Shandong Kehui Pharmaceutical Co., Ltd. is a modern high-tech pharmaceutical company that strictly complies with GMP requirements and produces high standards. The company was established in May 2017 and is located in the Yellow River Delta Medicine V
Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $3.0
Type:Lab/Research institutions
inquiryItems Standard Result Appearance A yellow crystalline powder Complies Melting point 171℃-175℃
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $250.0 / 350.0
Type:Trading Company
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:21829-25-4
Min.Order:10 Gram
Negotiable
Type:Manufacturers
inquiryUnique advantages for Nifedipine Cas 21829-25-4 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:Powder Storage:2-8°C Package:1kg/foil bag, 25kg/drum or as you requir
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $65.0
Type:Trading Company
inquiryHebei yanxi chemical co. LTD. has expanded a compositive entity from initially only as a small manufacturer. The company dedicated to the development, production and marketing of chemicals. Main products are Titanium dioxide(CAS13463-67-7). Lead a
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:21829-25-4
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We can do different t
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $20.0
Type:Trading Company
inquiryChinese Name: Nifedipine Chinese alias: Rixinping; Nifedipine; Xintongding; Nifedipine English Name: Nifedipine English alias: 2,6-Dimethyl-3,5-dicarbomethoxy-4-(2-nitrophenyl) -1,4-dihydropyridine; CAS No. 21829-25-4 EINECS No. 244-598-3 Mol
Cas:21829-25-4
Min.Order:100 Metric Ton
FOB Price: $3.0 / 5.0
Type:Other
inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:21829-25-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $1.0 / 10.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:21829-25-4
Min.Order:10 Gram
FOB Price: $146.0 / 176.0
Type:Trading Company
inquiry1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W
Cas:21829-25-4
Min.Order:1 Metric Ton
FOB Price: $20.0 / 30.0
Type:Trading Company
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr
Cas:21829-25-4
Min.Order:100 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:21829-25-4
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiry1. One of the domestic largest manufacturers of API; 2. High quality,competitive price and delivery in time; 3. Supplier of safe and ecofriendly products ; 4. Stable supply and efficient service; 5. Cooperate with scientific
Cas:21829-25-4
Min.Order:1 Kilogram
Negotiable
Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Nifedipine CAS: 21829-25-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates
Cas:21829-25-4
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:21829-25-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:21829-25-4
Min.Order:0
Negotiable
Type:Lab/Research institutions
inquiry1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi
Cas:21829-25-4
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:21829-25-4
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Hubei CuiRan Biotechnology Co., Ltd is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medicine)
Nifedipine CAS: 21829-25-4 Specification Items Specification Result Appearance Yellow crystalline powder Yellow crystalline powder Assay
Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
Cas:21829-25-4
Min.Order:1 Kilogram
FOB Price: $3.0 / 5.0
Type:Trading Company
inquiryConditions | Yield |
---|---|
With C23H3BF16N2O; ammonium acetate In toluene at 100℃; for 10h; Hantzsch Dihydropyridine Synthesis; | 95% |
With ammonium acetate; sodium dodecyl-sulfate; toluene-4-sulfonic acid for 1h; Hantzsch reaction; ultrasonic irradiation; | 92% |
With ammonium acetate at 75℃; for 3h; Hantzsch reaction; Neat (no solvent); | 92% |
1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylenemethaneamine
acetoacetic acid methyl ester
methyl 3-aminocrotonate
nifedipine
Conditions | Yield |
