Product Name

  • Name

    Ethyl 4,4,4-trifluorocrotonate

  • EINECS -0
  • CAS No. 25597-16-4
  • Article Data34
  • CAS DataBase
  • Density 1.191 g/cm3
  • Solubility
  • Melting Point
  • Formula C6H7 F3 O2
  • Boiling Point 114.5 °C at 760 mmHg
  • Molecular Weight 168.116
  • Flash Point 25.6 °C
  • Transport Information UN 3272 3/PG 3
  • Appearance Colorless and clear liquid
  • Safety 16-26-27-28-36/37/39
  • Risk Codes 10-36/37/38
  • Molecular Structure Molecular Structure of 25597-16-4 (Ethyl 4,4,4-trifluorocrotonate)
  • Hazard Symbols IrritantXi; FlammableF
  • Synonyms 2-Butenoicacid, 4,4,4-trifluoro-, ethyl ester, (E)-;(E)-Ethyl4,4,4-trifluorobut-2-enoate;Ethyl (E)-4,4,4-trifluorocrotonate;
  • PSA 26.30000
  • LogP 1.66800

Synthetic route

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In diethyl ether Ambient temperature;96%
With methanesulfonyl chloride; triethylamine In dichloromethane at -70 - 25℃; for 1h; Reagent/catalyst;87%
With triethylamine; p-toluenesulfonyl chloride82%
Togni's reagent II
887144-94-7

Togni's reagent II

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 24h; Sealed tube; stereoselective reaction;93%
ethyl 4,4,4-trifluoroacetoacetate
372-31-6

ethyl 4,4,4-trifluoroacetoacetate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
Stage #1: ethyl 4,4,4-trifluoroacetoacetate With sodium tetrahydroborate In diethyl ether
Stage #2: With phosphorus pentoxide In diethyl ether		70%
Multi-step reaction with 2 steps
1: 94 percent / sodium borohydride / toluene / 4.5 h / 20 °C
2: 69 percent / phosphorus pentoxide / 1 h
View Scheme
ethanol
64-17-5

ethanol

3-(trifluoromethyl)acrylic acid
406-94-0, 130130-81-3, 71027-02-6

3-(trifluoromethyl)acrylic acid

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With sulfuric acid Heating;
2,2,2-Trifluoroacetaldehyde
75-90-1

2,2,2-Trifluoroacetaldehyde

diethyl malonate
105-53-3

diethyl malonate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

A

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

B

ethyl (Z)-β-trifluoromethylacrylate
91600-34-9, 406-10-0, 25597-16-4

ethyl (Z)-β-trifluoromethylacrylate

Conditions
ConditionsYield
With phosphorus pentaoxide for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

A

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

B

ethyl 3,4,4,4-tetrafluorobutyrate
94725-82-3

ethyl 3,4,4,4-tetrafluorobutyrate

C

4,4,4-Trifluoro-3-fluorosulfinyloxy-butyric acid ethyl ester
344883-34-7

4,4,4-Trifluoro-3-fluorosulfinyloxy-butyric acid ethyl ester

Conditions
ConditionsYield
With sulfur tetrafluoride; sodium fluoride 1.) steel autoclave; 2.) 20 deg C, 60 h; Yield given. Multistep reaction. Yields of byproduct given;
...Expand
ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

phosphorus (V)-oxide

phosphorus (V)-oxide

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 3-hydroxy-4,4,4-trifluorobutyrate
372-30-5

ethyl 3-hydroxy-4,4,4-trifluorobutyrate

boroxide

boroxide

A

(E)-4,4,4-trifluorobut-2-enoate
406-94-0

(E)-4,4,4-trifluorobut-2-enoate

B

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
at 350℃;
...Expand
2-ethoxycarbonyl-1-(trifluoromethyl)ethyl pentanoate

2-ethoxycarbonyl-1-(trifluoromethyl)ethyl pentanoate

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
With sodium carbonate15.90 g (91%)
With caesium carbonate13.47 g (87%)
With sodium carbonate15.90 g (91%)
With caesium carbonate13.47g (87%)
diethoxyphosphoryl-acetic acid ethyl ester
867-13-0

diethoxyphosphoryl-acetic acid ethyl ester

2,2,2-Trifluoroacetaldehyde
75-90-1

2,2,2-Trifluoroacetaldehyde

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Conditions
ConditionsYield
Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With triethylamine; lithium bromide In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: 2,2,2-Trifluoroacetaldehyde In tetrahydrofuran at 0 - 20℃; for 1.08333h; Inert atmosphere;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

diethyl malonate
105-53-3

diethyl malonate

Diethyl 2-(ethoxycarbonyl)-3-(trifluoromethyl)glutarate

Diethyl 2-(ethoxycarbonyl)-3-(trifluoromethyl)glutarate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) r.t., 1 h;99%
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: ethyl 4,4,4-trifluorocrotonate In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #3: With hydrogenchloride; water In tetrahydrofuran Inert atmosphere;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine
93102-05-7

