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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

Jinan Finer Chemical Co., Ltd

Product informations Product Name (2R)-4-Benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one CAS No.

(2R)-4-Benzyl-2-{(1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethoxy}morpholin-3-one

Cas:287930-75-0

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

(2R)-4-Benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one CAS No.:287930-75-0 Name: (2R)-4-Benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis

(R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)Morpholin-3-one

Cas:287930-75-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2R)-4-Benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one

Cas:287930-75-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:1 Kilogram

FOB Price: $0.9 / 1.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE 287930-75-0

Cas:287930-75-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 287930-75-0 with best quality

Cas:287930-75-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 287930-75-0 Fosaprepitant Impurity C with best price

Cas:287930-75-0

Min.Order:10 Gram

Negotiable

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

99% Purity Aprepitant Intermediate CAS 287930-75-0 with low price.

Cas:287930-75-0

Min.Order:1 Kilogram

FOB Price: $860.0 / 900.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(2R)-4-Benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one 287930-75-0

Cas:287930-75-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE CAS:287930-75-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemi

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE CAS:287930-75-0

Cas:287930-75-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(2R)-4-Benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one

Cas:287930-75-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:287930-75-0

Cas:287930-75-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

(2R)-(TRIFLUOROMETHYL)-3-ONE cas no.287930-75-0 0.98

Cas:287930-75-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

(2R)-4-Benzyl-2-{(1R)-1-[3,5-Bis(Trifluoromethyl)phenyl]ethoxy}morpholin-3-one

Cas:287930-75-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONEAppearance:White powder Storage:Store in well-closed container, protected from light and in cool & dry place. Package:according to customers' requirements Application:Cance

Siwei Development Group Ltd.

Product name: (R)-4-Benzyl-2-((R)-1-(3,5-Bis(Trifluoromethyl)phenyl)ethoxy)Morpholin-3-one CAS No.: 287930-75-0 Molecule Formula:C21H19F6NO3 Molecule Weight:No Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Stan

Lower Price (R)-4-Benzyl-2-((R)-1-(3,5-Bis(Trifluoromethyl)phenyl)ethoxy)Morpholin-3-one

Cas:287930-75-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

(R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)Morpholin-3-one

Cas:287930-75-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: (2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE Synonyms: (2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE;(R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)M

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: (2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE Synonyms: (2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE;(R)-4-benzyl-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)Mor

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ (2R)-4-benzyl-2-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]morpholin-3-one /Manufacturer in China

Cas:287930-75-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

(2r)-4-benzyl-2-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]morpholin-3-one

Cas:287930-75-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Senova Technology Company Limited

1.High quality 2.High purity 3.Best price 4.Best service 5.Professional manufacturer 6.Loyal and honest supplier 7.Fast response to customer within 6 hours Application:Pharmaceutical Intermediate

Hubei Vanz Pharm Co.,Ltd

ISO/factory/goodqualityAppearance:off white Storage:Dry,cool place Package:drum Application:active pharmaceutical ingredients Transportation:by air/sea/express Port:shenzhen/shanghai

(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE

Cas:287930-75-0

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 3h; Further stages;
96%
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5 - 30℃; for 1h;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile for 2h;
Stage #3: With tetrahydrolinalool; potassium tert-butylate In hexane at -10 - -5℃; for 14h; Solvent;
96%
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 5℃; for 1h;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 25℃; for 4h; Temperature; Reagent/catalyst;
(R)-4-benzyl-2-hydroxy-morpholin-3-one

(R)-4-benzyl-2-hydroxy-morpholin-3-one

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
With di-chlorobenzyl azodicarboxylate; triphenylphosphine In dichloromethane at 10 - 20℃; for 12h; Concentration; Solvent; Reagent/catalyst;91.5%
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester
502536-97-2

2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester

A

C22H24N2O5

C22H24N2O5

B

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
327623-36-9

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

C

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In n-heptane; toluene at 20℃; for 1h;
(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
327623-36-9

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
With potassium tert-butylate In hexane; tert-butyl alcohol at 22℃; for 16h;
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester
502537-07-7

trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In acetonitrile at 20℃; for 2h;3.51 kg
Stage #1: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol; trifluoro-acetic acid 4-benzyl-3-oxo-morpholin-2-yl ester With boron trifluoride diethyl etherate In acetonitrile at 25℃;
Stage #2: With sodium hydroxide at 20℃; for 0.25h;
Stage #3: With linalool potassium at 92℃;
3,5-bis(trifluoromethyl)phenyl methyl ketone
30071-93-3

