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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Paeoniflorin Manufacturer/High quality/Best price/In stock

Cas:23180-57-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Paeoniflorin supplier in China

Cas:23180-57-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

Superiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best

White Peony Extract Paeoniflorin with best price and top quality

Cas:23180-57-6

Min.Order:1 Kilogram

FOB Price: $120.0 / 150.0

Type:Other

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Wuhan Fortuna Chemical Co.,Ltd

Stable stock and competitive price Appearance:Brown powder Storage:Stored in a cool&dry well-closed container,keep away from moisture and strong light/heat Package:1KG 5KG 25KG Application:As Pharm raw material Transportation:By Courier,Sea or ai

Paeoniflorin

Cas:23180-57-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Sleeping pills and stability.This product is white or white crystalline powder;Odourless and slightly bitter taste.Almost insoluble in water, soluble in hydrochloric acid.In acid or alkali and heat hydrolysis, oral drug under the action of gastric

Paeoniflorin

Cas:23180-57-6

Min.Order:10000 Gram

FOB Price: $1300.0

Type:Manufacturers

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Xi'an Quanao Biotech Co., Ltd.

We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,

Natural Top Grade White Peony Root Extract Powder 10:1

Cas:23180-57-6

Min.Order:2 Kilogram

FOB Price: $16.0 / 18.8

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Natural Extract 98% Paeoniflorin 23180-57-6 HACCP Manufacturer

Cas:23180-57-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Paeoniflorin

Cas:23180-57-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

Paeoniflorin

Cas:23180-57-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Paeoniflorin

Cas:23180-57-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Paeoniflorin CAS NO:23180-57-6 Grade:Medical scientific research and export Molecular formula: C23H28O11 Molecular weight:480.47 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability D

Paeoniflorin/ CAS:23180-57-6/raw material/ high-quality

Cas:23180-57-6

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Paeoniflorin/ LIDE PHARMA- Factory supply / Best price

Cas:23180-57-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Paeoniflorin Basic information Product Name: Paeoniflorin Synonyms: 5beta-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1h-3,4-dioxacyclobuta[cd]pen

TIANFU-CHEM Paeoniflorin 23180-57-6

Cas:23180-57-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Density: 1.3044 (rough estimate) Melting point: approximate 124 ℃ (dec.) Boiling point: 498.51 ° C (rough estimate) Specific rotation: -11.0~-15.0 ° (C=1, MeOHl) Flash point: 234.2 ° C Steam pressure: 1.07E-19mmHg at 25 ° C Solubility

Paeoniflorin 23180-57-6

Cas:23180-57-6

Min.Order:5 Kilogram

FOB Price: $20.0 / 80.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Best CAS 23180-57-6 with competitive price

Cas:23180-57-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: Paeoniflorin Synonyms: β-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]- CAS: 23180-57-6

Paeoniflorin

Cas:23180-57-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

Paeoniflorin Manufacturer 23180-57-6 For Analgesic, Calm

Cas:23180-57-6

Min.Order:10 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Paeoniflorin 23180-57-6

Cas:23180-57-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Supply Chinese herbaceous peony extract CAS:23180-57-6

Cas:23180-57-6

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

PaeoniflorinCAS:23180-57-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates

PaeoniflorinCAS:23180-57-6

Cas:23180-57-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Paeoniflorin

Cas:23180-57-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Leader Biochemical Group

Overview of Our Factories Our Factories production lines Our Factories R&D ability Our Factories warehouse Our Factorie

China Biggest Factory & Manufacturer supply Paeoniflorin

Cas:23180-57-6

Min.Order:1 Gram

FOB Price: $5.0 / 10.0

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Paeoniflorin

Cas:23180-57-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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ShangHai Soyoung Biotechnology Inc

Trade Assurance Get full protection for your orders 100% Product quality protection 100% On-time shipment protection 100% Payment protection Appearance:Light?Yellow?powder Storage:Store in a cool dry place, avoiding sunlight directly Package:25

Paeonia Lactiflora P.E.

