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Chemvon Biotechnology Co. Ltd.

Chemvon Biotechnology is one of the leading high-technology manufacturer in the field of pharmaceutical and fine chemical industry. From origins as a research group in technology service, chemvon has progressed into an integrated company with a k

Aprepitant

Cas:170729-80-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Aprepitant Manufacturer/High quality/Best price/In stock

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ---------------------------------------------------------------------------------------------

High purity Various Specifications Aprepitant CAS:170729-80-3

Cas:170729-80-3

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Aprepitant supplier in China

Cas:170729-80-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Kono Chem Co.,Ltd

We Puhopharma supply high quality of good pharmaceutical product. We specialize in controling the quality and reducing the impurities of Aprepitant . Our Aprepitant is with the best quality and the most competitive price in China. Our Aprepitant

CAS:170729-80-3 Aprepitant

Cas:170729-80-3

Min.Order:1 Kilogram

Negotiable

Type:Other

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

Aprepitant

Cas:170729-80-3

Min.Order:1 Metric Ton

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

inquiry

Hebei yanxi chemical co.,LTD.

Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa

Aprepitant CAS NO.170729-80-3

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White to off-white powder Storage:-20°C Freezer Package:100g/

Good quality Aprepitant CAS 170729-80-3 supplied by manufacturer

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $3500.0 / 4000.0

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Aprepitant API and intermediates 170729-80-3 3-Chloromethyl-1,2,4-triazolin-5-one[CAS:252742-72-6] (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate[CAS:200000-59-5] HANGZH

Aprepitant API 170729-80-3

Cas:170729-80-3

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Aprepitant

Cas:170729-80-3

Min.Order:1

Negotiable

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Aprepitant manufacturer with low price

Cas:170729-80-3

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Aprepitant 170729-80-3 ISO Producer

Cas:170729-80-3

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Aprepitant

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Aprepitant

Cas:170729-80-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name:Aprepitant CAS:170729-80-3 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability P

High purity Various Specifications Aprepitant CAS:170729-80-3

Cas:170729-80-3

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Aprepitant

Cas:170729-80-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Aprepitant In stock

Cas:170729-80-3

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 170729-80-3 with competitive price

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Chemical Name: Aprepitant Cas No.: 170729-80-3 Molecular Formula: C23H21F7N4O3 Molecular Weight: 534.43 Molecular Structure: Appearance:White powder Storage:Store in cool and dry

Aprepitant? CAS:170729-80-3

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best serv

Aprepitant Manufacturer For Chemotherapy Vomiting Medicine

Cas:170729-80-3

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Wholesales Supply 99% Original Powder Aprepitant CAS 170729-80-3 with Safe Delivery

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Aprepitant 170729-80-3

Cas:170729-80-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Antineoplastic drug Aprepitant/CAS:170729-80-3

Cas:170729-80-3

Min.Order:5 Kilogram

FOB Price: $3456.0 / 3886.8

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Aprepitant CAS: 170729-80-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate

Aprepitant CAS: 170729-80-3

Cas:170729-80-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Aprepitant

Cas:170729-80-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Top quality best price Aprepitant

Cas:170729-80-3

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional chemical raw materials and chemical reagents research and development production enterprises. We have several production line,So we can control the lowest price. We also have several

Aprepitant cas:170729-80-3

Cas:170729-80-3

Min.Order:25 Gram

FOB Price: $90.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Aprepitant

Cas:170729-80-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Aprepitant powder

Cas:170729-80-3

Min.Order:1 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

Synthetic route

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate

(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide at 0℃; for 3h;99%
2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester
219821-37-1

2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
In 5,5-dimethyl-1,3-cyclohexadiene for 3h; Reflux;98.4%
In 5,5-dimethyl-1,3-cyclohexadiene at 130 - 139℃; for 4h; Temperature;97.7%
In acetonitrile at 120 - 125℃;60.4%
C3H4BrN3O

C3H4BrN3O

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With diethyl sulfate; triethylamine; lithium diisopropyl amide In dimethylsulfoxide-d6; 5,5-dimethyl-1,3-cyclohexadiene at 33℃; for 14h; Temperature; Inert atmosphere;97.9%
C23H21F7N4O4

C23H21F7N4O4

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With triethylsilane; boron trifluoride diethyl etherate In acetonitrile at 0 - 35℃; for 5h;94%
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0 - 10℃; for 4h;92%
3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one
252742-72-6

3-(chloromethyl)-1H-1,2,4-triazol-5(4H)-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
171338-27-5

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;68%
N'-(1-amino-2-chloroethylidene)hydrazinecarboxylic acid methyl ester

