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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

[(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic acid 1,1-dimethylethyl ester

Cas:247068-82-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

[(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic acid 1,1-dimethylethyl ester CAS No.:247068-82-2 Name: [(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]but

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

tert-Butyl N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]-carbamate

Cas:247068-82-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 247068-82-2 with best quality

Cas:247068-82-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Qingdao Beluga Import and Export Co., LTD

CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester CAS:247068-82-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, produ

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic acid 1,1-dimethylethyl ester

Cas:247068-82-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

((1S)-3-METHYL-1-(((2R)-2-METHYLOXRANYL)CARBONYL)BUTYL)CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

Cas:247068-82-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Tert-butyl N-[(2s)-4-methyl-1-[(2r)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate CAS NO.247068-82-2

Cas:247068-82-2

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl esterAppearance:white powder Storage:Shading, sealed, dry place. Package:according to customers' requirements Application:pharmaceutical intermediates r

Siwei Development Group Ltd.

Product name: Tert-Butyl (S)-4-Methyl-1-((R)-2-Methyloxiran-2-yl)-1-Oxopentan-2-ylcarbamate CAS No.:247068-82-2 Molecule Formula:C14H25NO4 Molecule Weight:271.35 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:E

High Quality Tert-Butyl (S)-4-Methyl-1-((R)-2-Methyloxiran-2-yl)-1-Oxopentan-2-ylcarbamate in stock

Cas:247068-82-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

tert-butyl (S)-4-Methyl-1-((R)-2-Methyloxiran-2-yl)-1-oxopentan-2-ylcarbaMate

Cas:247068-82-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Intermediate0fPR171

Cas:247068-82-2

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester

Cas:247068-82-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

[(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic acid 1,1-dimethylethyl ester

Cas:247068-82-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

tert-butyl (S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylcarbamate

Cas:247068-82-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

tert-butyl ((S)-4-Methyl-1-((R)-2-Methyloxiran-2-yl)-1-oxopentan-2-yl)carbaMate

Cas:247068-82-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package: 1g/bag, 5g/bag, 10g/bag, 100g/bag, 1kg/bag or as per your request Application: It is

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

Antimex Chemical Limied

C14H25NO4 247068-82-2CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl esterAppearance:white powder Storage:Keep in dry and cool condition Package:as needed Application:oled api edc Transportation:by ai

Nanjing Fred Technology Co.,Ltd.

Fredchem focus on CRO/CMO business and its own R&D of API/Intermediates Package:Kilograms/MT Application:Pharmaceutical field Transportation:According to customer request Port:Shanghai

Luyunjia Chemistry Xiamen Limited

Specifications CAS No.: 247068-82-2 MF: C14H25NO4 Place of Origin: Zhejiang, China (Mainland) Type: Syntheses Material Intermediates Purity: 99.0% Min Brand Name: Luyunjia Model Number: High Purity Application: Fine Chemical Intermedi

247068-82-2 [(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic acid 1,1-dimethylethyl ester

Cas:247068-82-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

tert-butyl N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate

Cas:247068-82-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

tert-butyl {(1S,2S)-1-hydroxy-4-methyl-1-[(R)-2-methyloxiran-2-yl]pentan-2-yl}carbamate

tert-butyl {(1S,2S)-1-hydroxy-4-methyl-1-[(R)-2-methyloxiran-2-yl]pentan-2-yl}carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃; Green chemistry;91%
With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃; Cooling with ice;83.3%
With Dess-Martin periodane In dichloromethane at 0℃; for 3h; Dess-Martin Oxidation; Inert atmosphere;46%
With sodium hypochlorite; 2-azatricyclo[3.3.1.13,7]decan-2-ol; sodium hydrogencarbonate In water; toluene at 0℃; for 5h;5.96 g
With Dess-Martin periodane In dichloromethane at 20℃;
tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate
247068-81-1

tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With (R)-La-BINOL; triphenylphosphine; tert-butyl alcohol In toluene at 20℃; for 0.5h; Solvent;85%
With dihydrogen peroxide; benzonitrile; N-ethyl-N,N-diisopropylamine In methanol at 0℃;57%
With tetramethyl ammoniumhydroxide; urea hydrogen peroxide adduct In methanol; benzonitrile at -10℃; for 20h; Reagent/catalyst; Solvent; Inert atmosphere; stereoselective reaction;40%
tert-butyl ((R)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

