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ProName: (S)-(+)-Ketoprofen Manufacturer/High q... CasNo: 22161-81-5 Molecular Formula: C16H14O3 Appearance: white powder Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to

(S)-(+)-ketoprofen

Cas:22161-81-5

Min.Order:1 Kilogram

FOB Price: $2.6

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

(S)-(+)-Ketoprofen Manufacturer/High quality/Best price/In stock

Cas:22161-81-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality (S)- Ketoprofen supplier in China

Cas:22161-81-5

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of (S)-(+)-Ketoprofen Cas 22161-81-5 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:cool dry place Package:1kg/foil bag

Manufacturer high quality (S)-(+)-Ketoprofen Cas 22161-81-5 with good price and fast delivery

Cas:22161-81-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply (2S)-2-(3-benzoylphenyl)propanoic acid

Cas:22161-81-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Benzeneacetic acid,3-benzoyl-a-methyl-, (aS)- 22161-81-5 ISO Producer

Cas:22161-81-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Dexketoprofen

Cas:22161-81-5

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Ketoprofen English name ketoprofen Chinese alias: dexketoprofen; ketoprofen CAS: 22071-15-4; 22161-81-5 EINECS 244-759-8 Molecular formula C16H1403 Molecular weight 254.2806 Melting point: 93-96 C Content: 98.5-l0

Ketoprofen Manufacturer

Cas:22161-81-5

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

(S)-(+)-Ketoprofen 22161-81-5

Cas:22161-81-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

(S) - (+) -Ketoprofen CAS 22161-81-5

Cas:22161-81-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 22161-81-5 with high-quality service

Cas:22161-81-5

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pudo

22161-81-5/Ketoprofen

Cas:22161-81-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzeneacetic acid,3-benzoyl-a-methyl-, (aS)- 22161-81-5

Cas:22161-81-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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HANWAYS CHEMPHARM CO.,LIMITED

1.Prompt Goods; 2.Flexible payment terms; 3.Documents & Certificate support. Name: (S)-(+)-Ketoprofen Structure: Formula: C16H14O3 Molecular Weight : 254.28 Synonyms: (+)-hydratropicaci;(S)-(+)-KETOPROFEN;(S)-KETOPROFEN;(S)-(+)-3-BENZOYL-

Factory Supply High Quality (S)-(+)-Ketoprofen

Cas:22161-81-5

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Supply High Quality Ketoprofen CAS 22161-81-5 For research Use only

Cas:22161-81-5

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

(S)-(+)-Ketoprofen 99%

Cas:22161-81-5

Min.Order:1 Kilogram

FOB Price: $85.0 / 98.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

(S)-(+)-Ketoprofen CAS:22161-81-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interm

(S)-(+)-Ketoprofen CAS:22161-81-5

Cas:22161-81-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzeneacetic acid,3-benzoyl-a-methyl-, (aS)-

Cas:22161-81-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:22161-81-5

Cas:22161-81-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

S-(+)-Ketoprofen

Cas:22161-81-5

Min.Order:1 Kilogram

FOB Price: $80.0 / 100.0

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

(S)-(+)-ketoprofen CAS NO.22161-81-5

Cas:22161-81-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

S-ketoprofen 22161-81-5

Cas:22161-81-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

DexKetoprofen

Cas:22161-81-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

DEXKETOPROFEN

Cas:22161-81-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(S)-(+)-Ketoprofen

Cas:22161-81-5

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzeneacetic acid,3-benzoyl-a-methyl-, (aS)-

Cas:22161-81-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality (S)- Ketoprofen

Cas:22161-81-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

(S)-(+)-Ketoprofen Powder USP StandardAppearance:White or Almost White crystalline powder Storage:Store in refrigerator Package:according to customers' requirements Application:USP Standard APIs Transportation:By air(EMS or EUB or FedEx or TNT ect...

(S)-(+)-Ketoprofen Powder USP Standard

Cas:22161-81-5

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity (S)-(+)-Ketoprofen

Cas:22161-81-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Jiangsu Qianyu Molecular Technology Co., LTD.

