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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Monoethyl fumarate Manufacturer/High quality/Best price/In stock

Cas:2459-05-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Monoethyl Fumarate supplier in China

Cas:2459-05-4

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Hefei TNJ chemical industry co.,ltd

ISO KOSHER HALAL Appearance:White to off-white crystal powder Storage:normal condition Package:25kg/bag or as require Application:food additives or other additives Transportation:normal condition, by sea,by air Port:shanghai

2459-05-4

Cas:2459-05-4

Min.Order:25 Kilogram

Negotiable

Type:Trading Company

inquiry

Xi'an Quanao Biotech Co., Ltd.

We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,

Monoethyl Fumarate CAS 2459-05-4

Cas:2459-05-4

Min.Order:1 Kilogram

FOB Price: $37.0 / 40.0

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% Fumaric acid monoethyl ester 2459-05-4 Producer

Cas:2459-05-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Monoethyl fumarate CAS:2459-05-4

Cas:2459-05-4

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 2459-05-4 with best price

Cas:2459-05-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name Monoethyl fumarate Synonyms (2E)-4-Ethoxy-4-oxo-2-butenoic acid;2-Butenedioic acid (E)-, monoethyl ester;ETHYL ACID FUMARATE;ETHYL HYDROGEN FUMARATE;ETHYL FUMARATE;ETHYL FUMARATE MONOESTER;F

Monoethyl fumarate CAS: 2459-05-4

Cas:2459-05-4

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Ethyl fumarate

Cas:2459-05-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Monoethyl fumarate

Cas:2459-05-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2459-05-4

Cas:2459-05-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Monoethyl Fumarate

Cas:2459-05-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethyl fumarate

Cas:2459-05-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: Monoethyl Fumarate CAS No.:2459-05-4 Molecule Formula:C6H7O4 Molecule Weight:143.12 Purity: 96.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard TEST

Best Quality Monoethyl Fumarate

Cas:2459-05-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

Monoethyl fumarate 2459-05-4

Cas:2459-05-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

Monoethyl fumarate

Cas:2459-05-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Greenutra Resource Inc

Fumaric acid monoethyl esterAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

Fumaric acid monoethyl ester

Cas:2459-05-4

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Hot Sale Monoethyl Fumarate 2459-05-4

Cas:2459-05-4

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

Ethyl hydrogen fumarate

Cas:2459-05-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec (E)-4-Ethoxy-4-oxobut-2-enoic acid 100g

Cas:2459-05-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Monoethyl Fumarate

Cas:2459-05-4

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

diethyl Fumarate
623-91-6

diethyl Fumarate

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 8h; Ambient temperature;89%
With Candida antarctica lipase; water In 1,4-dioxane for 144h;78%
ethyl acetate
141-78-6

ethyl acetate

maleic acid
110-16-7

maleic acid

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With iron(III) perchlorate for 2h; Ambient temperature;87%
carbon dioxide
124-38-9

carbon dioxide

3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-acrylic acid ethyl ester
1263187-14-9

3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-acrylic acid ethyl ester

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With potassium methanolate; copper(l) chloride In N,N-dimethyl acetamide at 70℃; under 760.051 Torr; for 24h; Inert atmosphere; Schlenk technique; Sealed tube;76%
ethyl (2E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acrylate
1009307-13-4

ethyl (2E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acrylate

carbon dioxide
124-38-9

carbon dioxide

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With potassium methanolate; copper(l) chloride In N,N-dimethyl acetamide at 70℃; for 24h; Sealed tube; Schlenk technique;76%
malonic acid monoethyl ester
2459-05-4, 3249-53-4, 3990-03-2

malonic acid monoethyl ester

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With aluminum (III) chloride at 70℃; for 2h;58%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

ethyl 2-diazo-3-methyl-3-butenoate
126580-11-8

ethyl 2-diazo-3-methyl-3-butenoate

A

malonic acid monoethyl ester
2459-05-4, 3249-53-4, 3990-03-2

malonic acid monoethyl ester

B

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

C

diethyl 2-methylcyclobutene-1,3-dicarboxylate
1198173-63-5

diethyl 2-methylcyclobutene-1,3-dicarboxylate

Conditions
ConditionsYield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate In dichloromethane at 20℃; for 2h; Inert atmosphere;A n/a
B n/a
C 33%
maleic anhydride
108-31-6

