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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

5-CHLORO-N-ETHYL-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE

Cas:248281-84-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

CIVENTICHEM CV-4057 CAS 248281-84-7

Cas:248281-84-7

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 248281-84-7 with competitive price

Cas:248281-84-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Laquinimod

Cas:248281-84-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Laquinimod

Cas:248281-84-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

CIVENTICHEM CV-4057 CAS:248281-84-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic inte

CIVENTICHEM CV-4057 CAS:248281-84-7

Cas:248281-84-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Laquinimod

Cas:248281-84-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Laquinimod

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

5-Chloro-N-ethyl-4-hydroxy-1-Methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxaMide

Cas:248281-84-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

ABR-215062 Laquinimod 248281-84-7

Cas:248281-84-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

LAQUINIMOD

Cas:248281-84-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

laquinimod

Cas:248281-84-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Laquinimod

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-chloro-n-ethyl-4-hydroxy-1-methyl-2-oxo-n-phenylquinoline-3-carboxamide

Cas:248281-84-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Laquinimod

Cas:248281-84-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Laquinimod

Cas:248281-84-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

5-Chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid ethyl-phenyl-amide

Cas:248281-84-7

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Laquinimod

Cas:248281-84-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Laquinimod

Cas:248281-84-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

Laquinimod

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Other

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/Laquinimod/SAGECHEM/Manufacturer in China

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Lanquinimod Cas no.248281-84-7 98%

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Laquinimod

Cas:248281-84-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

Laquinimod

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING

CIVENTICHEM CV-4057

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

Laquinimod

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Laquinimod

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

CIVENTICHEM CV-4057

Cas:248281-84-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester
637027-41-9

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
In n-heptane for 6.58333h; Heating;98%
In n-heptane98%
In n-heptane for 4h; Product distribution / selectivity; Reflux; Molecular sieve;98%
In n-heptane for 6h; Reflux;97%
In octane; n-heptane at 112℃; for 5h; Inert atmosphere; Large scale;96%
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester
637027-41-9

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

A

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
In n-heptane Heating / reflux;A n/a
B 98%
In toluene Heating / reflux;A n/a
B 98%
In n-heptane for 6.58333h; Heating / reflux;A 0.03%
B 98%
In toluene for 3.25h; Heating / reflux;A 0.54%
B 90%
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester
637027-41-9

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

A

methanol
67-56-1

methanol

B

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
In n-heptane for 6.58333h; Product distribution / selectivity; Heating / reflux;A n/a
B 98%
5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt

5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
With hydrogenchloride In water96%
Stage #1: 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt With sodium hydroxide In water at 50℃; pH=12.5;
Stage #2: With hydrogenchloride In ethanol; water at 4℃; pH=5; Product distribution / selectivity;
56.2%
N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid
335640-50-1

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
With thionyl chloride; triethylamine In dichloromethane at 0 - 20℃; for 4.5h;87%
With dicyclohexyl-carbodiimide In toluene at 80℃; for 4h; Reagent/catalyst; Inert atmosphere; Large scale;62%
Stage #1: N-ethyl-N-phenylamine With dichlorotriphenylphosphorane In chloroform at 25 - 30℃; for 0.25h; Inert atmosphere;
Stage #2: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid In chloroform at 25 - 45℃; Product distribution / selectivity;
methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate
1379595-99-9

methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Stage #1: methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate With sodium methylate In tetrahydrofuran; methanol for 2h; Inert atmosphere; Reflux;
Stage #2: With water; sodium hydroxide In methanol at 5℃; for 0.5h;
Stage #3: With hydrogenchloride In methanol; water Product distribution / selectivity;
87%
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
248282-10-2

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.1 h / 100 °C / microwave irradiation
2: 98 percent / heptane / 6.58 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / HCl / acetic acid / 6 h / 60 °C
2: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C
View Scheme
5-chloro-1H-benzo[d][1,3]oxazine-2,4-dione
20829-96-3

5-chloro-1H-benzo[d][1,3]oxazine-2,4-dione

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NaH / dimethylformamide / 5 h / 20 °C
2: NaH / dimethylformamide / 5 h / 85 °C
3: 91 percent / HCl / acetic acid / 6 h / 60 °C
4: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: sodium carbonate / N,N-dimethyl-formamide / 1.25 h / 0 - 30 °C / Inert atmosphere
2.1: sodium methylate / N,N-dimethyl-formamide / 1.5 h / 25 - 85 °C / Inert atmosphere
2.2: 1.17 h / 80 - 85 °C
2.3: 2 h / 25 - 30 °C / pH 1
3.1: hydrogenchloride; acetic acid / 80 - 85 °C
4.1: dichlorotriphenylphosphorane / dichloromethane / 0.25 h / 25 - 30 °C / Inert atmosphere
4.2: 3 h / 25 - 45 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere
View Scheme
2-chloro-6-aminobenzoic acid
2148-56-3

