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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% -----------------------------------------------------------------------------------------------------------

High purity 24916-90-3 16-Alpha Methyl Epoxide (8DM)

Cas:24916-90-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

(9b,11b,16a)-9,11-Epoxy-17,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione CAS NO.24916-90-3

Cas:24916-90-3

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:Off-white or light yellow powder Storage:Refrigerator Package

High purity Dexamethasone 9,11-Epoxide CAS 24916-90-3 with favorable price

Cas:24916-90-3

Min.Order:1 Metric Ton

FOB Price: $1000.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

9β,11β-Epoxy-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

Cas:24916-90-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Dexamethasone 9,11-epoxide

Cas:24916-90-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

top 16-beta Methyl Epoxide

Cas:24916-90-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 24916-90-3 with best quality

Cas:24916-90-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Dexamethasone 9,11-epoxide

Cas:24916-90-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Pregna-1,4-diene-3,20-dione,9,11-epoxy-17,21-dihydroxy-16-methyl-, (9b,11b,16a)- 24916-90-3

Cas:24916-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Wuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides

Dexamethasone 9,11-epoxide CAS 24916-90-3

Cas:24916-90-3

Min.Order:100 Kilogram

FOB Price: $1.0 / 5.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Dexamethasone 9,11-epoxide CAS:24916-90-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

Dexamethasone 9,11-epoxide CAS:24916-90-3

Cas:24916-90-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pregna-1,4-diene-3,20-dione,9,11-epoxy-17,21-dihydroxy-16-methyl-, (9b,11b,16a)-

Cas:24916-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

16-betaMethylEpoxide/ 8DM 99% Manufactuered in China CAS NO.24916-90-3

Cas:24916-90-3

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products wi

Pharmaceutical grade 8-DM// 16-methyl Epoxide

Cas:24916-90-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:24916-90-3

Cas:24916-90-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Name (9b,11b,16a)-9,11-Epoxy-17,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione Sy

8DM

Cas:24916-90-3

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Strict quality control: good raw materials, good quality, Zenuo Biology has always regarded quality as the life of the enterprise. Zenuo Biology has an independent quality control department and long-term cooperation with the third-party detection

16-betaMethylEpoxide/ 8DM 99% Manufactuered in China

Cas:24916-90-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(9b,11b,16a)-9,11-Epoxy-17,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

Cas:24916-90-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

16-ALPHA-METHYL EPOXIDE (8DM)

Cas:24916-90-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

8-DM

Cas:24916-90-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

(9b,11b,16a)-9,11-Epoxy-17,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

Cas:24916-90-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Our Advantages Production: Advanced chemical equipment with years of experience.Staffs for producing various extract products. Quality Control:A complete set of Testing Professional and Analysis Equipment ensures the Quality Requirements and Speci

Dexamethasone 9,11-epoxide CAS 24916-90-3

Cas:24916-90-3

Min.Order:1 Kilogram

FOB Price: $150.0 / 180.0

Type:Trading Company

inquiry

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Methyl 1H-pyrazolo[3,4-c]pyridine-5-carboxylate

Cas:24916-90-3

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 16Alpha-Methyl Epoxide (8-Dm)

Cas:24916-90-3

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:Pale-Yellow Solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:as per your request Application:Dexamethasone intermediate. Transportation:as

16-beta Methyl Epoxide.

Cas:24916-90-3

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

16-beta Methyl Epoxide

Cas:24916-90-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 9b,11b-Epoxy-17,21-Dihydroxy-16a-Methylpregna-1,4-Diene-3,20-Dione CAS No.:24916-90-3 Molecule Formula:C22H28O5 Molecule Weight:372.45 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:En

High Quality 9b,11b-Epoxy-17,21-Dihydroxy-16a-Methylpregna-1,4-Diene-3,20-Dione on stock

Cas:24916-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

16-beta Methyl Epoxide

Cas:24916-90-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C26H33BrO8

C26H33BrO8

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With sodium hydroxide In methanol; dichloromethane at 0 - 5℃;93.3%
17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate
2884-51-7

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With sodium hydroxide In methanol at -10 - -5℃; for 2h; Reagent/catalyst; Temperature;84%
With water; sodium hydroxide In methanol; dichloromethane at -5 - 0℃; for 3h;
11α,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
78761-59-8