maleic anhydride

ethanol
64-17-5

ethanol

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With thionyl chloride
With TEA
Stage #1: maleic anhydride; ethanol at 60℃; for 3h;
Stage #2: With aluminum (III) chloride at 20 - 90℃; for 2h;
ethanol
64-17-5

ethanol

malic acid
617-48-1

malic acid

A

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

B

diethyl Fumarate
623-91-6

diethyl Fumarate

Conditions
ConditionsYield
With hydrogenchloride
ethanol
64-17-5

ethanol

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
at 120℃;
With hydrogenchloride
ethanol
64-17-5

ethanol

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

A

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

B

diethyl Fumarate
623-91-6

diethyl Fumarate

Conditions
ConditionsYield
With sulfuric acid
at 120℃;
Diethyl maleate
141-05-9

Diethyl maleate

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With potassium hydroxide; ethanol Schuetteln, Filtrieren, Verdunsten des Filtrats, Loesen des Rueckstands in Wasser und Schuetteln mit Aether aus; der waessr.Loesung mit Salzsaeure Uebersaettigen und mit Aether Ausschuetteln;
1,3,5,7,9,10-hexahydro-3,7,10-trimethylpyrimido<5,4-g>pteridine-2,4,6,8-tetrone
82639-48-3

1,3,5,7,9,10-hexahydro-3,7,10-trimethylpyrimido<5,4-g>pteridine-2,4,6,8-tetrone

diethyl Fumarate
623-91-6

diethyl Fumarate

A

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

B

3,7,10-trimethyl-(1H,3H,7H,10H)-pyrimido<5-4-g>pteridine-2,4,6,8-tetrone
82639-46-1

3,7,10-trimethyl-(1H,3H,7H,10H)-pyrimido<5-4-g>pteridine-2,4,6,8-tetrone

C

(2E)-but-2-enedioic acid
110-17-8

(2E)-but-2-enedioic acid

D

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 30℃; for 12h; Rate constant; pH=7.00;A 19 % Spectr.
B n/a
C 10 % Spectr.
D 32 % Chromat.
selenium(IV) oxide
7446-08-4

selenium(IV) oxide

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

A

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

B

diethyl Fumarate
623-91-6

diethyl Fumarate

Conditions
ConditionsYield
at 170℃;
glyoxylic acid ethyl ester
924-44-7

glyoxylic acid ethyl ester

diethylphosphonoacetic acid
3095-95-2

diethylphosphonoacetic acid

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
Stage #1: diethylphosphonoacetic acid With sodium hydride In 1,2-dimethoxyethane at 20℃;
Stage #2: glyoxylic acid ethyl ester In 1,2-dimethoxyethane at 20℃; Further stages.;
maleic anhydride
108-31-6

maleic anhydride

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
iodine In ethanol
but-2-enedioic acid tert-butyl ester ethyl ester
107679-25-4

but-2-enedioic acid tert-butyl ester ethyl ester

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
With water Alkaline conditions;
malonic acid monoethyl ester
2459-05-4, 3249-53-4, 3990-03-2

malonic acid monoethyl ester

thiourea
17356-08-0

thiourea

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Conditions
ConditionsYield
In water at 80 - 85℃; for 4h;112 g
[(dimethoxyphosphinothioyl)thio]-butanedioic acid, diethyl ester
121-75-5

[(dimethoxyphosphinothioyl)thio]-butanedioic acid, diethyl ester

A

malathion alpha-dicarboxylic acid
1190-28-9

malathion alpha-dicarboxylic acid

B

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

C

S-(1,2-dicarboethoxyethyl)O,S-dimethyl phosphorodithioate
3344-12-5

S-(1,2-dicarboethoxyethyl)O,S-dimethyl phosphorodithioate

D

malathion monocarboxylic acid
1190-29-0

malathion monocarboxylic acid

E

oxallic acid isobutyle nonyl ester

oxallic acid isobutyle nonyl ester

F

Diethyl maleate
141-05-9

Diethyl maleate

Conditions
ConditionsYield
With carboxylesterase from Escherichia coli IES-02 In aq. phosphate buffer at 37℃; for 1h; pH=7.5; Catalytic behavior; Enzymatic reaction;
Sorbyl alcohol
17102-64-6

Sorbyl alcohol

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

ethyl (2E,4E)-hexa-2,4-dien-1-yl fumarate
160386-62-9

ethyl (2E,4E)-hexa-2,4-dien-1-yl fumarate

Conditions
ConditionsYield
With dmap; 2`,3`-dideoxycytidine In dichloromethane Ambient temperature;100%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 3.5h;90%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

octa-4t,6t-dien-3-ol
186417-99-2

octa-4t,6t-dien-3-ol

(E)-But-2-enedioic acid ethyl ester (2E,4E)-1-ethyl-hexa-2,4-dienyl ester
186418-00-8

