Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:22818-40-2
Min.Order:1 Kilogram
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inquiryGood products, good service. We have professional sales team working on sales service for 15 years. Good products can win good market but can not stand long without good service. We have strict sales regulation and service procedure to make sure yo
Cas:22818-40-2
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
Cas:22818-40-2
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:22818-40-2
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:22818-40-2
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:22818-40-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:22818-40-2
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryCHENGDU YANXI is a comprehensive manufacturer and an international distribution of products throughout the world. Specialized in Scrap metal, Chemical raw materials, Paper products and color industry. We aim to become leading position in global dis
Cas:22818-40-2
Min.Order:1 Gram
FOB Price: $3.0
Type:Trading Company
inquiryName:D(-)-4-Hydroxyphenylglycine CAS NO:22818-40-2 Grade:Medical scientific research and export Molecular formula:C8H10N2O Molecular weight:150.1778 Product Quality 12 years of chemical raw materials Mature operation of the industry System
Cas:22818-40-2
Min.Order:25 Kilogram
FOB Price: $2.0 / 3.0
Type:Other
inquiryWe are a professional chemicals, APIs and plant extract leading manufacturer in China. We are specialized in chemical synthesis, process development of pharmaceutical intermediates, active pharmaceutical ingredients (APIs), plant extract and rare
Cas:22818-40-2
Min.Order:1 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:22818-40-2
Min.Order:1 Kilogram
FOB Price: $50.0 / 70.0
Type:Trading Company
inquiryHenan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the com
Cas:22818-40-2
Min.Order:1 Gram
FOB Price: $1000.0
Type:Lab/Research institutions
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:22818-40-2
Min.Order:1 Kilogram
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Type:Trading Company
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Cas:22818-40-2
Min.Order:10 Kilogram
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Type:Trading Company
inquiryProduct name D(-)-4-Hydroxyphenylglycine Synonyms 4-Hydroxy-D-phenylglycine D-2-(4-Hydroxyphenyl)glycine D-p-Hydroxyphenylglycine (R)-alpha
Cas:22818-40-2
Min.Order:5 Metric Ton
FOB Price: $1.0 / 2.0
Type:Other
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed containers
Cas:22818-40-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:22818-40-2
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:22818-40-2
Min.Order:1 Kilogram
FOB Price: $72.0 / 89.0
Type:Trading Company
inquiry4-Hydroxy-D-(-)-2-phenylglycine CAS:22818-40-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality o
Cas:22818-40-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:22818-40-2
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
PRODUCT DETAILS
Cas:22818-40-2
Min.Order:500 Kilogram
FOB Price: $1.0 / 2.0
Type:Lab/Research institutions
inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Appearance:White or off-white Solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common products:Se
Cas:22818-40-2
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryProduct Name:4-Hydroxy-D-(-)-2-phenylglycine CAS No.:22818-40-2 Molecular Formula:C8H9NO3 Molecular Weight:167.16 Assay : 99% EINECS No.:245-247-7 Place of Origin: China Packaging: 25kg/Drum Port : Any port of China Transportation: by air/by
Cas:22818-40-2
Min.Order:10 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
Cas:22818-40-2
Min.Order:0 Metric Ton
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Type:Lab/Research institutions
inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:22818-40-2
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Cas:22818-40-2
Min.Order:0
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Type:Lab/Research institutions
inquiryWhy Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu
Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff
Cas:22818-40-2
Min.Order:100 Gram
Negotiable
Type:Other
inquiryConditions | Yield |
---|---|
With nitrilase AY487533 In aq. acetate buffer at 20℃; for 1h; pH=8; Enzymatic reaction; enantioselective reaction; | 97.8% |
5-(4-hydroxy-phenyl)-imidazolidine-2,4-dione
