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Hangzhou Think Chemical Co. Ltd

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate CAS No.:191226-98-9 HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research a

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

TERT-BUTYL ((2S,3R)-3-HYDROXY-4-(N-ISOBUTYL-4-NITROPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YL)CARBAMATE

Cas:191226-98-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

{(1S,2R)-1-Benzyl-2-hydroxy-3-{isobutyl-[(4-nitrophenyl)-sulfonyl]-amino}-propyl}-carbamic acid tert-butyl ester

Cas:191226-98-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Competitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 191226-98-9 with competitive price

Cas:191226-98-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Orga

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamateCAS NO.191226-98-9

Cas:191226-98-9

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

191226-98-9 tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate CAS:191226-98-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

TERT-BUTYL [(1S,2R)-1-BENZYL-2-HYDROXY-3-[ISOBUTYL[(4-NITROPHENYL)SULFONYL]AMINO]PROPYL]CARBAMATE

Cas:191226-98-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl[(4-nitro-phenyl)sulfonyl)]amino]propyl]-carbamic Acid tert-Butyl Ester

Cas:191226-98-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

TERT-BUTYL ((2S,3R)-3-HYDROXY-4-(N-ISOBUTYL-4-NITROPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YL)CARBAMATE

Cas:191226-98-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

Product Name: tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate Synonyms: [(1S,2R)-1-Benzyl-2-hydroxy…Appearance:Solid powder Storage:Sealed,light and oxygen resistant Package:aluminum foil bag,carton

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tert-Butyl[(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

191226-98-9 CAS NO.191226-98-9

Cas:191226-98-9

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:Sealed in a cool ,dry and microtherm place , avoid light . Package:100g/bottle,1kg/bottle,25kg/drum or as per your request Application:It is an impo

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Guangdong Juda Chemical Industrial Co.,Limited

Factory supply high purity low priceAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

Wuhan Circle Star Chem-medical Technology co.,Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:White to Off-White Solid Storage:Keep it in dry,shady and cool place Package:as your requirement Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by Sea

tert-Butyl [(1S,2R)-1-benzyl-2-hydroxy-3-[isobutyl[(4-nitrophenyl)sulfonyl]amino]propyl]carbamate

Cas:191226-98-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol
160232-08-6

(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water at 20℃; for 21h;100%
With dmap; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 25℃; for 4h;98.2%
With sodium hydrogencarbonate In dichloromethane; water at 23℃; for 12h;96%
isobutylamine
78-81-9

isobutylamine

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
98760-08-8, 98818-34-9, 98818-35-0, 103127-56-6, 98737-29-2

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: isobutylamine; (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester for 3h; Heating;
Stage #2: 4-Nitrobenzenesulfonyl chloride With triethylamine In dichloromethane Reflux;
92.88%
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
98760-08-8, 98818-34-9, 98818-35-0, 103127-56-6, 98737-29-2

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 3 h / 80 °C
2: aq. Na2CO3 / CH2Cl2 / 0 - 20 °C
View Scheme
Multi-step reaction with 2 steps
1: propan-2-ol / 2 h / 80 °C
2: 0.88 g / triethylamine / CH2Cl2 / 4 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 97 percent / propan-2-ol / 3 h / 80 °C
2: 90 percent / Et3N / CH2Cl2 / 16 h
View Scheme
2(R)-((tert-butyloxycarbonyl)amino)-1,4-dichloro-3(S)-hydroxybutane
326479-99-6

2(R)-((tert-butyloxycarbonyl)amino)-1,4-dichloro-3(S)-hydroxybutane

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: p-TsOH*H2O / CH2Cl2
2.1: NaH / tetrahydrofuran
3.1: CuBr*SMe2 / tetrahydrofuran
4.1: p-TsOH*H2O
4.2: KOH / methanol
5.1: 90 percent / propan-2-ol / 5 h / 50 °C
6.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1: 100 percent / imidazole; DMAP / dimethylformamide / 12 h / 50 °C
2: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C
3: 75 percent / CuBr*Me2S / toluene; tetrahydrofuran / -78 - -20 °C
4: Bu4NF / tetrahydrofuran
5: 90 percent / propan-2-ol / 5 h / 50 °C
6: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 100 percent / imidazole; DMAP / dimethylformamide / 12 h / 50 °C
2.1: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C
3.1: 82 percent / Et3N / methanol / 18 h / 20 °C
4.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C
4.2: 75 percent / KOH / methanol / 2 h / 20 °C
5.1: 90 percent / propan-2-ol / 5 h / 50 °C
6.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
N-t-butyloxycarbonyl-2(S)-(1(S)-t-butyldimethylsilyloxy-2-chloroethyl)aziridine
326480-01-7