tert-butyl ((R)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tert-butyl methyl ether at 20℃; for 12h;84%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tert-butyl methyl ether at 20℃; for 24h; Reagent/catalyst; Inert atmosphere; Large scale; diastereoselective reaction;79%
tert-butyl N-[(2S)-1-(-2-methyloxirane-2-yl)-1-hydroxy-4-methylpentan-2-yl]carbamate
1609959-47-8

tert-butyl N-[(2S)-1-(-2-methyloxirane-2-yl)-1-hydroxy-4-methylpentan-2-yl]carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With Dess-Martin periodane In dichloromethane at 0℃; for 10h; Inert atmosphere;52%
With Dess-Martin periodane In dichloromethane at 0 - 20℃; Inert atmosphere;
With Dess-Martin periodane In acetonitrile at 0 - 30℃; for 3h;4.5 g
tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate
247068-81-1

tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate

A

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

B

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With dihydrogen peroxide; benzonitrile; N-ethyl-N,N-diisopropylamine at 0 - 4℃; for 43h; Alkaline aqueous solution;A 28%
B 48%
With i-PrEtN; dihydrogen peroxide In methanol; water; benzonitrile at 0 - 4℃; for 43h; Yield given; Yields of byproduct given;
Stage #1: tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate With C28H34F6MnN6O6S2; acetic acid In acetonitrile for 0.0833333h; Inert atmosphere;
Stage #2: With dihydrogen peroxide In acetonitrile at -20℃; for 2h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 13h;39%
(1-isobutyl-3-methyl-2-oxo-but-3-enyl)carbamic acid tert-butyl ester
1186298-17-8

(1-isobutyl-3-methyl-2-oxo-but-3-enyl)carbamic acid tert-butyl ester

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With 1,1,1-trifluoro-2-propanone; sodium hydrogencarbonate In water; acetonitrile at -10℃; Inert atmosphere;38%
N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide
87694-50-6

N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / diethyl ether / 2.5 h / -78 °C
2: H2O2, i-PrEtN / benzonitrile; H2O; methanol / 43 h / 0 - 4 °C
View Scheme
Multi-step reaction with 2 steps
1: tetrahydrofuran / 6 h / 0 °C / Inert atmosphere
2: potassium peroxymonosulfate; 1,1,1-trifluoro-2-propanone; sodium hydrogencarbonate / water; acetonitrile / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 6 h / 0 - 25 °C
2.1: sodium hydrogencarbonate
2.2: trifluoroacetone
2.3: 1 h / -10 °C
View Scheme
N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 3 h / 25 °C / Inert atmosphere
2: tetrahydrofuran / 6 h / 0 °C / Inert atmosphere
3: potassium peroxymonosulfate; 1,1,1-trifluoro-2-propanone; sodium hydrogencarbonate / water; acetonitrile / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
1.2: 3 h / 25 °C
2.1: tetrahydrofuran / 6 h / 0 - 25 °C
3.1: sodium hydrogencarbonate
3.2: trifluoroacetone
3.3: 1 h / -10 °C
View Scheme
Multi-step reaction with 3 steps
1.1: isobutyl chloroformate; 4-methyl-morpholine / dichloromethane / -10 - 20 °C
2.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine; dihydrogen peroxide / methanol / 2 h
View Scheme
tert-butyl N-[(4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl]carbamate
1609959-45-6

tert-butyl N-[(4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl]carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C
2: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 30 °C
2: Dess-Martin periodane / acetonitrile / 3 h / 0 - 30 °C
View Scheme
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C
2: Dess-Martin periodane / dichloromethane / 10 h / 0 °C / Inert atmosphere
View Scheme
tert-butyl ((3R,4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl)carbamate

tert-butyl ((3R,4S)-3-hydroxy-2,6-dimethylhept-1-en-4-yl)carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane / 1 h / 0 °C / Inert atmosphere
2: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: vanadium trisacetylacetonate; tert.-butylhydroperoxide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere; Green chemistry
2: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 20 °C / Green chemistry
View Scheme
Multi-step reaction with 2 steps
1: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane / 0 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane / 2 h / 0 °C
2: Dess-Martin periodane / dichloromethane / 20 °C
View Scheme
(1-isobutyl-2-oxobutyl)carbamic acid tert-butyl ester