---|---|
In methanol for 36h; Heating; | 82.6% |
1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylenemethaneamine
methyl 3-aminocrotonate
nifedipine
Conditions | Yield |
---|---|
In methanol; acetic acid | 82.6% |
acetoacetic acid methyl ester
2-nitro-benzaldehyde
methyl 3-aminocrotonate
nifedipine
Conditions | Yield |
---|---|
In ethanol Heating; | 80% |
With sodium tosylate In water for 0.3h; Time; Hantzsch Dihydropyridine Synthesis; Microwave irradiation; Reflux; Green chemistry; | 42% |
Conditions | Yield |
---|---|
In methanol; acetic acid | 78.5% |
acetoacetic acid methyl ester
nifedipine
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol; acetic acid | 76% |
methyl 3-aminocrotonate
2-(o-nitro)phenyl-tetrahydro-(2H)-1,3-oxazine
nifedipine
Conditions | Yield |
---|---|
In acetonitrile; trifluoroacetic acid for 12h; Ambient temperature; | 75% |
1-(2'-nitrophenyl)-N,N-bis-(2'-nitrophenyl)methylenemethanediamine
acetoacetic acid methyl ester
methyl 3-aminocrotonate
nifedipine
Conditions | Yield |
---|---|
In methanol for 46h; | 75% |
1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylenemethaneamine
acetoacetic acid methyl ester
nifedipine
Conditions | Yield |
---|---|
With ammonia In methanol; acetic acid | 74% |
With ammonia In methanol | 71% |
In methanol for 36h; Mechanism; Heating; |
methyl 3-aminocrotonate
2-(o-nitro)phenyl-4,4-dimethyloxazolidine
nifedipine
Conditions | Yield |
---|---|
In acetonitrile; trifluoroacetic acid for 10h; Ambient temperature; | 70% |
acetoacetic acid methyl ester
2-nitro-benzaldehyde
A
dimethyl 4,6-dimethyl-2-(2-nitrophenyl)-1,2-dihydropyridine-3,5-dicarboxylate
B
nifedipine
Conditions | Yield |
---|---|
With ammonia In methanol; water for 2h; Condensation; Hantzsch reaction; Heating; | A n/a B 68.1% |
Conditions | Yield |
---|---|
In dichloromethane at 40℃; for 5h; Cycloaddition; addition; | 65% |
methyl 3-aminocrotonate
2-nitro-benzaldehyde
A
nifedipine
6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester
Conditions | Yield |
---|---|
at 100℃; for 5h; | A 13.2% B 62% |
Conditions | Yield |
---|---|
pyridine In methanol | 62% |
2,4,6-tris(2-nitrophenyl)hexahydro-1,3,5-triazine
acetoacetic acid methyl ester
methyl 3-aminocrotonate
nifedipine
Conditions | Yield |
---|---|
In methanol for 25h; Heating; | 60% |
acetoacetic acid methyl ester
2-nitro-benzaldehyde
A
nifedipine
6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester
Conditions | Yield |
---|---|
With ammonium hydroxide In ethanol for 24h; Ambient temperature; Yields of byproduct given; | A n/a B 54.3% |
methyl (E)-3-aminocrotonate
acetoacetic acid methyl ester
2-nitro-benzaldehyde
nifedipine
Conditions | Yield |
---|---|
With sodium butylmonoglycolsulphate In water for 0.0666667h; Heating; Irradiation; microwave irradiation; | 35% |
methyl 3-aminocrotonate
A
nifedipine
Conditions | Yield |
---|---|
In isopropyl alcohol for 24h; Heating; | A 35% B 16% |
Conditions | Yield |
---|---|
In ethanol for 0.0666667h; Irradiation; | 32% |
methyl 2-(2'-nitrobenzylidene)acetoacetate
nifedipine
Conditions | Yield |
---|---|
With sodium methylate In isopropyl alcohol Heating; |
2-nitro-benzaldehyde
nifedipine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 88 percent / methanol 2: 70 percent / acetonitrile; trifluoroacetic acid / 10 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 93 percent / methanol 2: 75 percent / acetonitrile; trifluoroacetic acid / 12 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: 98 percent / ammonium acetate / propan-2-ol / 1.) 40 deg C, 15 min, 2.) RT, 7 h 2: 75 percent / methanol / 46 h View Scheme |
ammonium hydroxide
acetoacetic acid methyl ester
2-nitro-benzaldehyde
nifedipine
Conditions | Yield |
---|---|
In methanol |
acetoacetic acid methyl ester
2-nitro-benzaldehyde
A
nifedipine
B
nifedipine
Conditions | Yield |
---|---|
With C20H20MoN4O5; ammonium acetate; dihydrogen peroxide In water at 40℃; for 4h; Reagent/catalyst; Hantzsch Pyridine Synthesis; Green chemistry; |