Cas:23180-57-6

Min.Order:25 Kilogram

FOB Price: $30.0

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Paeoniflorin

Cas:23180-57-6

Min.Order:1 Kilogram

FOB Price: $30.0 / 50.0

Type:Lab/Research institutions

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS23180-57-6 Paeoniflorin

Cas:23180-57-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

paeoniflorin

Cas:23180-57-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

paeoniflorin

Cas:23180-57-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Paeoniflorin

Cas:23180-57-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Paeoniflorin

Cas:23180-57-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Synthetic route

C59H58O13

C59H58O13

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
With hydrogen; palladium dihydroxide In methanol; water; ethyl acetate100%
2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl trichloroacetimidate
74808-09-6

2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl trichloroacetimidate

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / BF3*Et2O / toluene / -78 °C
2: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
(1R,3aS,5R,6R,7aR)-1-Hydroxymethyl-7a-isopropenyl-3a-methyl-octahydro-3-oxa-1,6-cyclo-inden-5-ol

(1R,3aS,5R,6R,7aR)-1-Hydroxymethyl-7a-isopropenyl-3a-methyl-octahydro-3-oxa-1,6-cyclo-inden-5-ol

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1: Et3N / CH2Cl2
2: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 2.) CH2Cl2
3: KCN, 18-crown-6*MeCN / acetonitrile
4: 0.1 M aq. HCl / tetrahydrofuran
5: PhI(OAc)2, I2 / benzene / Irradiation
6: HCl / dioxane / 40 °C
7: (COCl)2, DMF / benzene
8: pyridine, DMAP / toluene
9: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
10: 71 percent / Et3N, DMAP / CH2Cl2
11: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
12: 67 percent / BF3*Et2O / toluene / -78 °C
13: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
(1S,3aS,5R,6R,7aR)-5-Hydroxy-7a-isopropenyl-3a-methyl-hexahydro-3-oxa-1,6-cyclo-indene-1-carboxylic acid methyl ester

(1S,3aS,5R,6R,7aR)-5-Hydroxy-7a-isopropenyl-3a-methyl-hexahydro-3-oxa-1,6-cyclo-indene-1-carboxylic acid methyl ester

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 15 steps
1: 47 percent / dicyclohexylcarbodiimide, DMAP / CH2Cl2
2: LiAlH4 / tetrahydrofuran
3: Et3N / CH2Cl2
4: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 2.) CH2Cl2
5: KCN, 18-crown-6*MeCN / acetonitrile
6: 0.1 M aq. HCl / tetrahydrofuran
7: PhI(OAc)2, I2 / benzene / Irradiation
8: HCl / dioxane / 40 °C
9: (COCl)2, DMF / benzene
10: pyridine, DMAP / toluene
11: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
12: 71 percent / Et3N, DMAP / CH2Cl2
13: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
14: 67 percent / BF3*Et2O / toluene / -78 °C
15: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
(1S,3aS,6R,7aR)-7a-Isopropenyl-3a-methyl-5-oxo-hexahydro-3-oxa-1,6-cyclo-indene-1-carboxylic acid methyl ester

(1S,3aS,6R,7aR)-7a-Isopropenyl-3a-methyl-5-oxo-hexahydro-3-oxa-1,6-cyclo-indene-1-carboxylic acid methyl ester

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 16 steps
1: NaBH4 / methanol / -20 °C
2: 47 percent / dicyclohexylcarbodiimide, DMAP / CH2Cl2
3: LiAlH4 / tetrahydrofuran
4: Et3N / CH2Cl2
5: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 2.) CH2Cl2
6: KCN, 18-crown-6*MeCN / acetonitrile
7: 0.1 M aq. HCl / tetrahydrofuran
8: PhI(OAc)2, I2 / benzene / Irradiation
9: HCl / dioxane / 40 °C
10: (COCl)2, DMF / benzene
11: pyridine, DMAP / toluene
12: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
13: 71 percent / Et3N, DMAP / CH2Cl2
14: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
15: 67 percent / BF3*Et2O / toluene / -78 °C
16: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
Benzoic acid (1S,3aS,5R,6R,7aR)-5-hydroxy-7a-isopropenyl-3a-methyl-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester

