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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantiti

High purity Ethyl 4,4,4-trifluoroacetoacetate 98% TOP1 supplier in China

Cas:372-31-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Zhejiang Haizhou Pharmaceutical Co., Ltd.

Quality Standard: Assay 98.5% min Certification: US-FDA, CEP, GMP, ISO For the production of agriculture chemicals, pharmaceutical products, and other applications. Package:250kg/drum Application:For the production of agriculture chemicals, pha

Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:50 Gram

Negotiable

Type:Manufacturers

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Ethyl 4,4,4-Trifluoroacetoacetate supplier in China

Cas:372-31-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

high purity lowest priceOverview Quick Details CAS No.: 372-31-6 Other Names: ETHYL 3-OXO-4,4,4-TRIFLU

ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:1 Metric Ton

FOB Price: $100.0

Type:Other

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Jinan Finer Chemical Co., Ltd

Product Description Product name Ethyl 4,4,4-trifluoroacetoacetate CAS 372-31-6 Assay ≥98% Appearance Colorless transparent liquid Capacity 500mt/year Min.package 100gram

Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:100 Gram

FOB Price: $10.0 / 12.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Ethyl 4,4,4-trifluoroacetoacetate 98% TOP1 supplier in China CAS NO.372-31-6

Cas:372-31-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

ISO Certification Technology: Technology innovation is our eternal pursuit,or we will be left behind.Our technology experts,all from famous universities and institutes,has rich experience and high achievements in chemical research.This makes sure

ETFAA

Cas:372-31-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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EAST CHEMSOURCES LIMITED

Ethyl 4,4,4-trifluoroacetoacetate Formula C6H7 F3 O3 Molecular Formula 184.1 CAS No. 372-31-6

Ethyl 3-oxo-4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:1 Kilogram

FOB Price: $2.0 / 3.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% ethyl 4,4,4-trifluoroacetoacetate 372-31-6 Producer

Cas:372-31-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Ethyl 4, 4, 4-Trifluoroacetoacetate

Cas:372-31-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4,4,4-Trifluoroacetoacetic acid ethyl ester

Cas:372-31-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Ethyl 4,4,4-trifluoroacetoacetate Basic information Product Name: Ethyl 4,4,4-trifluoroacetoacetate Synonyms: ETHYL 3-OXO-4,4,4-TRIFLUOROACETOACETATE;ETHYL 3-OXO,4,

TIANFU-CHEM Ethyl 4,4,4-trifluoroacetoacetate 372-31-6

Cas:372-31-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 372-31-6 with competitive price

Cas:372-31-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Ethyl-4,4,4-trifluoroacetoacetate Synonyms: ethyl 4,4,4-trifluoroacetoacetate: Ethyl 3-oxo-4,4,4-trifluoroacetoacetate; 4,4,4-Trifluoroacetoacetic acid ethyl ester; Trifluoro acetoacetic acid ethyl ester; ethyl trifluoroacetoacetate; ETFAA CA

Ethyl-4,4,4-trifluoroacetoacetate CAS:372-31-6

Cas:372-31-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 372-31-6 Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl 4,4,4-trifluoroacetoacetate 372-31-6

Cas:372-31-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: Ethyl 4,4,4-trifluoroacetoacetate CAS: 372-31-6 MF: C6H7F3O3 MW: 184.11 EINECS: 206-750-7 Ethyl 4,4,4-trifluoroacetoacetate Structure Ethyl 4,4,4-trifluoroacetoacetate Chemical Properties Melting point -39 °C Bo

372-31-6

Cas:372-31-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Product Name Ethyl 4,4,4-trifluoroacetoacetate CAS No. 372-31-6 Appearance Colorless transparent liquid Assay ≥99% Capacity 100mt/year MOQ 100G Application Used as

Ethyl 4, 4, 4-Trifluoroacetoacetate CAS No 372-31-6.