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
In water at 30℃; for 48h; 0.1 M potassium phosphate buffer (pH = 8.0); cells of Pseudomonas sp. AJ-11220 (bacterioal strain H-231); ivestigate steric configuration of the product; other time; | 94% |
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; Product distribution; pH 8.0; enzymatic reaction, other solvents, temperatures, reagents, times; | |
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; | |
Multistep reaction; |
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
In water at 30℃; for 48h; 0.1 M potassium phosphate buffer (pH = 8.0); cells of Pseudomonas sp. AJ-11220 (bacterioal strain H-231); investigate steric configuration of the product; other time; | 94% |
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
In water at 30℃; for 48h; 0.1 M potassium phosphate buffer (pH = 8.0); cells of Pseudomonas sp. AJ-11220 (bacterioal strain H-231); ivestigate steric configuration of the product; other time; | 94% |
toluene-4-sulfonic acid
acetonitrile
A
D-4-hydroxyphenylglycine
B
N-(p-methoxybenzyl)acetamide
Conditions | Yield |
---|---|
for 3.5h; Mechanism; Ambient temperature; | A 93% B 36% |
(R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With hydrogenchloride; water at 50℃; for 10h; | 93% |
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With ammonium hydroxide In water at 5℃; for 2h; | 91.6% |
methanol
4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate
A
D-4-hydroxyphenylglycine
B
D-2-p-hydroxyphenylglycine methyl ester
Conditions | Yield |
---|---|
With 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid In water at 20℃; under 3040.2 Torr; for 24h; | A 65% B n/a |
N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine
toluene-4-sulfonic acid
acetonitrile
A
N-tert-butylacetamide
B
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid; acetonitrile Mechanism; Ambient temperature; | A 51% B n/a |
(S)-2-Amino-3-{[(R)-carboxy-(4-hydroxy-phenyl)-methyl]-amino}-propionic acid
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With hydrogenchloride |
(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With sodium hydroxide |
5-[2-(methylthio)ethyl]imidazolidine-2,4-dione
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
In water at 30℃; for 24h; Product distribution; 0.1 M potassium phosphate buffer (pH = 8.0); bacterioal strain H-319; also H-968; |
α-(aminocarbonyl)amino-4-hydroxybenzeneacetic acid
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; | |
With potassium phosphate buffer; Pseudomonas sp. AJ-11220 In various solvent(s) at 30℃; for 2h; pH 7.5; enzymatic reaction; |
DL-5-cyanoethylhydantoin
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
In water at 30℃; for 24h; Product distribution; 0.1 M potassium phosphate buffer (pH = 8.0); bacterioal strain H-231; also H-618; |
complestatin
A
D-4-hydroxyphenylglycine
B
(R)-2-amino-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride; acetic acid at 105℃; for 22h; |
p-hydroxyphenylglycine
D-4-hydroxyphenylglycine
N-carbamyl-D-p-hydroxyphenylglycine
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite at 0℃; |
(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate
A
D-4-hydroxyphenylglycine
B
(S)-hydroxyphenylglycine
Conditions | Yield |
---|---|
With aminoacylase I from Aspergillus melleus; Tris buffer In water at 25℃; for 5h; pH=6.5; Title compound not separated from byproducts; |
(R)-methyl 2-amino-2-(4-hydroxyphenyl)acetate
A
D-4-hydroxyphenylglycine
B
(S)-hydroxyphenylglycine
C
D-2-p-hydroxyphenylglycine methyl ester
D
(S)-methyl 2-amino-2-(4-hydroxyphenyl)acetate
Conditions | Yield |
---|---|
With Bacillus licheniformis; sodium hydrogencarbonate; 1-ethyl-3-methylimidazolium acetate In water; water-d2 at 30℃; for 3h; |
(-)-nocardicin A
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aq. HCl 2: aq. HCl View Scheme |
p-hydroxyphenylglycine
A
D-4-hydroxyphenylglycine
B
(S)-hydroxyphenylglycine
Conditions | Yield |
---|---|
With hydrogenchloride; C15H13O4S(1-)*K(1+); C15H12ClO4S(1-)*K(1+) In water; isopropyl alcohol Resolution of racemate; | |
With sodium alginate chiral column In water Concentration; Reagent/catalyst; Resolution of racemate; | |
With R-(3,3'-dibromo-1,1'-binaphthyl)-20-crown-6 coated C18 silica gel column at 25℃; pH=2; Resolution of racemate; | |
With ChirosilRCA(+) at 50℃; Temperature; Resolution of racemate; Sonication; | |
With perchloric acid at 25℃; pH=1; Reagent/catalyst; Resolution of racemate; |
