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ZHANGJIAGANG HUAMAO FINE CHEMICAL CO.,LTD

Zhangjiagang Huamao Fine Chemical Co., Ltd. was founded in 2006. It is a Sino-US joint venture engaged in research and production. The company is situated in Yangtze River International Chemical Industrial Park, Free Trade Zone, Zhangjiagang. Based o

Tolmetin

Cas:26171-23-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Tolmetin Manufacturer/High quality/Best price/In stock

Cas:26171-23-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Tolmetin supplier in China

Cas:26171-23-3

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Tolmetin (base and/or unspecified salts)

Cas:26171-23-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Tolmetin CAS:26171-23-3

Cas:26171-23-3

Min.Order:1 Kilogram

FOB Price: $2.0 / 5.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Discount price CAS 26171-23-3 with best quality

Cas:26171-23-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-/ LIDE PHARMA- Factory supply / Best price

Cas:26171-23-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-

Cas:26171-23-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Pyrrole-2-aceticacid, 1-methyl-5-(4-methylbenzoyl)-

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Tolmetin

Cas:26171-23-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-Methyl-5-p-toluoylpyrrole-2-acetic acid

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

Tolmetin/High quality/Best price

Cas:26171-23-3

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity Tolmetin

Cas:26171-23-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Tolmetin

Cas:26171-23-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

1-Methyl-5-p-toluoylpyrrole-2-acetic acid

Cas:26171-23-3

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd.established since 2006 , has been actively developing specialty products for Finished Dosages, APIs, Intermediates, and Fine chemicals markets in North America, Europe, Korea, Japan, Mid-East and all over the World. Hu

Tolmetin

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Trading Company

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

BEST PRICE/Tolmetin CAS NO.26171-23-3

Cas:26171-23-3

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Product Name: Tolmetin Synonyms: Tolmetin;Tolmetine;TOLMETINUM;2-[1-Methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid;1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-;1-Methyl-5-p-toluoylpyrrole-2-acetic acid;5-[(p-Tolyl)carbonyl]-1-methyl

26171-23-3

Cas:26171-23-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

1-Methyl-5-p-toluoylpyrrole-2-acetic acid

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING

Tolmetin

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

Tolmetin

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetic acid

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY:1) Specialized in pharmaceutical and healthcare industrial since 19872) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days.4) We have warehouse in USA with quickly shipment . Application:API

99% up by HPLC Tolmetin 26171-23-3

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 1-Methyl-5-p-toluoylpyrrole-2-acetic acid 25g

Cas:26171-23-3

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

Tolmetin

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Tolmetin

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

CAS:26171-23-3 C15H15NO3Appearance:white poweder Storage:under the cool and dry area Package:Plastic vacuum packaging bag or bucket Application:CAS:26171-23-3 C15H15NO3 Transportation:by express or by sea

CAS:26171-23-3 C15H15NO3

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Ocean Chemical Co., Ltd.

★.Best quality according to requirement ★.Competitive price in China market ★.Mature Technical support ★.Professional logistic support

Tolmetin Acid Basis

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Pharm intermediate

tolmetin

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:off-white powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as prima

Tolmetin-d3

Cas:26171-23-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

ethyl 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate
52074-58-5

ethyl 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
With sodium hydroxide In methanol; water for 2h; Reflux;100%
With sodium hydroxide for 0.5h; Heating;95.2%
With water; sodium hydroxide at 60℃; for 2h; Temperature;78.8%
With water at 70℃; for 24h; Alkaline conditions;57.4 mg
1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetonitrile
26171-22-2

