h; Heating;A 21%
B 15%
1-methyl-3-nitro-1H-pyrazole
54210-32-1

1-methyl-3-nitro-1H-pyrazole

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

Conditions
ConditionsYield
With hydrogenchloride; tin(ll) chloride Reduction;
With hydrogen In methanol for 3h;
pivaloyl chloride
3282-30-2

pivaloyl chloride

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

C9H15N3O
1135343-82-6

C9H15N3O

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 20℃;100%
acetyl chloride
75-36-5

acetyl chloride

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

N-(1-methyl-1H-pyrazol-3-yl)-acetamide hydrochlorid

N-(1-methyl-1H-pyrazol-3-yl)-acetamide hydrochlorid

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 2h;100%
In tetrahydrofuran at 0 - 20℃; for 2h;100%
3-(chlorosulfonyl)benzenesulfonyl fluoride
2489-52-3

3-(chlorosulfonyl)benzenesulfonyl fluoride

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

3-(N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)benzene-1-sulfonyl fluoride

3-(N-(1-methyl-1H-pyrazol-3-yl)sulfamoyl)benzene-1-sulfonyl fluoride

Conditions
ConditionsYield
With pyridine In chloroform at 20℃; for 48h; chemoselective reaction;99%
4-(chlorosulfonyl)benzenesulfonyl fluoride

4-(chlorosulfonyl)benzenesulfonyl fluoride

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

C10H10FN3O4S2

C10H10FN3O4S2

Conditions
ConditionsYield
With pyridine In chloroform at 20℃; for 48h; chemoselective reaction;99%
bromochlorobenzene
106-39-8

bromochlorobenzene

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

N-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-amine

N-(4-chlorophenyl)-1-methyl-1H-pyrazol-3-amine

Conditions
ConditionsYield
With copper(l) iodide; N-(2,6-dimethylphenyl)-6-hydroxypicolinamide; potassium carbonate In dimethyl sulfoxide at 110℃;99%
2,5-hexanedione
110-13-4

2,5-hexanedione

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
34605-66-8

3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

Conditions
ConditionsYield
toluene-4-sulfonic acid In toluene for 4h; Reflux;98%
With acetic acid In toluene at 155℃;98.1%
With toluene-4-sulfonic acid In benzene at 115℃; for 4h;94%
methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole
34605-66-8

3-(2,5-dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole

Conditions
ConditionsYield
With acetic acid In toluene at 155℃;98.1%
1-(2-bromophenyl)pyrazole

1-(2-bromophenyl)pyrazole

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

N-(2-(1H-pyrazol-1-yl)phenyl)-1-methyl-1H-pyrazol-3-amine

N-(2-(1H-pyrazol-1-yl)phenyl)-1-methyl-1H-pyrazol-3-amine

Conditions
ConditionsYield
With copper(l) iodide; N-(2,6-dimethylphenyl)-6-hydroxypicolinamide; potassium carbonate In dimethyl sulfoxide at 110℃;98%
6-bromo-2-methoxypyridine
40473-07-2

6-bromo-2-methoxypyridine

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

6-methoxy-N-(1-methyl-1H-pyrazol-3-yl)pyridin-2-amine

6-methoxy-N-(1-methyl-1H-pyrazol-3-yl)pyridin-2-amine

Conditions
ConditionsYield
With copper(l) iodide; N-(2,6-dimethylphenyl)-6-hydroxypicolinamide; potassium carbonate In dimethyl sulfoxide at 110℃;98%
4-chloro-7-isothiocyanato-7-de(acetamide)colchicine
1267993-72-5

4-chloro-7-isothiocyanato-7-de(acetamide)colchicine

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

4-chloro-N-[(1-methylpyrazole-3-yl)thiocarbamoyl]deacetyl colchicine
1267992-51-7

4-chloro-N-[(1-methylpyrazole-3-yl)thiocarbamoyl]deacetyl colchicine

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere;96%
methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

1-methyl-1H-pyrazole-3-diazonium haxafluorophosphate

1-methyl-1H-pyrazole-3-diazonium haxafluorophosphate

Conditions
ConditionsYield
With hexafluorophosphoric acid; isopentyl nitrite In methanol at -20℃; for 1h;95%
5-chloro-2-methylphenylisothiocyanate
19241-36-2

5-chloro-2-methylphenylisothiocyanate

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

1-(5-chloro-2-methyl-phenyl)-3-(1-methyl-1H-pyrazol-3-yl)-thiourea
221089-29-8

1-(5-chloro-2-methyl-phenyl)-3-(1-methyl-1H-pyrazol-3-yl)-thiourea

Conditions
ConditionsYield
95%
(E)-(3-chloro-4-methanesulfonyl-phenyl)-isobutoxyimino-acetic acid
1033780-31-2

