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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

3-Chloromethyl-1,2,4-triazolin-5-one Manufacturer/High quality/Best price/In stock

Cas:252742-72-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 5-Chloromethyl-2,4-Dihydro-[1,2,4]Triazol-3-One supplier in China

Cas:252742-72-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hangzhou Think Chemical Co. Ltd

3-Chloromethyl-1,2,4-triazolin-5-one CAS No.:252742-72-6 Name: 3-Chloromethyl-1,2,4-triazolin-5-one Synonyms: 5-Chloromethyl-2,4-dihydro-[1,2,4]triazol-3-one

High purity 3-Chloromethyl-1,2,4-triazolin-5-one CAS No.:252742-72-6

Cas:252742-72-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 5-Chloromethyl-2,4-Dihydro-[1,2,4]Triazol-3-One

Cas:252742-72-6

Min.Order:1

Negotiable

Type:Other

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Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE

Cas:252742-72-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

5-(Chloromethyl)-1,2-dihydro-3H-1,2,4-triazol-3-one

Cas:252742-72-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1620.html Product Name 3-Chloromethyl-1,2,4-triazolin-5-one CAS No.

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE

Cas:252742-72-6

Min.Order:1 Metric Ton

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE CAS 252742-72-6

Cas:252742-72-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU CHEM-- 5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE

Cas:252742-72-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

StandardCAS 252742-72-6 with fast shipping

Cas:252742-72-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 252742-72-6 5-Chloromethyl-1H-[1,2,4]triazol-3-ol with best price

Cas:252742-72-6

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE CAS 252742-72-6 Aprepitant Intermediate hot selling!!!!

Cas:252742-72-6

Min.Order:1 Kilogram

FOB Price: $860.0 / 900.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Chloromethyl-1,2,4-triazolin-5-one 252742-72-6

Cas:252742-72-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE

Cas:252742-72-6

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Aprepitant intermediate, 5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE CAS:252742-72-6

Cas:252742-72-6

Min.Order:1 Kilogram

FOB Price: $81.4 / 86.2

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:252742-72-6

Cas:252742-72-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Fosaprepitant intermediate CAS: 252742-72-6 Purity:99% Stock:Fresh Package:25kg net per drum Application:252742-72-6

intermediate of Fosaprepitant

Cas:252742-72-6

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:1 Kilogram

FOB Price: $6.0 / 10.0

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE

Cas:252742-72-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

5-CHLOROMETHYL-2,4-DIHYDRO-[1,2,4]TRIAZOL-3-ONE

Cas:252742-72-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 5-Chloromethyl-2,4-Dihydro-[1,2,4]Triazol-3-One

Cas:252742-72-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

3-Chloromethyl-1,2,4-triazolin-5-oneAppearance:white powder Storage:closed and cool Package:according to customers' requirements Application:Aprepitant intermediate Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

3-Chloromethyl-1,2,4-triazolin-5-one

Cas:252742-72-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Synthetic route

semicarbazide hydrochloride
563-41-7

semicarbazide hydrochloride

2-chloro-1,1,1-trimethoxyethane
74974-54-2

2-chloro-1,1,1-trimethoxyethane

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
In methanol at 20℃; for 72h;98%
In methanol at 20℃;62%
In methanol at 20℃; for 72h;
In methanol at 20℃; for 144h;
In methanol at 20℃; for 3h;
5-hydroxymethyl-2,4-dihydro[1,2,4]triazol-3-one
24021-90-7

5-hydroxymethyl-2,4-dihydro[1,2,4]triazol-3-one

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
With thionyl chloride In acetonitrile at 5 - 20℃;90.7%
With thionyl chloride In acetonitrile at 20℃; for 18h;87%
With thionyl chloride In hexane; acetonitrile87.4%
With thionyl chloride at 20℃; for 18h; Inert atmosphere;
N4-semicarbazide hydrochloride

N4-semicarbazide hydrochloride

ethyl chloroacetimidate hydrochloride
36743-66-5

ethyl chloroacetimidate hydrochloride

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
In ethanol at 20℃; for 35h;62%
N4-semicarbazide hydrochloride

N4-semicarbazide hydrochloride

methyl 2-chloroacetimidate hydrochloride
70737-12-1

methyl 2-chloroacetimidate hydrochloride

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
In methanol for 70h;60%
2-chloro-1,1,1-trimethoxyethane
74974-54-2

2-chloro-1,1,1-trimethoxyethane

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

Conditions
ConditionsYield
In methanol; toluene
hydrazine carboxamide
4426-72-6, 51433-48-8

hydrazine carboxamide

2-chloro-1,1,1-trimethoxyethane
74974-54-2

2-chloro-1,1,1-trimethoxyethane

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

3-(aminomethyl)-1,4-dihydro-1,2,4-triazol-5-one
83160-78-5

3-(aminomethyl)-1,4-dihydro-1,2,4-triazol-5-one

Conditions
ConditionsYield
With ammonia In methanol at 20℃;100%
With ammonia In methanol at 20℃;
(2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
1242175-38-7

(2S,3S)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C23H21F7N4O3
1242175-40-1

C23H21F7N4O3

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃;99.2%
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate

(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃; for 3h;99%
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

(2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
380499-06-9

(2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

C23H21F7N4O3
1148113-53-4

C23H21F7N4O3

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃;99%
2-[1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
1242175-36-5

2-[1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C23H21F7N4O3
1242175-34-3

C23H21F7N4O3

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃;98.6%
2-[1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
170902-80-4

2-[1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C23H21F7N4O3
172822-28-5

