As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryProduct Detail Minimum Order Qty. 10 Gram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquirysupplier in China Appearance:Colorless and clear liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Used as Pharmaceutical Intermediates Tran
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
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inquiryProduct Name: Ethyl 4,4,4-trifluorocrotonate Synonyms: 4.4.4-TRIFLUOROCROTONIC ACID ETHYL ESTER;Ethyl (2E)-4,4,4-trifluoro-2-butenoate;ETHYL 4,4,4-TRIFLUOROCROTONATE;ETHYL 4,4,4-TRIFLUORO-TRANS-2-BUTENOATE;Ethyl 4,4,4-trifluorocrotonate 98%;Eth
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
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inquiryAppearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea
SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryethyl 3-hydroxy-4,4,4-trifluorobutyrate
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In diethyl ether Ambient temperature; | 96% |
With methanesulfonyl chloride; triethylamine In dichloromethane at -70 - 25℃; for 1h; Reagent/catalyst; | 87% |
With triethylamine; p-toluenesulfonyl chloride | 82% |
Togni's reagent II
(E)-4-ethoxy-4-oxobut-2-enoic acid
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 120℃; for 24h; Sealed tube; stereoselective reaction; | 93% |
ethyl 4,4,4-trifluoroacetoacetate
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
Stage #1: ethyl 4,4,4-trifluoroacetoacetate With sodium tetrahydroborate In diethyl ether Stage #2: With phosphorus pentoxide In diethyl ether | 70% |
Multi-step reaction with 2 steps 1: 94 percent / sodium borohydride / toluene / 4.5 h / 20 °C 2: 69 percent / phosphorus pentoxide / 1 h View Scheme |
ethanol
3-(trifluoromethyl)acrylic acid
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
With sulfuric acid Heating; |
2,2,2-Trifluoroacetaldehyde
diethyl malonate
ethyl 4,4,4-trifluorocrotonate
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
A
ethyl 4,4,4-trifluorocrotonate
B
ethyl (Z)-β-trifluoromethylacrylate
Conditions | Yield |
---|---|
With phosphorus pentaoxide for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
A
ethyl 4,4,4-trifluorocrotonate
B
ethyl 3,4,4,4-tetrafluorobutyrate
C
4,4,4-Trifluoro-3-fluorosulfinyloxy-butyric acid ethyl ester
Conditions | Yield |
---|---|
With sulfur tetrafluoride; sodium fluoride 1.) steel autoclave; 2.) 20 deg C, 60 h; Yield given. Multistep reaction. Yields of byproduct given; |
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
ethyl 4,4,4-trifluorocrotonate
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
A
(E)-4,4,4-trifluorobut-2-enoate
B
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
at 350℃; |
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
With sodium carbonate | 15.90 g (91%) |
With caesium carbonate | 13.47 g (87%) |
With sodium carbonate | 15.90 g (91%) |
With caesium carbonate | 13.47g (87%) |
diethoxyphosphoryl-acetic acid ethyl ester
2,2,2-Trifluoroacetaldehyde
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With triethylamine; lithium bromide In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 2,2,2-Trifluoroacetaldehyde In tetrahydrofuran at 0 - 20℃; for 1.08333h; Inert atmosphere; |
ethyl 4,4,4-trifluorocrotonate
diethyl malonate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) r.t., 1 h; | 99% |
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: ethyl 4,4,4-trifluorocrotonate In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran Inert atmosphere; |
ethyl 4,4,4-trifluorocrotonate
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine
ethyl (+/-)-(3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane for 16h; Inert atmosphere; Reflux; | 99% |
With trifluoroacetic acid In dichloromethane at 0 - 20℃; | 98% |
With trifluoroacetic acid In dichloromethane | 95% |
With trifluoroacetic acid In acetonitrile at 70℃; Continuous flow conditions; | 74% |
Conditions | Yield |
---|---|
With Cl4SnC2HNOBC6H5CH(CH3)2(C6H5)2CH2C10H7 In dichloromethane at -78℃; for 8h; Diels-Alder reaction; Inert atmosphere; optical yield given as %ee; stereoselective reaction; | 99% |
ethyl 4,4,4-trifluorocrotonate
propiophenone lithium enolate
(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate
Conditions | Yield |
---|---|
98% |
ethyl 4,4,4-trifluorocrotonate
1-phenyl-propan-1-one
(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Product distribution; multistep reaction; diastereoselectivity; other lithium enolates of ketones, esters or amides; | 98% |
With lithium diisopropyl amide 1) THF, -78 deg C, 2) -78 deg C, 0.5 h; Yield given. Multistep reaction; | |
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 0.5 h; Yield given; |
nitromethane
ethyl 4,4,4-trifluorocrotonate
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethylguanidine at 20℃; for 13h; Inert atmosphere; | 98% |
With N,N,N',N'-tetramethylguanidine at 20℃; for 13h; | 98% |
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C to r.t., 6.0 h; | 83% |
