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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality D-(-)Pare Hydroxyphenylglycine supplier in China

Cas:22818-40-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Good products, good service. We have professional sales team working on sales service for 15 years. Good products can win good market but can not stand long without good service. We have strict sales regulation and service procedure to make sure yo

D(-)-4-Hydroxy Phenylglycine

Cas:22818-40-2

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply D-N-(4-hydroxyphenyl)glycine

Cas:22818-40-2

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 22818-40-2 D-4-hydroxyphenylglycine Manufacturer

Cas:22818-40-2

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

D(-)-4-Hydroxyphenylglycine Manufacturer/High quality/Best price/In stock

Cas:22818-40-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

D-(-)-2-(4-Hydroxyphenyl)-glycine

Cas:22818-40-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

CHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis

CAS NO 22818-40-2 Pharmaceutical intermediates

Cas:22818-40-2

Min.Order:1 Gram

FOB Price: $3.0

Type:Trading Company

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Hubei DiBo chemical co., LTD

Name:D(-)-4-Hydroxyphenylglycine CAS NO:22818-40-2 Grade:Medical scientific research and export Molecular formula:C8H10N2O Molecular weight:150.1778 Product Quality 12 years of chemical raw materials Mature operation of the industry System

D(-)-4-Hydroxyphenylglycine/ CAS:22818-40-2/raw material/ high-quality

Cas:22818-40-2

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

We are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare

D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Pharmaceutical Intermediate D (-) -4-Hydroxyphenylglycine CAS 22818-40-2.

Cas:22818-40-2

Min.Order:1 Kilogram

FOB Price: $50.0 / 70.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com

TIANFU-CHEM - D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:1 Gram

FOB Price: $1000.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 22818-40-2 with best quality

Cas:22818-40-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality Raw Material CAS 22818-40-2 ,D(-)Alpha Parahydroxy Phenyglycine Base

Cas:22818-40-2

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product name D(-)-4-Hydroxyphenylglycine Synonyms 4-Hydroxy-D-phenylglycine D-2-(4-Hydroxyphenyl)glycine D-p-Hydroxyphenylglycine (R)-alpha

D(-)-4-Hydroxyphenylglycine CAS:22818-40-2

Cas:22818-40-2

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed containers

Factory price cas 22818-40-2 D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzeneacetic acid, a-amino-4-hydroxy-, (aR)- 22818-40-2

Cas:22818-40-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate,D(-)-4-Hydroxyphenylglycine CAS:22818-40-2

Cas:22818-40-2

Min.Order:1 Kilogram

FOB Price: $72.0 / 89.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

4-Hydroxy-D-(-)-2-phenylglycine CAS:22818-40-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o

4-Hydroxy-D-(-)-2-phenylglycine CAS:22818-40-2

Cas:22818-40-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Benzeneacetic acid, a-amino-4-hydroxy-, (aR)-

Cas:22818-40-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:22818-40-2

Cas:22818-40-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

PRODUCT DETAILS

China Largest Manufacturer factory sales 4-HYDROXY-D-PHENYLGLYCINE CAS 22818-40-2

Cas:22818-40-2

Min.Order:500 Kilogram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Triumph International Development Limilted

Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se

D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhengzhou Yuanli Biological Technology Co., Ltd.

Product Name:4-Hydroxy-D-(-)-2-phenylglycine CAS No.:22818-40-2 Molecular Formula:C8H9NO3 Molecular Weight:167.16 Assay : 99% EINECS No.:245-247-7 Place of Origin: China Packaging: 25kg/Drum Port : Any port of China Transportation: by air/by

99% 4-Hydroxy-D-(-)-2-phenylglycine supplier;High quality/Best price

Cas:22818-40-2

Min.Order:10 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

D(-)-4-HYDROXYPHENYLGLYCINE

Cas:22818-40-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

4-Hydroxy-D-(-)-2-phenylglycine

Cas:22818-40-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products D(-)-4-Hydroxyphenylglycine

Cas:22818-40-2

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Synthetic route

potassium cyanide

potassium cyanide

4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With nitrilase AY487533 In aq. acetate buffer at 20℃; for 1h; pH=8; Enzymatic reaction; enantioselective reaction;97.8%
5-(4-hydroxy-phenyl)-imidazolidine-2,4-dione
2420-17-9