(E)-(3-chloro-4-methanesulfonyl-phenyl)-isobutoxyimino-acetic acid

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-2-isobutoxyimino-N-(1-methyl-1H-pyrazol-3-yl)-acetamide
1033780-09-4

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-2-isobutoxyimino-N-(1-methyl-1H-pyrazol-3-yl)-acetamide

Conditions
ConditionsYield
Stage #1: (E)-(3-chloro-4-methanesulfonyl-phenyl)-isobutoxyimino-acetic acid; methyl-1 amino-3 pyrazole With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0℃; for 2h;
Stage #2: With sodium hydrogencarbonate In water
95%
2-chloro-5-fluoro-4-(3-nitrophenoxy)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine
1428775-55-6

2-chloro-5-fluoro-4-(3-nitrophenoxy)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

5-fluoro-N-(1-methyl-1H-pyrazol-3-yl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine
1428775-56-7

5-fluoro-N-(1-methyl-1H-pyrazol-3-yl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 140℃; for 0.75h; Inert atmosphere; Microwave irradiation;95%
bis(2,4,6-trichlorophenyl) 2-(3,5-dichlorophenyl)propanedioate

bis(2,4,6-trichlorophenyl) 2-(3,5-dichlorophenyl)propanedioate

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

6-(3,5-dichlorophenyl)-5-hydroxy-1-methylpyrazolo[1,5-a]pyrimidin-7-one

6-(3,5-dichlorophenyl)-5-hydroxy-1-methylpyrazolo[1,5-a]pyrimidin-7-one

Conditions
ConditionsYield
In toluene for 1h; Reflux;94%
methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

4-iodo-1-methyl-3-amino-1H-pyrazole

4-iodo-1-methyl-3-amino-1H-pyrazole

Conditions
ConditionsYield
With dihydrogen peroxide; iodine In ethanol; water at 15 - 35℃; for 6h;93.1%
methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

5-methylpyrazolodithiazolium chloride
89088-58-4

5-methylpyrazolodithiazolium chloride

Conditions
ConditionsYield
With disulfur dichloride In acetic acid 1) 0 deg C to ambient temp. 2) up to 65 deg C, 3h 3) 65 deg C, 2h;93%
2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid
1232365-39-7

2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

{1-[hydroxy-(1-methyl-1H-pyrazol-3-ylcarbamoyl)methyl]cyclobutyl}carbamic acid tert-butyl ester
1232365-56-8

{1-[hydroxy-(1-methyl-1H-pyrazol-3-ylcarbamoyl)methyl]cyclobutyl}carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid; methyl-1 amino-3 pyrazole With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: With HATU In N,N-dimethyl-formamide at 20℃; for 2h;
92%
Stage #1: 2-(1-((tert-butoxycarbonyl)amino)cyclobutyl)-2-hydroxyacetic acid; methyl-1 amino-3 pyrazole With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0℃; for 0.166667h;
Stage #2: With HATU In N,N-dimethyl-formamide at 20℃; for 2h;
92%
2-(1-(tert-butoxycarbonylamino)-3,3-difluorocyclobutyl)-2-hydroxyacetic acid
1232365-45-5

2-(1-(tert-butoxycarbonylamino)-3,3-difluorocyclobutyl)-2-hydroxyacetic acid

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

{3,3-difluoro-1-[hydroxy-(1-methyl-1H-pyrazol-3-ylcarbamoyl)methyl]cyclobutyl}carbamic acid tert-butyl ester
1311321-33-1

{3,3-difluoro-1-[hydroxy-(1-methyl-1H-pyrazol-3-ylcarbamoyl)methyl]cyclobutyl}carbamic acid tert-butyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 2h;92%
ethyl (2-chloroaceto)acetate
638-07-3

ethyl (2-chloroaceto)acetate

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

5-Chloromethyl-1-methyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
104164-03-6

5-Chloromethyl-1-methyl-1H-pyrazolo[1,5-a]pyrimidin-7-one

Conditions
ConditionsYield
With PPA at 100℃;91%
3-[(1S)-2-tert-butoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid
883907-39-9

3-[(1S)-2-tert-butoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

3-[(1S)-2-tert-butoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-5-[4-(methylsulfonyl)phenoxy]benzamide
883907-34-4

3-[(1S)-2-tert-butoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)-5-[4-(methylsulfonyl)phenoxy]benzamide

