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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4,4,4-Trifluorocrotonate supplier in China

Cas:25597-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4,4,4-Trifluorocrotonic acid ethyl ester

Cas:25597-16-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4,4,4-Trifluorocrotonic acid ethyl ester

Cas:25597-16-4

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

discount Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 25597-16-4 with best quality

Cas:25597-16-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:Liquid Storage:Store in sealed containers at cool & dry plac

CAS 25597-16-4 Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

2-Butenoic acid,4,4,4-trifluoro-, ethyl ester, (2E)-/ LIDE PHARMA- Factory supply / Best price

Cas:25597-16-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

2-Butenoic acid,4,4,4-trifluoro-, ethyl ester, (2E)-

Cas:25597-16-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Butenoic acid,4,4,4-trifluoro-, ethyl ester, (2E)-

Cas:25597-16-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Ethyl 4,4,4-trifluorocrotonate CAS:25597-16-4 98%min CAS NO.25597-16-4

Cas:25597-16-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:25597-16-4

Cas:25597-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

ETHYL 4,4,4-TRIFLUOROCROTONATE

Cas:25597-16-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4,4,4-Trifluorocrotonic acid ethyl ester

Cas:25597-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

supplier in China Appearance:Colorless and clear liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:Used as Pharmaceutical Intermediates Tran

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: Ethyl 4,4,4-trifluorocrotonate Synonyms: 4.4.4-TRIFLUOROCROTONIC ACID ETHYL ESTER;Ethyl (2E)-4,4,4-trifluoro-2-butenoate;ETHYL 4,4,4-TRIFLUOROCROTONATE;ETHYL 4,4,4-TRIFLUORO-TRANS-2-BUTENOATE;Ethyl 4,4,4-trifluorocrotonate 98%;Eth

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Ethyl4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ Ethyl 4,4,4-trifluorocrotonate /Manufacturer in China

Cas:25597-16-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Ethyl 4,4,4-trifluorocrotonate

Cas:25597-16-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In diethyl ether Ambient temperature;96%
With methanesulfonyl chloride; triethylamine In dichloromethane at -70 - 25℃; for 1h; Reagent/catalyst;87%
With triethylamine; p-toluenesulfonyl chloride82%
Togni's reagent II
887144-94-7

Togni's reagent II

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 24h; Sealed tube; stereoselective reaction;93%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
Stage #1: ethyl 4,4,4-trifluoroacetoacetate With sodium tetrahydroborate In diethyl ether
Stage #2: With phosphorus pentoxide In diethyl ether
70%
Multi-step reaction with 2 steps
1: 94 percent / sodium borohydride / toluene / 4.5 h / 20 °C
2: 69 percent / phosphorus pentoxide / 1 h
View Scheme
ethanol
64-17-5

ethanol

3-(trifluoromethyl)acrylic acid
406-94-0, 130130-81-3, 71027-02-6

3-(trifluoromethyl)acrylic acid

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With sulfuric acid Heating;
2,2,2-Trifluoroacetaldehyde
75-90-1

2,2,2-Trifluoroacetaldehyde

diethyl malonate
105-53-3

diethyl malonate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

A

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

B

ethyl (Z)-β-trifluoromethylacrylate
91600-34-9, 406-10-0, 25597-16-4

ethyl (Z)-β-trifluoromethylacrylate

Conditions
ConditionsYield
With phosphorus pentaoxide for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

A

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

B

ethyl 3,4,4,4-tetrafluorobutyrate
94725-82-3

ethyl 3,4,4,4-tetrafluorobutyrate

C

4,4,4-Trifluoro-3-fluorosulfinyloxy-butyric acid ethyl ester
344883-34-7

4,4,4-Trifluoro-3-fluorosulfinyloxy-butyric acid ethyl ester

Conditions
ConditionsYield
With sulfur tetrafluoride; sodium fluoride 1.) steel autoclave; 2.) 20 deg C, 60 h; Yield given. Multistep reaction. Yields of byproduct given;
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

phosphorus (V)-oxide

phosphorus (V)-oxide

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

boroxide

boroxide

A

(E)-4,4,4-trifluorobut-2-enoate
406-94-0

(E)-4,4,4-trifluorobut-2-enoate

B

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
at 350℃;
2-ethoxycarbonyl-1-(trifluoromethyl)ethyl pentanoate

2-ethoxycarbonyl-1-(trifluoromethyl)ethyl pentanoate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With sodium carbonate15.90 g (91%)
With caesium carbonate13.47 g (87%)
With sodium carbonate15.90 g (91%)
With caesium carbonate13.47g (87%)
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