5-(4-hydroxy-phenyl)-imidazolidine-2,4-dione

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
In water at 30℃; for 48h; 0.1 M potassium phosphate buffer (pH = 8.0); cells of Pseudomonas sp. AJ-11220 (bacterioal strain H-231); ivestigate steric configuration of the product; other time;94%
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; Product distribution; pH 8.0; enzymatic reaction, other solvents, temperatures, reagents, times;
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h;
Multistep reaction;
D-5-(p-hydroxyphenyl)hydantoin

D-5-(p-hydroxyphenyl)hydantoin

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
In water at 30℃; for 48h; 0.1 M potassium phosphate buffer (pH = 8.0); cells of Pseudomonas sp. AJ-11220 (bacterioal strain H-231); investigate steric configuration of the product; other time;94%
L-5-(p-hydroxyphenyl)hydantoin

L-5-(p-hydroxyphenyl)hydantoin

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
In water at 30℃; for 48h; 0.1 M potassium phosphate buffer (pH = 8.0); cells of Pseudomonas sp. AJ-11220 (bacterioal strain H-231); ivestigate steric configuration of the product; other time;94%
toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

D-2-(4-hydroxyphenyl)-2-(4-methoxybenzyloxycarbonylamino)acetic acid

D-2-(4-hydroxyphenyl)-2-(4-methoxybenzyloxycarbonylamino)acetic acid

acetonitrile
75-05-8

acetonitrile

A

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

B

N-(p-methoxybenzyl)acetamide
35103-34-5

N-(p-methoxybenzyl)acetamide

Conditions
ConditionsYield
for 3.5h; Mechanism; Ambient temperature;A 93%
B 36%
(R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine
54582-01-3

(R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With hydrogenchloride; water at 50℃; for 10h;93%
/PBLFF019-1440/

/PBLFF019-1440/

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With ammonium hydroxide In water at 5℃; for 2h;91.6%
methanol
67-56-1

methanol

4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate
1327278-14-7

4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate

A

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

B

D-2-p-hydroxyphenylglycine methyl ester
37763-23-8

D-2-p-hydroxyphenylglycine methyl ester

Conditions
ConditionsYield
With 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid In water at 20℃; under 3040.2 Torr; for 24h;A 65%
B n/a
N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine
27460-85-1

N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine

toluene-4-sulfonic acid
104-15-4

toluene-4-sulfonic acid

acetonitrile
75-05-8

acetonitrile

A

N-tert-butylacetamide
762-84-5

N-tert-butylacetamide

B

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With toluene-4-sulfonic acid; acetonitrile Mechanism; Ambient temperature;A 51%
B n/a
(S)-2-Amino-3-{[(R)-carboxy-(4-hydroxy-phenyl)-methyl]-amino}-propionic acid
60114-00-3

(S)-2-Amino-3-{[(R)-carboxy-(4-hydroxy-phenyl)-methyl]-amino}-propionic acid

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With hydrogenchloride
(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate
43189-38-4

(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With sodium hydroxide
5-[2-(methylthio)ethyl]imidazolidine-2,4-dione
13253-44-6

5-[2-(methylthio)ethyl]imidazolidine-2,4-dione

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
In water at 30℃; for 24h; Product distribution; 0.1 M potassium phosphate buffer (pH = 8.0); bacterioal strain H-319; also H-968;
α-(aminocarbonyl)amino-4-hydroxybenzeneacetic acid
72500-37-9

α-(aminocarbonyl)amino-4-hydroxybenzeneacetic acid

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h;
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; pH 7.5; enzymatic reaction;
DL-5-cyanoethylhydantoin
1007-06-3

DL-5-cyanoethylhydantoin

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
In water at 30℃; for 24h; Product distribution; 0.1 M potassium phosphate buffer (pH = 8.0); bacterioal strain H-231; also H-618;
complestatin
69598-75-0

complestatin

A

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

B

(R)-2-amino-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid
25698-18-4

(R)-2-amino-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

C

2-(3,5-dichloro-4-hydroxyphenyl)-2,2-dihydroxyacetic acid

2-(3,5-dichloro-4-hydroxyphenyl)-2,2-dihydroxyacetic acid

Conditions
ConditionsYield
With hydrogenchloride; acetic acid at 105℃; for 22h;
p-hydroxyphenylglycine
6324-01-2

p-hydroxyphenylglycine

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

N-carbamyl-D-p-hydroxyphenylglycine
68780-35-8

N-carbamyl-D-p-hydroxyphenylglycine

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite at 0℃;
(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate
43189-12-4