Benzoic acid (1S,3aS,5R,6R,7aR)-5-hydroxy-7a-isopropenyl-3a-methyl-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 2.) CH2Cl2
2: KCN, 18-crown-6*MeCN / acetonitrile
3: 0.1 M aq. HCl / tetrahydrofuran
4: PhI(OAc)2, I2 / benzene / Irradiation
5: HCl / dioxane / 40 °C
6: (COCl)2, DMF / benzene
7: pyridine, DMAP / toluene
8: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
9: 71 percent / Et3N, DMAP / CH2Cl2
10: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
11: 67 percent / BF3*Et2O / toluene / -78 °C
12: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
Benzoic acid (1S,3aS,6R,7aR)-7a-isopropenyl-3a-methyl-5-oxo-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester

Benzoic acid (1S,3aS,6R,7aR)-7a-isopropenyl-3a-methyl-5-oxo-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 11 steps
1: KCN, 18-crown-6*MeCN / acetonitrile
2: 0.1 M aq. HCl / tetrahydrofuran
3: PhI(OAc)2, I2 / benzene / Irradiation
4: HCl / dioxane / 40 °C
5: (COCl)2, DMF / benzene
6: pyridine, DMAP / toluene
7: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
8: 71 percent / Et3N, DMAP / CH2Cl2
9: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
10: 67 percent / BF3*Et2O / toluene / -78 °C
11: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
C20H22O5
154854-76-9

C20H22O5

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 71 percent / Et3N, DMAP / CH2Cl2
2: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
3: 67 percent / BF3*Et2O / toluene / -78 °C
4: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
Benzoic acid (1S,3aS,5R,6R,7aR)-5-cyano-5-hydroxy-7a-isopropenyl-3a-methyl-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester
154854-72-5

Benzoic acid (1S,3aS,5R,6R,7aR)-5-cyano-5-hydroxy-7a-isopropenyl-3a-methyl-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: PhI(OAc)2, I2 / benzene / Irradiation
2: HCl / dioxane / 40 °C
3: (COCl)2, DMF / benzene
4: pyridine, DMAP / toluene
5: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
6: 71 percent / Et3N, DMAP / CH2Cl2
7: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
8: 67 percent / BF3*Et2O / toluene / -78 °C
9: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
C21H21NO4
154854-73-6

C21H21NO4

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: HCl / dioxane / 40 °C
2: (COCl)2, DMF / benzene
3: pyridine, DMAP / toluene
4: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
5: 71 percent / Et3N, DMAP / CH2Cl2
6: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
7: 67 percent / BF3*Et2O / toluene / -78 °C
8: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
C21H22O6
154854-74-7

C21H22O6

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: (COCl)2, DMF / benzene
2: pyridine, DMAP / toluene
3: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
4: 71 percent / Et3N, DMAP / CH2Cl2
5: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
6: 67 percent / BF3*Et2O / toluene / -78 °C
7: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
C21H21ClO5

C21H21ClO5

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: pyridine, DMAP / toluene
2: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
3: 71 percent / Et3N, DMAP / CH2Cl2
4: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
5: 67 percent / BF3*Et2O / toluene / -78 °C
6: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
Benzoic acid (1S,3aS,5R,6R,7aR)-5-cyano-7a-isopropenyl-3a-methyl-5-trimethylsilanyloxy-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester

Benzoic acid (1S,3aS,5R,6R,7aR)-5-cyano-7a-isopropenyl-3a-methyl-5-trimethylsilanyloxy-hexahydro-3-oxa-1,6-cyclo-inden-1-ylmethyl ester

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: 0.1 M aq. HCl / tetrahydrofuran
2: PhI(OAc)2, I2 / benzene / Irradiation
3: HCl / dioxane / 40 °C
4: (COCl)2, DMF / benzene
5: pyridine, DMAP / toluene
6: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
7: 71 percent / Et3N, DMAP / CH2Cl2
8: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
9: 67 percent / BF3*Et2O / toluene / -78 °C
10: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
(1S,3aS,5R,6R,7aR)-7a-Isopropenyl-5-((R)-2-methoxy-2-phenyl-acetoxy)-3a-methyl-hexahydro-3-oxa-1,6-cyclo-indene-1-carboxylic acid methyl ester
154854-70-3