N-t-butyloxycarbonyl-2(S)-(1(S)-t-butyldimethylsilyloxy-2-chloroethyl)aziridine

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 75 percent / CuBr*Me2S / toluene; tetrahydrofuran / -78 - -20 °C
2: Bu4NF / tetrahydrofuran
3: 90 percent / propan-2-ol / 5 h / 50 °C
4: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 82 percent / Et3N / methanol / 18 h / 20 °C
2.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C
2.2: 75 percent / KOH / methanol / 2 h / 20 °C
3.1: 90 percent / propan-2-ol / 5 h / 50 °C
4.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
(S)-2-[(S)-2-Chloro-1-(tetrahydro-pyran-2-yloxy)-ethyl]-aziridine-1-carboxylic acid tert-butyl ester
357604-37-6

(S)-2-[(S)-2-Chloro-1-(tetrahydro-pyran-2-yloxy)-ethyl]-aziridine-1-carboxylic acid tert-butyl ester

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: CuBr*SMe2 / tetrahydrofuran
2.1: p-TsOH*H2O
2.2: KOH / methanol
3.1: 90 percent / propan-2-ol / 5 h / 50 °C
4.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
2(S)-t-butyldimethylsilyloxy-3(R)-(t-butyloxycarbonyl)amino-1,4-dichlorobutane
326480-00-6

2(S)-t-butyldimethylsilyloxy-3(R)-(t-butyloxycarbonyl)amino-1,4-dichlorobutane

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C
2: 75 percent / CuBr*Me2S / toluene; tetrahydrofuran / -78 - -20 °C
3: Bu4NF / tetrahydrofuran
4: 90 percent / propan-2-ol / 5 h / 50 °C
5: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C
2.1: 82 percent / Et3N / methanol / 18 h / 20 °C
3.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C
3.2: 75 percent / KOH / methanol / 2 h / 20 °C
4.1: 90 percent / propan-2-ol / 5 h / 50 °C
5.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
[(1R,2S)-3-Chloro-1-chloromethyl-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid tert-butyl ester
357604-36-5

[(1R,2S)-3-Chloro-1-chloromethyl-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid tert-butyl ester

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: NaH / tetrahydrofuran
2.1: CuBr*SMe2 / tetrahydrofuran
3.1: p-TsOH*H2O
3.2: KOH / methanol
4.1: 90 percent / propan-2-ol / 5 h / 50 °C
5.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
[(1S,2S)-1-Benzyl-3-chloro-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid tert-butyl ester
357604-38-7

[(1S,2S)-1-Benzyl-3-chloro-2-(tetrahydro-pyran-2-yloxy)-propyl]-carbamic acid tert-butyl ester

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: p-TsOH*H2O
1.2: KOH / methanol
2.1: 90 percent / propan-2-ol / 5 h / 50 °C
3.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
2(S)-t-butyldimethylsilyloxy-3(S)-(t-butyloxycarbonyl)amino-1-chloro-4-phenylbutane
326480-02-8

2(S)-t-butyldimethylsilyloxy-3(S)-(t-butyloxycarbonyl)amino-1-chloro-4-phenylbutane

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Bu4NF / tetrahydrofuran
2: 90 percent / propan-2-ol / 5 h / 50 °C
3: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane
357604-39-8