(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate

A

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

B

(S)-hydroxyphenylglycine
32462-30-9

(S)-hydroxyphenylglycine

Conditions
ConditionsYield
With aminoacylase I from Aspergillus melleus; Tris buffer In water at 25℃; for 5h; pH=6.5; Title compound not separated from byproducts;
(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate
43189-12-4

(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate

A

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

B

(S)-hydroxyphenylglycine
32462-30-9

(S)-hydroxyphenylglycine

C

D-2-p-hydroxyphenylglycine methyl ester
37763-23-8

D-2-p-hydroxyphenylglycine methyl ester

D

(S)-methyl 2-amino-2-(4-hydroxyphenyl)acetate
26531-82-8

(S)-methyl 2-amino-2-(4-hydroxyphenyl)acetate

Conditions
ConditionsYield
With Bacillus licheniformis; sodium hydrogencarbonate; 1-ethyl-3-methylimidazolium acetate In water; water-d2 at 30℃; for 3h;
(-)-nocardicin A
39391-39-4

(-)-nocardicin A

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. HCl
2: aq. HCl
View Scheme
p-hydroxyphenylglycine
6324-01-2

p-hydroxyphenylglycine

A

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

B

(S)-hydroxyphenylglycine
32462-30-9

(S)-hydroxyphenylglycine

Conditions
ConditionsYield
With hydrogenchloride; C15H13O4S(1-)*K(1+); C15H12ClO4S(1-)*K(1+) In water; isopropyl alcohol Resolution of racemate;
With sodium alginate chiral column In water Concentration; Reagent/catalyst; Resolution of racemate;
With R-(3,3'-dibromo-1,1'-binaphthyl)-20-crown-6 coated C18 silica gel column at 25℃; pH=2; Resolution of racemate;
With ChirosilRCA(+) at 50℃; Temperature; Resolution of racemate; Sonication;
With perchloric acid at 25℃; pH=1; Reagent/catalyst; Resolution of racemate;
N-phenylacetyl-(4-hydroxyphenyl)-glycine
54713-12-1

N-phenylacetyl-(4-hydroxyphenyl)-glycine

A

phenylacetic acid
103-82-2

phenylacetic acid

B

(R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine
54582-01-3

(R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine

C

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

D

(S)-hydroxyphenylglycine
32462-30-9

(S)-hydroxyphenylglycine

Conditions
ConditionsYield
With penicillin G acylase; water; sodium carbonate for 0.333333h; pH=8.0; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;
4-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)phenyl acetate
1327278-02-3

4-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)phenyl acetate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C
2: platinum(IV) oxide; hydrogen / 3040.2 Torr
3: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr
4: hydrogenchloride; water / 24 h / 90 - 100 °C
View Scheme
4-((S)-5,6-dihydro-2-oxo-5-phenyl-2H-1,4-oxazin-3-yl)phenyl acetate
1327278-09-0

4-((S)-5,6-dihydro-2-oxo-5-phenyl-2H-1,4-oxazin-3-yl)phenyl acetate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: platinum(IV) oxide; hydrogen / 3040.2 Torr
2: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr
3: hydrogenchloride; water / 24 h / 90 - 100 °C
View Scheme
4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate
1327278-14-7

4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr
2: hydrogenchloride; water / 24 h / 90 - 100 °C
View Scheme
4-(((S)-2-hydroxy-1-phenylethylcarbamoyl)methyl)phenyl acetate
1327277-97-3

4-(((S)-2-hydroxy-1-phenylethylcarbamoyl)methyl)phenyl acetate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C
1.2: 4 h / -78 - 20 °C
2.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C
3.1: platinum(IV) oxide; hydrogen / 3040.2 Torr
4.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr
5.1: hydrogenchloride; water / 24 h / 90 - 100 °C
View Scheme
4-acetoxyphenylacetyl chloride
65448-20-6

4-acetoxyphenylacetyl chloride

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: dichloromethane / 0 - 20 °C
2.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C
2.2: 4 h / -78 - 20 °C
3.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C
4.1: platinum(IV) oxide; hydrogen / 3040.2 Torr
5.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr
6.1: hydrogenchloride; water / 24 h / 90 - 100 °C
View Scheme
(4-acetoxyphenyl)acetic acid
38177-33-2

(4-acetoxyphenyl)acetic acid

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: thionyl chloride / 3 h / Reflux
2.1: dichloromethane / 0 - 20 °C
3.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C
3.2: 4 h / -78 - 20 °C
4.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C
5.1: platinum(IV) oxide; hydrogen / 3040.2 Torr
6.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr
7.1: hydrogenchloride; water / 24 h / 90 - 100 °C
View Scheme
D-2-p-hydroxyphenylglycine methyl ester
37763-23-8

