DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/1622.html Product Name 4-Benzyl-2-hydroxymorpholin-3-one CAS No. 2
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryProduct Name: 2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate Synonyms: 2-[(S)-(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine (2R,3R)-2,3-Dihydroxybutanedioate;
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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inquiry4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE CAS:287930-73-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryMassive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiryProduct name: 4-Benzyl-2-Hydroxy-Morpholin-2-One CAS No.: 287930-73-8 Molecule Formula:C11H13NO3 Molecule Weight:207.23 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard
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inquiryProduct Name: 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE Synonyms: Aprepitant Impurity 48;Fosaprepitant Impurity 23;4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE;3-Morpholinone,2-hydroxy-4-(phenylMethyl)-;2-Hydroxy-4-(phenylMethyl)-3-Morpholinone;Fosaprepitant Im
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
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inquiryWe are the manufacturer of this product in China. Our price is the lowest in China. CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD., founded in 1984, engages in pharmaceutical research, development, production, process design and techni
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inquiryLocated in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an
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SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in custom synthe
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
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inquiryStock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai
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inquiry1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate
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Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe
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inquiryR & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou
Glyoxilic acid
N-Benzylethanolamine
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
In tetrahydrofuran Reflux; | 91% |
In tetrahydrofuran Reflux; | 91% |
In tetrahydrofuran; water for 21h; Heating; | 76% |
In tetrahydrofuran; water at 60 - 65℃; for 8h; Inert atmosphere; | 27.5 g |
4-benzyl-morpholine-2,3-dione
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
With L-Selectride | 88% |
With sodium hydroxide; dihydrogen peroxide; L-Selectride In tetrahydrofuran; water at 10℃; for 1h; | 80% |
N-Benzylethanolamine
2,2-dihydroxyacetic acid
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
In tetrahydrofuran; water at 65℃; for 18h; | 75% |
methyl glyoxylate methyl hemi-acetal
N-Benzylethanolamine
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
15% |
Methoxy-(1-methoxy-1-methyl-ethoxy)-acetic acid methyl ester
N-Benzylethanolamine
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Stage #1: Methoxy-(1-methoxy-1-methyl-ethoxy)-acetic acid methyl ester; N-Benzylethanolamine With sodium hydride In tetrahydrofuran Stage #2: With hydrogenchloride Further stages.; |
N-Benzylethanolamine
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Stage #1: N-Benzylethanolamine; (1-ethoxy-ethoxy)-methoxy-acetic acid methyl ester With sodium hydride In tetrahydrofuran Stage #2: With hydrogenchloride Further stages.; |
N-Benzylethanolamine
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 88 percent / Li(sec-Bu)3BH View Scheme | |
Multi-step reaction with 2 steps 1: 68 percent / ethanol; hexane / 20 °C 2: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C View Scheme |
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
4-benzyl-2-hydroxy-morpholin-3-one
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
Conditions | Yield |
---|---|
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 3h; Further stages; | 96% |
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 2h; Stage #3: With tetrahydrolinalool; potassium tert-butylate In hexane at -10 - -5℃; for 14h; Solvent; | 96% |
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5℃; for 1h; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 25℃; for 4h; Temperature; Reagent/catalyst; |
trichloroacetonitrile
4-benzyl-2-hydroxy-morpholin-3-one
2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In n-heptane; toluene at 20℃; for 18h; | 91% |
trifluoroacetic anhydride
4-benzyl-2-hydroxy-morpholin-3-one
trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester
Conditions | Yield |
---|---|
In acetonitrile at 5 - 34℃; |
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3: tetrahydrofuran / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3: 0.76 g / tetrahydrofuran / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: tetrahydrofuran / 20 °C View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3: 0.96 g / tetrahydrofuran / 3 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: 0.96 g / tetrahydrofuran / 3 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C 4: 0.96 g / tetrahydrofuran / 3 h / 20 °C View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: acetonitrile / 5 - 34 °C 2.1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3.1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr 4.1: NaHCO3 / ethyl acetate 4.2: 84 percent / K2CO3; N-chlorosuccinimide; DBU / toluene; dimethylformamide / 5 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2.1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3.1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr 4.1: NaHCO3 / ethyl acetate 4.2: 84 percent / K2CO3; N-chlorosuccinimide; DBU / toluene; dimethylformamide / 5 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2.1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3.1: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C 4.1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr 5.1: NaHCO3 / ethyl acetate 5.2: 84 percent / K2CO3; N-chlorosuccinimide; DBU / toluene; dimethylformamide / 5 h / 20 °C View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
aprepitant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr View Scheme | |
Multi-step reaction with 5 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr 4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C 5: 0.96 kg / Darco / methanol / 1 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetonitrile / 5 - 34 °C 2.1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3.1: tetrahydrofuran / 20 - 30 °C 3.2: H2 / 10 percent Pd/C / methanol; tetrahydrofuran View Scheme | |
Multi-step reaction with 3 steps 1.1: acetonitrile / 5 - 34 °C 2.1: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3.1: tetrahydrofuran / 20 °C 3.2: H2 / 5 percent Pd/C / methanol View Scheme | |
Multi-step reaction with 3 steps 1.1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2.1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3.1: tetrahydrofuran / 20 - 30 °C 3.2: H2 / 10 percent Pd/C / methanol; tetrahydrofuran View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr View Scheme | |
Multi-step reaction with 3 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr View Scheme | |
Multi-step reaction with 4 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C 4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr View Scheme | |
Multi-step reaction with 2 steps 1.1: trifluoroacetic anhydride / acetonitrile / 1 h / 5 - 30 °C 1.2: 3 h 2.1: tetrahydrofuran; methanol / 0.92 h / 15 - 20 °C 2.3: 0.5 h / Reflux View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C View Scheme | |
Multi-step reaction with 2 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C View Scheme |
4-benzyl-2-hydroxy-morpholin-3-one
2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: acetonitrile / 5 - 34 °C 2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C 3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr 4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C View Scheme | |
Multi-step reaction with 4 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr 4: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C View Scheme | |
Multi-step reaction with 5 steps 1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C 2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C 3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C 4: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr 5: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: C32H52O6 With trifluoroacetic anhydride In acetonitrile at 0 - 20℃; for 1h; Stage #2: 4-benzyl-2-hydroxy-morpholin-3-one With boron trifluoride diethyl etherate In dichloromethane; acetonitrile for 40h; Stage #3: With sodium hydrogencarbonate In dichloromethane; water |
Conditions | Yield |
---|---|
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 0 - 20℃; for 1h; Stage #2: C32H52O6 With boron trifluoride diethyl etherate In dichloromethane; acetonitrile for 40h; |
4-benzyl-2-hydroxy-morpholin-3-one
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
Conditions | Yield |
---|---|
With potassium tetrahydrolinalool; triphenylphosphine at -10℃; for 6h; Reagent/catalyst; Temperature; | 80.2 g |
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
4-benzyl-2-hydroxy-morpholin-3-one
A
(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
B
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
Conditions | Yield |
---|---|
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 25℃; for 1h; Inert atmosphere; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 20 - 30℃; for 2h; stereoselective reaction; | A 39.5 g B 23.2 g |
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
4-benzyl-2-hydroxy-morpholin-3-one
Conditions | Yield |
---|---|
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 25℃; for 1h; Inert atmosphere; Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 20 - 30℃; for 2h; stereoselective reaction; | A 34 g B 31 g |
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