Cas:372-31-6

Min.Order:1 Gram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High quality Ethyl trifluoroacetoacetate CAS 372-31-6 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Mad

High quality Ethyl trifluoroacetoacetate CAS 372-31-6

Cas:372-31-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Ethyl 4,4,4-trifluoroacetoacetate CAS NO.372-31-6

Cas:372-31-6

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:372-31-6

Cas:372-31-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting Ethyl 4,4,4-trifluoroacetoacetate CAS:372-31-6, Please contact us by email freely. We are leading exporter in China. If you really n

Ethyl 4,4,4-trifluoroacetoacetate CAS:372-31-6 from FandaChem

Cas:372-31-6

Min.Order:1 Metric Ton

Negotiable

Type:Other

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 4,4,4-TRIFLUOROACETOACETATE

Cas:372-31-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

ethyl 4,4,4-trifluoroacetoacetate

Cas:372-31-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

ethyl acetate
141-78-6

ethyl acetate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium hydride In diethyl ether; paraffin reflux, 2 h and r.t., 12 h;85%
Stage #1: ethyl acetate With sodium ethanolate at 0 - 5℃; for 1h;
Stage #2: ethyl trifluoroacetate, at 0 - 65℃; for 25h;
70.7%
With diethyl ether; sodium ethanolate
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

trimethylsilyl trifluoroacetate
400-53-3

trimethylsilyl trifluoroacetate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With n-butyllithium In tetrahydrofuran
Stage #2: trimethylsilyl trifluoroacetate In tetrahydrofuran
Stage #3: With hydrogenchloride In tetrahydrofuran Further stages.;
55%
With n-butyllithium 1.) THF, -78 deg C, 20 min, 2.) THF, RT, 5 h; Yield given. Multistep reaction;
ethyl 2-fluoroacetate
459-72-3

ethyl 2-fluoroacetate

ethyl difluoroacetate
454-31-9

ethyl difluoroacetate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium hydride
Trifluoracetyl-glyoxylsaeure-aethylester-α-hydrazon
652-71-1

Trifluoracetyl-glyoxylsaeure-aethylester-α-hydrazon

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With quinoline In ethanol
3-acetoxy-4,4,4-trifluoro-but-2-enoic acid ethyl ester
2707-65-5

3-acetoxy-4,4,4-trifluoro-but-2-enoic acid ethyl ester

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium tetrahydroborate In ethanol
ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

ethyl acetate
141-78-6

ethyl acetate

A

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat
197850-97-8

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With ethanol; sulfuric acid; sodium at 90℃; for 48h; Heating;
With sodium ethanolate In ethanol for 48h; Heating;
3-tert-Butylperoxy-4,4,4-trifluoro-3-hydroxy-butyric acid ethyl ester
129657-54-1

3-tert-Butylperoxy-4,4,4-trifluoro-3-hydroxy-butyric acid ethyl ester

A

tert.-butylhydroperoxide
75-91-2

tert.-butylhydroperoxide

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
In tetrachloromethane at 20℃; Equilibrium constant; Rate constant;
ethanol
64-17-5

ethanol

2,2-Dimethyl-5-(2,2,2-trifluoro-1-hydroxy-ethylidene)-[1,3]dioxane-4,6-dione
693817-83-3

2,2-Dimethyl-5-(2,2,2-trifluoro-1-hydroxy-ethylidene)-[1,3]dioxane-4,6-dione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
at 70℃; for 6h; Ring cleavage; Decarboxylation;
ethyl acetate
141-78-6

ethyl acetate

sodium compound of orthotrifluoroacetic acid diethyl ester

sodium compound of orthotrifluoroacetic acid diethyl ester

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

diethyl ether
60-29-7

diethyl ether

ethyl trifluoroacetate,
383-63-1

ethyl trifluoroacetate,

sodium

sodium

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat
197850-97-8

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat

A

ethyl 3-trifluoromethyl-3-oxo-propionate
106260-08-6

ethyl 3-trifluoromethyl-3-oxo-propionate

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
In tetrahydrofuran-d8 Equilibrium constant;
ethyl 3-trifluoromethyl-3-oxo-propionate
106260-08-6

ethyl 3-trifluoromethyl-3-oxo-propionate

A

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat
197850-97-8

Aethyl-γ,γ,γ-trifluoracetoacetat-hydrat

B

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With water In tetrahydrofuran-d8 Equilibrium constant;
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