Our Advantages A. International Top level TechnologyOur company owned biomedicine experts are famous at home and abroad with rich experience in research and development in the field of efficient chiral functional molecules research and development an

Top Purity Supplier(S)-(+)-Ketoprofen

Cas:22161-81-5

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

(S)-3-methyl-2-phenylbutylammonium (S)-2-(3-benzoylphenyl)propionate

(S)-3-methyl-2-phenylbutylammonium (S)-2-(3-benzoylphenyl)propionate

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With hydrogenchloride In water at 50℃;98.3%
ketoprofen
22071-15-4

ketoprofen

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
96%
Multi-step reaction with 3 steps
1.1: oxalyl chloride / 12 h / 40 °C
2.1: rink amide linker modified polystyrene grafted crowns; piperidine; benzotriazolyloxy-tris(dimethylamino)phosphonium(1+) PF6(1-) / diisopropylethylamine / dimethylformamide / 12 h / 20 °C
2.2: triethylamine / tetrahydrofuran / 12 h / 0 °C
2.3: 104 mg / trifluoroacetic acid / CH2Cl2 / 0.67 h
3.1: LiOH / tetrahydrofuran; H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: oxalyl chloride / 12 h / 40 °C
2.1: triethylamine; (S)-(3-OH-4,4-di-Me-2-oxopyrrolidin-1-yl)CH2COOH on resin / tetrahydrofuran / 0 °C
2.2: LiOH*H2O / tetrahydrofuran; H2O / 4 h / 20 °C
View Scheme
(S)-2-(3-Benzoyl-phenyl)-propionic acid (S)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

(S)-2-(3-Benzoyl-phenyl)-propionic acid (S)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With sodium carbonate In methanol; water for 2h; Ambient temperature;95%
(2S)-[3-(2-hydroxy-1-methyl-ethyl)-phenyl]-phenyl-methanone
1173289-23-0

(2S)-[3-(2-hydroxy-1-methyl-ethyl)-phenyl]-phenyl-methanone

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With Jones reagent In acetone for 12h; Inert atmosphere;95%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen In water at 20℃; for 168h; Enzymatic reaction;95%
With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite In water; acetonitrile at 35℃; for 24h; aq. phosphate buffer;42%
(3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (αS)-α-(3-benzoylphenyl)propionate

(3S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl (αS)-α-(3-benzoylphenyl)propionate

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With hydrogenchloride; acetic acid for 2.5h; Heating;92%
3-(3-benzoyl-phenyl)-2S,3R-dimethyl-oxirane-2-carboxy-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexane ester

3-(3-benzoyl-phenyl)-2S,3R-dimethyl-oxirane-2-carboxy-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexane ester

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
Stage #1: 3-(3-benzoyl-phenyl)-2S,3R-dimethyl-oxirane-2-carboxy-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexane ester With sodium carbonate In dichloromethane; water for 1h;
Stage #2: With dihydrogen peroxide; acetic acid at 85℃; for 9h;
85.6%
(S)-ketoprofendiol

(S)-ketoprofendiol

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen In water at 20℃; for 168h; Enzymatic reaction;82%
C23H20O
1613507-33-7

C23H20O

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With sodium periodate; ruthenium(III) trichloride hydrate In tetrachloromethane; water; acetonitrile at 0 - 20℃; for 2h;69%
ketoprofen 2,2,2-trifluoroethyl ester

ketoprofen 2,2,2-trifluoroethyl ester

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With sodium hydroxide; Pseudomonas fluorescens MTCCB0015 cell-free extract In phosphate buffer at 37℃; for 20h; pH=7.50;40%
(+)-α-(3-benzylphenyl)propionic acid
22161-82-6

(+)-α-(3-benzylphenyl)propionic acid

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

(3-acetylphenyl)(phenyl)methanone
66067-44-5

(3-acetylphenyl)(phenyl)methanone

Conditions
ConditionsYield
With sodium hydroxide; potassium permanganate In water for 6h; Ambient temperature; Yields of byproduct given;A n/a
B 28.4%
(+)-α-(3-benzylphenyl)propionic acid
22161-82-6