In acetonitrile for 0.5h; Michael addition; | 90 % Spectr. |
ethyl 4,4,4-trifluorocrotonate
Ethyl isobutyrate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 1.0 h; | 98% |
ethyl 4,4,4-trifluorocrotonate
2,4-Dihydroxybenzaldehyde
Conditions | Yield |
---|---|
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 90℃; for 3h; | 98% |
ethyl 4,4,4-trifluorocrotonate
(RS)-5-(trifluoromethyl)pyrazolidin-3-one
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol for 18h; Reflux; | 98% |
ethyl 4,4,4-trifluorocrotonate
3-pentanone lithium enolate
(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxoheptanoate
Conditions | Yield |
---|---|
diastereoselective Michael addition reactions with other lithium enolates; | 97% |
97% |
ethyl 4,4,4-trifluorocrotonate
(E)-4,4,4-trifluorobut-2-enoate
Conditions | Yield |
---|---|
With sodium hydroxide In water | 96% |
With sodium hydroxide In tetrahydrofuran; water for 1.5h; Ambient temperature; | 93% |
With water; sodium hydroxide In ethanol at 20℃; for 19h; | 91% |
ethyl 4,4,4-trifluorocrotonate
1-methoxy-1,3-cyclohexadiene
Ethyl (1RS,2RS,3SR,4RS)-1-methoxy-3-trifluoromethylbicyclo<2.2.2>oct-5-ene-2-carboxylate
Conditions | Yield |
---|---|
With cis-2,3-dichlorobutenedioic acid; 2-tert-Butyl-4-methylphenol In benzene for 96h; Heating; | 96% |
ethyl 4,4,4-trifluorocrotonate
2-amino-benzenethiol
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 24h; | 95% |
ethyl 4,4,4-trifluorocrotonate
diethyl malonate
3-(trifluoromethyl)pentanedioic acid
Conditions | Yield |
---|---|
With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran; water; acetic acid | 95% |
ethyl 4,4,4-trifluorocrotonate
bis(pinacol)diborane
Conditions | Yield |
---|---|
With methanol; copper(l) iodide; potassium carbonate In tetrahydrofuran at 20℃; for 30h; Inert atmosphere; chemoselective reaction; | 95% |
ethyl 4,4,4-trifluorocrotonate
t-butoxycarbonylhydrazine
3-(N'-tert-butoxycarbonylhydrazino)-4,4,4-trifluorobutyric acid ethyl ester
Conditions | Yield |
---|---|
In methanol at 70℃; for 72h; Michael condensation; | 94% |
ethyl 4,4,4-trifluorocrotonate
sodium methylate
4,4,4-trifluoro-3-methoxybutanoic acid
Conditions | Yield |
---|---|
In methanol at 20℃; | 93.8% |
ethyl 4,4,4-trifluorocrotonate
cyclopentanone
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -40 deg C, 4.0 h; | 93% |
ethyl 4,4,4-trifluorocrotonate
3,5-dichlorosalicyclaldehyde
ethyl 6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine In dimethyl sulfoxide at 85℃; for 72h; | 93% |
regiospecific reaction; |
ethyl 4,4,4-trifluorocrotonate
ethyl 2,3-dibromo-4,4,4-trifluorobutanoate
Conditions | Yield |
---|---|
With bromine In tetrachloromethane for 5h; Heating; | 92% |
With bromine In tetrachloromethane at 20℃; Reflux; Inert atmosphere; | |
With bromine In tetrachloromethane at 20℃; Inert atmosphere; Reflux; |
ethyl 4,4,4-trifluorocrotonate
1-trifluoromethylprop-1-en-3-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether | 90% |
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether at 0℃; for 2h; Hydrogenolysis; | 90% |
With diisobutylaluminium hydride In tert-butyl methyl ether; toluene at -70 - 25℃; for 1h; Inert atmosphere; | 90% |
4-butanolide
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 3.0 h; | 90% |
ethyl 4,4,4-trifluorocrotonate
dimethyl methane phosphonate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 2.0 h; | 90% |
2-hydroxy-3-iodo-5-(trifluoromethoxy) benzaldehyde
ethyl 4,4,4-trifluorocrotonate
ethyl 8-iodo-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate
Conditions | Yield |
---|---|
With triethylamine at 85℃; for 66h; | 90% |
With triethylamine In N,N-dimethyl-formamide at 85℃; for 66h; | 90% |
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h; | 69% |
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h; | 69% |
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h; | 69% |
5-(benzyloxy)-4-bromo-2-hydroxybenzaldehyde
ethyl 4,4,4-trifluorocrotonate
Conditions | Yield |
---|---|
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 65℃; for 4h; | 89% |
Conditions | Yield |
---|---|
With Cl4SnC2HNOBC6H5CH(CH3)2(C6H5)2CH2C10H7 In dichloromethane at -78℃; for 8h; Diels-Alder reaction; Inert atmosphere; optical yield given as %ee; stereoselective reaction; | 89% |
ethyl 4,4,4-trifluorocrotonate
N-isopropyl oxazolidinone
(3R,4R,4'S)-Ethyl 3-(trifluoromethyl)-4-methyl-5-<4'-(1''-methylethyl)-2'-oxazolidinon-3'-yl>-5-oxopentanoate
Conditions | Yield |
---|---|
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Product distribution; multistep reaction; diastereoselectivity; other acyl oxazolidinones; | 88% |
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C; | 88% |
With lithium diisopropyl amide 1) THF, -78 deg C, 2) -78 deg C, 1.5 h; Yield given. Multistep reaction; |
ethyl 4,4,4-trifluorocrotonate
methylhydrazine
1-methyl-5-(trifluoromethyl)-2,3,4,5-tetrahydropyrazol-3-one
Conditions | Yield |
---|---|
at 20℃; | 88% |
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