2,2,2-Trifluoroacetaldehyde
75-90-1

2,2,2-Trifluoroacetaldehyde

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With triethylamine; lithium bromide In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: 2,2,2-Trifluoroacetaldehyde In tetrahydrofuran at 0 - 20℃; for 1.08333h; Inert atmosphere;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

diethyl malonate
105-53-3

diethyl malonate

Diethyl 2-(ethoxycarbonyl)-3-(trifluoromethyl)glutarate

Diethyl 2-(ethoxycarbonyl)-3-(trifluoromethyl)glutarate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) r.t., 1 h;99%
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: ethyl 4,4,4-trifluorocrotonate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #3: With hydrogenchloride; water In tetrahydrofuran Inert atmosphere;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine
93102-05-7

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

ethyl (+/-)-(3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate
152188-51-7

ethyl (+/-)-(3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 16h; Inert atmosphere; Reflux;99%
With trifluoroacetic acid In dichloromethane at 0 - 20℃;98%
With trifluoroacetic acid In dichloromethane95%
With trifluoroacetic acid In acetonitrile at 70℃; Continuous flow conditions;74%
2-methylfuran
534-22-5

2-methylfuran

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

C11H13F3O3
1353275-83-8

C11H13F3O3

Conditions
ConditionsYield
With Cl4SnC2HNOBC6H5CH(CH3)2(C6H5)2CH2C10H7 In dichloromethane at -78℃; for 8h; Diels-Alder reaction; Inert atmosphere; optical yield given as %ee; stereoselective reaction;99%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

propiophenone lithium enolate
57204-88-3

propiophenone lithium enolate

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate
138690-13-8, 138921-71-8, 138921-72-9

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate

Conditions
ConditionsYield
98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate
138690-13-8, 138921-71-8, 138921-72-9

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Product distribution; multistep reaction; diastereoselectivity; other lithium enolates of ketones, esters or amides;98%
With lithium diisopropyl amide 1) THF, -78 deg C, 2) -78 deg C, 0.5 h; Yield given. Multistep reaction;
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 0.5 h; Yield given;
nitromethane
75-52-5

nitromethane

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester
328-62-1

4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

Conditions
ConditionsYield
With N,N,N',N'-tetramethylguanidine at 20℃; for 13h; Inert atmosphere;98%
With N,N,N',N'-tetramethylguanidine at 20℃; for 13h;98%
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C to r.t., 6.0 h;83%
In acetonitrile for 0.5h; Michael addition;90 % Spectr.
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Diethyl 2,2-dimethyl-3-(trifluoromethyl)glutarate

Diethyl 2,2-dimethyl-3-(trifluoromethyl)glutarate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 1.0 h;98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

2,4-Dihydroxybenzaldehyde
95-01-2

2,4-Dihydroxybenzaldehyde

ethyl 6-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate

ethyl 6-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 90℃; for 3h;98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

(RS)-5-(trifluoromethyl)pyrazolidin-3-one
1248565-79-8

(RS)-5-(trifluoromethyl)pyrazolidin-3-one

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 18h; Reflux;98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

3-pentanone lithium enolate
1063719-01-6

3-pentanone lithium enolate

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxoheptanoate
138852-11-6, 138852-12-7

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxoheptanoate

Conditions
ConditionsYield
diastereoselective Michael addition reactions with other lithium enolates;97%
97%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

(E)-4,4,4-trifluorobut-2-enoate
406-94-0

(E)-4,4,4-trifluorobut-2-enoate

Conditions
ConditionsYield
With sodium hydroxide In water96%
With sodium hydroxide In tetrahydrofuran; water for 1.5h; Ambient temperature;93%
With water; sodium hydroxide In ethanol at 20℃; for 19h;91%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

1-methoxy-1,3-cyclohexadiene
2161-90-2

1-methoxy-1,3-cyclohexadiene

Ethyl (1RS,2RS,3SR,4RS)-1-methoxy-3-trifluoromethylbicyclo<2.2.2>oct-5-ene-2-carboxylate
133961-04-3

Ethyl (1RS,2RS,3SR,4RS)-1-methoxy-3-trifluoromethylbicyclo<2.2.2>oct-5-ene-2-carboxylate

Conditions
ConditionsYield
With cis-2,3-dichlorobutenedioic acid; 2-tert-Butyl-4-methylphenol In benzene for 96h; Heating;96%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

ethyl 3-(2-aminophenyl)thio-4,4,4-trifluorobutyrate

ethyl 3-(2-aminophenyl)thio-4,4,4-trifluorobutyrate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 24h;95%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

diethyl malonate
105-53-3

diethyl malonate

3-(trifluoromethyl)pentanedioic acid
4162-55-4

3-(trifluoromethyl)pentanedioic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran; water; acetic acid95%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

ethyl 4,4,4-trifluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate

ethyl 4,4,4-trifluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate

Conditions
ConditionsYield
With methanol; copper(l) iodide; potassium carbonate In tetrahydrofuran at 20℃; for 30h; Inert atmosphere; chemoselective reaction;95%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