Conditions
ConditionsYield
Stage #1: 3-[(1S)-2-tert-butoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 25℃; for 2h;
Stage #2: methyl-1 amino-3 pyrazole In acetonitrile at 60℃; for 18h; Product distribution / selectivity;
91%
Stage #1: 3-[(1S)-2-tert-butoxy-1-methylethoxy]-5-[4-(methylsulfonyl)phenoxy]benzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 1.08333h;
Stage #2: methyl-1 amino-3 pyrazole In tetrahydrofuran; toluene at 60℃; for 18h; Product distribution / selectivity;
3-[4-(azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]benzoic acid
937842-58-5

3-[4-(azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]benzoic acid

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

3-[4-(Azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide
937842-59-6

3-[4-(Azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Conditions
ConditionsYield
Stage #1: 3-[4-(azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]benzoic acid With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In acetonitrile at 0 - 20℃; for 1.3h;
Stage #2: methyl-1 amino-3 pyrazole In acetonitrile at 20℃; for 0.333333h; Product distribution / selectivity;
90%
Stage #1: 3-[4-(azetidin-1-ylcarbonyl)phenoxy]-5-[(1S)-2-tert-butoxy-1-methylethoxy]benzoic acid With 1,1'-carbonyldiimidazole In acetonitrile at 25℃; for 1.08333h;
Stage #2: methyl-1 amino-3 pyrazole In acetonitrile at 50℃; Product distribution / selectivity;
89%
methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

4-bromo-1-methyl-1H-pyrazol-3-ylamine
146941-72-2

4-bromo-1-methyl-1H-pyrazol-3-ylamine

Conditions
ConditionsYield
With bromine In ethanol at 0 - 15℃; for 1h;89.4%
With sodium hydroxide; bromine In dichloromethane; water
3-bromo-4-methylbenzoic acid
7697-26-9

3-bromo-4-methylbenzoic acid

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

3 -bromo-4-methyl-N-(1-methyl-1H-pyrazol-3-yl)benzamide

3 -bromo-4-methyl-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15℃; for 12h;89.2%
ortho-bromophenylacetic acid
18698-97-0

ortho-bromophenylacetic acid

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

2-(2-bromophenyl)-N-(1-methyl-1H-pyrazol-3-yl)acetamide
1609551-50-9

2-(2-bromophenyl)-N-(1-methyl-1H-pyrazol-3-yl)acetamide

Conditions
ConditionsYield
Stage #1: ortho-bromophenylacetic acid With oxalyl dichloride In dichloromethane at 0 - 20℃; for 2h;
Stage #2: methyl-1 amino-3 pyrazole In dichloromethane at 0 - 20℃;
88%
6-chloro-4-(2-methylpyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

6-chloro-4-(2-methylpyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

6-[(1-methyl-1H-pyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

6-[(1-methyl-1H-pyrazol-3-yl)amino]-4-(2-methylpyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate In toluene at 90℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube;88%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

4-trifluoromethyl-6-hydroxy-2-methylpyrazolo<3,4-b>pyridine

4-trifluoromethyl-6-hydroxy-2-methylpyrazolo<3,4-b>pyridine

Conditions
ConditionsYield
In acetic acid for 4h; Heating;87.4%
di(tert-butyl)chlorophosphine
13716-10-4

di(tert-butyl)chlorophosphine

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

P,P-di(tert-butyl)-N-(1-methyl-1H-pyrazol-3-yl)phosphinous amide
1367863-21-5

P,P-di(tert-butyl)-N-(1-methyl-1H-pyrazol-3-yl)phosphinous amide

Conditions
ConditionsYield
With triethylamine at 125℃; for 72h; Inert atmosphere;87%
2-[(3-bromo-4-nitrophenoxy)methyl]quinoline

2-[(3-bromo-4-nitrophenoxy)methyl]quinoline

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

1-methyl-N-[2-nitro-5-(quinolin-2-ylmethoxy)phenyl]-1H-pyrazol-3-amine

1-methyl-N-[2-nitro-5-(quinolin-2-ylmethoxy)phenyl]-1H-pyrazol-3-amine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In toluene at 85℃; for 2h; Buchwald-Hartwig Coupling; Inert atmosphere;87%
tert-butyl {3-[(2-chloro-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}carbamate
1428775-59-0

tert-butyl {3-[(2-chloro-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}carbamate

methyl-1 amino-3 pyrazole
1904-31-0

methyl-1 amino-3 pyrazole

tert-butyl (3-((2-((1-methyl-1H-pyrazol-3-yl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamate

tert-butyl (3-((2-((1-methyl-1H-pyrazol-3-yl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)carbamate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 140℃; for 0.75h; Buchwald-Hartwig Coupling; Microwave irradiation;87%

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