(1-isobutyl-2-oxobutyl)carbamic acid tert-butyl ester

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: piperdinium acetate; piperidine / tetrahydrofuran / 8 h / 68 °C / Green chemistry
2: aluminum isopropoxide; isopropyl alcohol / toluene / 50 °C / Green chemistry
3: vanadium trisacetylacetonate; tert.-butylhydroperoxide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere; Green chemistry
4: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 20 °C / Green chemistry
View Scheme
Multi-step reaction with 4 steps
1: piperidine; piperidinyl acetate / tetrahydrofuran / 3 h / Reflux
2: aluminum isopropoxide / toluene; isopropyl alcohol / 20 - 50 °C
3: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane / 0 °C / Inert atmosphere
4: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 20 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1: piperdinium acetate; piperidine / tetrahydrofuran / 12 h / 68 °C
2: aluminum isopropoxide; isopropyl alcohol / toluene / 3 h / 50 °C
3: tert.-butylhydroperoxide; tris(acetylacetonato)vanadium(III) / dichloromethane / 12 h / 0 - 20 °C
4: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 6 h
View Scheme
N-tert-butoxycarbonyl-L-leucine
13139-15-6

N-tert-butoxycarbonyl-L-leucine

A

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

B

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: isobutyl chloroformate; 4-methyl-morpholine; triethylamine / dichloromethane / -20 - 20 °C / Inert atmosphere
2: tetrahydrofuran / 6 h / 0 - 5 °C / Inert atmosphere
3: sodium hypochlorite; pyridine / water / 2 h / -5 - 0 °C
View Scheme
Multi-step reaction with 3 steps
1.1: Trimethylacetic acid / Isopropyl acetate / -10 - 0 °C
1.2: -10 - 25 °C
2.1: isopropylmagnesium chloride; magnesium / tetrahydrofuran; n-heptane / 3 h / -10 - 42 °C / Inert atmosphere
3.1: acetic acid; dihydrogen peroxide; C28H34F6MnN6O6S2 / acetonitrile / 2 h / -20 °C
View Scheme
N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide
87694-50-6

N-(tert-butoxycarbonyl)-L-leucine-N'-methoxy-N'-methylamide

A

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

B

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tetrahydrofuran / 6 h / 0 - 5 °C / Inert atmosphere
2: sodium hypochlorite; pyridine / water / 2 h / -5 - 0 °C
View Scheme
tert-butyl N-[(2S)-1-(-2-methyloxirane-2-yl)-1-hydroxy-4-methylpentan-2-yl]carbamate
1609959-47-8

tert-butyl N-[(2S)-1-(-2-methyloxirane-2-yl)-1-hydroxy-4-methylpentan-2-yl]carbamate

A

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

B

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With Dess-Martin periodane In acetonitrile at 5 - 20℃; Inert atmosphere;
L-leucine
61-90-5

L-leucine

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 20 h / 25 - 30 °C
2.1: 4-methyl-morpholine; chloroformic acid ethyl ester / dichloromethane / 0.33 h / -15 - -10 °C / Inert atmosphere
2.2: 2 h / -15 - -10 °C
3.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 50 - 55 °C / Inert atmosphere
3.2: 8.25 h / 0 - 30 °C
4.1: potassium carbonate; benzonitrile; dihydrogen peroxide / methanol / 6 h / 25 - 30 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 20 h / 25 - 30 °C
2.1: 4-methyl-morpholine; chloroformic acid ethyl ester / dichloromethane / 0.33 h / -15 - -10 °C / Inert atmosphere
2.2: 2 h / -15 - -10 °C
3.1: magnesium; iodine / tetrahydrofuran / 2.5 h / 50 - 55 °C / Inert atmosphere
3.2: 8.25 h / 0 - 30 °C
4.1: potassium carbonate; benzonitrile; dihydrogen peroxide / methanol / 6 h / 25 - 30 °C
View Scheme
tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate
247068-81-1

tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate

A

tert-butyl [(1R)-3-methyl-1-[[(2S)-2-methyloxiran-2-yl]carbonyl]butyl]carbamate

tert-butyl [(1R)-3-methyl-1-[[(2S)-2-methyloxiran-2-yl]carbonyl]butyl]carbamate

B

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With dihydrogen peroxide; potassium hydroxide; N-(4-iodobenzyl)cinchoninium bromide at 0 - 4℃; Catalytic behavior; Reagent/catalyst; Temperature; Overall yield = 97 %; Overall yield = 131 g; Optical yield = 84 %ee;
N-Boc-D-Leu
16937-99-8