2-chloro-6-aminobenzoic acid

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dioxane / 1 h / 20 °C
2: NaH / dimethylformamide / 5 h / 20 °C
3: NaH / dimethylformamide / 5 h / 85 °C
4: 91 percent / HCl / acetic acid / 6 h / 60 °C
5: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: 1,4-dioxane / 12 - 20 °C
2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: 1,4-dioxane / 12 - 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere; Large scale
3: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere
View Scheme
5-chloro-N-methylisatoic anhydride
40707-01-5

5-chloro-N-methylisatoic anhydride

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaH / dimethylformamide / 5 h / 85 °C
2: 91 percent / HCl / acetic acid / 6 h / 60 °C
3: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium methylate / N,N-dimethyl-formamide / 1.5 h / 25 - 85 °C / Inert atmosphere
1.2: 1.17 h / 80 - 85 °C
1.3: 2 h / 25 - 30 °C / pH 1
2.1: hydrogenchloride; acetic acid / 80 - 85 °C
3.1: dichlorotriphenylphosphorane / dichloromethane / 0.25 h / 25 - 30 °C / Inert atmosphere
3.2: 3 h / 25 - 45 °C
View Scheme
Multi-step reaction with 2 steps
1: mineral oil; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere
2: n-heptane; octane / 5 h / 112 °C / Inert atmosphere; Large scale
View Scheme
Multi-step reaction with 3 steps
1: mineral oil; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere
2: hydrogenchloride; acetic acid; water / acetic anhydride / 2 h / 20 - 85 °C / Inert atmosphere; Large scale
3: dicyclohexyl-carbodiimide / toluene / 4 h / 80 °C / Inert atmosphere; Large scale
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere
1.2: 5 h / 80 °C
2.1: n-heptane / 6 h / Reflux
View Scheme
N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
248282-10-2

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
In n-heptane
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester
637027-41-9

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride; acetic acid / 80 - 85 °C
2.1: dichlorotriphenylphosphorane / dichloromethane / 0.25 h / 25 - 30 °C / Inert atmosphere
2.2: 3 h / 25 - 45 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride; acetic acid; water / acetic anhydride / 2 h / 20 - 85 °C / Inert atmosphere; Large scale
2: dicyclohexyl-carbodiimide / toluene / 4 h / 80 °C / Inert atmosphere; Large scale
View Scheme
N-ethyl-N-phenylamine
103-69-5

N-ethyl-N-phenylamine

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: dichloromethane / 14 h / 20 °C / Inert atmosphere
2.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C
2.2: 0 - 5 °C / pH 2 - 3
3.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere
3.2: 1 h / 0 - 5 °C
3.3: 0 - 20 °C
4.1: sodium methylate / tetrahydrofuran; methanol / 2 h / Inert atmosphere; Reflux
4.2: 0.5 h / 5 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / acetone / 2 h / 2 - 20 °C / Inert atmosphere
2: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere
View Scheme
3-(Ethyl(phenyl)amino)-3-oxopropanoic acid
118081-77-9

3-(Ethyl(phenyl)amino)-3-oxopropanoic acid

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere
1.2: 1 h / 0 - 5 °C
1.3: 0 - 20 °C
2.1: sodium methylate / tetrahydrofuran; methanol / 2 h / Inert atmosphere; Reflux
2.2: 0.5 h / 5 °C
View Scheme
methyl 3-(N-ethyl-N-phenylamino)-3-oxopropionate
142613-14-7

methyl 3-(N-ethyl-N-phenylamino)-3-oxopropionate

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C
1.2: 0 - 5 °C / pH 2 - 3
2.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere
2.2: 1 h / 0 - 5 °C
2.3: 0 - 20 °C
3.1: sodium methylate / tetrahydrofuran; methanol / 2 h / Inert atmosphere; Reflux
3.2: 0.5 h / 5 °C
View Scheme
C10H10ClNO4

C10H10ClNO4

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetyl chloride / 1,4-dioxane / 10 h / 45 °C / Inert atmosphere; Large scale
2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: acetyl chloride / 1,4-dioxane / 10 h / 45 °C / Inert atmosphere; Large scale
2: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere; Large scale
3: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1.1: acetyl chloride / 1,4-dioxane / 10 h / 45 °C / Inert atmosphere; Large scale
2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: mineral oil; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere
4.1: n-heptane; octane / 5 h / 112 °C / Inert atmosphere; Large scale
View Scheme
5-chloro-N-methylisatoic anhydride
40707-01-5

