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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

2-(Methylthio)pyrazine Manufacturer/High quality/Best price/In stock

Cas:21948-70-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Methylthiopyrazine supplier in China

Cas:21948-70-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

Tengzhou Runlong Fragrance Co., Ltd.

1、Our factory passed ISO 9001, ISO 14001, ISO 22000 system certification; HALAL 、KOSHER、FCC AND FDA certificate are available. We can provide customers with better prices, and the supply is stable. 2、We founded in 2004,10% of the staff have more tha

FEMA 3231 2-Methylthiopyrazine or 2-(methylthio)pyrazine or 2-(methylsulfanyl)pyrazine

Cas:21948-70-9

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

inquiry

COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2-Methylthio Pyrazine

Cas:21948-70-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

21948-70-9 2-(Methylthio)pyrazine

Cas:21948-70-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 21948-70-9 with best quality

Cas:21948-70-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product name (Methylthio)pyrazine CAS Number 21948-70-9 Synonyms Pyrazine,2-(Methylthio)-;PYRAZINYLMETHYL SULFIDE;(METHYLTHIO)PYRAZINE;METHYL PYRAZINYL SULFIDE;FEMA NUMBER 3231;FEMA 3231;2-(METHYLTHIO)PYRAZINE;2-M

(Methylthio)pyrazine CAS:21948-70-9

Cas:21948-70-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China and Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediat

21948-70-9 2-(Methylthio)pyrazineCAS NO.: 21948-70-9

Cas:21948-70-9

Min.Order:1 Kilogram

FOB Price: $4.0 / 5.0

Type:Lab/Research institutions

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pyrazine,2-(methylthio)- 21948-70-9

Cas:21948-70-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

2-(Methylthio)pyrazine CAS NO.21948-70-9 CAS NO.21948-70-9

Cas:21948-70-9

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 21948-70-9 ,2-Methylthio pyrazine

Cas:21948-70-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

2-(Methylthio)pyrazine CAS: 21948-70-9 Specification Item Standard Test Results Identification A.H-NMR:Comply with the structure Complies B.LC-MS:Comply

Factory supply 2-(Methylthio)pyrazine

Cas:21948-70-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-(Methylthio)Pyrazine

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Methylthio pyrazine

Cas:21948-70-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Methylthiopyrazine

Cas:21948-70-9

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Pyrazine,2-(methylthio)-

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-Methylthio pyrazine

Cas:21948-70-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 2-Methylthiopyrazine CAS No.:21948-70-9 Molecule Formula:C5H6N2S Molecule Weight:126.18 Purity: 99.0% Package: 25kg/drum Description:Clear colorless to slightly yellow liquid Manufacture Standards:Enterprise Standard

Best Quality 2-Methylthiopyrazine with good supplier

Cas:21948-70-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

2-(Methylthio)pyrazine

Cas:21948-70-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Methylthio pyrazine

Cas:21948-70-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-(Methylthio)pyrazine

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Methylthio pyrazine

Cas:21948-70-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

2-Methylthio pyrazine

Cas:21948-70-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2-Methylthiopyrazine

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

2-Methylthio pyrazine

Cas:21948-70-9

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

2-(Methylthio)pyrazine

Cas:21948-70-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

2-Methylthiopyrazine

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2-Methylthiopyrazine

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-Methylthiopyrazine

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

2-(Methylthio)pyrazine

Cas:21948-70-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

2-chloropyrazin
14508-49-7

2-chloropyrazin

sodium thiomethoxide
5188-07-8

sodium thiomethoxide

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 80℃; for 0.0138889h; microwave irradiation;88%
In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;49%
Dimethyldisulphide
624-92-0

Dimethyldisulphide

2-iodopyrazine
32111-21-0

2-iodopyrazine

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane; fac-tris(2-phenylpyridinato-N,C2')iridium(III); dimethyl sulfoxide In acetonitrile at 20℃; for 24h; Irradiation; Sealed tube; chemoselective reaction;85%
2-bromopyrazine
56423-63-3