(E)-But-2-enedioic acid ethyl ester (2E,4E)-1-ethyl-hexa-2,4-dienyl ester

Conditions
ConditionsYield
With dmap; 2`,3`-dideoxycytidine In dichloromethane Ambient temperature;100%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

4-methoxy-aniline
104-94-9

4-methoxy-aniline

(E)–4-((4-methoxyphenyl)amino)-4-oxobut-2-enoic acid
37904-20-4

(E)–4-((4-methoxyphenyl)amino)-4-oxobut-2-enoic acid

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With oxalyl dichloride; N,N-dimethyl-formamide In benzene at 20℃; for 4h; Inert atmosphere;
Stage #2: 4-methoxy-aniline With caesium carbonate In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #3: With potassium hydroxide; water In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;
100%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

4-nitro-aniline
100-01-6

4-nitro-aniline

fumaric acid mono-N-(4-nitrophenyl)amide
37904-21-5

fumaric acid mono-N-(4-nitrophenyl)amide

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With oxalyl dichloride; N,N-dimethyl-formamide In benzene at 20℃; for 4h; Inert atmosphere;
Stage #2: 4-nitro-aniline With caesium carbonate In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #3: With potassium hydroxide; water In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;
100%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

(-)-(4E,6Z)-(1'R,2R,3S)-1,2,3-trihydroxy-1,3-O-ethylidene-4,6-octadiene
937172-42-4

(-)-(4E,6Z)-(1'R,2R,3S)-1,2,3-trihydroxy-1,3-O-ethylidene-4,6-octadiene

(-)-(4E,6Z)-(1'R,2R,3S)-1,3-dihydroxy-1,3-O-ethylidene-4,6-octadien-2-yl ethyl fumarate
937172-48-0

(-)-(4E,6Z)-(1'R,2R,3S)-1,3-dihydroxy-1,3-O-ethylidene-4,6-octadien-2-yl ethyl fumarate

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With dmap In dichloromethane at 20℃; for 0.166667h; Inert atmosphere;
Stage #3: (-)-(4E,6Z)-(1'R,2R,3S)-1,2,3-trihydroxy-1,3-O-ethylidene-4,6-octadiene In dichloromethane for 1h; Inert atmosphere; Reflux;
100%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

4-hydroxy-1-naphthaldehyde
7770-45-8

4-hydroxy-1-naphthaldehyde

4-aminomethylphenol
696-60-6

4-aminomethylphenol

C29H32N2O6

C29H32N2O6

Conditions
ConditionsYield
With lithium chloride; sodium hydroxide In water at 50℃; under 7500.75 Torr; for 1h; pH=7; Inert atmosphere; Microwave irradiation;100%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

4-hydroxy-1-naphthaldehyde
7770-45-8

4-hydroxy-1-naphthaldehyde

benzylamine
100-46-9

benzylamine

C29H32N2O5

C29H32N2O5

Conditions
ConditionsYield
With lithium chloride; sodium hydroxide In water at 50℃; under 7500.75 Torr; for 1h; pH=7; Inert atmosphere; Microwave irradiation;100%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

N-methyl-1-naphthalenemethylamine hydrochloride
65473-13-4

N-methyl-1-naphthalenemethylamine hydrochloride

trans-3-(N-methyl-1-naphthylmethylcarbamoyl)propenoic acid ethyl ester

trans-3-(N-methyl-1-naphthylmethylcarbamoyl)propenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane
Stage #2: N-methyl-1-naphthalenemethylamine hydrochloride In dichloromethane Further stages.;
99%
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 0.5h;
Stage #2: N-methyl-1-naphthalenemethylamine hydrochloride In dichloromethane at 20℃; for 4h; Further stages.;
99%
piperidine
110-89-4

piperidine

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

trans-3-(1-piperidylcarbonyl)propenoic acid ethyl ester
92912-62-4

trans-3-(1-piperidylcarbonyl)propenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 0.5h;
Stage #2: piperidine In dichloromethane at 20℃; for 4h; Further stages.;
99%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