1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetonitrile

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Stage #1: 1-Methyl-5-(4-methylbenzoyl)pyrrole-2-acetonitrile With water; sodium hydroxide In ethanol for 6h; Reflux;
Stage #2: With hydrogenchloride at 20℃;
98%
With sodium hydroxide In ethanol for 15h; Heating;74%
With sodium hydroxide; sodium chloride In ethanol
In sodium hydroxide; ethanol
With sodium hydroxide; sodium chloride In ethanol
methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
33369-52-7

methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
With lithium hydroxide In tetrahydrofuran; water at 20℃;98%
With water; sodium hydroxide at 60℃; for 2h; Temperature;82.2%
Stage #1: methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate With water; sodium hydroxide at 20℃; for 48h; Inert atmosphere;
Stage #2: With hydrogenchloride In water at 20℃; Inert atmosphere;
78%
tolmetin sodium
35711-34-3

tolmetin sodium

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
With hydrogenchloride In water95%
With water at 20 - 25℃; for 1h; pH=1.5 - 4.0; Product distribution / selectivity; Acidic aqueous solution;
With water at 20℃; Acidic conditions;
1-Methyl-2-(2,2,2-trichloro-1-hydroxyethyl)-5-p-toluoylpyrrole

1-Methyl-2-(2,2,2-trichloro-1-hydroxyethyl)-5-p-toluoylpyrrole

methylthiol
74-93-1

methylthiol

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
With potassium hydroxide In water; dimethyl sulfoxide; ethyl acetate89%
C18H21NO3

C18H21NO3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
With sodium hydroxide at 60℃; for 2h;75%
1-methyl-2-formyl-5-p-methylbenzylpyrrole

1-methyl-2-formyl-5-p-methylbenzylpyrrole

Bromoform
75-25-2

Bromoform

ethanethiol
75-08-1

ethanethiol

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
With potassium hydroxide In water; acetonitrile70%
1-Methyl-2-(2,2,2-trichloro-1-hydroxyethyl)-5-p-toluoylpyrrole

1-Methyl-2-(2,2,2-trichloro-1-hydroxyethyl)-5-p-toluoylpyrrole

ethanethiol
75-08-1

ethanethiol

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
With potassium hydroxide In water; dimethyl sulfoxide; ethyl acetate70%
Conditions
ConditionsYield
With phosphate buffer at 37℃; for 6h; pH=7.4; Kinetics; Further Variations:; Reagents; Hydrolysis;
N-Methylpyrrole
96-54-8

N-Methylpyrrole

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1) POCl3 / 1) RT, 4 h, 2) 1,2-dichloroethane, 40 h
2: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h
3: 60 percent / triton B / tetrahydrofuran / 4 h / Heating
4: 35 percent / HCl / ethanol / 70 h / Ambient temperature
5: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating
View Scheme
Multi-step reaction with 5 steps
1.1: dichloromethane / 1 h / -10 - 0 °C / Inert atmosphere
1.2: 0.5 h / 0 °C / pH 10 / Inert atmosphere
1.3: 0.5 h / Inert atmosphere
2.1: hydrazine hydrate; potassium hydroxide / water / 8 h / 100 °C / Inert atmosphere
2.2: 20 °C / pH 2 / Inert atmosphere
3.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere
4.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere
5.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere
5.2: 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 5 steps
1.1: dichloromethane / 1 h / -10 - 0 °C
1.2: 0.5 h / -10 - 0 °C / pH 10
2.1: hydrazine hydrate; potassium hydroxide / water / 5 h / 100 °C
3.1: potassium carbonate / dichloromethane / 3 h / 30 °C
4.1: o-xylene / 24 h / 145 °C
5.1: sodium hydroxide / methanol; water / 2 h / 30 °C
View Scheme
1-metil-5-p-metilbenzoil-1H-pirrolo-2-carbossialdeide
75820-72-3

1-metil-5-p-metilbenzoil-1H-pirrolo-2-carbossialdeide

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 60 percent / triton B / tetrahydrofuran / 4 h / Heating
2: 35 percent / HCl / ethanol / 70 h / Ambient temperature
3: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating
View Scheme
1-(methylsulfinyl)-1-methylthio-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene
85380-92-3

1-(methylsulfinyl)-1-methylthio-2-(1-methyl-5-p-toluoyl-2-pyrrolyl)ethylene

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 35 percent / HCl / ethanol / 70 h / Ambient temperature
2: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating
View Scheme
(1-methyl-1H-pyrrol-2-yl)-p-tolylmethanone
62128-31-8