(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: TBAF / tetrahydrofuran / 0.67 h / 20 °C
1.2: 75 percent / KOH / methanol / 2 h / 20 °C
2.1: 90 percent / propan-2-ol / 5 h / 50 °C
3.1: 88 percent / Et3N / CH2Cl2 / 12 h / 20 °C
View Scheme
tert-butyl ((2S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
1229623-13-5

tert-butyl ((2S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium hydrogencarbonate / dichloromethane / 5 h / Reflux
2.1: triethylamine / dichloromethane / Reflux
2.2: Reflux
View Scheme
1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane
220871-52-3

1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: isopropyl alcohol / 6 h / 80 °C
2: triethylamine / dichloromethane / 12 h / 0 - 20 °C
View Scheme
N-(tert-butoxycarbonyl)-L-phenylalanine chlorohydrine

N-(tert-butoxycarbonyl)-L-phenylalanine chlorohydrine

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / dichloromethane / 5 h / Reflux
2: triethylamine / dichloromethane / Reflux
View Scheme
4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1,4-dioxane / 1 h / 10 - 25 °C
2: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 1,4-dioxane / 6 h / 80 - 85 °C
View Scheme
N-isobutyl-4-nitrobenzenesulfonamide
89840-80-2

N-isobutyl-4-nitrobenzenesulfonamide

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
98760-08-8, 98818-34-9, 98818-35-0, 103127-56-6, 98737-29-2

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In 1,4-dioxane at 80 - 85℃; for 6h;10 g
tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate
165727-45-7

tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium carbonate / water / 3 h / 60 - 65 °C
2: triethylamine / dichloromethane / 40 - 45 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium hydroxide / ethanol / 15 - 20 °C / Large scale
2: triethylamine / isopropyl alcohol / 40 - 60 °C / Large scale
View Scheme
C15H20N3O3(1+)
910642-68-1

C15H20N3O3(1+)

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: hydrogenchloride
2: aluminum isopropoxide / isopropyl alcohol / 3 h / Reflux
3: sodium carbonate / water / 3 h / 60 - 65 °C
4: triethylamine / dichloromethane / 40 - 45 °C
View Scheme
(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
102123-74-0

(S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aluminum isopropoxide / isopropyl alcohol / 3 h / Reflux
2: sodium carbonate / water / 3 h / 60 - 65 °C
3: triethylamine / dichloromethane / 40 - 45 °C
View Scheme
Multi-step reaction with 3 steps
1: aluminum isopropoxide / isopropyl alcohol / 3 h / Reflux
2: sodium carbonate / water / 3 h / 60 - 65 °C
3: triethylamine / dichloromethane / 40 - 45 °C
View Scheme
Multi-step reaction with 3 steps
1: aluminum sec-butoxide / toluene; 2-methyl-propan-1-ol / 15 - 20 °C / Large scale
2: potassium hydroxide / ethanol / 15 - 20 °C / Large scale
3: triethylamine / isopropyl alcohol / 40 - 60 °C / Large scale
View Scheme
N-tert-butoxycarbonyl-L-phenylalanine
13734-34-4

N-tert-butoxycarbonyl-L-phenylalanine

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine
2: aluminum sec-butoxide / toluene; 2-methyl-propan-1-ol / 15 - 20 °C / Large scale
3: potassium hydroxide / ethanol / 15 - 20 °C / Large scale
4: triethylamine / isopropyl alcohol / 40 - 60 °C / Large scale
View Scheme
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
98760-08-8

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: isopropyl alcohol / 20 - 30 °C
2: triethylamine / dichloromethane / 15 - 25 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride
251105-80-3

N-(3S-amino-2R-hydroxy-4-phenylbutyl)-N-isobutyl-4-nitro-benzenesulfonamide hydrochloride

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 3h;100%
With trifluoroacetic acid In dichloromethane for 3h;83%
With trifluoroacetic acid In dichloromethane at 25℃; for 2h;69.2%
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide
169280-56-2

