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inquiryProduct Name: Tolmetin Synonyms: Tolmetin;Tolmetine;TOLMETINUM;2-[1-Methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid;1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-;1-Methyl-5-p-toluoylpyrrole-2-acetic acid;5-[(p-Tolyl)carbonyl]-1-methyl
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inquiryISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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CAS:26171-23-3 C15H15NO3Appearance:white poweder Storage:under the cool and dry area Package:Plastic vacuum packaging bag or bucket Application:CAS:26171-23-3 C15H15NO3 Transportation:by express or by sea
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inquiry★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support
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ethyl 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; water for 2h; Reflux; | 100% |
With sodium hydroxide for 0.5h; Heating; | 95.2% |
With water; sodium hydroxide at 60℃; for 2h; Temperature; | 78.8% |
With water at 70℃; for 24h; Alkaline conditions; | 57.4 mg |
1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetonitrile
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Stage #1: 1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetonitrile With water; sodium hydroxide In ethanol for 6h; Reflux; Stage #2: With hydrogenchloride at 20℃; | 98% |
With sodium hydroxide In ethanol for 15h; Heating; | 74% |
With sodium hydroxide; sodium chloride In ethanol | |
In sodium hydroxide; ethanol | |
With sodium hydroxide; sodium chloride In ethanol |
methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With lithium hydroxide In tetrahydrofuran; water at 20℃; | 98% |
With water; sodium hydroxide at 60℃; for 2h; Temperature; | 82.2% |
Stage #1: methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate With water; sodium hydroxide at 20℃; for 48h; Inert atmosphere; Stage #2: With hydrogenchloride In water at 20℃; Inert atmosphere; | 78% |
tolmetin sodium
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With hydrogenchloride In water | 95% |
With water at 20 - 25℃; for 1h; pH=1.5 - 4.0; Product distribution / selectivity; Acidic aqueous solution; | |
With water at 20℃; Acidic conditions; |
methylthiol
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With potassium hydroxide In water; dimethyl sulfoxide; ethyl acetate | 89% |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With sodium hydroxide at 60℃; for 2h; | 75% |
Conditions | Yield |
---|---|
With potassium hydroxide In water; acetonitrile | 70% |
ethanethiol
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With potassium hydroxide In water; dimethyl sulfoxide; ethyl acetate | 70% |
B
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With phosphate buffer at 37℃; for 6h; pH=7.4; Kinetics; Further Variations:; Reagents; Hydrolysis; |
N-Methylpyrrole
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1) POCl3 / 1) RT, 4 h, 2) 1,2-dichloroethane, 40 h 2: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h 3: 60 percent / triton B / tetrahydrofuran / 4 h / Heating 4: 35 percent / HCl / ethanol / 70 h / Ambient temperature 5: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating View Scheme | |
Multi-step reaction with 5 steps 1.1: dichloromethane / 1 h / -10 - 0 °C / Inert atmosphere 1.2: 0.5 h / 0 °C / pH 10 / Inert atmosphere 1.3: 0.5 h / Inert atmosphere 2.1: hydrazine hydrate; potassium hydroxide / water / 8 h / 100 °C / Inert atmosphere 2.2: 20 °C / pH 2 / Inert atmosphere 3.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere 4.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere 5.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere 5.2: 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 5 steps 1.1: dichloromethane / 1 h / -10 - 0 °C 1.2: 0.5 h / -10 - 0 °C / pH 10 2.1: hydrazine hydrate; potassium hydroxide / water / 5 h / 100 °C 3.1: potassium carbonate / dichloromethane / 3 h / 30 °C 4.1: o-xylene / 24 h / 145 °C 5.1: sodium hydroxide / methanol; water / 2 h / 30 °C View Scheme |
1-metil-5-p-metilbenzoil-1H-pirrolo-2-carbossialdeide
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 60 percent / triton B / tetrahydrofuran / 4 h / Heating 2: 35 percent / HCl / ethanol / 70 h / Ambient temperature 3: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating View Scheme |
1-(methylsulfinyl)-1-methylthio-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 35 percent / HCl / ethanol / 70 h / Ambient temperature 2: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating View Scheme |
(1-methyl-1H-pyrrol-2-yl)-p-tolylmethanone
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h 2: 60 percent / triton B / tetrahydrofuran / 4 h / Heating 3: 35 percent / HCl / ethanol / 70 h / Ambient temperature 4: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere 2: water / 24 h / 70 °C / Alkaline conditions View Scheme |