N-Boc-D-Leu

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran; tert-butyl methyl ether / 1 h / 0 - 5 °C
1.2: 1 h / 0 - 10 °C
2.1: 2-bromoprop-1-ene; magnesium / tetrahydrofuran / 0 - 50 °C / Inert atmosphere
3.1: acetic acid; dihydrogen peroxide / acetonitrile; water / 2 h / -20 - -10 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tert-butyl methyl ether / 12 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: tert-butyl methyl ether / 1.42 h / 0 - 5 °C / Inert atmosphere; Large scale
2: tert-butyl methyl ether / 1.5 h / 0 - 10 °C / Inert atmosphere; Large scale
3: magnesium; iodine / tetrahydrofuran; 2-methyltetrahydrofuran / 26 h / 40 - 45 °C / Inert atmosphere; Flow reactor; Large scale
4: dihydrogen peroxide; acetic acid; C30H36F6MnN6O6S2 / acetonitrile; water / 3.5 h / -20 - -15 °C / Inert atmosphere; Large scale
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / tert-butyl methyl ether / 24 h / 20 °C / Inert atmosphere; Large scale
View Scheme
(R)-tert-butyl (4-methyl-1-morpholino-1-oxopentan-2-yl)carbamate

(R)-tert-butyl (4-methyl-1-morpholino-1-oxopentan-2-yl)carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2-bromoprop-1-ene; magnesium / tetrahydrofuran / 0 - 50 °C / Inert atmosphere
2: acetic acid; dihydrogen peroxide / acetonitrile; water / 2 h / -20 - -10 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tert-butyl methyl ether / 12 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: magnesium; iodine / tetrahydrofuran; 2-methyltetrahydrofuran / 26 h / 40 - 45 °C / Inert atmosphere; Flow reactor; Large scale
2: dihydrogen peroxide; acetic acid; C30H36F6MnN6O6S2 / acetonitrile; water / 3.5 h / -20 - -15 °C / Inert atmosphere; Large scale
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tert-butyl methyl ether / 24 h / 20 °C / Inert atmosphere; Large scale
View Scheme
(R)-tert-butyl (2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate

(R)-tert-butyl (2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetic acid; dihydrogen peroxide / acetonitrile; water / 2 h / -20 - -10 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tert-butyl methyl ether / 12 h / 20 °C
View Scheme
(S)-tert-butyl (4-methyl-1-morpholino-1-oxopentan-2-yl)carbamate
173899-64-4

(S)-tert-butyl (4-methyl-1-morpholino-1-oxopentan-2-yl)carbamate

A

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

tert-butyl ((S)-4-methyl-1-((S)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate

B

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: isopropylmagnesium chloride; magnesium / tetrahydrofuran; n-heptane / 3 h / -10 - 42 °C / Inert atmosphere
2: acetic acid; dihydrogen peroxide; C28H34F6MnN6O6S2 / acetonitrile / 2 h / -20 °C
View Scheme
C14H27NO3

C14H27NO3

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: tert.-butylhydroperoxide; tris(acetylacetonato)vanadium(III) / dichloromethane / 12 h / 0 - 20 °C
2: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 6 h
View Scheme
C14H27NO4

C14H27NO4

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide for 6h;
Boc-Leu-Cl
338972-00-2

Boc-Leu-Cl

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / isopropyl alcohol
2: tetrahydrofuran / 19 h / -10 - 25 °C / Inert atmosphere; Large scale
3: sodium hypochlorite; pyridine / water / 4.75 h / -15 - -5 °C
View Scheme
[(R)-1-(Imidazole-1-carbonyl)-3-methyl-butyl]-carbamic acid tert-butyl ester
54430-65-8

[(R)-1-(Imidazole-1-carbonyl)-3-methyl-butyl]-carbamic acid tert-butyl ester

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tert-butyl methyl ether / 1.5 h / 0 - 10 °C / Inert atmosphere; Large scale
2: magnesium; iodine / tetrahydrofuran; 2-methyltetrahydrofuran / 26 h / 40 - 45 °C / Inert atmosphere; Flow reactor; Large scale
3: dihydrogen peroxide; acetic acid; C30H36F6MnN6O6S2 / acetonitrile; water / 3.5 h / -20 - -15 °C / Inert atmosphere; Large scale
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tert-butyl methyl ether / 24 h / 20 °C / Inert atmosphere; Large scale
View Scheme
heptafluorobutyric Acid
375-22-4

heptafluorobutyric Acid

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C9H17NO2*C4HF7O2

C9H17NO2*C4HF7O2

Conditions
ConditionsYield
In dichloromethane at 0 - 23℃; for 2h; Inert atmosphere;94%
trifluoroacetic acid
76-05-1

trifluoroacetic acid

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

Conditions
ConditionsYield
In dichloromethane at 20℃; for 4h;88%
With trifluoroacetic acid
In dichloromethane for 0.5h; Inert atmosphere;
4-chlorobenzoyl chloride
586-75-4