(+)-α-(3-benzylphenyl)propionic acid

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

(3-acetylphenyl)(phenyl)methanone
66067-44-5

(3-acetylphenyl)(phenyl)methanone

C

R-ketoprofen
56105-81-8

R-ketoprofen

Conditions
ConditionsYield
With sodium hydroxide; potassium permanganate In water for 6h; Ambient temperature; Yield given;A n/a
B 28.4%
C n/a
ethyl 2-<3-benzoylphenyl>propionate
60658-04-0

ethyl 2-<3-benzoylphenyl>propionate

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With Tris-HCl buffer at 30℃; for 96h; semipurified lipase of Candida cylindraceae in Tris-HCl buffer;23.04%
With native lipase from Candida rugosa; water
With Thermotoga maritima esterase Tm1160 In aq. acetate buffer at 70℃; for 23h; pH=5.5; Enzymatic reaction; enantioselective reaction;n/a
alpha-(m-benzoylphenyl)propionitrile
42872-30-0

alpha-(m-benzoylphenyl)propionitrile

A

(2R)-2-[3-(phenylcarbonyl)phenyl]propanamide

(2R)-2-[3-(phenylcarbonyl)phenyl]propanamide

B

(S)-2-(3-benzoylphenyl)propanamide
162681-69-8

(S)-2-(3-benzoylphenyl)propanamide

C

(S)-2-(3-benzoylphenyl)propanenitrile
1421692-22-9

(S)-2-(3-benzoylphenyl)propanenitrile

D

(2R)-[3-(phenylcarbonyl)phenyl]propanenitrile
161527-65-7

(2R)-[3-(phenylcarbonyl)phenyl]propanenitrile

E

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With Rhodococcus erythropolis SET1 cells In aq. phosphate buffer at 25℃; pH=7; Microbiological reaction; enantioselective reaction;A n/a
B n/a
C n/a
D n/a
E 20%
Conditions
ConditionsYield
With sodium hydroxide; Pseudomonas fluorescens MTCCB0015 cell-free extract In phosphate buffer at 37℃; for 20h; pH=7.50;18%

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

R-ketoprofen
56105-81-8

R-ketoprofen

Conditions
ConditionsYield
With sodium hydroxide In water at 40℃; for 7.55h; titrisol buffer pH 8, carboxylesterase NP; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With tris hydrochloride; S. solfataricus esterase In water at 60℃; for 32h; pH=7.0; Enzymatic reaction;
ketoprofen
22071-15-4

ketoprofen

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

R-ketoprofen
56105-81-8

R-ketoprofen

Conditions
ConditionsYield
With phosphate buffer; sodium dodecyl-sulfate; vancomycin at 20℃; Product distribution; electrophoretic enantioseparations, various substrates;
EtOH, TAPS/Tris buffer, pH 7.7;
lipase from Candida rugosa In 2,2,4-trimethylpentane; acetone Product distribution / selectivity; Resolution of racemate;
ethyl 2-<3-benzoylphenyl>propionate
60658-04-0

ethyl 2-<3-benzoylphenyl>propionate

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

(R)-(-)-2-(3-benzoylphenyl)propionic acid ethyl ester
136656-96-7

(R)-(-)-2-(3-benzoylphenyl)propionic acid ethyl ester

Conditions
ConditionsYield
In water Title compound not separated from byproducts;
2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid
114315-58-1

2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

(R)-ketoprofen chloroethyl ester
122674-99-1

(R)-ketoprofen chloroethyl ester

Conditions
ConditionsYield
With phosphate buffer; C. cylindracea lipase; dextromethorphan at 24℃; for 192h; Product distribution; without amine, enetioselectivity of hydrolysis;
(2R,3S,1''RS)-3-<3'-(hydroxyphenylmethyl)phenyl>butane-1,2-diol

(2R,3S,1''RS)-3-<3'-(hydroxyphenylmethyl)phenyl>butane-1,2-diol

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With ruthenium trichloride; sodium periodate Yield given;
With ruthenium trichloride; sodium periodate In tetrachloromethane; water; acetonitrile Ambient temperature;
(+)-α-(3-benzylphenyl)propionic acid
22161-82-6

(+)-α-(3-benzylphenyl)propionic acid

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With potassium permanganate
With potassium permanganate; phosphate buffer In water; benzene for 16h; Ambient temperature;
α-(3-benzoylphenyl)acrylic acid
74614-67-8

α-(3-benzoylphenyl)acrylic acid

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

R-ketoprofen
56105-81-8

R-ketoprofen

Conditions
ConditionsYield
With (-)-Diop; chloro(1,5-hexadiene)rhodium(I) dimer; hydrogen; triethylamine; benzene In ethanol under 53200 Torr; for 20h; Ambient temperature; Yield given. Title compound not separated from byproducts;
With (-)-Diop; chloro(1,5-hexadiene)rhodium(I) dimer; hydrogen; triethylamine In ethanol; benzene under 11172 - 77140 Torr; Product distribution; different solvents, without NEt3, with KOH; other object: optical yield;
2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid
114315-58-1

