Laquinimod supplier | CasNO.248281-84-7

Name
CIVENTICHEM CV-4057
EINECS 692-155-1
CAS No. 248281-84-7
Article Data19
CAS DataBase
Density 1.396 g/cm³
Solubility
Melting Point 201 °C (decomp)
Formula C₁₉H₁₇ClN₂O₃
Boiling Point 484.799 °C at 760 mmHg
Molecular Weight 356.809
Flash Point 246.998 °C
Transport Information
Appearance
Safety 45
Risk Codes 25
Molecular Structure
Hazard Symbols T
Synonyms ABR 215062;N-Ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide;N-Ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide;3-Quinolinecarboxamide,5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-;
PSA 87.42000
LogP 3.09358

Synthetic route

: 637027-41-9
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

: 103-69-5
N-ethyl-N-phenylamine

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
In n-heptane for 6.58333h; Heating;	98%
In n-heptane	98%
In n-heptane for 4h; Product distribution / selectivity; Reflux; Molecular sieve;	98%
In n-heptane for 6h; Reflux;	97%
In octane; n-heptane at 112℃; for 5h; Inert atmosphere; Large scale;	96%

: 637027-41-9
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

: 103-69-5
N-ethyl-N-phenylamine

A: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B: 248281-84-7
laquinimod

Conditions

Conditions	Yield
In n-heptane Heating / reflux;	A n/a B 98%
In toluene Heating / reflux;	A n/a B 98%
In n-heptane for 6.58333h; Heating / reflux;	A 0.03% B 98%
In toluene for 3.25h; Heating / reflux;	A 0.54% B 90%

...Expand

: 637027-41-9
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

: 103-69-5
N-ethyl-N-phenylamine

A: 67-56-1
methanol

B: 248281-84-7
laquinimod

Conditions

Conditions	Yield
In n-heptane for 6.58333h; Product distribution / selectivity; Heating / reflux;	A n/a B 98%

...Expand

: 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
With hydrogenchloride In water	96%
Stage #1: 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt With sodium hydroxide In water at 50℃; pH=12.5; Stage #2: With hydrogenchloride In ethanol; water at 4℃; pH=5; Product distribution / selectivity;	56.2%

: 103-69-5
N-ethyl-N-phenylamine

: 335640-50-1
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
With thionyl chloride; triethylamine In dichloromethane at 0 - 20℃; for 4.5h;	87%
With dicyclohexyl-carbodiimide In toluene at 80℃; for 4h; Reagent/catalyst; Inert atmosphere; Large scale;	62%
Stage #1: N-ethyl-N-phenylamine With dichlorotriphenylphosphorane In chloroform at 25 - 30℃; for 0.25h; Inert atmosphere; Stage #2: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid In chloroform at 25 - 45℃; Product distribution / selectivity;

: 1379595-99-9
methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Stage #1: methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate With sodium methylate In tetrahydrofuran; methanol for 2h; Inert atmosphere; Reflux; Stage #2: With water; sodium hydroxide In methanol at 5℃; for 0.5h; Stage #3: With hydrogenchloride In methanol; water Product distribution / selectivity;	87%

: 248282-10-2
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.1 h / 100 °C / microwave irradiation 2: 98 percent / heptane / 6.58 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 91 percent / HCl / acetic acid / 6 h / 60 °C 2: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme

: 20829-96-3
5-chloro-1H-benzo[d][1,3]oxazine-2,4-dione

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: NaH / dimethylformamide / 5 h / 20 °C 2: NaH / dimethylformamide / 5 h / 85 °C 3: 91 percent / HCl / acetic acid / 6 h / 60 °C 4: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: sodium carbonate / N,N-dimethyl-formamide / 1.25 h / 0 - 30 °C / Inert atmosphere 2.1: sodium methylate / N,N-dimethyl-formamide / 1.5 h / 25 - 85 °C / Inert atmosphere 2.2: 1.17 h / 80 - 85 °C 2.3: 2 h / 25 - 30 °C / pH 1 3.1: hydrogenchloride; acetic acid / 80 - 85 °C 4.1: dichlorotriphenylphosphorane / dichloromethane / 0.25 h / 25 - 30 °C / Inert atmosphere 4.2: 3 h / 25 - 45 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere 1.2: 2 h / 20 °C / Inert atmosphere 2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere View Scheme