2-bromopyrazine

boron dimethyl-trifluoro sulphide
353-43-5

boron dimethyl-trifluoro sulphide

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

Conditions
ConditionsYield
In neat (no solvent) at 60℃; for 16h; Sealed tube;57%
S-adenosyl-L-methionine

S-adenosyl-L-methionine

2-mercaptopyrazine
38521-06-1

2-mercaptopyrazine

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

Conditions
ConditionsYield
With rat liver microsomes In phosphate buffer at 37℃; for 0.5h; pH=7.5; Enzyme kinetics; Methylation; Enzymatic reaction;
2-chloropyrazin
14508-49-7

2-chloropyrazin

methyl iodide
74-88-4

methyl iodide

A

1,4-pyrazine
290-37-9

1,4-pyrazine

B

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

Conditions
ConditionsYield
Stage #1: 2-chloropyrazin With potassium tert-butylate; thiourea In dimethyl sulfoxide for 3h; UV-irradiation;
Stage #2: methyl iodide In water; dimethyl sulfoxide
A n/a
B 83 % Chromat.
silver perchlorate

silver perchlorate

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2Ag(1+)*2C5H6N2S*2ClO4(1-)

2Ag(1+)*2C5H6N2S*2ClO4(1-)

Conditions
ConditionsYield
In acetonitrile at 20℃; for 0.0833333h;95%
tributyl(4-chlorophenyl)stannane
17151-48-3

tributyl(4-chlorophenyl)stannane

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2 (4-chlorophenyl)-pyrazine
108030-79-1

2 (4-chlorophenyl)-pyrazine

Conditions
ConditionsYield
With trans benzyl(chloro)bis(triphenylphosphine)palladium(II); copper(I) 2-hydroxy-3-methylbenzoate In tetrahydrofuran at 50℃;92%
trimethylsilyl cyanide
7677-24-9

trimethylsilyl cyanide

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

3-(methylthio)pyrazine-2-carbonitrile
128142-12-1

3-(methylthio)pyrazine-2-carbonitrile

Conditions
ConditionsYield
Stage #1: 2-(methylthio)pyrazine With trifluoromethylsulfonic anhydride In chloroform at 20℃; for 1h; Inert atmosphere; Sealed tube;
Stage #2: trimethylsilyl cyanide In chloroform at 60℃; for 3h; Inert atmosphere; Sealed tube;
Stage #3: With 4-methyl-morpholine In chloroform at 60℃; for 17h; Inert atmosphere; Sealed tube;
92%
2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

methyl iodide
74-88-4

methyl iodide

1-methyl-3-(methylthio)pyrazin-1-ium iodide

1-methyl-3-(methylthio)pyrazin-1-ium iodide

Conditions
ConditionsYield
at 80℃; for 2h;90%
zinc trimethylacetate

zinc trimethylacetate

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

(3-(methylthio)pyrazin-2-yl)zinc pivalate

(3-(methylthio)pyrazin-2-yl)zinc pivalate

Conditions
ConditionsYield
Stage #1: 2-(methylthio)pyrazine With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex In tetrahydrofuran at -20℃; for 4h; Inert atmosphere; Schlenk technique;
Stage #2: zinc trimethylacetate In tetrahydrofuran at 0 - 25℃; for 0.25h; Inert atmosphere; Schlenk technique;
89%
3-amino-4-fluorotoluene
452-84-6

3-amino-4-fluorotoluene

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

N-(2-fluoro-5-methylphenyl)pyrazin-2-amine

N-(2-fluoro-5-methylphenyl)pyrazin-2-amine

Conditions
ConditionsYield
With potassium hexamethylsilazane at 100℃; for 16h; Inert atmosphere;89%
With potassium hexamethylsilazane In tetrahydrofuran at 100℃; for 16h; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;89%
silver trifluoromethanesulfonate
2923-28-6

silver trifluoromethanesulfonate

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

[Ag(2-(methylthio)pyrazine)(trifluoromethylsulfonate)]n

[Ag(2-(methylthio)pyrazine)(trifluoromethylsulfonate)]n

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h; Darkness; Inert atmosphere;88%
benzyl(bromo)zinc
62673-31-8

benzyl(bromo)zinc

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-benzylpyrazine
28217-95-0

2-benzylpyrazine

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 55 - 60℃; for 1h; Substitution; benzylation;86%
tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 60℃; for 2h;45%
p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-(4-methoxybenzyl)pyrazine
89815-18-9