2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

R-ketoprofen
56105-81-8

R-ketoprofen

Conditions
ConditionsYield
With water at 40℃; for 40h; Candida rugosa lipase, pH 5; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With Candida rugosa lipase (Lipase OF); Tween-80 In water at 30℃; for 24h; pH=2.5; Title compound not separated from byproducts;
Conditions
ConditionsYield
With human serum albumin In water at 37℃; pH=7.4; Enzyme kinetics; Hydrolysis; Enzymatic reaction; isotonic 0.067 phosphate buffer;
2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid
114315-58-1

2-chloroethyl ester of 2-(3-benzoylphenyl)propionic acid

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With lipase OF I In water at 37℃; for 36h; pH=3;

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

R-ketoprofen
56105-81-8

R-ketoprofen

Conditions
ConditionsYield
Stage #1: ketoprofen chloride With (S)-(3-OH-4,4-di-Me-2-oxopyrrolidin-1-yl)CH2COOH on resin; triethylamine In tetrahydrofuran at 0℃;
Stage #2: With lithium hydroxide In tetrahydrofuran; water at 20℃; for 4h; Further stages. Title compound not separated from byproducts.;
(S)-2-(3-Benzoyl-phenyl)-propionic acid (S)-1-carbamoylmethyl-4,4-dimethyl-2-oxo-pyrrolidin-3-yl ester
362470-63-1

(S)-2-(3-Benzoyl-phenyl)-propionic acid (S)-1-carbamoylmethyl-4,4-dimethyl-2-oxo-pyrrolidin-3-yl ester

A

S-ketoprofen
22161-81-5

S-ketoprofen

B

R-ketoprofen
56105-81-8

R-ketoprofen

C

(S)-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)acetamide

(S)-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)acetamide

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; water at 20℃; for 1h;
S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: rink amide linker modified polystyrene grafted crowns; piperidine; benzotriazolyloxy-tris(dimethylamino)phosphonium(1+) PF6(1-) / diisopropylethylamine / dimethylformamide / 12 h / 20 °C
1.2: triethylamine / tetrahydrofuran / 12 h / 0 °C
1.3: 104 mg / trifluoroacetic acid / CH2Cl2 / 0.67 h
2.1: LiOH / tetrahydrofuran; H2O / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 93 percent / Et3N / CH2Cl2 / 3 h / 0 °C
2: 92 percent / 2 N HCl, AcOH / 2.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: Et3N / tetrahydrofuran / -10 °C
2: 95 percent / Na2CO3 / methanol; H2O / 2 h / Ambient temperature
View Scheme
2-(3-bromophenyl)-2-methyl-[1,3]dioxolane
39172-32-2

2-(3-bromophenyl)-2-methyl-[1,3]dioxolane

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: 1.) Mg, I2 / 1.) anhydrous THF, 4 h, 60 deg C, 2.) THF
2: 97 percent / H2O, 10percent HCl / methanol / 1 h / Ambient temperature
3: 1.) t-BuOK / 1.) anhydrous THF, 30 min, RT, 2.) THF, RT, 24 h
4: 58 percent / LAH / diethyl ether / 6 h / -78 °C
5: 1.) (L)-(+)-diisopropyl tartrate, 4A sieves, Ti(OiPr)4, t-BuOOH / 1.) CH2Cl2, 1 h, 2.) CH2Cl2, -20 deg C, 3.5 h
6: H2, 1M NaOH / 10percent Pd/C / ethanol / Ambient temperature
7: LiBr, NCS / methanol / Ambient temperature
8: TsOH / Ambient temperature
9: 1.) t-BuLi / 1.) Et2O, hexane, -78 deg C, 2.) Et2O, hexane, RT
10: H2O, 5percent HCl / methanol / RT, then -20 deg C
11: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / Ambient temperature
View Scheme
1-[3-(trimethylsilyl)phenyl]ethanone
17983-62-9