: 2148-56-3
2-chloro-6-aminobenzoic acid

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: dioxane / 1 h / 20 °C 2: NaH / dimethylformamide / 5 h / 20 °C 3: NaH / dimethylformamide / 5 h / 85 °C 4: 91 percent / HCl / acetic acid / 6 h / 60 °C 5: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: 1,4-dioxane / 12 - 20 °C 2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere 2.2: 2 h / 20 °C / Inert atmosphere 3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: 1,4-dioxane / 12 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere; Large scale 3: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere View Scheme

: 40707-01-5
5-chloro-N-methylisatoic anhydride

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: NaH / dimethylformamide / 5 h / 85 °C 2: 91 percent / HCl / acetic acid / 6 h / 60 °C 3: 87 percent / SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: sodium methylate / N,N-dimethyl-formamide / 1.5 h / 25 - 85 °C / Inert atmosphere 1.2: 1.17 h / 80 - 85 °C 1.3: 2 h / 25 - 30 °C / pH 1 2.1: hydrogenchloride; acetic acid / 80 - 85 °C 3.1: dichlorotriphenylphosphorane / dichloromethane / 0.25 h / 25 - 30 °C / Inert atmosphere 3.2: 3 h / 25 - 45 °C View Scheme
Multi-step reaction with 2 steps 1: mineral oil; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere 2: n-heptane; octane / 5 h / 112 °C / Inert atmosphere; Large scale View Scheme
Multi-step reaction with 3 steps 1: mineral oil; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere 2: hydrogenchloride; acetic acid; water / acetic anhydride / 2 h / 20 - 85 °C / Inert atmosphere; Large scale 3: dicyclohexyl-carbodiimide / toluene / 4 h / 80 °C / Inert atmosphere; Large scale View Scheme
Multi-step reaction with 2 steps 1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere 1.2: 5 h / 80 °C 2.1: n-heptane / 6 h / Reflux View Scheme

: 103-69-5
N-ethyl-N-phenylamine

: 248282-10-2
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
In n-heptane

: 637027-41-9
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride; acetic acid / 80 - 85 °C 2.1: dichlorotriphenylphosphorane / dichloromethane / 0.25 h / 25 - 30 °C / Inert atmosphere 2.2: 3 h / 25 - 45 °C View Scheme
Multi-step reaction with 2 steps 1: hydrogenchloride; acetic acid; water / acetic anhydride / 2 h / 20 - 85 °C / Inert atmosphere; Large scale 2: dicyclohexyl-carbodiimide / toluene / 4 h / 80 °C / Inert atmosphere; Large scale View Scheme

: 103-69-5
N-ethyl-N-phenylamine

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: dichloromethane / 14 h / 20 °C / Inert atmosphere 2.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C 2.2: 0 - 5 °C / pH 2 - 3 3.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere 3.2: 1 h / 0 - 5 °C 3.3: 0 - 20 °C 4.1: sodium methylate / tetrahydrofuran; methanol / 2 h / Inert atmosphere; Reflux 4.2: 0.5 h / 5 °C View Scheme
Multi-step reaction with 2 steps 1: triethylamine / acetone / 2 h / 2 - 20 °C / Inert atmosphere 2: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere View Scheme

Yield

Multi-step reaction with 4 steps
1.1: dichloromethane / 14 h / 20 °C / Inert atmosphere
2.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C
2.2: 0 - 5 °C / pH 2 - 3
3.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere
3.2: 1 h / 0 - 5 °C
3.3: 0 - 20 °C
4.1: sodium methylate / tetrahydrofuran; methanol / 2 h / Inert atmosphere; Reflux
4.2: 0.5 h / 5 °C
View Scheme