Trifluoroacetaldehyde ethyl hemiacetal
433-27-2

Trifluoroacetaldehyde ethyl hemiacetal

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Stage #1: ethyl trifluoroacetaldehyde hemiacetal With sulfuric acid at 70 - 150℃; for 0.133333h; microwave irradiation;
Stage #2: diazoacetic acid ethyl ester In dichloromethane at 20℃; for 0.25h; Further stages.;
15 % Chromat.
ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate
18955-75-4

ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diisopropyl ether
2: H2O; methanol / Heating
3: quinoline / ethanol
View Scheme
Trifluoracetyl-glyoxylsaeure-aethylester-triphenylphosphazin-(2)
2559-41-3

Trifluoracetyl-glyoxylsaeure-aethylester-triphenylphosphazin-(2)

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: H2O; methanol / Heating
2: quinoline / ethanol
View Scheme
sodium 4-ethoxy-1,1,1-trifluoro-4-oxobut-2-en-2-olate
22466-45-1

sodium 4-ethoxy-1,1,1-trifluoro-4-oxobut-2-en-2-olate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With hydrogenchloride In water at 5 - 10℃; for 3h; pH=1 - 3;
1,1,1-trifluoro-2-propanone
421-50-1

1,1,1-trifluoro-2-propanone

Diethyl carbonate
105-58-8

Diethyl carbonate

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
With sodium hydride In toluene Inert atmosphere; Reflux;
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

N-(4-hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-guanidine

N-(4-hydroxy-6-trifluoromethyl-pyrimidin-2-yl)-guanidine

Conditions
ConditionsYield
Stage #1: biguanide sulfate With sodium hydroxide In ethanol at 0 - 20℃;
Stage #2: ethyl 4,4,4-trifluoroacetoacetate In ethanol for 2.5h; Heating; Further stages.;
100%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

benzyl alcohol
100-51-6

benzyl alcohol

benzyl 4,4,4-trifluoroacetoacetate
83097-87-4

benzyl 4,4,4-trifluoroacetoacetate

Conditions
ConditionsYield
In toluene at 120℃; for 5h; Dean-Stark;100%
In toluene Heating;
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-(2-hydroxy-benzylidene)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one
68761-48-8

4-(2-hydroxy-benzylidene)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one

5-ethoxylcarbonyl-6-hydroxy-4-(2-hydroxyphenyl)-1-phenyl-3-methyl-6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran

5-ethoxylcarbonyl-6-hydroxy-4-(2-hydroxyphenyl)-1-phenyl-3-methyl-6-(trifluoromethyl)-1,4,5,6-tetrahydropyrazolo[3,4-b]pyran

Conditions
ConditionsYield
With ammonium acetate In ethanol at 20℃; for 2h;100%
aluminum ethoxide
555-75-9

aluminum ethoxide

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

acetylacetone
123-54-6

acetylacetone

monoacetylacetonate aluminum bis(ethyl-4,4,4-trifluoroacetoacetate)

monoacetylacetonate aluminum bis(ethyl-4,4,4-trifluoroacetoacetate)

Conditions
ConditionsYield
In toluene at 20℃; for 24h;100%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate
363-58-6

ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

Conditions
ConditionsYield
With sulfuryl dichloride In dichloromethane at -5 - 20℃;99.3%
With chlorine In acetone95%
With chlorine at 0 - 30℃; Cooling with acetone-dry ice;95%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

recorcinol
108-46-3

recorcinol

7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
575-03-1

7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one

Conditions
ConditionsYield
With iodine In toluene at 80℃; Pechmann reaction;99%
With magnesium bis(trifluoromethane solfonyl)imide In neat (no solvent) at 80℃; for 0.416667h; Pechmann Condensation;97%
indium(III) chloride at 65℃; for 0.5h; von Pechmann reaction;96%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