(1S,3aS,5R,6R,7aR)-7a-Isopropenyl-5-((R)-2-methoxy-2-phenyl-acetoxy)-3a-methyl-hexahydro-3-oxa-1,6-cyclo-indene-1-carboxylic acid methyl ester

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 14 steps
1: LiAlH4 / tetrahydrofuran
2: Et3N / CH2Cl2
3: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -60 deg C, 2.) CH2Cl2
4: KCN, 18-crown-6*MeCN / acetonitrile
5: 0.1 M aq. HCl / tetrahydrofuran
6: PhI(OAc)2, I2 / benzene / Irradiation
7: HCl / dioxane / 40 °C
8: (COCl)2, DMF / benzene
9: pyridine, DMAP / toluene
10: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
11: 71 percent / Et3N, DMAP / CH2Cl2
12: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
13: 67 percent / BF3*Et2O / toluene / -78 °C
14: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
C26H25NO5S

C26H25NO5S

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1.) O2, 2.) (MeO)3P / 1.) toluene, 80 deg C, 2.) toluene
2: 71 percent / Et3N, DMAP / CH2Cl2
3: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
4: 67 percent / BF3*Et2O / toluene / -78 °C
5: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
C25H24O8
154854-78-1

C25H24O8

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 67 percent / BF3*Et2O / toluene / -78 °C
2: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
C28H28O7
154854-77-0

C28H28O7

paeoniflorin
23180-57-6

paeoniflorin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) O3, MeOH, 2.) p-NO2-C6H4COCl, Et3N, DMAP / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2
2: 67 percent / BF3*Et2O / toluene / -78 °C
3: 100 percent / H2 / Pd(OH)2 / methanol; ethyl acetate; H2O
View Scheme
acetic anhydride
108-24-7

acetic anhydride

paeoniflorin
23180-57-6

paeoniflorin

paeoniflorin tetra-O-acetate

paeoniflorin tetra-O-acetate

Conditions
ConditionsYield
With pyridine at 20 - 22℃;83%
3,4,6-tri-O-benzyl-D-glucal epoxide
74372-90-0

3,4,6-tri-O-benzyl-D-glucal epoxide

paeoniflorin
23180-57-6

paeoniflorin

A

C50H56O16

C50H56O16

B

C50H56O16

C50H56O16

Conditions
ConditionsYield
With 4-nitrophenylboronic acid; water In acetonitrile at -10℃; for 6h; Inert atmosphere; regioselective reaction;A 73%
B 7%
O-[(α-D-mannopyranosyl)-(1->6)-(α-D-mannopyranosyl)-(1->3)-β-D-mannopyranosyl]-(1->4)-(1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-methyloxazoline
861695-58-1

O-[(α-D-mannopyranosyl)-(1->6)-(α-D-mannopyranosyl)-(1->3)-β-D-mannopyranosyl]-(1->4)-(1,2-dideoxy-α-D-glucopyrano)-[2,1-d]-2-methyloxazoline

paeoniflorin
23180-57-6

paeoniflorin

C49H71NO31
1093135-93-3

C49H71NO31

Conditions
ConditionsYield
With endo-β-N-acetylglucosaminidase from Arthrobactor protophormiae In dimethyl sulfoxide at 23℃; for 2h; pH=7.0; aq. phosphate buffer; Enzymatic reaction;60%
benzoyl chloride
98-88-4

benzoyl chloride

paeoniflorin
23180-57-6

paeoniflorin

paeoniflorin tetra-O-benzoate

paeoniflorin tetra-O-benzoate

Conditions
ConditionsYield
With pyridine at 20 - 22℃; for 48h;58%
benzoyl chloride
98-88-4