11α,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / -15 °C
2: phosphorus pentachloride / tetrahydrofuran / -85 °C
3: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; N,N-dimethyl-formamide / 1 h / 20 °C
4: sodium hydroxide / dichloromethane; methanol / 0 - 5 °C
View Scheme
Carbonic acid 2-((8S,9S,10R,11R,13S,14S,16R,17R)-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester ethyl ester

Carbonic acid 2-((8S,9S,10R,11R,13S,14S,16R,17R)-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester ethyl ester

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phosphorus pentachloride / tetrahydrofuran / -85 °C
2: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; N,N-dimethyl-formamide / 1 h / 20 °C
3: sodium hydroxide / dichloromethane; methanol / 0 - 5 °C
View Scheme
17α-hydroxy-16α-methyl-21-ethoxycarbonyloxypregna-1,4,9(11)-triene-3,20-dione
89561-92-2

17α-hydroxy-16α-methyl-21-ethoxycarbonyloxypregna-1,4,9(11)-triene-3,20-dione

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: perchloric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; N,N-dimethyl-formamide / 1 h / 20 °C
2: sodium hydroxide / dichloromethane; methanol / 0 - 5 °C
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid
159264-49-0

9,11-epoxy-17α-hydroxy-16α-methyl-3-oxandrosta-1,4-diene-17β-carboxylic acid

Conditions
ConditionsYield
With periodic acid In tetrahydrofuran; water at 0 - 5℃; for 2h;98.7%
acetic anhydride
108-24-7

acetic anhydride

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate
2884-51-7

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate

Conditions
ConditionsYield
With potassium acetate In ISOPROPYLAMIDE at 20℃; for 2h;98%
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
83881-08-7

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With Vilsmeier reagent In tetrahydrofuran Reagent/catalyst; Solvent; Inert atmosphere;86%
Multi-step reaction with 2 steps
1: triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 0 - 5 °C
2: CH2Cl2; methanol / 3.5 h / 40 - 42 °C
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-methanesulfonate
223776-47-4

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-methanesulfonate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 4h; Ambient temperature;84%
With pyridine at -5 - 0℃; for 5h;
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

A

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
83881-08-7

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

B

9β,11β-epoxy-17α-hydroxy-17β-(4-(R)-hydroxy-2,2-dioxido-1,2-oxathiolan-4-yl)-16α-methylandrosta-1,4-diene-3-one
223776-51-0

9β,11β-epoxy-17α-hydroxy-17β-(4-(R)-hydroxy-2,2-dioxido-1,2-oxathiolan-4-yl)-16α-methylandrosta-1,4-diene-3-one

Conditions
ConditionsYield
With dmap; methanesulfonyl chloride In dichloromethane for 4h; Heating;A 69%
B 1.1%
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

A

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
83881-08-7

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

B

9β,11β-epoxy-17α-hydroxy-17β-(4-(R)-hydroxy-2,2-dioxido-1,2-oxathiolan-4-yl)-16α-methylandrosta-1,4-diene-3-one
223776-51-0

9β,11β-epoxy-17α-hydroxy-17β-(4-(R)-hydroxy-2,2-dioxido-1,2-oxathiolan-4-yl)-16α-methylandrosta-1,4-diene-3-one

Conditions
ConditionsYield
With dmap In dichloromethane for 4h; Heating;A 69%
B 1.1%
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

C22H28O6
134429-25-7

C22H28O6

Conditions
ConditionsYield
With selenium(IV) oxide In 1,4-dioxane at 80℃; for 1h;33.5%
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

9β,11β-epoxy-17α,21-dihydroxy-16α-methyl-1,4-pregnadien-3,20-dione 21-tosylate

9β,11β-epoxy-17α,21-dihydroxy-16α-methyl-1,4-pregnadien-3,20-dione 21-tosylate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 0 - 5℃;
With triethylamine hydrochloride In dichloromethane at -5 - 5℃; for 9h;
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

mometasone
105102-22-5

mometasone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / 4-DMAP, CH3SO2Cl / CH2Cl2 / 4 h / Heating
2: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 69 percent / 4-DMAP / CH2Cl2 / 4 h / Heating
2: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Mometasone furoate
83919-23-7

Mometasone furoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 69 percent / 4-DMAP, CH3SO2Cl / CH2Cl2 / 4 h / Heating
2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature
3: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: 69 percent / 4-DMAP / CH2Cl2 / 4 h / Heating
2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature
3: 83 percent / conc. HCl / acetic acid / 3 h / Ambient temperature
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