4-amino-N-(2R,3S)(3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide

Conditions
ConditionsYield
Stage #1: [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester With palladium 10% on activated carbon; ammonium formate; acetic acid In tetrahydrofuran at 15 - 20℃; Large scale;
Stage #2: With hydrogenchloride In tetrahydrofuran; water at 35 - 45℃; Large scale;
99.4%
Stage #1: [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester With triethanolamine; hydrogen; palladium 10% on activated carbon In methanol at 40 - 45℃; for 2h;
Stage #2: With hydrogenchloride; water for 2h; Reflux;
Stage #3: With sodium hydroxide In water; isopropyl alcohol at 20℃; for 10h; pH=9 - 10;
95%
Multi-step reaction with 2 steps
1: 95 percent / H2 / Pd/C / ethyl acetate / 11 h / 23 °C
2: CF3COOH / CH2Cl2 / 0.67 h / 23 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-S-(N-tert-butyloxyformamido)-[2R-hydroxy-1-[(4-aminophenylsulfonyl)(2-methylpropyl)]amino]-4-phenylbutane
183004-94-6

3-S-(N-tert-butyloxyformamido)-[2R-hydroxy-1-[(4-aminophenylsulfonyl)(2-methylpropyl)]amino]-4-phenylbutane

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol at 22 - 30℃; Product distribution / selectivity;97%
With hydrogen; palladium dihydroxide In ethyl acetate for 4h;95%
With hydrogen; palladium on activated charcoal In ethyl acetate at 23℃; for 11h;95%
oxalic acid
144-62-7

oxalic acid

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

1-benzyl-2-hydroxy-3-([isobutyl-(4-aminobenzenesulfonyl)amino]propyl)carbamic acid tert-butyl ester oxalate

1-benzyl-2-hydroxy-3-([isobutyl-(4-aminobenzenesulfonyl)amino]propyl)carbamic acid tert-butyl ester oxalate

Conditions
ConditionsYield
Stage #1: [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester With hydrogen In isopropyl alcohol at 25 - 35℃; under 3750.38 - 4500.45 Torr;
Stage #2: oxalic acid In toluene at 0 - 30℃; for 3h; Solvent; Reagent/catalyst;
90%
1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione
138499-08-8

1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

4-nitro-N-((2R(syn),3S)-2-hydroxy-4-phenyl-3-((S)-tetrahydrofuran-3-yloxycarbonylamino)-butyl)-N-isobutylbenzenesulfonamide
160231-69-6

4-nitro-N-((2R(syn),3S)-2-hydroxy-4-phenyl-3-((S)-tetrahydrofuran-3-yloxycarbonylamino)-butyl)-N-isobutylbenzenesulfonamide

Conditions
ConditionsYield
Stage #1: [(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester With hydrogenchloride In dichloromethane for 1.5h;
Stage #2: 1-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}oxy)-2,5-pyrrolidinedione With triethylamine In dichloromethane at 20℃; for 4h; Further stages.;
85%
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]amine hydrochloride
244634-31-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]amine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane at 0 - 20℃;85%
With hydrogenchloride In ethanol80%
With hydrogenchloride In ethanol; water at 75 - 80℃; for 1h;173 g
With hydrogenchloride In ethanol; dichloromethane; water at 5 - 80℃; for 2h; Solvent;330 g
bis-(p-nitrophenyl) carbonate
5070-13-3

bis-(p-nitrophenyl) carbonate

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester 4-nitro-phenyl ester
229495-94-7

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester 4-nitro-phenyl ester

Conditions
ConditionsYield
With lithium hydroxide In N,N-dimethyl-formamide at 20℃; for 2h;80%
Allyl chloroformate
2937-50-0

Allyl chloroformate

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Carbonic acid allyl ester (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester
599173-46-3

Carbonic acid allyl ester (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at 0 - 20℃;36%
methyl chloroformate
79-22-1

methyl chloroformate

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester methyl ester
599173-45-2

Carbonic acid (1R,2S)-2-tert-butoxycarbonylamino-1-{[isobutyl-(4-nitro-benzenesulfonyl)-amino]-methyl}-3-phenyl-propyl ester methyl ester

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran at 0 - 20℃; for 3h;13%
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