N-phenylacetyl-(4-hydroxyphenyl)-glycine
A
phenylacetic acid
B
(R)-N-phenylacetyl-D-(4-hydroxyphenyl)-glycine
C
D-4-hydroxyphenylglycine
D
(S)-hydroxyphenylglycine
Conditions | Yield |
---|---|
With penicillin G acylase; water; sodium carbonate for 0.333333h; pH=8.0; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantioselective reaction; |
4-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)phenyl acetate
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C 2: platinum(IV) oxide; hydrogen / 3040.2 Torr 3: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 4: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme |
4-((S)-5,6-dihydro-2-oxo-5-phenyl-2H-1,4-oxazin-3-yl)phenyl acetate
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: platinum(IV) oxide; hydrogen / 3040.2 Torr 2: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 3: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme |
4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 2: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme |
4-(((S)-2-hydroxy-1-phenylethylcarbamoyl)methyl)phenyl acetate
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C 1.2: 4 h / -78 - 20 °C 2.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C 3.1: platinum(IV) oxide; hydrogen / 3040.2 Torr 4.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 5.1: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme |
4-acetoxyphenylacetyl chloride
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: dichloromethane / 0 - 20 °C 2.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C 2.2: 4 h / -78 - 20 °C 3.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C 4.1: platinum(IV) oxide; hydrogen / 3040.2 Torr 5.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 6.1: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme |
(4-acetoxyphenyl)acetic acid
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: thionyl chloride / 3 h / Reflux 2.1: dichloromethane / 0 - 20 °C 3.1: diethylamino-sulfur trifluoride / dichloromethane / 1.25 h / -78 °C 3.2: 4 h / -78 - 20 °C 4.1: selenium(IV) oxide / ethyl acetate / 1 h / 75 °C 5.1: platinum(IV) oxide; hydrogen / 3040.2 Torr 6.1: 20 wt.% Pd(OH)2 on activated carbon; hydrogen; trifluoroacetic acid / water / 24 h / 20 °C / 3040.2 Torr 7.1: hydrogenchloride; water / 24 h / 90 - 100 °C View Scheme |
D-2-p-hydroxyphenylglycine methyl ester
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With hydrogenchloride; water at 90 - 100℃; for 24h; | |
With sulfuric acid In water at 2℃; for 0.0833333h; pH=8.7; Enzymatic reaction; | |
With water Enzymatic reaction; |
methanol
D-4-hydroxyphenylglycine
D-2-p-hydroxyphenylglycine methyl ester
Conditions | Yield |
---|---|
With thionyl chloride at 20℃; for 10h; | 100% |
With thionyl chloride at 20℃; for 10h; | 100% |
With thionyl chloride at 20℃; for 15h; | 100% |
di-tert-butyl dicarbonate
D-4-hydroxyphenylglycine
N-(tert-butoxycarbonyl)-D-(4-hydroxyphenyl)glycine
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water at 0 - 20℃; | 100% |
With sodium carbonate In water; acetone at 20℃; | 100% |
With sodium hydroxide In 1,3-dioxane; water at 20℃; for 4h; | 99% |
methanol
D-4-hydroxyphenylglycine
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride at -15℃; Inert atmosphere; Reflux; | 100% |
With thionyl chloride at 0 - 75℃; for 2h; | 100% |
With acetyl chloride at 0 - 55℃; for 19.5h; Inert atmosphere; Large scale reaction; | 99% |
D-4-hydroxyphenylglycine
methyl chloroformate
(R)-2-(4-hydroxyphenyl)-2-[(methoxycarbonyl)amino]acetic acid
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran; water at 20℃; | 99% |
Conditions | Yield |
---|---|
With thionyl chloride at 25℃; for 4h; Time; Reflux; Large scale; | 98.72% |
di-tert-butyl dicarbonate
D-4-hydroxyphenylglycine
N-tert-butyloxycarbonyl-L-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran; water for 16h; Ambient temperature; pH=8; | 98% |
D-4-hydroxyphenylglycine
N-(allyloxycarbonyloxy)succinimide
(R)-N-<(allyloxy)carbonyl>-2-(4-hydroxyphenyl)glycine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In acetone at 20℃; for 5h; | 98% |
D-4-hydroxyphenylglycine
methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride In methanol at 20℃; for 10h; | 98% |
With thionyl chloride In methanol at 0 - 20℃; |
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
With potassium tetrachloroplatinate; water-d2; hydrogen chloride for 24h; Schlenk technique; Reflux; Inert atmosphere; | 98% |
