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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-BENZYL-2-HYDROXYMORPHOLIN-3-ONE

Cas:287930-73-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/1622.html Product Name 4-Benzyl-2-hydroxymorpholin-3-one CAS No. 2

4-Benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:1 Gram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Benzyl-2-Hydroxy-Morpholin-3-One :287930-73-8

Cas:287930-73-8

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE 287930-73-8

Cas:287930-73-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 287930-73-8 with best quality

Cas:287930-73-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name: 2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate Synonyms: 2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate;

4-Benzyl-2-hydroxymorpholin-3-one CAS: 287930-73-8

Cas:287930-73-8

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

2-Hydroxy-4-(phenylMethyl)-3-Morpholinone CAS NO 287930-73-8

Cas:287930-73-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

3-Morpholinone,2-hydroxy-4-(phenylmethyl)- 287930-73-8

Cas:287930-73-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE CAS:287930-73-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE CAS:287930-73-8

Cas:287930-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

3-Morpholinone,2-hydroxy-4-(phenylmethyl)-

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

Cas:287930-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-amino-2-(furan-2-ylmethyl)propanoic acid

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

Cas:287930-73-8

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Factory supply high quality 4-Benzyl-2-hydroxy-morpholin-3-one,287930-73-8 CAS NO.287930-73-8

Cas:287930-73-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 4-Benzyl-2-Hydroxy-Morpholin-2-One CAS No.: 287930-73-8 Molecule Formula:C11H13NO3 Molecule Weight:207.23 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard

Lower Price 4-Benzyl-2-Hydroxy-Morpholin-2-One

Cas:287930-73-8

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Synonyms: Aprepitant Impurity 48;Fosaprepitant Impurity 23;4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE;3-Morpholinone,2-hydroxy-4-(phenylMethyl)-;2-Hydroxy-4-(phenylMethyl)-3-Morpholinone;Fosaprepitant Im

4-Benzyl-2-hydroxymorpholin-3-one 287930-73-8 C11H13NO3

Cas:287930-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

Cas:287930-73-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE

Cas:287930-73-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

We are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and techni

high 4-Benzyl-2-hydroxy-morpholin-3-one 287930-73-8

Cas:287930-73-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

4-benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe

SAGECHEM/4-Benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Benzyl-2-hydroxy-morpholin-3-one

Cas:287930-73-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Benzyl-2-hydroxy-morpholin-3-one Cas no.287930-73-8 98%

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate

4-Benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Other

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

4-benzyl-2-hydroxymorpholin-3-one

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

4-Benzyl-2-hydroxy-morpholin-3-one

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-Benzyl-2-hydroxyMorpholin-3-one

Cas:287930-73-8

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

Glyoxilic acid
298-12-4

Glyoxilic acid

N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

Conditions
ConditionsYield
In tetrahydrofuran Reflux;91%
In tetrahydrofuran Reflux;91%
In tetrahydrofuran; water for 21h; Heating;76%
In tetrahydrofuran; water at 60 - 65℃; for 8h; Inert atmosphere;27.5 g
4-benzyl-morpholine-2,3-dione
110843-90-8

4-benzyl-morpholine-2,3-dione

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

Conditions
ConditionsYield
With L-Selectride88%
With sodium hydroxide; dihydrogen peroxide; L-Selectride In tetrahydrofuran; water at 10℃; for 1h;80%
N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

2,2-dihydroxyacetic acid
563-96-2

2,2-dihydroxyacetic acid

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

Conditions
ConditionsYield
In tetrahydrofuran; water at 65℃; for 18h;75%
methyl glyoxylate methyl hemi-acetal
109745-70-2, 19757-97-2

methyl glyoxylate methyl hemi-acetal

N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

Conditions
ConditionsYield
15%
Methoxy-(1-methoxy-1-methyl-ethoxy)-acetic acid methyl ester
108228-02-0

Methoxy-(1-methoxy-1-methyl-ethoxy)-acetic acid methyl ester

N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

Conditions
ConditionsYield
Stage #1: Methoxy-(1-methoxy-1-methyl-ethoxy)-acetic acid methyl ester; N-Benzylethanolamine With sodium hydride In tetrahydrofuran
Stage #2: With hydrogenchloride Further stages.;
N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