4-chlorobenzoyl chloride

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C16H20BrNO3
1373929-36-2

C16H20BrNO3

Conditions
ConditionsYield
Stage #1: tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate With trifluoroacetic acid In dichloromethane at 25℃; for 1.5h;
Stage #2: 4-chlorobenzoyl chloride With N-ethyl-N,N-diisopropylamine In chloroform at 25℃; for 16h;
61%
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

trichloroacetic acid
76-03-9

trichloroacetic acid

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trichloroacetic acid salt

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trichloroacetic acid salt

Conditions
ConditionsYield
In n-heptane; dichloromethane; tert-butyl methyl ether at 0 - 20℃; Inert atmosphere;36%
C17H31N3O5

C17H31N3O5

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C26H46N4O6
1418206-49-1

C26H46N4O6

Conditions
ConditionsYield
Stage #1: tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate With trifluoroacetic acid In dichloromethane at 25℃; for 1h;
Stage #2: C17H31N3O5 With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 25℃; for 12h;
23%
trifluoroacetic acid
76-05-1

trifluoroacetic acid

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C10H17NO4*C2HF3O2

C10H17NO4*C2HF3O2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C51H88N6O8

C51H88N6O8

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 130 mg / PyBOP; DiPEA / CH2Cl2; dimethylformamide / 3 h
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C59H103N7O10

C59H103N7O10

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 27.3 percent / BOP; DiPEA / dimethylformamide / 3 h
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C55H95N7O10

C55H95N7O10

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 27.3 percent / BOP; DiPEA / dimethylformamide / 3 h
2: 91 percent / TFA / CH2Cl2 / 0.5 h
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C23H28N4O4

C23H28N4O4

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 8.6 mg / BOP; DiPEA / CH2Cl2 / 1 h
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl) amino)-1-oxopentan-2-yl)carbamate

benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl) amino)-1-oxopentan-2-yl)carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 18.7 mg / PyBOP; DiPEA / CH2Cl2 / 1 h
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

(2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one
247068-84-4

(2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one

Conditions
ConditionsYield
With trifluoroacetic acid at 20℃; for 0.0333333 - 0.333333h;
With trifluoroacetic acid In dichloromethane at 25℃; for 1.5h; Inert atmosphere;
With trifluoroacetic acid In dichloromethane at 0 - 20℃; for 1h;
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C16H20BrNO3
1373929-36-2

C16H20BrNO3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 1.5 h / 25 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 25 °C / Inert atmosphere
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Carmaphycin A
1374216-80-4

Carmaphycin A

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 1.5 h / 25 °C / Inert atmosphere
2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 25 °C / Inert atmosphere
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

Carmaphycin B
1374216-81-5

Carmaphycin B

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trifluoroacetic acid / dichloromethane / 1.5 h / 25 °C / Inert atmosphere
2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 25 °C / Inert atmosphere
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C40H53N5O7S
1545468-56-1

C40H53N5O7S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane
2: N-ethyl-N,N-diisopropylamine; DEPBT / dichloromethane / 2 h
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C44H61N7O8
1545469-05-3

C44H61N7O8

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: dichloromethane
2: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
3: dichloromethane / 4 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C42H55N5O8S
1545468-57-2

C42H55N5O8S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane
2: N-ethyl-N,N-diisopropylamine; DEPBT / dichloromethane / 2 h
3: pyridine / 20 °C
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C44H60N6O8S
1545468-58-3

C44H60N6O8S

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dichloromethane
2: N-ethyl-N,N-diisopropylamine; DEPBT / dichloromethane / 2 h
3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C37H58N6O9
1545468-59-4

C37H58N6O9

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dichloromethane
2.1: N-ethyl-N,N-diisopropylamine; DEPBT / dichloromethane / 0.5 h
2.2: 20 °C
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C
3.2: 6 h / 20 °C
View Scheme
tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate
247068-82-2

tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

C43H58N6O8S
1545468-60-7

C43H58N6O8S

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: dichloromethane
2.1: DEPBT / dichloromethane / 2 h / 0 °C
2.2: 0 - 20 °C
View Scheme

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