(1-methyl-1H-pyrrol-2-yl)-p-tolylmethanone

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h
2: 60 percent / triton B / tetrahydrofuran / 4 h / Heating
3: 35 percent / HCl / ethanol / 70 h / Ambient temperature
4: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere
2: water / 24 h / 70 °C / Alkaline conditions
View Scheme
morpholino(p-tolyl)methanone
63833-44-3

morpholino(p-tolyl)methanone

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 1) POCl3 / 1) RT, 4 h, 2) 1,2-dichloroethane, 40 h
2: 50 percent / 1) POCl3 / 1) 1,2-dichloroethane, reflux, 30 min, 2) 50-60 deg C, 2 h
3: 60 percent / triton B / tetrahydrofuran / 4 h / Heating
4: 35 percent / HCl / ethanol / 70 h / Ambient temperature
5: 95.2 percent / 10percent aq. NaOH / 0.5 h / Heating
View Scheme
1-methylpyrrole-2-acetic acid
21898-59-9

1-methylpyrrole-2-acetic acid

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere
2.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere
3.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / dichloromethane / 3 h / 30 °C
2: o-xylene / 24 h / 145 °C
3: sodium hydroxide / methanol; water / 2 h / 30 °C
View Scheme
2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetic acid
21898-43-1

2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetic acid

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: hydrazine hydrate; potassium hydroxide / water / 8 h / 100 °C / Inert atmosphere
1.2: 20 °C / pH 2 / Inert atmosphere
2.1: toluene-4-sulfonic acid / 8 h / 70 °C / Inert atmosphere
3.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere
4.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere
4.2: 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: hydrazine hydrate; potassium hydroxide / water / 5 h / 100 °C
2: potassium carbonate / dichloromethane / 3 h / 30 °C
3: o-xylene / 24 h / 145 °C
4: sodium hydroxide / methanol; water / 2 h / 30 °C
View Scheme
N-methyl-2-(methoxycarbonylmethyl)pyrrole
51856-79-2

N-methyl-2-(methoxycarbonylmethyl)pyrrole

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: DBN / toluene / 4 h / 115 °C / Inert atmosphere
2.1: water; sodium hydroxide / 48 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: o-xylene / 24 h / 145 °C
2: sodium hydroxide / methanol; water / 2 h / 30 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux
1.2: 0.5 h / 20 °C
2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 18 h / 70 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h
4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux
1.2: 0.5 h / 20 °C
2.1: bis(dibenzylideneacetone)-palladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N,N,N,-tetramethylethylenediamine / N,N-dimethyl-formamide / 0.06 h / 160 °C / Sealed tube; Microwave irradiation
3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h
4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 4-methyl-morpholine / o-xylene / 12 h / Reflux
2: sodium hydroxide; water / 2 h / 60 °C
View Scheme
4-iodobenzoic acid chloride
1711-02-0

4-iodobenzoic acid chloride

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux
1.2: 0.5 h / 20 °C
2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 18 h / 70 °C
3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h
4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 1-amino-3-(dimethylamino)propane / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / Reflux
1.2: 0.5 h / 20 °C
2.1: bis(dibenzylideneacetone)-palladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N,N,N,-tetramethylethylenediamine / N,N-dimethyl-formamide / 0.06 h / 160 °C / Sealed tube; Microwave irradiation
3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h
4.1: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C
View Scheme
methyl 2-(5-(4-iodobenzoyl)-1-methyl-1H-pyrrol-2-yl)acetate

methyl 2-(5-(4-iodobenzoyl)-1-methyl-1H-pyrrol-2-yl)acetate

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bis(dibenzylideneacetone)-palladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N,N,N,-tetramethylethylenediamine / N,N-dimethyl-formamide / 0.06 h / 160 °C / Sealed tube; Microwave irradiation
2: palladium 10% on activated carbon; hydrogen / methanol / 3 h
3: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / 18 h / 70 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 3 h
3: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C
View Scheme
methyl 2-(5-(4-cyanobenzoyl)-1-methyl-1H-pyrrol-2-yl)acetate
617721-38-7

methyl 2-(5-(4-cyanobenzoyl)-1-methyl-1H-pyrrol-2-yl)acetate

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol / 3 h
2: sodium hydroxide / methanol; tetrahydrofuran; water / 16 h / 20 °C
View Scheme
1-methyl-2-pyrroleacetonitrile
24437-41-0