morpholino(p-tolyl)methanone
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1) POCl3 / 1) RT, 4 h, 2) 1,2-dichloroethane, 40 h 2: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h 3: 60 percent / triton B / tetrahydrofuran / 4 h / Heating 4: 35 percent / HCl / ethanol / 70 h / Ambient temperature 5: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating View Scheme |
1-methylpyrrole-2-acetic acid
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere 2.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere 3.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere 3.2: 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / dichloromethane / 3 h / 30 °C 2: o-xylene / 24 h / 145 °C 3: sodium hydroxide / methanol; water / 2 h / 30 °C View Scheme |
2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetic acid
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: hydrazine hydrate; potassium hydroxide / water / 8 h / 100 °C / Inert atmosphere 1.2: 20 °C / pH 2 / Inert atmosphere 2.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere 3.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere 4.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere 4.2: 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 4 steps 1: hydrazine hydrate; potassium hydroxide / water / 5 h / 100 °C 2: potassium carbonate / dichloromethane / 3 h / 30 °C 3: o-xylene / 24 h / 145 °C 4: sodium hydroxide / methanol; water / 2 h / 30 °C View Scheme |
N-methyl-2-(methoxycarbonylmethyl)pyrrole
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere 2.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere 2.2: 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: o-xylene / 24 h / 145 °C 2: sodium hydroxide / methanol; water / 2 h / 30 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux 1.2: 0.5 h / 20 °C 2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 18 h / 70 °C 3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h 4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux 1.2: 0.5 h / 20 °C 2.1: bis(dibenzylideneacetone)-palladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N,N,N,-tetramethylethylenediamine / N,N-dimethyl-formamide / 0.06 h / 160 °C / Sealed tube; Microwave irradiation 3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h 4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 4-methyl-morpholine / o-xylene / 12 h / Reflux 2: sodium hydroxide; water / 2 h / 60 °C View Scheme |
4-iodobenzoic acid chloride
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux 1.2: 0.5 h / 20 °C 2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 18 h / 70 °C 3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h 4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux 1.2: 0.5 h / 20 °C 2.1: bis(dibenzylideneacetone)-palladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N,N,N,-tetramethylethylenediamine / N,N-dimethyl-formamide / 0.06 h / 160 °C / Sealed tube; Microwave irradiation 3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h 4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: bis(dibenzylideneacetone)-palladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N,N,N,-tetramethylethylenediamine / N,N-dimethyl-formamide / 0.06 h / 160 °C / Sealed tube; Microwave irradiation 2: palladium 10% on activated carbon; hydrogen / methanol / 3 h 3: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 18 h / 70 °C 2: palladium 10% on activated carbon; hydrogen / methanol / 3 h 3: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C View Scheme |
methyl 2-(5-(4-cyanobenzoyl)-1-methyl-1H-pyrrol-2-yl)acetate
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: palladium 10% on activated carbon; hydrogen / methanol / 3 h 2: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C View Scheme |
1-methyl-2-pyrroleacetonitrile
4-methyl-benzoyl chloride
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: aluminium trichloride / 1,1-dichloroethane; hexane; benzene 2: sodium hydroxide; sodium chloride / ethanol View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium ethanolate / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere 2: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C 3: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere 4: water / 24 h / 70 °C / Alkaline conditions View Scheme |
2-(4-methylbenzoyl)pyrrole
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C 2: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere 3: water / 24 h / 70 °C / Alkaline conditions View Scheme |
4-methyl-benzaldehyde