1-[3-(trimethylsilyl)phenyl]ethanone

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: 1.) t-BuOK / 1.) anhydrous THF, 30 min, RT, 2.) THF, RT, 24 h
2: 58 percent / LAH / diethyl ether / 6 h / -78 °C
3: 1.) (L)-(+)-diisopropyl tartrate, 4A sieves, Ti(OiPr)4, t-BuOOH / 1.) CH2Cl2, 1 h, 2.) CH2Cl2, -20 deg C, 3.5 h
4: H2, 1M NaOH / 10percent Pd/C / ethanol / Ambient temperature
5: LiBr, NCS / methanol / Ambient temperature
6: TsOH / Ambient temperature
7: 1.) t-BuLi / 1.) Et2O, hexane, -78 deg C, 2.) Et2O, hexane, RT
8: H2O, 5percent HCl / methanol / RT, then -20 deg C
9: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / Ambient temperature
View Scheme
benzaldehyde
100-52-7

benzaldehyde

sodium cyanate

sodium cyanate

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) t-BuLi / 1.) Et2O, hexane, -78 deg C, 2.) Et2O, hexane, RT
2: H2O, 5percent HCl / methanol / RT, then -20 deg C
3: RuCl3*H2O, NaIO4 / CCl4; acetonitrile; H2O / Ambient temperature
View Scheme
2-deoxy-2-amino-1,3,4,6-tetra-O-triethylsilyl-β-D-glucopyranosyl

2-deoxy-2-amino-1,3,4,6-tetra-O-triethylsilyl-β-D-glucopyranosyl

S-ketoprofen
22161-81-5

S-ketoprofen

2-deoxy-2-(2-(3-benzoylphenyl) propanoic acid)amino-1,3,4,6-tetra-O-triethylsilyl-β-D-glucopyranosyl

2-deoxy-2-(2-(3-benzoylphenyl) propanoic acid)amino-1,3,4,6-tetra-O-triethylsilyl-β-D-glucopyranosyl

Conditions
ConditionsYield
With N,N-dimethylbutylamine; dimethylamino sulfonyl chloride; dmap In acetonitrile at 0 - 20℃; for 12h;100%
methanol
67-56-1

methanol

S-ketoprofen
22161-81-5

S-ketoprofen

Conditions
ConditionsYield
With thionyl chloride at 0℃; Reflux;100%
S-ketoprofen
22161-81-5

S-ketoprofen

(2S)-[3-(2-hydroxy-1-methyl-ethyl)-phenyl]-phenyl-methanone
1173289-23-0

(2S)-[3-(2-hydroxy-1-methyl-ethyl)-phenyl]-phenyl-methanone

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 20℃;99%
With borane-THF In tetrahydrofuran at -20 - 20℃;55%
methanol
67-56-1

methanol

S-ketoprofen
22161-81-5

S-ketoprofen

methyl (2S)-2-(3-benzoylphenyl)propanoate

methyl (2S)-2-(3-benzoylphenyl)propanoate

Conditions
ConditionsYield
With sulfuric acid Reflux;98%
Stage #1: methanol; S-ketoprofen for 0.5h; Reflux;
Stage #2: With sulfuric acid at 80 - 90℃;
85.3%
With sulfuric acid for 6h; Heating;
S-ketoprofen
22161-81-5

S-ketoprofen

2-amino-2-hydroxymethyl-1,3-propanediol
77-86-1

2-amino-2-hydroxymethyl-1,3-propanediol

Enantyum

Enantyum

Conditions
ConditionsYield
In ethanol; water at 20℃; for 0.5h;92%
In ethanol at 20℃; for 0.5h;92%
In ethanol; butanone; xylene at 0 - 55℃;85%
In ethanol; butanone; xylene at 0 - 55℃;84%
In ethanol; water Product distribution / selectivity;
(4-(but-3-en-1-yn-1-yl)phenyl)methanol

(4-(but-3-en-1-yn-1-yl)phenyl)methanol

S-ketoprofen
22161-81-5

S-ketoprofen

4-(but-3-en-1-yn-1-yl)benzyl (S)-2-(3-benzoylphenyl)propanoate

4-(but-3-en-1-yn-1-yl)benzyl (S)-2-(3-benzoylphenyl)propanoate

Conditions
ConditionsYield
With dmap; diisopropyl-carbodiimide In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique;90%
L-Tyr-OMe
1080-06-4

L-Tyr-OMe

S-ketoprofen
22161-81-5

S-ketoprofen

N-(2-(S)-(3-benzoyl)phenyl)propionyl-(S)-tyrosine methyl ester

N-(2-(S)-(3-benzoyl)phenyl)propionyl-(S)-tyrosine methyl ester

Conditions
ConditionsYield
Stage #1: L-Tyr-OMe; S-ketoprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: With triethylamine In N,N-dimethyl-formamide at 20℃; for 20h;
85%
N-propyl-1H-indol-5-amine
1042539-24-1