N'-(1-amino-2-chloroethylidene)hydrazinecarboxylic acid methyl ester

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
171338-27-5

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Stage #1: N'-(1-amino-2-chloroethylidene)hydrazinecarboxylic acid methyl ester; [2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 3h;
Stage #2: In acetonitrile at 110℃; under 1125.11 Torr; for 55h; Product distribution / selectivity;
53%
2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine
219821-37-1

2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With pyrographite In methanol at 60℃; for 1h;0.96 kg
In toluene at 140℃; for 3h;
at 135 - 137℃; for 2h;
(2R,3S)-4-benzyl-2-[1R-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine p-toluenesulfonate salt

(2R,3S)-4-benzyl-2-[1R-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine p-toluenesulfonate salt

N-methoxycarbonyl-2-chloroacetamidrazone

N-methoxycarbonyl-2-chloroacetamidrazone

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20 - 23℃; for 1.5h; Product distribution / selectivity;
3,5-bis(trifluoromethyl)phenyl methyl ketone
30071-93-3

3,5-bis(trifluoromethyl)phenyl methyl ketone

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97 percent / borane-methyl sulfide complex; (S)-Me-CBS / various solvent(s); toluene / 1 h / -5 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 5 steps
1: 97 percent / borane-methyl sulfide complex; (S)-Me-CBS / various solvent(s); toluene / 1 h / -5 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
5: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: 97 percent / borane-methyl sulfide complex; (S)-Me-CBS / various solvent(s); toluene / 1 h / -5 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 4 steps
1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
3: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
4: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 3 steps
1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
4-benzyl-morpholine-2,3-dione
110843-90-8

4-benzyl-morpholine-2,3-dione

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C
2: acetonitrile / 5 - 34 °C
3: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 6 steps
1: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C
2: acetonitrile / 5 - 34 °C
3: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
5: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
6: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C
2: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
3: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 76 percent / tetrahydrofuran; H2O / 21 h / Heating
2: acetonitrile / 5 - 34 °C
3: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 6 steps
1: 76 percent / tetrahydrofuran; H2O / 21 h / Heating
2: acetonitrile / 5 - 34 °C
3: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
5: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
6: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: 76 percent / tetrahydrofuran; H2O / 21 h / Heating
2: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
3: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
2: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 - 20 °C
2: potassium hydroxide / ethanol; water / 0.2 h / 90 - 100 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate / N,N-dimethyl-formamide / 10 - 20 °C
2: potassium hydroxide / ethanol; water / 0.2 h / 90 - 100 °C
View Scheme
Multi-step reaction with 2 steps
1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / 5,5-dimethyl-1,3-cyclohexadiene; dimethyl sulfoxide / 20 - 25 °C / Inert atmosphere
2: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 135 - 141 °C / Inert atmosphere
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 5 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
5: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester
502537-07-7

trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 4 steps
1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
3: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
4: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester
502536-97-2

2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
2: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 3 steps
1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 4 steps
1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
3: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
4: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 5 steps
1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
2: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
5: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
327623-36-9

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 4 steps
1: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
2: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
3: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
4: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 3 steps
1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
2: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
3: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol; water / 4.5 h / 50 - 60 °C / 26252.6 Torr
2.1: sodium hydroxide / acetonitrile / 2.5 h / 30 - 40 °C
3.1: tetrahydrofuran / 1 h / 15 - 25 °C
3.2: 1 h / 20 - 65 °C
4.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 5 h / 0 - 35 °C
View Scheme
(2S,3R)-3-(4-fluorophenyl)-4-[(1R)-1-phenylethyl]-2-morpholinol
472968-68-6

(2S,3R)-3-(4-fluorophenyl)-4-[(1R)-1-phenylethyl]-2-morpholinol

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: K2CO3 / toluene / 5 h / 20 °C
2: 14.3 g / BF3*Et2O / tetrahydrofuran / 1 h / -20 °C
3: TsOH*H2O; hydrogen / 5percent Pd/C / ethanol; toluene / 3 h / 30 °C / 2068.65 Torr
4: NCS; K2CO3 / dimethylformamide / 0.5 h / 0 °C
5: DBU / dimethylformamide / 3 h / 0 - 20 °C
6: hydrogen / 5percent Pd/C / dimethylformamide; ethanol / 2 h / 20 °C / 2068.65 Torr
View Scheme
(3R)-[3-(4-fluorophenyl)]-4-[(1R)-1-phenylethyl]-2-morpholinone