3,5-bis(trifluoromethyl)phenyl methyl ketone

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / borane-methyl sulfide complex; (S)-Me-CBS / various solvent(s); toluene / 1 h / -5 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 97 percent / borane-methyl sulfide complex; (S)-Me-CBS / various solvent(s); toluene / 1 h / -5 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
View Scheme
Multi-step reaction with 2 steps
1: 97 percent / borane-methyl sulfide complex; (S)-Me-CBS / various solvent(s); toluene / 1 h / -5 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1.1: dimethylsulfide borane complex / tert-butyl methyl ether / 1 h / -10 - -5 °C / Inert atmosphere
2.1: trifluoroacetic anhydride / acetonitrile / 1 h / 25 °C / Inert atmosphere
2.2: 2 h / 20 - 30 °C
View Scheme
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
2: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
View Scheme
4-benzyl-morpholine-2,3-dione
110843-90-8

4-benzyl-morpholine-2,3-dione

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C
2: acetonitrile / 5 - 34 °C
3: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C
2: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
3: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
4: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
View Scheme
Multi-step reaction with 3 steps
1: 80 percent / lithium tri(sec-butyl)borohydride; sodium hydroxide; hydrogen peroxide / tetrahydrofuran; H2O / 1 h / 10 °C
2: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
3: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
View Scheme
N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / tetrahydrofuran; H2O / 21 h / Heating
2: acetonitrile / 5 - 34 °C
3: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 76 percent / tetrahydrofuran; H2O / 21 h / Heating
2: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
3: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
4: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
View Scheme
Multi-step reaction with 3 steps
1: 76 percent / tetrahydrofuran; H2O / 21 h / Heating
2: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
3: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
View Scheme
4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: acetonitrile / 5 - 34 °C
2: 3.51 kg / BF3*Et2O / acetonitrile / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
3: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
View Scheme
Multi-step reaction with 2 steps
1: 91 percent / DBU / toluene; heptane / 18 h / 20 °C
2: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
View Scheme
2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester
502536-97-2

2,2,2-trichloro-acetimidic acid 4-benzyl-3-oxo-morpholin-2-yl ester

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: boron trifluoride etherate / toluene; heptane / 1 h / 20 °C
2: KO-t-Bu / 2-methyl-propan-2-ol; hexane / 16 h / 22 °C
View Scheme
C12H7F9O2

C12H7F9O2

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
With potassium tetrahydrolinalool; triphenylphosphine at -10℃; for 6h; Reagent/catalyst; Temperature;80.2 g
(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol
368-63-8, 68120-60-5, 127852-28-2

(R)-[3,5-bis(trifluoromethyl)phenyl]ethanol

4-benzyl-2-hydroxy-morpholin-3-one
287930-73-8

4-benzyl-2-hydroxy-morpholin-3-one

A

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
327623-36-9

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

B

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Stage #1: 4-benzyl-2-hydroxy-morpholin-3-one With trifluoroacetic anhydride In acetonitrile at 25℃; for 1h; Inert atmosphere;
Stage #2: (R)-[3,5-bis(trifluoromethyl)phenyl]ethanol With boron trifluoride diethyl etherate In acetonitrile at 20 - 30℃; for 2h; stereoselective reaction;
A 39.5 g
B 23.2 g
N-Benzylethanolamine
104-63-2

N-Benzylethanolamine

A

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
327623-36-9

(2S,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

B

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water; tetrahydrofuran / 8 h / 60 - 65 °C / Inert atmosphere
2.1: trifluoroacetic anhydride / acetonitrile / 1 h / 25 °C / Inert atmosphere
2.2: 2 h / 20 - 30 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

C14H13F6NO3

C14H13F6NO3

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In methanol; water at 50 - 60℃; under 26252.6 Torr; for 4.5h;99%
4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

Conditions
ConditionsYield
Stage #1: 4-flourophenylmagnesium bromide; (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one In tetrahydrofuran; methanol at 15 - 20℃; for 0.916667h;
Stage #2: With palladium 10% on activated carbon; ammonium formate; toluene-4-sulfonic acid In tetrahydrofuran; methanol
Stage #3: With hydrogenchloride In di-isopropyl ether; water for 0.5h; Reflux;
94.7%
With hydrogenchloride; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal In tetrahydrofuran; methanol at 20 - 25℃; under 1034.32 Torr; for 3h;47.6 g
Stage #1: 4-flourophenylmagnesium bromide; (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one With toluene-4-sulfonic acid In tetrahydrofuran; methanol at 0 - 10℃;
Stage #2: In methanol at 20 - 30℃; under 1034.32 Torr; for 4h; High pressure;
1-Bromo-4-fluorobenzene
460-00-4

1-Bromo-4-fluorobenzene

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

Conditions
ConditionsYield
Stage #1: 1-Bromo-4-fluorobenzene; (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one With palladium on activated charcoal; hydrogen; magnesium In tetrahydrofuran
Stage #2: With hydrogenchloride In tetrahydrofuran; water Reagent/catalyst;
93.1%
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenylmorpholine
171338-33-3

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenylmorpholine

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide; (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one In tetrahydrofuran at 15 - 25℃; for 0.5h;
Stage #2: With 5%-palladium/activated carbon; hydrogen; toluene-4-sulfonic acid In tetrahydrofuran; methanol at 10 - 35℃; under 258.581 Torr; for 4h;
53%
4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
171338-27-5