1-methyl-2-pyrroleacetonitrile

4-methyl-benzoyl chloride
874-60-2

4-methyl-benzoyl chloride

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminium trichloride / 1,1-dichloroethane; hexane; benzene
2: sodium hydroxide; sodium chloride / ethanol
View Scheme
[1-(pyrimidin-2-yl)-1H-pyrrol-2-yl](p-tolyl)methanone

[1-(pyrimidin-2-yl)-1H-pyrrol-2-yl](p-tolyl)methanone

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium ethanolate / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere
2: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C
3: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere
4: water / 24 h / 70 °C / Alkaline conditions
View Scheme
2-(4-methylbenzoyl)pyrrole
55895-62-0

2-(4-methylbenzoyl)pyrrole

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C
2: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere
3: water / 24 h / 70 °C / Alkaline conditions
View Scheme
4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: tert.-butylhydroperoxide; palladium diacetate; Trimethylacetic acid / toluene; decane / 1.5 h / 60 °C / Inert atmosphere; Sealed tube
2: sodium ethanolate / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere
3: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C
4: triphenylphosphine; sodium periodate; sodium acetate; acetic acid; manganese (II) acetate tetrahydrate / 24 h / 70 °C / Inert atmosphere
5: water / 24 h / 70 °C / Alkaline conditions
View Scheme
C10H13NO4

C10H13NO4

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 h / 190 °C
2: 4-methyl-morpholine / o-xylene / 12 h / Reflux
3: sodium hydroxide; water / 2 h / 60 °C
View Scheme
C11H15NO4

C11H15NO4

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 h / 190 °C
2: 4-methyl-morpholine / o-xylene / 12 h / Reflux
3: sodium hydroxide / 2 h / 60 °C
View Scheme
C10H15NO2

C10H15NO2

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 4-methyl-morpholine / o-xylene / 12 h / Reflux
2: sodium hydroxide / 2 h / 60 °C
View Scheme
2-(carboxymethyl)-1-methyl-1H-pyrrole-3-carboxylic acid
83863-74-5

2-(carboxymethyl)-1-methyl-1H-pyrrole-3-carboxylic acid

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / 1 h / Reflux
2: 2 h / 190 °C
3: 4-methyl-morpholine / o-xylene / 12 h / Reflux
4: sodium hydroxide; water / 2 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride / water / 1 h / Reflux
2: 2 h / 190 °C
3: 4-methyl-morpholine / o-xylene / 12 h / Reflux
4: sodium hydroxide / 2 h / 60 °C
View Scheme
Multi-step reaction with 4 steps
1: sulfuric acid / 1 h / Reflux
2: 2 h / 190 °C
3: 4-methyl-morpholine / o-xylene / 12 h / Reflux
4: sodium hydroxide; water / 2 h / 60 °C
View Scheme
C9H11NO4

C9H11NO4

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 h / 190 °C
2: 4-methyl-morpholine / o-xylene / 12 h / Reflux
3: sodium hydroxide; water / 2 h / 60 °C
View Scheme
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

temozolomide
85622-93-1

temozolomide

methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
33369-52-7

methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube;81%
methanol
67-56-1

methanol

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
33369-52-7

methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate

Conditions
ConditionsYield
With sulfuric acid for 3h; Reflux;77%
With sulfuric acid for 3h; Reflux;
carbon dioxide
1111-72-4

carbon dioxide

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

[13C]tolmetin

[13C]tolmetin

Conditions
ConditionsYield
With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate In dimethyl sulfoxide at 20℃; under 760.051 Torr; for 0.0833333h; Glovebox; Inert atmosphere; Sealed tube; Irradiation;75%
Stage #1: 1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid With caesium carbonate In methanol at 20℃; for 1h; Inert atmosphere;
Stage #2: carbon dioxide In dimethyl sulfoxide at 150℃; for 0.0833333h; Inert atmosphere; Cooling with liquid nitrogen;
5.7 mg
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