5-chloro-N-methylisatoic anhydride

methyl 3-(N-ethyl-N-phenylamino)-3-oxopropionate
142613-14-7

methyl 3-(N-ethyl-N-phenylamino)-3-oxopropionate

laquinimod
248281-84-7

laquinimod

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl acetamide; mineral oil at 85℃; for 7h; Inert atmosphere;110 g
laquinimod
248281-84-7

laquinimod

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

Conditions
ConditionsYield
In water; toluene at 140℃; for 4h;100%
Multi-step reaction with 2 steps
1: toluene; H2O / 1 h / 100 °C
2: 98 percent / dimethylsulfoxide / 1.5 h / 70 °C
View Scheme
laquinimod
248281-84-7

laquinimod

N-ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide calcium salt

N-ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide calcium salt

Conditions
ConditionsYield
With calcium acetate In ethanol; water at 70℃; for 0.5h;98%
laquinimod
248281-84-7

laquinimod

5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt

5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt

Conditions
ConditionsYield
With sodium hydroxide In ethanol; water for 1.75h; Inert atmosphere; Large scale;95%
With sodium methylate In methanol at 20 - 30℃;94%
With sodium hydroxide In ethanol; water at 20℃; for 6.58333h; pH=8 - 12;90%
laquinimod
248281-84-7

laquinimod

1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3'-[1]ethylindolin-[2]-one]

1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3'-[1]ethylindolin-[2]-one]

Conditions
ConditionsYield
With ammonium cerium (IV) nitrate; acetic acid In ethanol at 20℃; for 1h;95%
L-lysine
56-87-1

L-lysine

laquinimod
248281-84-7

laquinimod

laquinimod L-lysine salt

laquinimod L-lysine salt

Conditions
ConditionsYield
In methanol Solvent;92.7%
aniline
62-53-3

aniline

laquinimod
248281-84-7

laquinimod

ABR-215174

ABR-215174

Conditions
ConditionsYield
In toluene at 100℃; for 1h;92%
laquinimod
248281-84-7

laquinimod

N-ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide iron (III) salt

N-ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide iron (III) salt

Conditions
ConditionsYield
With iron(III) sulfate In chloroform; water at 40℃;85%
cholin hydroxide
123-41-1

cholin hydroxide

laquinimod
248281-84-7

laquinimod

laquinimod choline hydroxide salt
1609005-03-9

laquinimod choline hydroxide salt

Conditions
ConditionsYield
In methanol for 0.166667h; Solvent;76.3%
methanol
67-56-1

methanol

laquinimod
248281-84-7

laquinimod

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester
637027-41-9

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
at 100℃; for 0.1h; microwave irradiation;
methanol
67-56-1

methanol

laquinimod
248281-84-7

laquinimod

A

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester
637027-41-9

1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

C

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid
335640-50-1

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics;
propan-1-ol
71-23-8

propan-1-ol

laquinimod
248281-84-7

laquinimod

A

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid n-propyl ester

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid n-propyl ester

C

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid
335640-50-1

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics; Further Variations:; reaction partner content;
ethanol
64-17-5

ethanol

laquinimod
248281-84-7

laquinimod

A

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid
335640-50-1

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

C

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
248282-10-2

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

Conditions
ConditionsYield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics; Further Variations:; Reagents;
isopropyl alcohol
67-63-0

isopropyl alcohol

laquinimod
248281-84-7

laquinimod

A

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid isopropyl ester

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid isopropyl ester

C

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid
335640-50-1

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics;
laquinimod
248281-84-7

laquinimod

A

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid
335640-50-1

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions
ConditionsYield
In water; toluene at 100℃; for 1h;
laquinimod
248281-84-7

laquinimod

5-chloro-1,2-dihydro-4-methoxy-1-methyl-2-oxo-3-quinolinecarboxylic acid methyl ester

5-chloro-1,2-dihydro-4-methoxy-1-methyl-2-oxo-3-quinolinecarboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.1 h / 100 °C / microwave irradiation
2: 37 percent / DBU / N,N-dimethyl-acetamide / 20 h / 20 °C
View Scheme
laquinimod
248281-84-7

laquinimod

5-chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid methyl ester

5-chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 0.1 h / 100 °C / microwave irradiation
2: 39 percent / DBU / N,N-dimethyl-acetamide / 20 h / 20 °C
View Scheme
propan-1-ol
71-23-8

propan-1-ol

laquinimod
248281-84-7

laquinimod

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid n-propyl ester

5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid n-propyl ester

Conditions
ConditionsYield
With hydrogenchloride In water at 45 - 60℃; for 4h; Reactivity;
Reflux;
With hydrogenchloride at 45 - 60℃; for 4h; Reactivity;

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