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: tert.-butylhydroperoxide; palladium diacetate; Trimethylacetic acid / toluene; decane / 1.5 h / 60 °C / Inert atmosphere; Sealed tube 2: sodium ethanolate / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere 3: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C 4: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere 5: water / 24 h / 70 °C / Alkaline conditions View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2 h / 190 °C 2: 4-methyl-morpholine / o-xylene / 12 h / Reflux 3: sodium hydroxide; water / 2 h / 60 °C View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2 h / 190 °C 2: 4-methyl-morpholine / o-xylene / 12 h / Reflux 3: sodium hydroxide / 2 h / 60 °C View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 4-methyl-morpholine / o-xylene / 12 h / Reflux 2: sodium hydroxide / 2 h / 60 °C View Scheme |
2-(carboxymethyl)-1-methyl-1H-pyrrole-3-carboxylic acid
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / 1 h / Reflux 2: 2 h / 190 °C 3: 4-methyl-morpholine / o-xylene / 12 h / Reflux 4: sodium hydroxide; water / 2 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: hydrogenchloride / water / 1 h / Reflux 2: 2 h / 190 °C 3: 4-methyl-morpholine / o-xylene / 12 h / Reflux 4: sodium hydroxide / 2 h / 60 °C View Scheme | |
Multi-step reaction with 4 steps 1: sulfuric acid / 1 h / Reflux 2: 2 h / 190 °C 3: 4-methyl-morpholine / o-xylene / 12 h / Reflux 4: sodium hydroxide; water / 2 h / 60 °C View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2 h / 190 °C 2: 4-methyl-morpholine / o-xylene / 12 h / Reflux 3: sodium hydroxide; water / 2 h / 60 °C View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
temozolomide
methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 81% |
methanol
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
Conditions | Yield |
---|---|
With sulfuric acid for 3h; Reflux; | 77% |
With sulfuric acid for 3h; Reflux; |
Conditions | Yield |
---|---|
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 0.0833333h; Glovebox; Inert atmosphere; Sealed tube; Irradiation; | 75% |
Stage #1: 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid With caesium carbonate In methanol at 20℃; for 1h; Inert atmosphere; Stage #2: carbon dioxide In dimethyl sulfoxide at 150℃; for 0.0833333h; Inert atmosphere; Cooling with liquid nitrogen; | 5.7 mg |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
2-methoxy-phenol
1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester
Conditions | Yield |
---|---|
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 30℃; | 70% |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With trifluorormethanesulfonic acid; bis(4-methoxyphenyl)selenide In chloroform at 20℃; for 16h; Reagent/catalyst; | 70% |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With 2,4,6-trimethyl-pyridine; 2,4,6-Triisopropylthiophenol; water-d2; 9-(2-mesityl)-10-methylacridinium perchlorate In dichloromethane Irradiation; | 69% |
N-(2-hydroxyethyl)nicotinamide
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In acetonitrile | 68% |
trifluoroethylamine
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
acetonitrile
Conditions | Yield |
---|---|
With copper(l) iodide; tert.-butylnitrite at 65℃; for 12h; | 67% |
amino acetic acid guacil ester hydrochloride
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide In acetone at -5 - 30℃; for 5h; | 60% |
Togni's reagent
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With 2,2'-dipyridyl ketone; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; copper dichloride; N,N,N',N'-tetramethylguanidine In ethyl acetate at 20℃; for 12h; Inert atmosphere; Irradiation; Sealed tube; chemoselective reaction; | 43% |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
1,5-dimethyl-2-(4-methylbenzoyl)pyrrole
Conditions | Yield |
---|---|
In water Rate constant; Mechanism; Irradiation; |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
A
1,5-dimethyl-2-(4-methylbenzoyl)pyrrole
Conditions | Yield |
---|---|
With copper(II) ion In water pH=7.4; Product distribution; Kinetics; Further Variations:; Reagents; various Cu(2+) concentrations; also in the absence of Cu(2+); Decarboxylation; photodecarboxylation; Irradiation; |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With tritium; Crabtree's catalyst In dichloromethane | |
With tritium; Crabtree's catalyst regioselective reaction; |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
With tritium; polystyrene-bound PPh3-[(COD)Ir(PCy3)(Py)]PF6 complex In dichloromethane at 20℃; for 3h; |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 68 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / acetonitrile 2: 79 percent / CH2Cl2; acetonitrile / 144 h / 20 °C 3: 100 percent / NaHCO3; Na2S2O4 / H2O; ethyl acetate / 0.25 h / 0 °C / pH 7 View Scheme |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 68 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / acetonitrile 2: 79 percent / CH2Cl2; acetonitrile / 144 h / 20 °C View Scheme |
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