N-propyl-1H-indol-5-amine

S-ketoprofen
22161-81-5

S-ketoprofen

2-(3-benzoylphenyl)-N-(1H-indol-5-yl)-N-propylpropanamide
1239447-67-6

2-(3-benzoylphenyl)-N-(1H-indol-5-yl)-N-propylpropanamide

Conditions
ConditionsYield
Stage #1: S-ketoprofen With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: N-propyl-1H-indol-5-amine In N,N-dimethyl-formamide at 20℃; for 2h;
81%
3β-acetoxy-7β-hydroxycholest-5-ene
17974-77-5

3β-acetoxy-7β-hydroxycholest-5-ene

S-ketoprofen
22161-81-5

S-ketoprofen

(3S,7R,10R,13R,17R)-3-acetoxy-10,13-dimethyl-17-((R)-6-methylheptan-2yl)2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl (2S)-2-(3-benzoylphenyl)-propanoate

(3S,7R,10R,13R,17R)-3-acetoxy-10,13-dimethyl-17-((R)-6-methylheptan-2yl)2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl (2S)-2-(3-benzoylphenyl)-propanoate

Conditions
ConditionsYield
Stage #1: S-ketoprofen With dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h;
Stage #2: 3β-acetoxy-7β-hydroxycholest-5-ene With dmap at 0℃;
77%
7,8-dihydro-8-oxo-2'-deoxyadenosine
31077-24-4, 62471-63-0

7,8-dihydro-8-oxo-2'-deoxyadenosine

S-ketoprofen
22161-81-5

S-ketoprofen

5'-KP-8-oxodA
1069110-42-4

5'-KP-8-oxodA

Conditions
ConditionsYield
With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 0℃;76%
1-bromo-2-(triisopropylsilyl)acetylene
111409-79-1

1-bromo-2-(triisopropylsilyl)acetylene

S-ketoprofen
22161-81-5

S-ketoprofen

(S)-2-(5-benzoyl-2-((triisopropylsilyl)ethynyl)phenyl)propanoic acid

(S)-2-(5-benzoyl-2-((triisopropylsilyl)ethynyl)phenyl)propanoic acid

Conditions
ConditionsYield
With N-tert-butoxycarbonyl-L-phenylalanine; silver(I) acetate; sodium acetate; palladium diacetate In 1,2-dichloro-ethane at 60℃; for 16h; Sealed tube; Schlenk technique;76%
epicholesterol
474-77-1

epicholesterol

S-ketoprofen
22161-81-5

S-ketoprofen

epi-cholesteryl (S)-2-(3-benzoylphenyl)propionate
913843-19-3

epi-cholesteryl (S)-2-(3-benzoylphenyl)propionate

Conditions
ConditionsYield
Stage #1: S-ketoprofen With dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h;
Stage #2: epicholesterol With dmap In dichloromethane at 0℃; for 8h;
74%
N-propyl-1H-indol-6-amine
1378801-54-7

N-propyl-1H-indol-6-amine

S-ketoprofen
22161-81-5

S-ketoprofen

2-(3-benzoylphenyl)-N-(1H-indol-6-yl)-N-propylpropanamide
1239447-58-5

2-(3-benzoylphenyl)-N-(1H-indol-6-yl)-N-propylpropanamide

Conditions
ConditionsYield
Stage #1: S-ketoprofen With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: N-propyl-1H-indol-6-amine In N,N-dimethyl-formamide at 20℃; for 2h;
73%
S-ketoprofen
22161-81-5

S-ketoprofen

5-aminomethylindole
81881-74-5

5-aminomethylindole

N-((1H-indol-5-yl)methyl)-2-(3-benzoylphenyl)propanamide
1239447-45-0

N-((1H-indol-5-yl)methyl)-2-(3-benzoylphenyl)propanamide

Conditions
ConditionsYield
Stage #1: S-ketoprofen With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 5-aminomethylindole In N,N-dimethyl-formamide at 20℃; for 2h;
73%
(S)-4-(3-aminoazepan-1-yl)coumarin