(1-ethoxy-ethoxy)-methoxy-acetic acid methyl ester

(1-ethoxy-ethoxy)-methoxy-acetic acid methyl ester

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

Conditions
ConditionsYield
Stage #1: N-Benzylethanolamine; (1-ethoxy-ethoxy)-methoxy-acetic acid methyl ester With sodium hydride In tetrahydrofuran
Stage #2: With hydrogenchloride Further stages.;
N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / Li(sec-Bu)3BH
View Scheme
Multi-step reaction with 2 steps
1: 68 percent / ethanol; hexane / 20 °C
2: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C
View Scheme
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 3h; Further stages;
96%
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 2h;
Stage #3: With tetrahydrolinalool; potassium tert-butylate In hexane at -10 - -5℃; for 14h; Solvent;
96%
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5℃; for 1h;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 25℃; for 4h; Temperature; Reagent/catalyst;
trichloroacetonitrile
545-06-2

trichloroacetonitrile

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester
502536-97-2

2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In n-heptane; toluene at 20℃; for 18h;91%
trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester
502537-07-7

trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester

Conditions
ConditionsYield
In acetonitrile at 5 - 34℃;
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(3R*)-4-benzyl-3-[(1S*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

(3R*)-4-benzyl-3-[(1S*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: tetrahydrofuran / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 0.76 g / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: tetrahydrofuran / 20 °C
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(3R*)-4-benzyl-3-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

(3R*)-4-benzyl-3-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 0.96 g / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: 0.96 g / tetrahydrofuran / 3 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
4: 0.96 g / tetrahydrofuran / 3 h / 20 °C
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2R)-2-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-3-dehydromorpholine

(2R)-2-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-3-dehydromorpholine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetonitrile / 5 - 34 °C
2.1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3.1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4.1: NaHCO3 / ethyl acetate
4.2: 84 percent / K2CO3; N-chlorosuccinimide; DBU / toluene; dimethylformamide / 5 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2.1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3.1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4.1: NaHCO3 / ethyl acetate
4.2: 84 percent / K2CO3; N-chlorosuccinimide; DBU / toluene; dimethylformamide / 5 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2.1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3.1: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
4.1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
5.1: NaHCO3 / ethyl acetate
5.2: 84 percent / K2CO3; N-chlorosuccinimide; DBU / toluene; dimethylformamide / 5 h / 20 °C
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 5 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
5: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
171338-27-5

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetonitrile / 5 - 34 °C
2.1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3.1: tetrahydrofuran / 20 - 30 °C
3.2: H2 / 10 percent Pd/C / methanol; tetrahydrofuran
View Scheme
Multi-step reaction with 3 steps
1.1: acetonitrile / 5 - 34 °C
2.1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3.1: tetrahydrofuran / 20 °C
3.2: H2 / 5 percent Pd/C / methanol
View Scheme
Multi-step reaction with 3 steps
1.1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2.1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3.1: tetrahydrofuran / 20 - 30 °C
3.2: H2 / 10 percent Pd/C / methanol; tetrahydrofuran
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 3 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 4 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 2 steps
1.1: trifluoroacetic anhydride / acetonitrile / 1 h / 5 - 30 °C
1.2: 3 h
2.1: tetrahydrofuran; methanol / 0.92 h / 15 - 20 °C
2.3: 0.5 h / Reflux
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

C22H24N2O5

C22H24N2O5

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
327623-36-9

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine
219821-37-1

2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
View Scheme
Multi-step reaction with 4 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
View Scheme
Multi-step reaction with 5 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
5: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
View Scheme
C32H52O6
1334043-16-1

C32H52O6

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

C43H63NO8
1334040-33-3

C43H63NO8

Conditions
ConditionsYield
Stage #1: C32H52O6 With trifluoroacetic anhydride In acetonitrile at 0 - 20℃; for 1h;
Stage #2: 4-benzyl-2-hydroxy-morpholin-3-one With boron trifluoride diethyl etherate In dichloromethane; acetonitrile for 40h;
Stage #3: With sodium hydrogencarbonate In dichloromethane; water
C32H52O6

C32H52O6

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

C43H63NO8
1334040-33-3

C43H63NO8

Conditions
ConditionsYield
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 0 - 20℃; for 1h;
Stage #2: C32H52O6 With boron trifluoride diethyl etherate In dichloromethane; acetonitrile for 40h;
C12H7F9O2

C12H7F9O2

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
With potassium tetrahydrolinalool; triphenylphosphine at -10℃; for 6h; Reagent/catalyst; Temperature;80.2 g
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

A

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
327623-36-9

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

B

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 25℃; for 1h; Inert atmosphere;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 20 - 30℃; for 2h; stereoselective reaction;
A 39.5 g
B 23.2 g
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

A

C21H19F6NO3

C21H19F6NO3

B

C21H19F6NO3

C21H19F6NO3

Conditions
ConditionsYield
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 25℃; for 1h; Inert atmosphere;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 20 - 30℃; for 2h; stereoselective reaction;
A 34 g
B 31 g

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