Multi-step reaction with 2 steps
1: triethylamine / acetone / 2 h / 2 - 20 °C / Inert atmosphere
2: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere
View Scheme

: 118081-77-9
3-(Ethyl(phenyl)amino)-3-oxopropanoic acid

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere 1.2: 1 h / 0 - 5 °C 1.3: 0 - 20 °C 2.1: sodium methylate / tetrahydrofuran; methanol / 2 h / Inert atmosphere; Reflux 2.2: 0.5 h / 5 °C View Scheme

: 142613-14-7
methyl 3-(N-ethyl-N-phenylamino)-3-oxopropionate

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C 1.2: 0 - 5 °C / pH 2 - 3 2.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere 2.2: 1 h / 0 - 5 °C 2.3: 0 - 20 °C 3.1: sodium methylate / tetrahydrofuran; methanol / 2 h / Inert atmosphere; Reflux 3.2: 0.5 h / 5 °C View Scheme

: C10H10ClNO4

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetyl chloride / 1,4-dioxane / 10 h / 45 °C / Inert atmosphere; Large scale 2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere 2.2: 2 h / 20 °C / Inert atmosphere 3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: acetyl chloride / 1,4-dioxane / 10 h / 45 °C / Inert atmosphere; Large scale 2: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C / Inert atmosphere; Large scale 3: sodium hydride / mineral oil; N,N-dimethyl acetamide / 7 h / 85 °C / Inert atmosphere View Scheme
Multi-step reaction with 4 steps 1.1: acetyl chloride / 1,4-dioxane / 10 h / 45 °C / Inert atmosphere; Large scale 2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 45 °C / Inert atmosphere 2.2: 2 h / 20 °C / Inert atmosphere 3.1: mineral oil; N,N-dimethyl acetamide / 5 h / 85 °C / Inert atmosphere 4.1: n-heptane; octane / 5 h / 112 °C / Inert atmosphere; Large scale View Scheme

: 40707-01-5
5-chloro-N-methylisatoic anhydride

: 142613-14-7
methyl 3-(N-ethyl-N-phenylamino)-3-oxopropionate

: 248281-84-7
laquinimod

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl acetamide; mineral oil at 85℃; for 7h; Inert atmosphere;	110 g

: 248281-84-7
laquinimod

: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

Conditions

Conditions	Yield
In water; toluene at 140℃; for 4h;	100%
Multi-step reaction with 2 steps 1: toluene; H2O / 1 h / 100 °C 2: 98 percent / dimethylsulfoxide / 1.5 h / 70 °C View Scheme

: 248281-84-7
laquinimod

: N-ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide calcium salt

Conditions

Conditions	Yield
With calcium acetate In ethanol; water at 70℃; for 0.5h;	98%

: 248281-84-7
laquinimod

: 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide sodium salt

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 1.75h; Inert atmosphere; Large scale;	95%
With sodium methylate In methanol at 20 - 30℃;	94%
With sodium hydroxide In ethanol; water at 20℃; for 6.58333h; pH=8 - 12;	90%

: 248281-84-7
laquinimod

: 1H,3H-spiro[5-chloro-1-methylquinoline-2,4-dione-3,3'-[1]ethylindolin-[2]-one]

Conditions

Conditions	Yield
With ammonium cerium (IV) nitrate; acetic acid In ethanol at 20℃; for 1h;	95%

: 56-87-1
L-lysine

: 248281-84-7
laquinimod

: laquinimod L-lysine salt

Conditions

Conditions	Yield
In methanol Solvent;	92.7%

: 62-53-3
aniline

: 248281-84-7
laquinimod

: ABR-215174

Conditions

Conditions	Yield
In toluene at 100℃; for 1h;	92%

: 248281-84-7
laquinimod

: N-ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide iron (III) salt

Conditions

Conditions	Yield
With iron(III) sulfate In chloroform; water at 40℃;	85%

: 123-41-1
cholin hydroxide

: 248281-84-7
laquinimod

: 1609005-03-9
laquinimod choline hydroxide salt

Conditions

Conditions	Yield
In methanol for 0.166667h; Solvent;	76.3%

: 67-56-1
methanol

: 248281-84-7
laquinimod

: 637027-41-9
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

Conditions

Conditions	Yield
at 100℃; for 0.1h; microwave irradiation;