N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

ethyl (+/-)-(3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate
152188-51-7

ethyl (+/-)-(3R,4R)-1-benzyl-4-(trifluoromethyl)pyrrolidine-3-carboxylate

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 16h; Inert atmosphere; Reflux;99%
With trifluoroacetic acid In dichloromethane at 0 - 20℃;98%
With trifluoroacetic acid In dichloromethane95%
With trifluoroacetic acid In acetonitrile at 70℃; Continuous flow conditions;74%
2-methylfuran
534-22-5

2-methylfuran

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

C11H13F3O3
1353275-83-8

C11H13F3O3

Conditions
ConditionsYield
With Cl4SnC2HNOBC6H5CH(CH3)2(C6H5)2CH2C10H7 In dichloromethane at -78℃; for 8h; Diels-Alder reaction; Inert atmosphere; optical yield given as %ee; stereoselective reaction;99%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

propiophenone lithium enolate
57204-88-3

propiophenone lithium enolate

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate
138690-13-8, 138921-71-8, 138921-72-9

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate

Conditions
ConditionsYield
98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

1-phenyl-propan-1-one
93-55-0

1-phenyl-propan-1-one

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate
138690-13-8, 138921-71-8, 138921-72-9

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Product distribution; multistep reaction; diastereoselectivity; other lithium enolates of ketones, esters or amides;98%
With lithium diisopropyl amide 1) THF, -78 deg C, 2) -78 deg C, 0.5 h; Yield given. Multistep reaction;
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 0.5 h; Yield given;
nitromethane
75-52-5

nitromethane

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester
328-62-1

4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

Conditions
ConditionsYield
With N,N,N',N'-tetramethylguanidine at 20℃; for 13h; Inert atmosphere;98%
With N,N,N',N'-tetramethylguanidine at 20℃; for 13h;98%
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C to r.t., 6.0 h;83%
In acetonitrile for 0.5h; Michael addition;90 % Spectr.
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Ethyl isobutyrate
97-62-1

Ethyl isobutyrate

Diethyl 2,2-dimethyl-3-(trifluoromethyl)glutarate

Diethyl 2,2-dimethyl-3-(trifluoromethyl)glutarate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 1.0 h;98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

2,4-Dihydroxybenzaldehyde
95-01-2

2,4-Dihydroxybenzaldehyde

ethyl 6-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate

ethyl 6-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 90℃; for 3h;98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

(RS)-5-(trifluoromethyl)pyrazolidin-3-one
1248565-79-8

(RS)-5-(trifluoromethyl)pyrazolidin-3-one

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 18h; Reflux;98%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

3-pentanone lithium enolate
1063719-01-6

3-pentanone lithium enolate

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxoheptanoate
138852-11-6, 138852-12-7

(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxoheptanoate

Conditions
ConditionsYield
diastereoselective Michael addition reactions with other lithium enolates;97%
97%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

(E)-4,4,4-trifluorobut-2-enoate
406-94-0

(E)-4,4,4-trifluorobut-2-enoate

Conditions
ConditionsYield
With sodium hydroxide In water96%
With sodium hydroxide In tetrahydrofuran; water for 1.5h; Ambient temperature;93%
With water; sodium hydroxide In ethanol at 20℃; for 19h;91%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

1-methoxy-1,3-cyclohexadiene
2161-90-2

1-methoxy-1,3-cyclohexadiene

Ethyl (1RS,2RS,3SR,4RS)-1-methoxy-3-trifluoromethylbicyclo<2.2.2>oct-5-ene-2-carboxylate
133961-04-3

Ethyl (1RS,2RS,3SR,4RS)-1-methoxy-3-trifluoromethylbicyclo<2.2.2>oct-5-ene-2-carboxylate

Conditions
ConditionsYield
With cis-2,3-dichlorobutenedioic acid; 2-tert-Butyl-4-methylphenol In benzene for 96h; Heating;96%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