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

Conditions
ConditionsYield
Stage #1: 4-flourophenylmagnesium bromide; (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one In tetrahydrofuran at 20℃;
Stage #2: With hydrogen; 5 percent Pd/C In methanol Further stages.;
Stage #1: 4-flourophenylmagnesium bromide; (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one In tetrahydrofuran at 15 - 25℃; for 0.5h;
Stage #2: With 5%-palladium/activated carbon; hydrogen; toluene-4-sulfonic acid In tetrahydrofuran; methanol at 0 - 25℃; under 1034.32 Torr; for 3h;
4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[1S,2R,(2αR*)]-2-(2-aminoethoxy)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)ethan-1-ol

[1S,2R,(2αR*)]-2-(2-aminoethoxy)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)ethan-1-ol

B

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine
171338-27-5

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

Conditions
ConditionsYield
Stage #1: 4-flourophenylmagnesium bromide; (2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one In tetrahydrofuran at 20 - 30℃;
Stage #2: With hydrogen; 10 percent Pd/C In tetrahydrofuran; methanol Further stages.;
A 5.96 g
B n/a
4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

(3R*)-4-benzyl-3-[(1S*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

(3R*)-4-benzyl-3-[(1S*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

Conditions
ConditionsYield
In tetrahydrofuran at 20℃;
4-flourophenylmagnesium bromide
352-13-6

4-flourophenylmagnesium bromide

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

(3R*)-4-benzyl-3-[(1S*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

(3R*)-4-benzyl-3-[(1S*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

(3R*)-4-benzyl-3-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

(3R*)-4-benzyl-3-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-3-(4-fluorophenyl)morpholin-2-one

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 3h;A 0.76 g
B 0.96 g
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

(2R)-2-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-3-dehydromorpholine

(2R)-2-[(1R*)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-3-dehydromorpholine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
2.1: NaHCO3 / ethyl acetate
2.2: 84 percent / K2CO3; N-chlorosuccinimide; DBU / toluene; dimethylformamide / 5 h / 20 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

C34H32F7NO3

C34H32F7NO3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 20 - 30 °C
1.2: 5.96 g / H2 / 10 percent Pd/C / methanol; tetrahydrofuran
2.1: K2CO3 / dimethylformamide / 120 h / 20 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

C36H32F7NSO7

C36H32F7NSO7

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 20 - 30 °C
1.2: 5.96 g / H2 / 10 percent Pd/C / methanol; tetrahydrofuran
2.1: ethyl acetate; aq. NaHCO3 / 2 h / 20 °C
2.2: triehtylamine / CH2Cl2 / 2 h / 0 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

aprepitant
170729-80-3

aprepitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
View Scheme
Multi-step reaction with 3 steps
1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
2: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
3: 0.96 kg / Darco / methanol / 1 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 5%-palladium/activated carbon; hydrogen / methanol; water / 4.5 h / 50 - 60 °C / 26252.6 Torr
2.1: sodium hydroxide / acetonitrile / 2.5 h / 30 - 40 °C
3.1: tetrahydrofuran / 1 h / 15 - 25 °C
3.2: 1 h / 20 - 65 °C
4.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 5 h / 0 - 35 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

(2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
380499-06-9

(2R,3R)-2-[(1R)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 20 - 30 °C
1.2: 5.96 g / H2 / 10 percent Pd/C / methanol; tetrahydrofuran
2.1: ethyl acetate; aq. NaHCO3 / 2 h / 20 °C
2.2: triehtylamine / CH2Cl2 / 2 h / 0 °C
3.1: 46 mg / triethylamine / acetonitrile / 20 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine
219821-37-1

2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-4-fluorophenyl-4-2-(N-methylcarboxyactamidrazono)morpholine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 47.6 g / 4-toluenesulfonic acid; H2; HCl / Pd/C / tetrahydrofuran; methanol / 3 h / 20 - 25 °C / 1034.32 Torr
2: potassium carbonate / toluene; dimethylsulfoxide / 2 h / 15 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 0.5 h / 15 - 25 °C
1.2: 3 h / 0 - 25 °C / 1034.32 Torr
2.1: hydrogenchloride / water
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-N-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

[2R-[2α(R*),3α]]-N-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tetrahydrofuran / 0.5 h / 15 - 25 °C
1.2: 3 h / 0 - 25 °C / 1034.32 Torr
2.1: hydrogenchloride / water
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenylmorpholine hydrochloride

[2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-phenylmorpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tetrahydrofuran / 0.5 h / 15 - 25 °C
1.2: 4 h / 10 - 35 °C / 258.58 Torr
2.1: hydrogenchloride / water
View Scheme
(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one
287930-75-0

(2R,2αR)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]]ethoxy-morpholin-3-one

[2R-[2α(R*),3α]]-N-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

[2R-[2α(R*),3α]]-N-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 0.5 h / 15 - 25 °C
1.2: 3 h / 0 - 25 °C / 1034.32 Torr
2.1: hydrogenchloride / water
3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
4.1: hydrogenchloride / water
View Scheme

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