benzoyl chloride

paeoniflorin
23180-57-6

paeoniflorin

A

C58H48O16

C58H48O16

B

C58H48O16

C58H48O16

Conditions
ConditionsYield
With pyridine at 0 - 22℃;A 49%
B 36%
methanol
67-56-1

methanol

paeoniflorin
23180-57-6

paeoniflorin

A

3-O-methylpaeoniflorin

3-O-methylpaeoniflorin

B

4-oxo-9-O-methylpaeoniflorin
209969-75-5

4-oxo-9-O-methylpaeoniflorin

Conditions
ConditionsYield
With cation exchanger KU-2-8 (H+) for 2h; Reflux; Overall yield = 90 %; Overall yield = 296 mg;A 40%
B 42%
paeoniflorin
23180-57-6

paeoniflorin

A

7S-paeonimetaboline I
99624-67-6

7S-paeonimetaboline I

B

7R-paeonimetaboline I
112018-99-2

7R-paeonimetaboline I

C

paeonimetaboline II
111950-55-1

paeonimetaboline II

Conditions
ConditionsYield
With Bacteroides fragilis ss. thetaotus In water at 37℃; for 12h; Product distribution;A 12.6%
B 6.2%
C 0.9%
paeoniflorin
23180-57-6

paeoniflorin

A

7S-paeonimetaboline I
99624-67-6

7S-paeonimetaboline I

B

7R-paeonimetaboline I
112018-99-2

7R-paeonimetaboline I

Conditions
ConditionsYield
With GAM broth; Lactobacillus brevis In water at 37℃; for 12h; Product distribution;A 11%
B 9.6%
paeoniflorin
23180-57-6

paeoniflorin

8-O-debenzoylpaeoniflorin

8-O-debenzoylpaeoniflorin

Conditions
ConditionsYield
With sodium hydroxide In methanol for 0.166667h; Ambient temperature;124.4 mg
thiobenzoic acid
98-91-9

thiobenzoic acid

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-benzoylthiopaeonimetabolin I
118045-44-6

(7S)-8-benzoylthiopaeonimetabolin I

B

(7R)-8-benzoylthiopaeonimetabolin I
118138-70-8

(7R)-8-benzoylthiopaeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3;A 20 mg
B 10 mg
Cyclohexanethiol
1569-69-3

Cyclohexanethiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7R)-8-cyclohexylthiopaeonimetabolin I

(7R)-8-cyclohexylthiopaeonimetabolin I

B

(7S)-8-cyclohexylthiopaeonimetabolin I

(7S)-8-cyclohexylthiopaeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
1-thiopropane
107-03-9

1-thiopropane

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-(n-propylthio)paeonimetabolin I

(7S)-8-(n-propylthio)paeonimetabolin I

B

(7R)-8-(n-propylthio)paeonimetabolin I

(7R)-8-(n-propylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
prop-2-ene-1-thiol
870-23-5

prop-2-ene-1-thiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-allylthiopaeonimetabolin I

(7S)-8-allylthiopaeonimetabolin I

B

(7R)-8-allylthiopaeonimetabolin I

(7R)-8-allylthiopaeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
1-methyl-1-propanethiol
513-53-1

1-methyl-1-propanethiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-(sec-butylthio)paeonimetabolin I

(7S)-8-(sec-butylthio)paeonimetabolin I

B

(7R)-8-(sec-butylthio)paeonimetabolin I

(7R)-8-(sec-butylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
2-methylpropanethiol-1
513-44-0

2-methylpropanethiol-1

paeoniflorin
23180-57-6

paeoniflorin

A

(7R)-8-(iso-butylthio)paeonimetabolin I

(7R)-8-(iso-butylthio)paeonimetabolin I

B

(7S)-8-(iso-butylthio)paeonimetabolin I

(7S)-8-(iso-butylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
1-butanethiol
109-79-5

1-butanethiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-(n-butylthio)paeonimetabolin I

(7S)-8-(n-butylthio)paeonimetabolin I

B

(7R)-8-(n-butylthio)paeonimetabolin I

(7R)-8-(n-butylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
Hexanethiol
111-31-9

Hexanethiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-(n-hexylthio)paeonimetabolin I