2-amino-benzenethiol
137-07-5

2-amino-benzenethiol

ethyl 3-(2-aminophenyl)thio-4,4,4-trifluorobutyrate

ethyl 3-(2-aminophenyl)thio-4,4,4-trifluorobutyrate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 24h;95%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

diethyl malonate
105-53-3

diethyl malonate

3-(trifluoromethyl)pentanedioic acid
4162-55-4

3-(trifluoromethyl)pentanedioic acid

Conditions
ConditionsYield
With hydrogenchloride; potassium hydroxide; tetrabutylammomium bromide In tetrahydrofuran; water; acetic acid95%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

ethyl 4,4,4-trifluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate

ethyl 4,4,4-trifluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate

Conditions
ConditionsYield
With methanol; copper(l) iodide; potassium carbonate In tetrahydrofuran at 20℃; for 30h; Inert atmosphere; chemoselective reaction;95%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

3-(N'-tert-butoxycarbonylhydrazino)-4,4,4-trifluorobutyric acid ethyl ester
1123546-28-0

3-(N'-tert-butoxycarbonylhydrazino)-4,4,4-trifluorobutyric acid ethyl ester

Conditions
ConditionsYield
In methanol at 70℃; for 72h; Michael condensation;94%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

sodium methylate
124-41-4

sodium methylate

4,4,4-trifluoro-3-methoxybutanoic acid
1343115-14-9

4,4,4-trifluoro-3-methoxybutanoic acid

Conditions
ConditionsYield
In methanol at 20℃;93.8%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

cyclopentanone
120-92-3

cyclopentanone

Ethyl 3-(2'-oxocyclopentyl)-3-(trifluoromethyl)propionate

Ethyl 3-(2'-oxocyclopentyl)-3-(trifluoromethyl)propionate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -40 deg C, 4.0 h;93%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

3,5-dichlorosalicyclaldehyde
90-60-8

3,5-dichlorosalicyclaldehyde

ethyl 6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate
1160474-53-2

ethyl 6,8-dichloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With triethylamine In dimethyl sulfoxide at 85℃; for 72h;93%
regiospecific reaction;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 2,3-dibromo-4,4,4-trifluorobutanoate
363-57-5

ethyl 2,3-dibromo-4,4,4-trifluorobutanoate

Conditions
ConditionsYield
With bromine In tetrachloromethane for 5h; Heating;92%
With bromine In tetrachloromethane at 20℃; Reflux; Inert atmosphere;
With bromine In tetrachloromethane at 20℃; Inert atmosphere; Reflux;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

1-trifluoromethylprop-1-en-3-ol
83706-94-9

1-trifluoromethylprop-1-en-3-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether90%
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether at 0℃; for 2h; Hydrogenolysis;90%
With diisobutylaluminium hydride In tert-butyl methyl ether; toluene at -70 - 25℃; for 1h; Inert atmosphere;90%
4-butanolide
96-48-0

4-butanolide

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

Ethyl 3-butan-4'-olid-2'-yl-3-(trifluoromethyl)propionate

Ethyl 3-butan-4'-olid-2'-yl-3-(trifluoromethyl)propionate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 3.0 h;90%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

dimethyl methane phosphonate
756-79-6

dimethyl methane phosphonate

(E)-Dimethyl 2-oxo-5,5,5-trifluoro-3-pentenylphosphonate

(E)-Dimethyl 2-oxo-5,5,5-trifluoro-3-pentenylphosphonate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C, 2.0 h;90%
2-hydroxy-3-iodo-5-(trifluoromethoxy) benzaldehyde
775330-11-5

2-hydroxy-3-iodo-5-(trifluoromethoxy) benzaldehyde

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 8-iodo-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate
775330-12-6

ethyl 8-iodo-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With triethylamine at 85℃; for 66h;90%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 66h;90%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h;69%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h;69%
With triethylamine In N,N-dimethyl-formamide at 85℃; for 48h;69%
5-(benzyloxy)-4-bromo-2-hydroxybenzaldehyde
775335-97-2

5-(benzyloxy)-4-bromo-2-hydroxybenzaldehyde

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

ethyl 6-(benzyloxy)-7-bromo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

ethyl 6-(benzyloxy)-7-bromo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 65℃; for 4h;89%
3-bromofurane
22037-28-1