(S)-4-(3-aminoazepan-1-yl)coumarin

S-ketoprofen
22161-81-5

S-ketoprofen

C31H30N2O4

C31H30N2O4

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.5h;73%
N-((1H-indol-5-yl)methyl)propan-1-amine
946774-68-1

N-((1H-indol-5-yl)methyl)propan-1-amine

S-ketoprofen
22161-81-5

S-ketoprofen

N-((1H-indol-5-yl)methyl)-2-(3-benzoylphenyl)-N-propylpropanamide
1239447-69-8

N-((1H-indol-5-yl)methyl)-2-(3-benzoylphenyl)-N-propylpropanamide

Conditions
ConditionsYield
Stage #1: S-ketoprofen With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: N-((1H-indol-5-yl)methyl)propan-1-amine In N,N-dimethyl-formamide at 20℃; for 2h;
72%
methanesulfonamide
3144-09-0

methanesulfonamide

S-ketoprofen
22161-81-5

S-ketoprofen

N-[2-(3-benzoyl-phenyl)-propionyl]-methanesulfonamide

N-[2-(3-benzoyl-phenyl)-propionyl]-methanesulfonamide

Conditions
ConditionsYield
Stage #1: S-ketoprofen With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 2h;
Stage #2: methanesulfonamide With 1,2-diazabicyclo[5.4.0]undec-7-ene In dichloromethane for 4h;
70.5%
D-tyrosine methyl ester
3410-66-0

D-tyrosine methyl ester

S-ketoprofen
22161-81-5

S-ketoprofen

N-(2-(S)-(3-benzoyl)phenyl)propionyl-(R)-tyrosine methyl ester

N-(2-(S)-(3-benzoyl)phenyl)propionyl-(R)-tyrosine methyl ester

Conditions
ConditionsYield
Stage #1: D-tyrosine methyl ester; S-ketoprofen With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: With triethylamine In N,N-dimethyl-formamide at 20℃; for 20h;
70%
5-amino-1H-indole
5192-03-0

5-amino-1H-indole

S-ketoprofen
22161-81-5

S-ketoprofen

2-(3-benzoylphenyl)-N-(1H-indol-5-yl)propanamide
1239447-47-2

2-(3-benzoylphenyl)-N-(1H-indol-5-yl)propanamide

Conditions
ConditionsYield
Stage #1: S-ketoprofen With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 5-amino-1H-indole In N,N-dimethyl-formamide at 20℃; for 2h;
69%
7α-hydroxycholest-5-en-3β-yl 3-acetate
19317-90-9

7α-hydroxycholest-5-en-3β-yl 3-acetate

S-ketoprofen
22161-81-5

S-ketoprofen

(3S,7S,10R,13R,17R)-3-acetoxy-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl (2S)-2-(3-benzoylphenyl)-propanoate

(3S,7S,10R,13R,17R)-3-acetoxy-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl (2S)-2-(3-benzoylphenyl)-propanoate

Conditions
ConditionsYield
Stage #1: S-ketoprofen With dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 0.5h;
Stage #2: 7α-hydroxycholest-5-en-3β-yl 3-acetate With dmap at 0℃;
68%
S-ketoprofen
22161-81-5

S-ketoprofen

N-(tert-butyloxycarbonyl)-L-threonine tert-butyl ester
30588-71-7

N-(tert-butyloxycarbonyl)-L-threonine tert-butyl ester

3-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-2(S)-tert-butoxycarbonylamino-butyric acid tert-butyl ester
852055-86-8

3-[2(S)-(3-benzoyl-phenyl)-propionyloxy]-2(S)-tert-butoxycarbonylamino-butyric acid tert-butyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 4h;67%
N1-(1H-indol-6-yl)-N3,N3-dimethylpropane-1,3-diamine
1239447-42-7

N1-(1H-indol-6-yl)-N3,N3-dimethylpropane-1,3-diamine

S-ketoprofen
22161-81-5

S-ketoprofen

2-(3-benzoylphenyl)-N-(3-(dimethylamino)propyl)-N-(1H-indol-6-yl)propanamide
1239447-64-3

2-(3-benzoylphenyl)-N-(3-(dimethylamino)propyl)-N-(1H-indol-6-yl)propanamide

Conditions
ConditionsYield
Stage #1: S-ketoprofen With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: N1-(1H-indol-6-yl)-N3,N3-dimethylpropane-1,3-diamine In N,N-dimethyl-formamide at 20℃; for 2h;
67%
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