N-methylaniline
100-61-8

N-methylaniline

(E)-4-(methylphenylamino)-4-oxo-2-butenoic acid ethyl ester
1027101-46-7

(E)-4-(methylphenylamino)-4-oxo-2-butenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 0.5h;
Stage #2: N-methylaniline In dichloromethane at 20℃; for 4h; Further stages.;
99%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

benzyl-methyl-amine
103-67-3

benzyl-methyl-amine

(E)-4-[methyl(phenylmethyl)amino]-4-oxo-2-butenoic acid ethyl ester
945379-56-6

(E)-4-[methyl(phenylmethyl)amino]-4-oxo-2-butenoic acid ethyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 25℃;98%
76%
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane
Stage #2: benzyl-methyl-amine In dichloromethane Further stages.;
76%
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 0.5h;
Stage #2: benzyl-methyl-amine In dichloromethane at 20℃; for 4h; Further stages.;
76%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

fumaric acid ethyl ester mono chloride
26367-48-6

fumaric acid ethyl ester mono chloride

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 24h;97%
With oxalyl dichloride In N,N-dimethyl-formamide93%
With dmap; oxalyl dichloride In dichloromethane at 20℃; for 1.5h;93%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

(+/-)-2-(Bromomethyl)-1-butanol
40893-97-8

(+/-)-2-(Bromomethyl)-1-butanol

(+/-)-Ethyl (E)-3-((2-(bromomethyl)butoxy)carbonyl)prop-2-enoate
155529-26-3

(+/-)-Ethyl (E)-3-((2-(bromomethyl)butoxy)carbonyl)prop-2-enoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide97%
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; Ambient temperature;97%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Di(tert-butyl)-N-(3-aminopropyl)-N,N'-(ethan-1,2-diyl)bis
142039-01-8

Di(tert-butyl)-N-(3-aminopropyl)-N,N'-(ethan-1,2-diyl)bis

3-{3-[BOC-(2-BOC-Aminoethyl)-amino]-propylcarbamoyl}-acrylic acid ethyl ester

3-{3-[BOC-(2-BOC-Aminoethyl)-amino]-propylcarbamoyl}-acrylic acid ethyl ester

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;97%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

(2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)prop-2-en-1-ol
610768-33-7

(2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)prop-2-en-1-ol

(2E)-2-butenedioic acid (2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl ester ethyl ester
610768-45-1

(2E)-2-butenedioic acid (2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl ester ethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at -78 - 20℃; for 4h;97%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Benzyl isocyanide
88333-03-3, 10340-91-7

Benzyl isocyanide

pivalaldehyde
630-19-3

pivalaldehyde

benzylamine
100-46-9

benzylamine

(E)-ethyl 4-(benzyl(1-(benzylamino)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobut-2-enoate

(E)-ethyl 4-(benzyl(1-(benzylamino)-3,3-dimethyl-1-oxobutan-2-yl)amino)-4-oxobut-2-enoate

Conditions
ConditionsYield
In dichloromethane at 200℃; under 13501.4 Torr; for 0.333333h; Ugi reaction; microwave irradiation;97%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

C8H13N3O3S
220378-49-4

C8H13N3O3S

(2E)-2-butenedioic acid (2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl ester ethyl ester
610768-45-1

(2E)-2-butenedioic acid (2E)-3-(1-dimethylsulfamoyl-1H-imidazol-4-yl)-2-propenyl ester ethyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere;97%
N-(2-pyrimidyl)indole
221044-05-9

N-(2-pyrimidyl)indole

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

(E)-3-(1-pyrimidin-2-yl-1H-indol-2-yl)-acrylic acid ethyl ester

(E)-3-(1-pyrimidin-2-yl-1H-indol-2-yl)-acrylic acid ethyl ester

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; 2,2-dimethylpropanoic anhydride In toluene at 140℃; for 1h; Inert atmosphere; stereoselective reaction;97%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

benzyl bromide
100-39-0

benzyl bromide

1-benzyl-4-ethyl-(2E)-but-2-endioate

1-benzyl-4-ethyl-(2E)-but-2-endioate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;97%
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 16h;42.9 g
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

(-)-(E)-(1'R,2R,3S)-1,2,3-trihydroxy-1,3-O-ethylidene-5-methyl-4,6-heptadiene
1310682-99-5

(-)-(E)-(1'R,2R,3S)-1,2,3-trihydroxy-1,3-O-ethylidene-5-methyl-4,6-heptadiene

(-)-(E)-(1'R,2R,3S)-1,3-dihydroxy-1,3-O-ethylidene-5-methyl-4,6-heptadien-2-yl ethyl fumarate
1310683-04-5