methyl 2-(2'-nitrobenzylidene)acetoacetate
methyl 3-aminocrotonate
nifedipine
Conditions | Yield |
---|---|
With 2-Picolinic acid In methanol at 55℃; Reflux; |
nifedipine
dimethyl 2,6-dimethyl-4-(2-nitrosophenyl)pyridine-3,5-dicarboxylate
Conditions | Yield |
---|---|
With phosphate buffer In ethanol Irradiation; | 100% |
With phosphate buffer In ethanol Rate constant; Irradiation; other reagent; | 100% |
With ruthenium(II) tris(2,2'-bipyridine) hexafluorophosphate In acetic acid; acetonitrile at 15℃; Irradiation; | 92% |
nifedipine
Conditions | Yield |
---|---|
With GLUTATHIONE In ethanol; water Mechanism; Irradiation; | 100% |
Multi-step reaction with 2 steps 1: 63 percent / argon / CH2Cl2 / 4 h / UV-irradiation 2: 24 percent / glutathione / ethanol; H2O / 0.5 h / 60 °C View Scheme | |
Multi-step reaction with 2 steps 1: 100 percent / phosphate buffer / ethanol / Irradiation; other reagent 2: glutathione / ethanol; H2O / 1 h / 60 °C View Scheme |
nifedipine
nifedipine
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; iron(III)phthalocyanine chloride; acetic acid at 20℃; for 0.0833333h; | 96% |
With potassium bromate; iron(III) chloride In water; acetonitrile for 0.583333h; Heating; | 95% |
With iodine In acetonitrile for 0.666667h; ultrasound irradiation; | 94% |
nifedipine
dimethyl 2,6-bis(methyl-d3)-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Conditions | Yield |
---|---|
With TFA-d; water-d2 In 1-methyl-pyrrolidin-2-one at 50℃; for 24h; Temperature; Reagent/catalyst; Schlenk technique; Inert atmosphere; | 96% |
With water-d2; trifluoroacetic anhydride In chloroform-d1; [(2)H6]acetone at 57℃; for 168h; |
nifedipine
(2S,3R,4S,5S,6R)-2,6-Dimethyl-4-(2-nitro-phenyl)-piperidine-3,5-dicarboxylic acid dimethyl ester
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid at 50℃; for 3h; | 94% |
nifedipine
A
dimethyl 2,6-dimethyl-4-(2-nitrosophenyl)pyridine-3,5-dicarboxylate
B
nifedipine
Conditions | Yield |
---|---|
In chloroform Product distribution; Mechanism; Irradiation; addition of sodium benzoate; different light conditions; | A 94% B 6% |
In potassium bromide at 25℃; Rate constant; Irradiation; t0.1, t0.5; | |
With air In methanol Quantum yield; Further Variations:; Solvents; Reagents; Irradiation; | |
In water UV-irradiation; |
nifedipine
2,6-Dimethyl-4-(2-nitrosophenyl)-3,5-pyridinedicarboxylic acid dimethyl estter
Conditions | Yield |
---|---|
In acetonitrile for 0.5h; Photolysis; Capped tube; | 94% |
Conditions | Yield |
---|---|
at 20℃; for 48h; Saturated solution; | 85.3% |
nifedipine
A
dimethyl 2,6-dimethyl-4-(2-nitrosophenyl)pyridine-3,5-dicarboxylate
B
dimer of 2,6-dimethyl-3,5-di(carbomethoxy)-4-(2'-nitrosophenyl)pyridine
Conditions | Yield |
---|---|
In methanol for 0.75h; Irradiation; | A 85% B 4% |
Conditions | Yield |
---|---|
at 20℃; for 48h; Saturated solution; | 79.5% |
nifedipine
methyl iodide
dimethyl 1,2,6-trimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Conditions | Yield |
---|---|
Stage #1: nifedipine; methyl iodide With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.166667h; Stage #2: With potassium carbonate In N,N-dimethyl-formamide; mineral oil for 0.5h; | 76% |
Conditions | Yield |
---|---|
With triethylamine In toluene for 0.5h; Reflux; | 75% |
Conditions | Yield |
---|---|
With triethylamine In toluene for 0.5h; Reflux; | 75% |
Conditions | Yield |
---|---|
With triethylamine In toluene for 0.5h; Reflux; | 72% |
Conditions | Yield |
---|---|
With triethylamine In toluene for 0.5h; Reflux; | 71% |
Conditions | Yield |
---|---|
With triethylamine In toluene for 0.5h; Reflux; | 69% |
Conditions | Yield |
---|---|
With triethylamine In toluene for 0.5h; Reflux; | 68% |
nifedipine
(2R,3S,4R)-2,6-Dimethyl-4-(2-nitro-phenyl)-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid dimethyl ester
Conditions | Yield |
---|---|
With triethylsilane; trifluoroacetic acid for 0.5h; Ambient temperature; | 66% |
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