Conditions
ConditionsYield
With formic acid; C18H24ClIrN3 In water at 80℃; for 8h; Schlenk technique; Inert atmosphere; chemoselective reaction;99%
With sodium tetrahydroborate In diethyl ether 1.) 0-5 deg C, 1 h, 2.) r.t., overnight;98%
With sodium tetrahydroborate In diethyl ether97%
7-ethyl-1H-indole
22867-74-9

7-ethyl-1H-indole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-(7-ethyl-1H-indol-3-yl)-4,4,4-trifluoro-3-hydroxybutanoate

ethyl 3-(7-ethyl-1H-indol-3-yl)-4,4,4-trifluoro-3-hydroxybutanoate

Conditions
ConditionsYield
With (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate In dichloromethane at 20℃; for 76h; Friedel-Crafts reaction; optical yield given as %ee; enantioselective reaction;99%
4-chlorobenzylamine
104-86-9

4-chlorobenzylamine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate
1384849-55-1

ethyl 3-(4-chlorobenzyl)amino-4,4,4-trifluorobut-2-enoate

Conditions
ConditionsYield
Stage #1: 4-chlorobenzylamine With acetic acid In chloroform at 20℃; for 0.0833333h;
Stage #2: ethyl 4,4,4-trifluoroacetoacetate In chloroform for 5h; Reflux;
99%
6-methylbenzothiazol-2-ylamine
2536-91-6

6-methylbenzothiazol-2-ylamine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

8-methyl-2-(trifluoromethyl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one

8-methyl-2-(trifluoromethyl)-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one

Conditions
ConditionsYield
With indium(III) triflate In toluene at 100℃; for 16h; regioselective reaction;99%
4-hydrazinobenzene-1-sulfonamide hydrochloride
17852-52-7, 27918-19-0

4-hydrazinobenzene-1-sulfonamide hydrochloride

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
627094-59-1

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Conditions
ConditionsYield
In ethanol at 24℃; Reflux; Inert atmosphere;99%
1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Pechmann Condensation; Glovebox; Inert atmosphere;99%
5-methylcyclohexan-1,3-dione
4341-24-6

5-methylcyclohexan-1,3-dione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

7-methyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

7-methyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;99%
dimedone
126-81-8

dimedone

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

7,7-dimethyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

7,7-dimethyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;99%
5-phenyl-cyclohexane-1,3-dione
493-72-1

5-phenyl-cyclohexane-1,3-dione

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

7-phenyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

7-phenyl-4-(trifluoromethyl)-7,8-dihydro-2H-chromene-2,5(6H)-dione

Conditions
ConditionsYield
With 2-(Dimethylamino)pyridine In 1,2-dichloro-ethane at 120℃; for 16h; Pechmann Condensation; Glovebox; Inert atmosphere;99%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-aminosulfonylphenylhydrazine
4392-54-5

4-aminosulfonylphenylhydrazine

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
627094-59-1

4-(5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Conditions
ConditionsYield
In ethanol for 12h; Reflux;99%
orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate
571-55-1

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

Conditions
ConditionsYield
With acetic anhydride at 120 - 140℃; for 7h; Condensation;98%
With acetic anhydride at 135℃; for 18h;97.1%
In acetic anhydride for 8h; Reflux;95%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

5-(trifluoromethyl)-4-pyrazolin-3-one
76480-99-4

5-(trifluoromethyl)-4-pyrazolin-3-one

Conditions
ConditionsYield
With hydrazine hydrate In ethanol; water for 18h; Heating;98%
With water; hydrazine hydrate
With ethanol; hydrazine hydrate
5-amino-1,2-dihydropyrazol-3-one
28491-52-3

5-amino-1,2-dihydropyrazol-3-one

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4-trifluoromethyl-6-hydroxy-3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine

4-trifluoromethyl-6-hydroxy-3-oxo-2,3-dihydropyrazolo<3,4-b>pyridine

Conditions
ConditionsYield
With acetic acid for 2h; Heating;98%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

m-Hydroxyaniline
591-27-5

m-Hydroxyaniline

Coumarin 151
53518-15-3

Coumarin 151

Conditions
ConditionsYield
With magnesium bis(trifluoromethane solfonyl)imide In neat (no solvent) at 80℃; for 0.416667h; Pechmann Condensation;98%
With sulfuric acid In ethanol at 80℃;83%
With zinc(II) chloride In ethanol for 12h; Heating;69%
With zinc(II) chloride In ethanol Reflux;12%
With zinc(II) chloride In ethanol for 12h; Reflux;
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 3-amino-4,4,4-trifluorocrotonate
141860-78-8

ethyl 3-amino-4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With ammonium acetate In cyclohexane; isopropyl alcohol98%
With ammonium acetate In ethanol; water88%
With ammonia
2,3;4,5-di-O-isopropylidene-β-D-fructopyranose
20880-92-6

2,3;4,5-di-O-isopropylidene-β-D-fructopyranose

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4,4,4-Trifluoro-3-oxo-butyric acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl ester

4,4,4-Trifluoro-3-oxo-butyric acid (3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl ester

Conditions
ConditionsYield
With vermiculite In toluene for 48h; Heating;98%
((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol
4099-85-8

((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

4,4,4-Trifluoro-3-oxo-butyric acid (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

4,4,4-Trifluoro-3-oxo-butyric acid (3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Conditions
ConditionsYield
With vermiculite In toluene for 48h; Heating;98%
indole
120-72-9

indole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

3-hydroxy-3-(indol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

3-hydroxy-3-(indol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions
ConditionsYield
With K-10 montmorillonite In toluene at 70℃; for 1h; Friedel-Crafts hydroxyalkylation;98%
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

3-hydroxy-3-(2-methylindol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

3-hydroxy-3-(2-methylindol-3-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions
ConditionsYield
With K-10 montmorillonite In toluene at 70℃; for 0.75h; Friedel-Crafts hydroxyalkylation;98%
pyrrole
109-97-7

pyrrole

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

3-hydroxy-3-(pyrrol-2-yl)-4,4,4-trifluorobutanoic acid ethyl ester

3-hydroxy-3-(pyrrol-2-yl)-4,4,4-trifluorobutanoic acid ethyl ester

Conditions
ConditionsYield
With K-10 montmorillonite In toluene at 70℃; for 0.5h; Friedel-Crafts hydroxyalkylation;98%
phenylhydrazine
100-63-0

phenylhydrazine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one
321-07-3

1-phenyl-3-(trifluoromethyl)-1H-pyrazol-5(4H)-one

Conditions
ConditionsYield
at 150 - 160℃; for 3h;98%
With acetic acid for 6h; Reflux;90%
With acetic acid Reflux;90%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate
85571-85-3

ethyl (3R)-4,4,4-trifluoro-3-hydroxybutanoate

Conditions
ConditionsYield
With α-D-glucose 6-phosphate; permeabilized cells of Bacillus pumilus Phe-C3; NADPH In various solvent(s) at 25℃; for 24h; pH=7.0;98%
With glucose dehydrogenase; pET28-bmgdh-cgcr; sodium carbonate In aq. phosphate buffer; toluene at 30℃; for 12h; pH=6.5; Enzymatic reaction; enantioselective reaction;92%
With nicotinamide adenine dinucleotide phosphate; isopropyl alcohol In dimethyl sulfoxide at 30℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;66%
phenylhydrazine
100-63-0

phenylhydrazine

ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole
96145-98-1

1-phenyl-3-trifluoromethyl-5-hydroxypyrazole

Conditions
ConditionsYield
With acetic acid at 10 - 80℃; for 6.5h;98%
In ethanol at 24℃; for 12h; Reflux; Inert atmosphere;92%
In ethanol for 12h; Reflux;92%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

methylamine
74-89-5

methylamine

3-methylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester
507448-65-9

3-methylamino-4,4,4-trifluorobut-2-enoic acid ethyl ester

Conditions
ConditionsYield
With acetic acid In ethanol; methyl cyclohexane at 80 - 90℃; under 760.051 Torr; for 3 - 4h; Product distribution / selectivity;98%
With acetic acid In methyl cyclohexane at 80 - 85℃; for 3 - 8h; Product distribution / selectivity;88.5%
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