(3R)-[3-(4-fluorophenyl)]-4-[(1R)-1-phenylethyl]-2-morpholinone

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: DIBALH / toluene; tetrahydrofuran / 0.5 h / -20 °C
2: K2CO3 / toluene / 5 h / 20 °C
3: 14.3 g / BF3*Et2O / tetrahydrofuran / 1 h / -20 °C
4: TsOH*H2O; hydrogen / 5percent Pd/C / ethanol; toluene / 3 h / 30 °C / 2068.65 Torr
5: NCS; K2CO3 / dimethylformamide / 0.5 h / 0 °C
6: DBU / dimethylformamide / 3 h / 0 - 20 °C
7: hydrogen / 5percent Pd/C / dimethylformamide; ethanol / 2 h / 20 °C / 2068.65 Torr
View Scheme
2,2,2-Trichloro-acetimidic acid (2R,3R)-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholin-2-yl ester
472968-69-7

2,2,2-Trichloro-acetimidic acid (2R,3R)-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholin-2-yl ester

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 14.3 g / BF3*Et2O / tetrahydrofuran / 1 h / -20 °C
2: TsOH*H2O; hydrogen / 5percent Pd/C / ethanol; toluene / 3 h / 30 °C / 2068.65 Torr
3: NCS; K2CO3 / dimethylformamide / 0.5 h / 0 °C
4: DBU / dimethylformamide / 3 h / 0 - 20 °C
5: hydrogen / 5percent Pd/C / dimethylformamide; ethanol / 2 h / 20 °C / 2068.65 Torr
View Scheme
(2R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine
380499-07-0

(2R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen / 5percent Pd/C / dimethylformamide; ethanol / 2 h / 20 °C / 2068.65 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: potassium formate / palladium on carbon / ethanol; water / 2 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 20 °C
2.2: 55 h / 110 °C / 1125.11 Torr
View Scheme
(2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
380499-06-9

(2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: NCS; K2CO3 / dimethylformamide / 0.5 h / 0 °C
2: DBU / dimethylformamide / 3 h / 0 - 20 °C
3: hydrogen / 5percent Pd/C / dimethylformamide; ethanol / 2 h / 20 °C / 2068.65 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hypochlorite; potassium carbonate / acetonitrile / 0.25 h
1.2: 14 h / 20 °C
2.1: potassium formate / palladium on carbon / ethanol; water / 2 h / 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hypochlorite; potassium carbonate / acetonitrile / 0.25 h
1.2: 14 h / 20 °C
2.1: potassium formate / palladium on carbon / ethanol; water / 2 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 20 °C
3.2: 55 h / 110 °C / 1125.11 Torr
View Scheme
(2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-4-chloro-3-(4-fluoro-phenyl)-morpholine

(2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-4-chloro-3-(4-fluoro-phenyl)-morpholine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: DBU / dimethylformamide / 3 h / 0 - 20 °C
2: hydrogen / 5percent Pd/C / dimethylformamide; ethanol / 2 h / 20 °C / 2068.65 Torr
View Scheme
(2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine
472968-70-0

(2R,3R)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-4-((R)-1-phenyl-ethyl)-morpholine

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: TsOH*H2O; hydrogen / 5percent Pd/C / ethanol; toluene / 3 h / 30 °C / 2068.65 Torr
2: NCS; K2CO3 / dimethylformamide / 0.5 h / 0 °C
3: DBU / dimethylformamide / 3 h / 0 - 20 °C
4: hydrogen / 5percent Pd/C / dimethylformamide; ethanol / 2 h / 20 °C / 2068.65 Torr
View Scheme
C27H31F7N4O4
1349902-81-3

C27H31F7N4O4

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 90 - 100℃; for 1h; Reagent/catalyst; Solvent; Large scale;
C25H27F7N4O4

C25H27F7N4O4

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 90 - 100℃; for 0.2h;
(2S,3R)-4-benzyl-3-(4-fluorophenyl)morpholin-2-ol
1185503-10-9

(2S,3R)-4-benzyl-3-(4-fluorophenyl)morpholin-2-ol

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / toluene / 1 h / -10 °C
2.1: hydrogen; toluene-4-sulfonic acid / palladium 10% on activated carbon / methanol / 16 h / 20 °C
3.1: sodium hypochlorite; potassium carbonate / acetonitrile / 0.25 h
3.2: 14 h / 20 °C
4.1: potassium formate / palladium on carbon / ethanol; water / 2 h / 20 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: boron trifluoride diethyl etherate / toluene / 1 h / -10 °C
2.1: hydrogen; toluene-4-sulfonic acid / palladium 10% on activated carbon / methanol / 16 h / 20 °C
3.1: sodium hypochlorite; potassium carbonate / acetonitrile / 0.25 h
3.2: 14 h / 20 °C
4.1: potassium formate / palladium on carbon / ethanol; water / 2 h / 20 °C
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 20 °C
5.2: 55 h / 110 °C / 1125.11 Torr
View Scheme
1-deoxy-1-(methylamino)-D-glucitol
6284-40-8