2-(4-methoxybenzyl)pyrazine

Conditions
ConditionsYield
Stage #1: p-methoxybenzyl chloride With lithium chloride; zinc Inert atmosphere;
Stage #2: 2-(methylthio)pyrazine With bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether In tetrahydrofuran at 25℃; Inert atmosphere;
84%
(4-methoxybenzyl)zinc chloride * lithium chloride

(4-methoxybenzyl)zinc chloride * lithium chloride

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-(4-methoxybenzyl)pyrazine
89815-18-9

2-(4-methoxybenzyl)pyrazine

Conditions
ConditionsYield
Stage #1: 2-(methylthio)pyrazine With bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether In tetrahydrofuran for 0.166667h; Inert atmosphere; Large scale reaction;
Stage #2: (4-methoxybenzyl)zinc chloride * lithium chloride In tetrahydrofuran at 25℃; for 15h; Inert atmosphere;
84%
dimethylsulfide
75-18-3

dimethylsulfide

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-(methylthio)-6-((methylthio)methyl)pyrazine

2-(methylthio)-6-((methylthio)methyl)pyrazine

Conditions
ConditionsYield
With chloro-trimethyl-silane; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate at 20℃; for 16h; Inert atmosphere; Irradiation; Sealed tube;84%
silver nitrate

silver nitrate

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

[Ag(2-(methylthio)pyrazine)(NO3)]n

[Ag(2-(methylthio)pyrazine)(NO3)]n

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h; Darkness; Inert atmosphere;84%
1-naphthylzinc iodide–lithium chloride

1-naphthylzinc iodide–lithium chloride

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-(naphthalen-1-yl)pyrazine
560993-92-2

2-(naphthalen-1-yl)pyrazine

Conditions
ConditionsYield
Stage #1: 2-(methylthio)pyrazine With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate In tetrahydrofuran for 0.166667h; Inert atmosphere;
Stage #2: 1-naphthylzinc iodide–lithium chloride In tetrahydrofuran at 25℃; for 18h; Inert atmosphere;
83%
2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-iodo-3-(methylthio)pyrazine
58139-09-6

2-iodo-3-(methylthio)pyrazine

Conditions
ConditionsYield
Stage #1: 2-(methylthio)pyrazine With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; boron trifluoride diethyl etherate In tetrahydrofuran at -40℃; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran at -40 - 25℃; Inert atmosphere; regioselective reaction;
81%
2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

ethyl 2-bromomethyl-2-propenoate
17435-72-2

ethyl 2-bromomethyl-2-propenoate

ethyl 2-{[3-(methylsulfanyl)pyrazin-2-yl]methyl}prop-2-enoate
1259092-22-2

ethyl 2-{[3-(methylsulfanyl)pyrazin-2-yl]methyl}prop-2-enoate

Conditions
ConditionsYield
Stage #1: 2-(methylthio)pyrazine With tmp4Zr*4MgCl2*6LiCl In tetrahydrofuran at -35℃; for 0.333333h; Inert atmosphere;
Stage #2: ethyl 2-bromomethyl-2-propenoate With iodine In tetrahydrofuran at -40℃; for 1h; Inert atmosphere; regioselective reaction;
81%
tricarbonyldichlororuthenium (II) dimer

tricarbonyldichlororuthenium (II) dimer

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

[Ru(CO)3Cl2(2-thiomethylpyrazine-κN4)]
878002-96-1

[Ru(CO)3Cl2(2-thiomethylpyrazine-κN4)]