3-(N'-tert-butoxycarbonylhydrazino)-4,4,4-trifluorobutyric acid ethyl ester
1123546-28-0

3-(N'-tert-butoxycarbonylhydrazino)-4,4,4-trifluorobutyric acid ethyl ester

Conditions
ConditionsYield
In methanol at 70℃; for 72h; Michael condensation;94%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

sodium methylate
124-41-4

sodium methylate

4,4,4-trifluoro-3-methoxybutanoic acid
1343115-14-9

4,4,4-trifluoro-3-methoxybutanoic acid

Conditions
ConditionsYield
In methanol at 20℃;93.8%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

cyclopentanone
120-92-3

cyclopentanone

Ethyl 3-(2'-oxocyclopentyl)-3-(trifluoromethyl)propionate

Ethyl 3-(2'-oxocyclopentyl)-3-(trifluoromethyl)propionate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -40 deg C, 4.0 h;93%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

3,5-dichlorosalicyclaldehyde
90-60-8

3,5-dichlorosalicyclaldehyde

ethyl 6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate
1160474-53-2

ethyl 6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With triethylamine In dimethyl sulfoxide at 85℃; for 72h;93%
regiospecific reaction;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 2,3-dibromo-4,4,4-trifluorobutanoate
363-57-5

ethyl 2,3-dibromo-4,4,4-trifluorobutanoate

Conditions
ConditionsYield
With bromine In tetrachloromethane for 5h; Heating;92%
With bromine In tetrachloromethane at 20℃; Reflux; Inert atmosphere;
With bromine In tetrachloromethane at 20℃; Inert atmosphere; Reflux;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

1-trifluoromethylprop-1-en-3-ol
83706-94-9

1-trifluoromethylprop-1-en-3-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether90%
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether at 0℃; for 2h; Hydrogenolysis;90%
With diisobutylaluminium hydride In tert-butyl methyl ether; toluene at -70 - 25℃; for 1h; Inert atmosphere;90%
4-butanolide
96-48-0

4-butanolide

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Ethyl 3-butan-4'-olid-2'-yl-3-(trifluoromethyl)propionate

Ethyl 3-butan-4'-olid-2'-yl-3-(trifluoromethyl)propionate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 3.0 h;90%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

(E)-Dimethyl 2-oxo-5,5,5-trifluoro-3-pentenylphosphonate

(E)-Dimethyl 2-oxo-5,5,5-trifluoro-3-pentenylphosphonate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 2.0 h;90%
2-hydroxy-3-iodo-5-(trifluoromethoxy) benzaldehyde
775330-11-5

2-hydroxy-3-iodo-5-(trifluoromethoxy) benzaldehyde

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 8-iodo-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate
775330-12-6

ethyl 8-iodo-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With triethylamine at 85℃; for 66h;90%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 66h;90%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h;69%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h;69%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h;69%
5-(benzyloxy)-4-bromo-2-hydroxybenzaldehyde
775335-97-2

5-(benzyloxy)-4-bromo-2-hydroxybenzaldehyde

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 6-(benzyloxy)-7-bromo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

ethyl 6-(benzyloxy)-7-bromo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 65℃; for 4h;89%
3-bromofurane
22037-28-1

3-bromofurane

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

C10H10BrF3O3
1353275-81-6

C10H10BrF3O3

Conditions
ConditionsYield
With Cl4SnC2HNOBC6H5CH(CH3)2(C6H5)2CH2C10H7 In dichloromethane at -78℃; for 8h; Diels-Alder reaction; Inert atmosphere; optical yield given as %ee; stereoselective reaction;89%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

N-isopropyl oxazolidinone
77877-19-1

N-isopropyl oxazolidinone

(3R,4R,4'S)-Ethyl 3-(trifluoromethyl)-4-methyl-5-<4'-(1''-methylethyl)-2'-oxazolidinon-3'-yl>-5-oxopentanoate
138809-19-5

(3R,4R,4'S)-Ethyl 3-(trifluoromethyl)-4-methyl-5-<4'-(1''-methylethyl)-2'-oxazolidinon-3'-yl>-5-oxopentanoate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Product distribution; multistep reaction; diastereoselectivity; other acyl oxazolidinones;88%
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C;88%
With lithium diisopropyl amide 1) THF, -78 deg C, 2) -78 deg C, 1.5 h; Yield given. Multistep reaction;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

methylhydrazine
60-34-4

methylhydrazine

1-methyl-5-(trifluoromethyl)-2,3,4,5-tetrahydropyrazol-3-one
153893-99-3

1-methyl-5-(trifluoromethyl)-2,3,4,5-tetrahydropyrazol-3-one

Conditions
ConditionsYield
at 20℃;88%

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