(7S)-8-(n-hexylthio)paeonimetabolin I

B

(7R)-8-(n-hexylthio)paeonimetabolin I

(7R)-8-(n-hexylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3;A 19 mg
B 10 mg
toluene-3-thiol
108-40-7

toluene-3-thiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-(m-tolylthio)paeonimetabolin I

(7S)-8-(m-tolylthio)paeonimetabolin I

B

(7R)-8-(m-tolylthio)paeonimetabolin I

(7R)-8-(m-tolylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
cyclopentylthiol
1679-07-8

cyclopentylthiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-cyclopentylthiopaeonimetabolin I

(7S)-8-cyclopentylthiopaeonimetabolin I

B

(7R)-8-cyclopentylthiopaeonimetabolin I

(7R)-8-cyclopentylthiopaeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
thiophenol
108-98-5

thiophenol

paeoniflorin
23180-57-6

paeoniflorin

A

(7R)-8-phenylthio-paeonimetabolin I

(7R)-8-phenylthio-paeonimetabolin I

B

(7S)-8-phenylthio-paeonimetabolin I

(7S)-8-phenylthio-paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
2-propanethiol
75-33-2

2-propanethiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7R)-8-(iso-propylthio)paeonimetabolin I

(7R)-8-(iso-propylthio)paeonimetabolin I

B

(7S)-8-(iso-propylthio)paeonimetabolin I

(7S)-8-(iso-propylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
para-thiocresol
106-45-6

para-thiocresol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-(p-tolylthio)paeonimetabolin I

(7S)-8-(p-tolylthio)paeonimetabolin I

B

(7R)-8-(p-tolylthio)paeonimetabolin I

(7R)-8-(p-tolylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
phenylmethanethiol
100-53-8

phenylmethanethiol

paeoniflorin
23180-57-6

paeoniflorin

A

(7S)-8-benzylthiopaeonimetabolin I

(7S)-8-benzylthiopaeonimetabolin I

B

(7R)-8-benzylthiopaeonimetabolin I

(7R)-8-benzylthiopaeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
paeoniflorin
23180-57-6

paeoniflorin

2-Naphthalenethiol
91-60-1

2-Naphthalenethiol

A

(7S)-8-(2-naphthylthio)paeonimetabolin I

(7S)-8-(2-naphthylthio)paeonimetabolin I

B

(7R)-8-(2-naphthylthio)paeonimetabolin I

(7R)-8-(2-naphthylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
paeoniflorin
23180-57-6

paeoniflorin

thioacetic acid
507-09-5

thioacetic acid

A

(7R)-8-acetylthiopaeonimetabolin I

(7R)-8-acetylthiopaeonimetabolin I

B

(7S)-8-acetylthiopaeonimetabolin I

(7S)-8-acetylthiopaeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
paeoniflorin
23180-57-6

paeoniflorin

2-thiocresol
137-06-4

2-thiocresol

A

(7R)-8-(o-tolylthio)paeonimetabolin I

(7R)-8-(o-tolylthio)paeonimetabolin I

B

(7S)-8-(o-tolylthio)paeonimetabolin I

(7S)-8-(o-tolylthio)paeonimetabolin I

Conditions
ConditionsYield
With Lactobacillus brevis In phosphate buffer at 37℃; for 6h; pH=7.3; Title compound not separated from byproducts;
paeoniflorin
23180-57-6

paeoniflorin

C23H26O11

C23H26O11

Conditions
ConditionsYield
With sodium periodate In methanol; water at 20℃; for 1h;
paeoniflorin
23180-57-6

paeoniflorin

paeoniflorigenin

paeoniflorigenin

Conditions
ConditionsYield
With β-glucosidase In dimethyl sulfoxide at 37℃; for 5h;
2-[2-(2-{2-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzoic acid

2-[2-(2-{2-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-4-(3-trifluoromethyl-3H-diazirin-3-yl)-benzoic acid

paeoniflorin
23180-57-6

paeoniflorin

C41H54F3N5O16S

C41H54F3N5O16S

Conditions
ConditionsYield
Multistep reaction;

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