Conditions
ConditionsYield
In ethanol soln. of (Ru(CO)3Cl2)2 in degassed EtOH mixed with soln. of 2-methylthiopyrazine in degassed EtOH; mixt. stirred for 17 h; ppt. filtered off; washed with EtOH; dried under vac.; elem. anal.;80%
Cyclohexanethiol
1569-69-3

Cyclohexanethiol

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-(cyclohexylthio)pyrazine
135763-82-5

2-(cyclohexylthio)pyrazine

Conditions
ConditionsYield
With Singacycle A1; lithium hexamethyldisilazane In toluene at 80℃; for 2h; Glovebox; Sealed tube;80%
silver(I) hexafluorophosphate
26042-63-7

silver(I) hexafluorophosphate

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

[Ag(2-(methylthio)pyrazine)2(PF6)]n

[Ag(2-(methylthio)pyrazine)2(PF6)]n

Conditions
ConditionsYield
In methanol at 20℃; for 0.5h; Darkness; Inert atmosphere;79%
phenylacetylene
536-74-3

phenylacetylene

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-(2-phenylethynyl)pyrazine
96129-41-8

2-(2-phenylethynyl)pyrazine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine In tetrahydrofuran at 100℃; for 1h; Sonogashira-type coupling; Microwave irradiation;74%
3-EtOC(=O)C6H4ZnI*LiCl

3-EtOC(=O)C6H4ZnI*LiCl

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

ethyl 3-pyrazin-2-ylbenzoate
1217817-54-3

ethyl 3-pyrazin-2-ylbenzoate

Conditions
ConditionsYield
With bis(acetylacetonate)nickel(II); bis[2-(diphenylphosphino)phenyl] ether In tetrahydrofuran at 25℃; for 14h; Inert atmosphere;74%
morpholine
110-91-8

morpholine

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

4-(pyrazin-2-yl)morpholine
5625-94-5

4-(pyrazin-2-yl)morpholine

Conditions
ConditionsYield
With potassium hexamethylsilazane In toluene at 60℃; for 24h; Schlenk technique; Inert atmosphere;71%
4-methoxyphenylacetylen
768-60-5

4-methoxyphenylacetylen

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-((4-methoxyphenyl)ethynyl)pyrazine
1131447-26-1

2-((4-methoxyphenyl)ethynyl)pyrazine

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine In tetrahydrofuran at 100℃; for 1h; Sonogashira-type coupling; Microwave irradiation;70%
2-cyclohexylacetylene
931-48-6

2-cyclohexylacetylene

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

C12H14N2
1131447-29-4

C12H14N2

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine In tetrahydrofuran at 100℃; for 1h; Sonogashira-type coupling; Microwave irradiation;68%
3-Trifluoromethylbenzyl chloride
705-29-3

3-Trifluoromethylbenzyl chloride

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

2-[3-(trifluoromethyl)benzyl]pyrazine
1009309-82-3

2-[3-(trifluoromethyl)benzyl]pyrazine

Conditions
ConditionsYield
Stage #1: 3-Trifluoromethylbenzyl chloride With lithium chloride; zinc Inert atmosphere;
Stage #2: 2-(methylthio)pyrazine With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate In tetrahydrofuran at 25℃; Inert atmosphere;
68%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

2-(methylthio)pyrazine
21948-70-9

2-(methylthio)pyrazine

(4-methoxyphenyl)(3-(methylthio)pyrazin-2-yl)methanol
1426318-77-5

(4-methoxyphenyl)(3-(methylthio)pyrazin-2-yl)methanol

Conditions
ConditionsYield
Stage #1: 2-(methylthio)pyrazine With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; boron trifluoride diethyl etherate In tetrahydrofuran at -40℃; for 0.166667h; Inert atmosphere; Schlenk technique;
Stage #2: 4-methoxy-benzaldehyde In tetrahydrofuran at -40℃; for 1h; Inert atmosphere; Schlenk technique;
Stage #3: With ammonia; water; ammonium chloride In tetrahydrofuran Inert atmosphere; Schlenk technique;
67%

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