: 67-56-1
methanol

: 248281-84-7
laquinimod

A: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B: 637027-41-9
1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester

C: 335640-50-1
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics;

...Expand

: 71-23-8
propan-1-ol

: 248281-84-7
laquinimod

A: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid n-propyl ester

C: 335640-50-1
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics; Further Variations:; reaction partner content;

...Expand

: 64-17-5
ethanol

: 248281-84-7
laquinimod

A: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B: 335640-50-1
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

C: 248282-10-2
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

Conditions

Conditions	Yield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics; Further Variations:; Reagents;

...Expand

: 67-63-0
isopropyl alcohol

: 248281-84-7
laquinimod

A: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid isopropyl ester

C: 335640-50-1
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With water; trifluoroacetic acid In dimethyl sulfoxide; acetonitrile at 50℃; for 2h; Kinetics;

...Expand

: 248281-84-7
laquinimod

A: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline

B: 335640-50-1
5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
In water; toluene at 100℃; for 1h;

: 248281-84-7
laquinimod

: 5-chloro-1,2-dihydro-4-methoxy-1-methyl-2-oxo-3-quinolinecarboxylic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.1 h / 100 °C / microwave irradiation 2: 37 percent / DBU / N,N-dimethyl-acetamide / 20 h / 20 °C View Scheme

: 248281-84-7
laquinimod

: 5-chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 0.1 h / 100 °C / microwave irradiation 2: 39 percent / DBU / N,N-dimethyl-acetamide / 20 h / 20 °C View Scheme

: 71-23-8
propan-1-ol

: 248281-84-7
laquinimod

: 5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid n-propyl ester

Conditions

Conditions	Yield
With hydrogenchloride In water at 45 - 60℃; for 4h; Reactivity;
Reflux;
With hydrogenchloride at 45 - 60℃; for 4h; Reactivity;

Laquinimod Chemical Properties

IUPAC Name: 5-Chloro-N-ethyl-2-hydroxy-1-methyl-4-oxo-N-phenylquinoline-3-carboxamide
Canonical SMILES: CCN(C1=CC=CC=C1)C(=O)C2=C(N(C3=C(C2=O)C(=CC=C3)Cl)C)O
InChI: InChI=1S/C19H17ClN2O3/c1-3-22(12-8-5-4-6-9-12)19(25)16-17(23)15-13(20)10-7-11-14(15)21(2)18(16)24/h4-11,24H,3H2,1-2H3
InChIKey: PVTNCGYZIYKPJX-UHFFFAOYSA-N
Molecular Weight: 356.80288 [g/mol]
Molecular Formula: C₁₉H₁₇ClN₂O₃
XLogP3-AA: 4.3
H-Bond Donor: 1
H-Bond Acceptor: 4
Index of Refraction: 1.674
Molar Refractivity: 96.003 cm³
Molar Volume: 255.663 cm³
Surface Tension: 64.288 dyne/cm
Density: 1.396 g/cm³
Flash Point: 246.998 °C
Enthalpy of Vaporization: 79.015 kJ/mol
Boiling Point: 484.799 °C at 760 mmHg
Vapour Pressure of Laquinimod (CAS NO.248281-84-7): 0 mmHg at 25 °C

Laquinimod Specification

Laquinimod (CAS NO.248281-84-7), its Synonyms are 5-Chloro-N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide ; N-Ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide ; N-Ethyl-N-phenyl-5-chloro-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide ; 3-Quinolinecarboxamide, 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl- .

Product Name

CIVENTICHEM CV-4057

Synthetic route

Laquinimod Chemical Properties

Laquinimod Specification

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