C23H21F7N4O3

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃;98.6%
(2S,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
1185503-48-3

(2S,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C23H21F7N4O3
1185502-97-9

C23H21F7N4O3

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃;98.2%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
(2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
327623-37-0

(2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-[{(2S,3R)-2-((1S)-1-3,5-bis(trifluoro-methyl)phenylethoxy)-3-(4-fluorophenyl)-4-morpholinyl}methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
172822-29-6

5-[{(2S,3R)-2-((1S)-1-3,5-bis(trifluoro-methyl)phenylethoxy)-3-(4-fluorophenyl)-4-morpholinyl}methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃;98%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;
(2R,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
170729-79-0

(2R,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C23H21F7N4O3
170902-81-5

C23H21F7N4O3

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃;98%
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 10℃; for 4h;92%
dibenzyl phosphochloridate
538-37-4

dibenzyl phosphochloridate

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C17H17ClN3O4P

C17H17ClN3O4P

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at -5℃; Reagent/catalyst;91%
C14H13F6NO3

C14H13F6NO3

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C17H16F6N4O4

C17H16F6N4O4

Conditions
ConditionsYield
With sodium hydroxide In acetonitrile at 30 - 40℃; for 2.5h;89%
O-Trimethylsilylhydroxylamine
22737-36-6

O-Trimethylsilylhydroxylamine

4-bromobenzyl mercaptan
19552-10-4

4-bromobenzyl mercaptan

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-({[(4-bromophenyl)methyl]thio}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
935760-75-1

5-({[(4-bromophenyl)methyl]thio}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 12h;88%
4-bromobenzyl mercaptan
19552-10-4

4-bromobenzyl mercaptan

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-({[(4-bromophenyl)methyl]thio}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
935760-75-1

5-({[(4-bromophenyl)methyl]thio}methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12h;88%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C17H17ClN3O4P

C17H17ClN3O4P

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -5℃;86%
3-chloro-5-((2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile
1155846-86-8

3-chloro-5-((2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

3-chloro-5-((2-oxo-1-((5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile
1338226-05-3

3-chloro-5-((2-oxo-1-((5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at -10 - 10℃; for 9h; Large scale;81%
Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amine
606929-58-2

Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one
606929-61-7

5-[(Benzyl-{3-[(R)-1-(3,5-bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutyl}-amino)-methyl]-2,4-dihydro-[1,2,4]triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 9h;77%
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
171338-27-5

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;68%
phenylmethanethiol
100-53-8

phenylmethanethiol

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-[(benzylthio)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
866602-60-0

5-[(benzylthio)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 20.5h;61%
N-(2,4-dichlorobenzyl)-7-[(3RS,5SR)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxamide
874481-18-2

N-(2,4-dichlorobenzyl)-7-[(3RS,5SR)-3,5-dimethylpiperazin-1-yl]-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxamide

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

N-(2,4-dichlorobenzyl)-7-{(3RS,5SR)-3,5-dimethyl-4-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]piperazin-1-yl}-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxamide

N-(2,4-dichlorobenzyl)-7-{(3RS,5SR)-3,5-dimethyl-4-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]piperazin-1-yl}-6-fluoro-8-methoxy-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydroquinoline-3-carboxamide

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetonitrile at 50℃;40%
3,4-dihydro-2H-pyrido[3,2-b ][1,4]oxazine
20348-23-6

3,4-dihydro-2H-pyrido[3,2-b ][1,4]oxazine

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

C10H11N5O2

C10H11N5O2

Conditions
ConditionsYield
Stage #1: 3,4-dihydro-2H-pyrido[3,2-b ][1,4]oxazine With potassium hexamethylsilazane In N,N-dimethyl-formamide; toluene at 0℃; for 0.333333h;
Stage #2: 3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one In N,N-dimethyl-formamide; toluene at 20℃; for 2h;
36%
cis-4-[[3,5-bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

cis-4-[[3,5-bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidine hydrochloride

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-[[cis-4-[[3,5-bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

5-[[cis-4-[[3,5-bis(trifluoromethyl)benzyl]oxy]-3-phenylpiperidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide); water at 0℃; for 3h;29%
4-(2-fluorophenoxymethyl)piperidine hydrochloride
614731-22-5

4-(2-fluorophenoxymethyl)piperidine hydrochloride

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-(4-(2-Fluorophenoxymethyl)piperidino]methyl-2,4-dihydro-[1,2,4]triazol-3-one
614729-03-2

5-(4-(2-Fluorophenoxymethyl)piperidino]methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In water; ethyl acetate; acetonitrile21%
2-(2-Fluorophenyl)-1-(piperidin-4-yl)ethanone hydrochloride
614729-48-5

2-(2-Fluorophenyl)-1-(piperidin-4-yl)ethanone hydrochloride

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

5-[4-(2-(2-Fluorophenyl)acetyl]piperidino]methyl-2,4-dihydro-[1,2,4]triazol-3-one
614729-09-8

5-[4-(2-(2-Fluorophenyl)acetyl]piperidino]methyl-2,4-dihydro-[1,2,4]triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In diethyl ether; water; ethyl acetate; acetonitrile7%
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
171338-27-5

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
172822-29-6

5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃; for 4h;
benzyl[(2S,3S)-2-phenyl-3-piperidinyl]carbamate

benzyl[(2S,3S)-2-phenyl-3-piperidinyl]carbamate

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

benzyl[(2S,3S)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-phenyl-3-piperidinyl]carbamate

benzyl[(2S,3S)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl]-2-phenyl-3-piperidinyl]carbamate

Conditions
ConditionsYield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 1h;
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