D-2-p-hydroxyphenylglycine methyl ester

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

Conditions
ConditionsYield
With hydrogenchloride; water at 90 - 100℃; for 24h;
With sulfuric acid In water at 2℃; for 0.0833333h; pH=8.7; Enzymatic reaction;
With water Enzymatic reaction;
methanol
67-56-1

methanol

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

D-2-p-hydroxyphenylglycine methyl ester
37763-23-8

D-2-p-hydroxyphenylglycine methyl ester

Conditions
ConditionsYield
With thionyl chloride at 20℃; for 10h;100%
With thionyl chloride at 20℃; for 10h;100%
With thionyl chloride at 20℃; for 15h;100%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine
27460-85-1

N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water at 0 - 20℃;100%
With sodium carbonate In water; acetone at 20℃;100%
With sodium hydroxide In 1,3-dioxane; water at 20℃; for 4h;99%
methanol
67-56-1

methanol

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride
57591-61-4, 68697-60-9, 127369-30-6, 134694-94-3

methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at -15℃; Inert atmosphere; Reflux;100%
With thionyl chloride at 0 - 75℃; for 2h;100%
With acetyl chloride at 0 - 55℃; for 19.5h; Inert atmosphere; Large scale reaction;99%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

methyl chloroformate
79-22-1

methyl chloroformate

(R)-2-(4-hydroxyphenyl)-2-[(methoxycarbonyl)amino]acetic acid
77568-43-5

(R)-2-(4-hydroxyphenyl)-2-[(methoxycarbonyl)amino]acetic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃;99%
methanol
67-56-1

methanol

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

α-phenylethanesulfonic acid
86963-42-0

α-phenylethanesulfonic acid

C9H11NO3*C8H10O3S

C9H11NO3*C8H10O3S

Conditions
ConditionsYield
With thionyl chloride at 25℃; for 4h; Time; Reflux; Large scale;98.72%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine
69651-48-5

N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; water for 16h; Ambient temperature; pH=8;98%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

N-(allyloxycarbonyloxy)succinimide
135544-68-2

N-(allyloxycarbonyloxy)succinimide

(R)-N-<(allyloxy)carbonyl>-2-(4-hydroxyphenyl)glycine
84792-41-6

(R)-N-<(allyloxy)carbonyl>-2-(4-hydroxyphenyl)glycine

Conditions
ConditionsYield
With sodium hydrogencarbonate In acetone at 20℃; for 5h;98%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride
57591-61-4, 68697-60-9, 127369-30-6, 134694-94-3

methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride

Conditions
ConditionsYield
With thionyl chloride In methanol at 20℃; for 10h;98%
With thionyl chloride In methanol at 0 - 20℃;
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

D-3,5- 2H2-4-hydroxyphenylglycine

D-3,5- 2H2-4-hydroxyphenylglycine

Conditions
ConditionsYield
With potassium tetrachloroplatinate; water-d2; hydrogen chloride for 24h; Schlenk technique; Reflux; Inert atmosphere;98%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

acetic anhydride
108-24-7

acetic anhydride

N-acetyl-(R)-2-(4-hydroxyphenyl)glycine
37784-23-9

N-acetyl-(R)-2-(4-hydroxyphenyl)glycine

Conditions
ConditionsYield
In acetic acid for 30h; Ambient temperature;96.6%
With sodium hydrogencarbonate In water for 0.166667h; Ambient temperature; Yield given;
With sodium hydroxide In water at 0 - 5℃; for 2.5h;
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(2R)-2-Amino-2-(4-hydroxycyclohexyl)acetic Acid
209460-85-5

(2R)-2-Amino-2-(4-hydroxycyclohexyl)acetic Acid

Conditions
ConditionsYield
With hydrogen; nickel In water at 85℃; under 112509 Torr; for 4h;96%
With hydrogen; Ni-Raney
With sodium hydroxide; hydrogen; nickel In water at 80℃; under 5171.48 Torr; for 72h;
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

N,N-diisopropyl-3-phenyl-2-propen-1-amine
87462-12-2

N,N-diisopropyl-3-phenyl-2-propen-1-amine

2-amino-2-(3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)acetic acid
1333234-68-6

2-amino-2-(3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)acetic acid

Conditions
ConditionsYield
With methanesulfonic acid at 120℃; for 20h;96%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine
173948-30-6

(E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine

2-amino-2-(3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)acetic acid
1333234-68-6