3-bromofurane

ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

C10H10BrF3O3
1353275-81-6

C10H10BrF3O3

Conditions
ConditionsYield
With Cl4SnC2HNOBC6H5CH(CH3)2(C6H5)2CH2C10H7 In dichloromethane at -78℃; for 8h; Diels-Alder reaction; Inert atmosphere; optical yield given as %ee; stereoselective reaction;89%
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

N-isopropyl oxazolidinone
77877-19-1

N-isopropyl oxazolidinone

(3R,4R,4'S)-Ethyl 3-(trifluoromethyl)-4-methyl-5-<4'-(1''-methylethyl)-2'-oxazolidinon-3'-yl>-5-oxopentanoate
138809-19-5

(3R,4R,4'S)-Ethyl 3-(trifluoromethyl)-4-methyl-5-<4'-(1''-methylethyl)-2'-oxazolidinon-3'-yl>-5-oxopentanoate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; Product distribution; multistep reaction; diastereoselectivity; other acyl oxazolidinones;88%
With lithium diisopropyl amide In tetrahydrofuran; hexane 1.) -78 deg C, 30 min, 2.) -78 deg C;88%
With lithium diisopropyl amide 1) THF, -78 deg C, 2) -78 deg C, 1.5 h; Yield given. Multistep reaction;
ethyl 4,4,4-trifluorocrotonate
25597-16-4

ethyl 4,4,4-trifluorocrotonate

methylhydrazine
60-34-4

methylhydrazine

1-methyl-5-(trifluoromethyl)-2,3,4,5-tetrahydropyrazol-3-one
153893-99-3

1-methyl-5-(trifluoromethyl)-2,3,4,5-tetrahydropyrazol-3-one

Conditions
ConditionsYield
at 20℃;88%

Ethyl 4,4,4-trifluorocrotonate Chemical Properties

IUPAC Name: Ethyl (E)-4,4,4-trifluorobut-2-enoate 
Molecular Formula: C6H7 F3 O2
Molecular Weight: 168.1138
Density: 1.191 g/cm3
Boiling Point: 114.5 °C at 760 mmHg
Flash Point: 25 ºC
Appearance: colorless and clear liquid
Freely Rotating Bonds: 3
Polar Surface Area: 26.3 Å2
Index of Refraction: 1.372
Molar Refractivity: 32.13 cm3
Molar Volume: 141 cm3
Polarizability: 12.73 ×10-24 cm3
Surface Tension: 22.2 dyne/cm
Enthalpy of Vaporization: 35.29 kJ/mol
Vapour Pressure: 19.9 mmHg at 25°C
The Cas Register Number  of 2-Butenoic acid,4,4,4-trifluoro-, ethyl ester, (2E)- is 25597-16-4 . The chemical synonyms of 2-Butenoic acid,4,4,4-trifluoro-, ethyl ester, (2E)- (CAS NO.25597-16-4) are 4.4.4-Trifluorocrotonic acid ethyl ester ; Ethyl 4,4,4-trifluorocrotonate ; Ethyl  4,4,4-Trifluoro-trans-2-butenoate ; Ethyl (2E)-4,4,4-trifluoro-2-butenoate ; Ethyl 4,4,4-trifluorocrotonate 98% ; Ethyl4,4,4-trifluorocrotonate98% ; 2-Butenoic acid, 4,4,4-trifluoro-, ethyl ester, (2E)- ; 4,4,4-trifluorocrotonate . The molecular structure of 2-Butenoic acid,4,4,4-trifluoro-, ethyl ester, (2E)- (CAS NO.25597-16-4) is.

Ethyl 4,4,4-trifluorocrotonate Uses

 2-Butenoic acid,4,4,4-trifluoro-, ethyl ester, (2E)- (CAS NO.25597-16-4) is used in organic reagent, pharmaceutical intermediate.

Ethyl 4,4,4-trifluorocrotonate Safety Profile

Hazard Codes: IrritantXi ,FlammableF
Risk Statements: 10-36/37-36/37/38 
R10: Flammable. 
R36/37: Irritating to eyes and respiratory system. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-27-28-36/37/39-37/39 
S16: Keep away from sources of ignition. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S27: Take off immediately all contaminated clothing. 
S28: After contact with skin, wash immediately with plenty of soap-suds. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S37/39: Wear suitable gloves and eye/face protection.
RIDADR: UN 3272 3/PG 3
WGK Germany: 3
Hazard Note: Flammable
HazardClass: 3
PackingGroup: III

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