9,11-Epoxidemometasone furoate
83881-09-8

9,11-Epoxidemometasone furoate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 69 percent / 4-DMAP, CH3SO2Cl / CH2Cl2 / 4 h / Heating
2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 69 percent / 4-DMAP / CH2Cl2 / 4 h / Heating
2: 3.44 g / Et3N, 4-DMAP / CH2Cl2 / 6 h / Ambient temperature
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

9β,11β-epoxy-16α-methyl-17α,21-oxidopregna-1,4-diene-3,20-dione

9β,11β-epoxy-16α-methyl-17α,21-oxidopregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / Et3N / tetrahydrofuran / 4 h / Ambient temperature
2: 80 percent / DBU / CH2Cl2 / 2 h / Heating
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

17β-(2,2-dioxido-3,4-dehydro-1,2-oxathiolan-4-yl)-9β,11β-epoxy-17α-hydroxy-16α-methylandrosta-1,4-dien-3-one 17-(2-furoate)
223776-50-9

17β-(2,2-dioxido-3,4-dehydro-1,2-oxathiolan-4-yl)-9β,11β-epoxy-17α-hydroxy-16α-methylandrosta-1,4-dien-3-one 17-(2-furoate)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.1 percent / 4-DMAP, CH3SO2Cl / CH2Cl2 / 4 h / Heating
2: 10 mg / 4-DMAP, Et3N / CH2Cl2 / 5 h / Ambient temperature
View Scheme
Multi-step reaction with 2 steps
1: 1.1 percent / 4-DMAP / CH2Cl2 / 4 h / Heating
2: 10 mg / 4-DMAP, Et3N / CH2Cl2 / 5 h / Ambient temperature
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

9α-chloro-11β,17α-dihydroxy-17β-(2,2-dioxido-3,4-dehydro-1,2-oxathiolan-4-yl)-16α-methylandrosta-1,4-dien-3-one 17-(2-furoate)

9α-chloro-11β,17α-dihydroxy-17β-(2,2-dioxido-3,4-dehydro-1,2-oxathiolan-4-yl)-16α-methylandrosta-1,4-dien-3-one 17-(2-furoate)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.1 percent / 4-DMAP, CH3SO2Cl / CH2Cl2 / 4 h / Heating
2: 10 mg / 4-DMAP, Et3N / CH2Cl2 / 5 h / Ambient temperature
3: 87 percent / conc. HCl / acetic acid / 2 h / Ambient temperature
View Scheme
Multi-step reaction with 3 steps
1: 1.1 percent / 4-DMAP / CH2Cl2 / 4 h / Heating
2: 10 mg / 4-DMAP, Et3N / CH2Cl2 / 5 h / Ambient temperature
3: 87 percent / conc. HCl / acetic acid / 2 h / Ambient temperature
View Scheme
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-(4-dimethylaminopyridinium methanesulfonate)

17α,21-dihydroxy-9β,11β-epoxy-16α-methylpregna-1,4-diene-3,20-dione 21-(4-dimethylaminopyridinium methanesulfonate)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / Et3N / tetrahydrofuran / 4 h / Ambient temperature
2: 91 percent / CH2Cl2 / 3 h / Heating
View Scheme
t-butyldimethylsiyl triflate
69739-34-0

t-butyldimethylsiyl triflate

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

9β,11β-epoxy-3,21-di(t-butyldimethylsilyloxy)-17α-hydroxy-16α-methylpregna-1,3,5-triene-20-one

9β,11β-epoxy-3,21-di(t-butyldimethylsilyloxy)-17α-hydroxy-16α-methylpregna-1,3,5-triene-20-one

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at -4 - 20℃; for 0.25h;
dichloromethane
75-09-2

dichloromethane

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
83881-08-7

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With triethylamine In methanol; water
methanol-dichloromethane

methanol-dichloromethane

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

epoxyparamethasone
23961-95-7

epoxyparamethasone

Conditions
ConditionsYield
methanolic potassium hydroxide
17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
24916-90-3

17α,21-dihydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione
83881-08-7

21-chloro-17α-hydroxy-9β,11β-oxido-16α-methylpregna-1,4-diene-3,20-dione

Conditions
ConditionsYield
With triethylamine In methanol; dichloromethane; water

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