1-deoxy-1-(methylamino)-D-glucitol

aprepitant
170729-80-3

aprepitant

Fosaprepitant dimeglumine

Fosaprepitant dimeglumine

Conditions
ConditionsYield
Stage #1: aprepitant With dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; sodium hexamethyldisilazane In tetrahydrofuran at -3℃; for 2h;
Stage #2: 1-deoxy-1-(methylamino)-D-glucitol With palladium 10% on activated carbon; hydrogen In methanol; water for 4h;
98%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

aprepitant
170729-80-3

aprepitant

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester
265121-01-5

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester

Conditions
ConditionsYield
With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 1h; Temperature; Inert atmosphere;93.6%
With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 1h; Temperature; Inert atmosphere;93.6%
With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.25h; phosphorylation;90%
Dibenzyl phosphite
17176-77-1

Dibenzyl phosphite

aprepitant
170729-80-3

aprepitant

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester
265121-01-5

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester

Conditions
ConditionsYield
With triethylamine In tetrachloromethane; dichloromethane at 0 - 10℃; Reagent/catalyst; Solvent;92.4%
Dimethyl phosphite
868-85-9

Dimethyl phosphite

aprepitant
170729-80-3

aprepitant

C25H26F7N4O6P

C25H26F7N4O6P

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tert-butyl methyl ether at 0 - 30℃;90.6%
phosphonic acid diethyl ester
762-04-9

phosphonic acid diethyl ester

aprepitant
170729-80-3

aprepitant

C27H30F7N4O6P

C27H30F7N4O6P

Conditions
ConditionsYield
With dmap In chloroform at 0 - 20℃;90.4%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

aprepitant
170729-80-3

aprepitant

dibenzyl fosaprepitant

dibenzyl fosaprepitant

Conditions
ConditionsYield
Stage #1: aprepitant With lithium hydroxide monohydrate In 1-methyl-pyrrolidin-2-one at 20℃; for 0.5h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In 1-methyl-pyrrolidin-2-one at 25 - 30℃; for 0.5h; Quantum yield;
87.4%
aprepitant
170729-80-3

aprepitant

fosaprepitant

fosaprepitant

Conditions
ConditionsYield
With dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; sodium hexamethyldisilazane In tetrahydrofuran at -3℃; for 2h;86.7%
Multi-step reaction with 3 steps
1: sodium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -20 °C
2: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 5171.62 Torr
3: hydrogenchloride / water; methanol / 0.08 h / 0 - 5 °C / pH 1
View Scheme
Multi-step reaction with 2 steps
1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
2: borane pyridine; methanol / 2 h / 20 °C / Inert atmosphere
View Scheme
C26H22ClO3P

C26H22ClO3P

aprepitant
170729-80-3

aprepitant

C49H42F7N4O6P

C49H42F7N4O6P

Conditions
ConditionsYield
Stage #1: aprepitant With sodium hexamethyldisilazane In tetrahydrofuran at -5 - 5℃; for 0.5h; Inert atmosphere; Cooling with ice;
Stage #2: C26H22ClO3P In tetrahydrofuran at 5 - 20℃; for 1h; Solvent;
82%
benzyl methyl phosphonate
53148-24-6

benzyl methyl phosphonate

aprepitant
170729-80-3

aprepitant

C31H30F7N4O6P

C31H30F7N4O6P

Conditions
ConditionsYield
With triethylamine In tetrachloromethane; dichloromethane at 0 - 10℃; Reagent/catalyst; Solvent;81.1%
aprepitant
170729-80-3

aprepitant

5-(((2R,3S)-2-((R)-1-(3-(difluoromethyl-d)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

5-(((2R,3S)-2-((R)-1-(3-(difluoromethyl-d)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With deuteroacetic acid; magnesium In dimethylsulfoxide-d6; d(4)-methanol; water-d2 at 20℃; for 2h; regioselective reaction;43%
aprepitant
170729-80-3

aprepitant

5-(((2R,3S)-2-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

5-(((2R,3S)-2-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With magnesium; acetic acid In water; dimethyl sulfoxide at 20℃; for 2h; regioselective reaction;41%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

aprepitant
170729-80-3

aprepitant

A

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester
265121-01-5

[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic acid bis(phenylmethyl)ester

B

C44H41F7N4O9P2

C44H41F7N4O9P2

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 0.75h; phosphorylation;A 39%
B 5 % Chromat.
aprepitant
170729-80-3

aprepitant

A

5-(((2R,3S)-2-((R)-1-(3-(fluoromethyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

5-(((2R,3S)-2-((R)-1-(3-(fluoromethyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

B

5-(((2R,3S)-2-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

5-(((2R,3S)-2-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
With magnesium; acetic acid In water; dimethyl sulfoxide at 20℃; for 5h; regioselective reaction;A 16%
B 22%
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