2-amino-2-(3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)acetic acid

Conditions
ConditionsYield
Stage #1: D-4-hydroxyphenylglycine; (E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine With methanesulfonic acid at 120℃; for 20h;
Stage #2: With sodium hydroxide In water pH=7;
96%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(fluorenylmethoxy)carbonyl chloride
28920-43-6

(fluorenylmethoxy)carbonyl chloride

Nα-Fmoc-(4-hydroxy)-D-phenylglycine
178119-93-2

Nα-Fmoc-(4-hydroxy)-D-phenylglycine

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran; water for 8.41667h;95%
With sodium carbonate In 1,4-dioxane at 0 - 20℃; for 2h;
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

C14H12N2O5

C14H12N2O5

Conditions
ConditionsYield
With potassium carbonate In ethanol; water at 100℃; for 16h; sealed tube;95%
benzyloxycarbonyl succinimide

benzyloxycarbonyl succinimide

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid
26787-75-7

(R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid

Conditions
ConditionsYield
With potassium carbonate In water; acetone at 15 - 35℃; pH=8-9;95%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

benzyl chloroformate
501-53-1

benzyl chloroformate

(R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid
26787-75-7

(R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water; toluene at 0 - 20℃; for 1.5h;93%
With sodium carbonate In dichloromethane; water at 0 - 25℃;88%
With sodium hydrogencarbonate In water at 18 - 25℃; for 2.33333h; Inert atmosphere;53%
With sodium hydrogencarbonate In water for 1h;
With potassium hydroxide In water at 0 - 20℃; for 0.0833333h;
ethanol
64-17-5

ethanol

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate
43189-38-4

(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate

Conditions
ConditionsYield
Stage #1: ethanol; D-4-hydroxyphenylglycine With methanesulfonic acid at 10 - 78℃; for 2h;
Stage #2: With sodium hydroxide; water In water at 5 - 40℃; for 3h; pH=7 - 7.5;
92%
Stage #1: ethanol; D-4-hydroxyphenylglycine With methanesulfonic acid at 10 - 78℃; for 2h;
Stage #2: With sodium hydroxide In water at 5 - 40℃; for 3h; pH=7.0 - 7.5;
92%
Stage #1: ethanol; D-4-hydroxyphenylglycine With methanesulfonic acid at 10 - 78℃; Large scale reaction;
Stage #2: With sodium hydroxide In water at 5℃; for 3h; Large scale reaction;
90%
With thionyl chloride at 20℃; for 10h;
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(R),6(S)-bis(4-hydroxyphenyl)piperazine-2,5-dione

(R),6(S)-bis(4-hydroxyphenyl)piperazine-2,5-dione

Conditions
ConditionsYield
In ethylene glycol for 24h; Reflux;92%
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

benzoyl chloride
98-88-4

benzoyl chloride

(R)-2-benzamido-2-(4-hydroxyphenyl)acetic acid
37784-33-1

(R)-2-benzamido-2-(4-hydroxyphenyl)acetic acid

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 3h;88%
With sodium carbonate In dichloromethane; water at 0 - 25℃;66%
With sodium hydrogencarbonate
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(R)-4'-hydroxy-3',5'-diiodophenylglycine
792892-61-6

(R)-4'-hydroxy-3',5'-diiodophenylglycine

Conditions
ConditionsYield
With Iodine monochloride; acetic acid at 20℃; for 72h;87%
With Iodine monochloride In acetic acid78%
With Iodine monochloride; acetic acid at 20℃; for 72h; Inert atmosphere;65%
With Iodine monochloride; acetic acid at 20℃; for 72h; Inert atmosphere;
D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

methyl 4-methoxyphenyl-D-phenylglycinate
78307-39-8

methyl 4-methoxyphenyl-D-phenylglycinate

Conditions
ConditionsYield
In methanol; diethyl ether for 24h; Ambient temperature;86%
methanol
67-56-1

methanol

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

D-4-hydroxyphenylglycine
22818-40-2

D-4-hydroxyphenylglycine

(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate
143323-49-3, 141518-55-0

(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

Conditions
ConditionsYield
Stage #1: methanol; D-4-hydroxyphenylglycine With thionyl chloride at 0℃; for 18h; Heating / reflux;
Stage #2: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine In methanol for 4h; pH=4 - 10;
85%
Stage #1: methanol; D-4-hydroxyphenylglycine With thionyl chloride Heating / reflux;
Stage #2: di-tert-butyl dicarbonate With triethylamine In 1,4-dioxane; water at 25℃;
83%

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