D-4-hydroxyphenylglycine
acetic anhydride
N-acetyl-(R)-2-(4-hydroxyphenyl)glycine
Conditions | Yield |
---|---|
In acetic acid for 30h; Ambient temperature; | 96.6% |
With sodium hydrogencarbonate In water for 0.166667h; Ambient temperature; Yield given; | |
With sodium hydroxide In water at 0 - 5℃; for 2.5h; |
D-4-hydroxyphenylglycine
(2R)-2-Amino-2-(4-hydroxycyclohexyl)acetic Acid
Conditions | Yield |
---|---|
With hydrogen; nickel In water at 85℃; under 112509 Torr; for 4h; | 96% |
With hydrogen; Ni-Raney | |
With sodium hydroxide; hydrogen; nickel In water at 80℃; under 5171.48 Torr; for 72h; |
D-4-hydroxyphenylglycine
N,N-diisopropyl-3-phenyl-2-propen-1-amine
2-amino-2-(3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)acetic acid
Conditions | Yield |
---|---|
With methanesulfonic acid at 120℃; for 20h; | 96% |
D-4-hydroxyphenylglycine
(E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine
2-amino-2-(3-(3-(diisopropylamino)-1-phenylpropyl)-4-hydroxyphenyl)acetic acid
Conditions | Yield |
---|---|
Stage #1: D-4-hydroxyphenylglycine; (E)-N,N-diisopropyl-3-phenylprop-2-en-1-amine With methanesulfonic acid at 120℃; for 20h; Stage #2: With sodium hydroxide In water pH=7; | 96% |
D-4-hydroxyphenylglycine
(fluorenylmethoxy)carbonyl chloride
Nα-Fmoc-(4-hydroxy)-D-phenylglycine
Conditions | Yield |
---|---|
With sodium hydrogencarbonate In tetrahydrofuran; water for 8.41667h; | 95% |
With sodium carbonate In 1,4-dioxane at 0 - 20℃; for 2h; |
Conditions | Yield |
---|---|
With potassium carbonate In ethanol; water at 100℃; for 16h; sealed tube; | 95% |
D-4-hydroxyphenylglycine
(R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid
Conditions | Yield |
---|---|
With potassium carbonate In water; acetone at 15 - 35℃; pH=8-9; | 95% |
D-4-hydroxyphenylglycine
benzyl chloroformate
(R)-2-(((benzyloxy)carbonyl)amino)-2-(4-hydroxyphenyl)acetic acid
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water; toluene at 0 - 20℃; for 1.5h; | 93% |
With sodium carbonate In dichloromethane; water at 0 - 25℃; | 88% |
With sodium hydrogencarbonate In water at 18 - 25℃; for 2.33333h; Inert atmosphere; | 53% |
With sodium hydrogencarbonate In water for 1h; | |
With potassium hydroxide In water at 0 - 20℃; for 0.0833333h; |
ethanol
D-4-hydroxyphenylglycine
(R)-ethyl 2-amino-2-(4-hydroxyphenyl)acetate
Conditions | Yield |
---|---|
Stage #1: ethanol; D-4-hydroxyphenylglycine With methanesulfonic acid at 10 - 78℃; for 2h; Stage #2: With sodium hydroxide; water In water at 5 - 40℃; for 3h; pH=7 - 7.5; | 92% |
Stage #1: ethanol; D-4-hydroxyphenylglycine With methanesulfonic acid at 10 - 78℃; for 2h; Stage #2: With sodium hydroxide In water at 5 - 40℃; for 3h; pH=7.0 - 7.5; | 92% |
Stage #1: ethanol; D-4-hydroxyphenylglycine With methanesulfonic acid at 10 - 78℃; Large scale reaction; Stage #2: With sodium hydroxide In water at 5℃; for 3h; Large scale reaction; | 90% |
With thionyl chloride at 20℃; for 10h; |
D-4-hydroxyphenylglycine
Conditions | Yield |
---|---|
In ethylene glycol for 24h; Reflux; | 92% |
D-4-hydroxyphenylglycine
benzoyl chloride
(R)-2-benzamido-2-(4-hydroxyphenyl)acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 3h; | 88% |
With sodium carbonate In dichloromethane; water at 0 - 25℃; | 66% |
With sodium hydrogencarbonate |
D-4-hydroxyphenylglycine
(R)-4'-hydroxy-3',5'-diiodophenylglycine
Conditions | Yield |
---|---|
With Iodine monochloride; acetic acid at 20℃; for 72h; | 87% |
With Iodine monochloride In acetic acid | 78% |
With Iodine monochloride; acetic acid at 20℃; for 72h; Inert atmosphere; | 65% |
With Iodine monochloride; acetic acid at 20℃; for 72h; Inert atmosphere; |
diazomethane
D-4-hydroxyphenylglycine
methyl 4-methoxyphenyl-D-phenylglycinate
Conditions | Yield |
---|---|
In methanol; diethyl ether for 24h; Ambient temperature; | 86% |
methanol
di-tert-butyl dicarbonate
D-4-hydroxyphenylglycine
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate
Conditions | Yield |
---|---|
Stage #1: methanol; D-4-hydroxyphenylglycine With thionyl chloride at 0℃; for 18h; Heating / reflux; Stage #2: di-tert-butyl dicarbonate With N-ethyl-N,N-diisopropylamine In methanol for 4h; pH=4 - 10; | 85% |
Stage #1: methanol; D-4-hydroxyphenylglycine With thionyl chloride Heating / reflux; Stage #2: di-tert-butyl dicarbonate With triethylamine In 1,4-dioxane; water at 25℃; | 83% |
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