(-)-(E)-(1'R,2R,3S)-1,3-dihydroxy-1,3-O-ethylidene-5-methyl-4,6-heptadien-2-yl ethyl fumarate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 1h; Inert atmosphere; Reflux;96%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

pivaloyl chloride
3282-30-2

pivaloyl chloride

C11H16O5

C11H16O5

Conditions
ConditionsYield
With triethylamine In dichloromethane at -25 - 20℃; Solvent; Temperature; Time; Cooling with acetone-dry ice;96%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

Benzyl isocyanide
88333-03-3, 10340-91-7

Benzyl isocyanide

β-naphthaldehyde
66-99-9

β-naphthaldehyde

4-methoxy-benzylamine
2393-23-9

4-methoxy-benzylamine

(E)-ethyl 4-((2-(benzylamino)-1-(naphthalen-2-yl)-2-oxoethyl)(4-methoxybenzyl)amino)-4-oxobut-2-enoate

(E)-ethyl 4-((2-(benzylamino)-1-(naphthalen-2-yl)-2-oxoethyl)(4-methoxybenzyl)amino)-4-oxobut-2-enoate

Conditions
ConditionsYield
In dichloromethane at 200℃; under 13501.4 Torr; for 0.333333h; Ugi reaction; microwave irradiation;95%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

tert-butylisonitrile
119072-55-8, 7188-38-7

tert-butylisonitrile

α-methyl-p-hydroxybenzylamine
134855-87-1

α-methyl-p-hydroxybenzylamine

pivalaldehyde
630-19-3

pivalaldehyde

C24H36N2O5

C24H36N2O5

Conditions
ConditionsYield
In water at 200℃; under 13501.4 Torr; microwave irradiation;95%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

N-benzyl-1-(4-fluorophenyl)methanamine
55096-88-3

N-benzyl-1-(4-fluorophenyl)methanamine

trans-3-(benzyl-4-fluorobenzyl)carbamoylpropenoic acid ethyl ester
1027101-48-9

trans-3-(benzyl-4-fluorobenzyl)carbamoylpropenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 0.5h;
Stage #2: N-benzyl-1-(4-fluorophenyl)methanamine In dichloromethane at 20℃; for 4h; Further stages.;
95%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

dibutylamine
111-92-2

dibutylamine

trans-3-dibutylcarbamoylpropenoic acid ethyl ester
109447-28-1

trans-3-dibutylcarbamoylpropenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 0.5h;
Stage #2: dibutylamine In dichloromethane at 20℃; for 4h; Further stages.;
95%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

diethylamine
109-89-7

diethylamine

trans-3-diethylcarbamoylpropenoic acid ethyl ester
110793-11-8

trans-3-diethylcarbamoylpropenoic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate In dichloromethane at -20℃; for 0.5h;
Stage #2: diethylamine In dichloromethane at 20℃; for 4h; Further stages.;
95%
morpholine
110-91-8

morpholine

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

(E)-4-(4-morpholinyl)-4-oxo-2-butenoic acid ethyl ester
92912-63-5

(E)-4-(4-morpholinyl)-4-oxo-2-butenoic acid ethyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 25℃;95%
(S)-3-amino-2-(tert-butyldiphenylsilanyloxy)propylcarbamic acid tert-butyl ester
1007217-08-4

(S)-3-amino-2-(tert-butyldiphenylsilanyloxy)propylcarbamic acid tert-butyl ester

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

C30H42N2O6Si
1373889-07-6

C30H42N2O6Si

Conditions
ConditionsYield
With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 20℃; for 12h; Inert atmosphere;94%
isocyanate de chlorosulfonyle
1189-71-5

isocyanate de chlorosulfonyle

(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

(E)-4-ethoxy-4-oxobut-2-enoic anhydride
675876-18-3

(E)-4-ethoxy-4-oxobut-2-enoic anhydride

Conditions
ConditionsYield
With triethylamine In dichloromethane at -25 - 10℃; for 6.5h; Solvent; Temperature; Time; Cooling with acetone-dry ice;94%
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

2,2-Diphenylethylamine
3963-62-0

2,2-Diphenylethylamine

fumaric acid mono-2,2-diphenylethylamide monoethyl ester
573986-11-5

fumaric acid mono-2,2-diphenylethylamide monoethyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane at 20℃; for 20h;93%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane85%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 24h;85%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 48h; Inert atmosphere;71%

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