C28H39N3O6S

C28H39N3O6S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / H2 / Pd/C / ethyl acetate / 11 h / 23 °C
2: CF3COOH / CH2Cl2 / 0.67 h / 23 °C
3: 75 percent / iPr2NEt / acetonitrile / 8 h / 23 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
3: SnCl2*2H2O / ethyl acetate / 80 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
3: SnCl2*2H2O / ethyl acetate / 80 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide
919081-52-0

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide
919081-33-7

2-oxo-3-phenyl-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(3-fluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

3-(3-fluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
3: SnCl2*2H2O / ethyl acetate / 80 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(3-fluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide
919081-34-8

3-(3-fluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(4-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide
919081-38-2

3-(4-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(3,4-difluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

3-(3,4-difluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
3: SnCl2*2H2O / ethyl acetate / 80 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(3-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide
919081-37-1

3-(3-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(3-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

3-(3-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
3: SnCl2*2H2O / ethyl acetate / 80 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(4-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

3-(4-acetyl-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
3: SnCl2*2H2O / ethyl acetate / 80 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

3-(3,4-difluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide
919081-35-9

3-(3,4-difluoro-phenyl)-2-oxo-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

2-oxo-3-(3-trifluoromethyl-phenyl)-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

2-oxo-3-(3-trifluoromethyl-phenyl)-oxazolidine-5-carboxylic acid {3-[(4-amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
3: SnCl2*2H2O / ethyl acetate / 80 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

2-oxo-3-(3-trifluoromethyl-phenyl)-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide
919081-36-0

2-oxo-3-(3-trifluoromethyl-phenyl)-oxazolidine-5-carboxylic acid {1-benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: TFA / CH2Cl2 / 1 h
2: Et3N / tetrahydrofuran / 20 °C
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

(S)-N-{(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide

(S)-N-{(1S,2R)-3-[(4-Amino-benzenesulfonyl)-isobutyl-amino]-1-benzyl-2-hydroxy-propyl}-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2 / Pd(OH)2 on carbon / ethyl acetate / 1 h
2: 0.75 g / trifluoroacetic acid / CH2Cl2 / 20 °C
3: 45 percent / 3-dimethoxyphosphoryloxy-1,2,3-benzotriazine-4(3H)-one; triethylamine / tetrahydrofuran / 4 h
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

(S)-N-{(1S,2R)-3-[(4-aminobenzenesulfonyl)isobutylamino]-1-benzyl-2-hydroxypropyl}-2-[3-(2-ethylthiazol-4-ylmethyl)-2-oxo-2,3-dihydroimidazol-1-yl]-3-methylbutyramide

(S)-N-{(1S,2R)-3-[(4-aminobenzenesulfonyl)isobutylamino]-1-benzyl-2-hydroxypropyl}-2-[3-(2-ethylthiazol-4-ylmethyl)-2-oxo-2,3-dihydroimidazol-1-yl]-3-methylbutyramide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2 / Pd(OH)2 on carbon / ethyl acetate / 1 h
2: 0.75 g / trifluoroacetic acid / CH2Cl2 / 20 °C
3: 51 percent / N-hydroxysuccinimide; 1,3-dicyclohexylcarbodiimide; N-methylmorpholine / CH2Cl2 / 18 h
View Scheme
[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester
191226-98-9

[(1S,2R)-3-[(4-nitrophenylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester

(S)-N-{(1S,2R)-3-[(4-aminobenzenesulfonyl)isobutylamino]-1-benzyl-2-hydroxypropyl}-2-[3-(2-ethylthiazol-4-ylmethyl)-2-oxoimidazolidin-1-yl]-3-methylbutyramide

(S)-N-{(1S,2R)-3-[(4-aminobenzenesulfonyl)isobutylamino]-1-benzyl-2-hydroxypropyl}-2-[3-(2-ethylthiazol-4-ylmethyl)-2-oxoimidazolidin-1-yl]-3-methylbutyramide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: H2 / Pd(OH)2 on carbon / ethyl acetate / 1 h
2: 0.75 g / trifluoroacetic acid / CH2Cl2 / 20 °C
3: N-hydroxysuccinimide; 1,3-dicyclohexylcarbodiimide; N-methylmorpholine / CH2Cl2 / 18 h
View Scheme
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