2-methoxy-phenol
90-05-1

2-methoxy-phenol

1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester
1207070-76-5

1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester

Conditions
ConditionsYield
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 30℃;70%
2-((trifluoromethyl)thio)benzo[d]isothiazol-3(2H)-one 1,1-dioxide

2-((trifluoromethyl)thio)benzo[d]isothiazol-3(2H)-one 1,1-dioxide

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

3-trifluoromethylthiotolemtin

3-trifluoromethylthiotolemtin

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; bis(4-methoxyphenyl)selenide In chloroform at 20℃; for 16h; Reagent/catalyst;70%
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

C14H14(2)HNO

C14H14(2)HNO

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; 2,4,6-Triisopropylthiophenol; water-d2; 9-(2-mesityl)-10-methylacridinium perchlorate In dichloromethane Irradiation;69%
N-(2-hydroxyethyl)nicotinamide
6265-73-2

N-(2-hydroxyethyl)nicotinamide

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester
761415-92-3

[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid 2-[(pyridine-3-carbonyl)-amino]-ethyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In acetonitrile68%
trifluoroethylamine
753-90-2

trifluoroethylamine

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

acetonitrile
75-05-8

acetonitrile

N-acetyl-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]-N-(2,2,2-trifluoroethyl)acetamide

N-acetyl-2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]-N-(2,2,2-trifluoroethyl)acetamide

Conditions
ConditionsYield
With copper(l) iodide; tert.-butylnitrite at 65℃; for 12h;67%
amino acetic acid guacil ester hydrochloride
75368-99-9

amino acetic acid guacil ester hydrochloride

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

amtolmetin guacil

amtolmetin guacil

Conditions
ConditionsYield
With potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide In acetone at -5 - 30℃; for 5h;60%
Togni's reagent
887144-97-0

Togni's reagent

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

(1-methyl-5-(2,2,2-trifluoroethyl)-1H-pyrrol-2-yl)(p-tolyl)methanone

(1-methyl-5-(2,2,2-trifluoroethyl)-1H-pyrrol-2-yl)(p-tolyl)methanone

Conditions
ConditionsYield
With 2,2'-dipyridyl ketone; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; copper dichloride; N,N,N',N'-tetramethylguanidine In ethyl acetate at 20℃; for 12h; Inert atmosphere; Irradiation; Sealed tube; chemoselective reaction;43%
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

1,5-dimethyl-2-(4-methylbenzoyl)pyrrole
62128-36-3

1,5-dimethyl-2-(4-methylbenzoyl)pyrrole

Conditions
ConditionsYield
In water Rate constant; Mechanism; Irradiation;
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

A

1,5-dimethyl-2-(4-methylbenzoyl)pyrrole
62128-36-3

1,5-dimethyl-2-(4-methylbenzoyl)pyrrole

B

(1-methyl-5-{2-[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-ethyl}-1H-pyrrol-2-yl)-p-tolyl-methanone

(1-methyl-5-{2-[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-ethyl}-1H-pyrrol-2-yl)-p-tolyl-methanone

Conditions
ConditionsYield
With copper(II) ion In water pH=7.4; Product distribution; Kinetics; Further Variations:; Reagents; various Cu(2+) concentrations; also in the absence of Cu(2+); Decarboxylation; photodecarboxylation; Irradiation;
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

C15H11(3)H4NO3

C15H11(3)H4NO3

Conditions
ConditionsYield
With tritium; Crabtree's catalyst In dichloromethane
With tritium; Crabtree's catalyst regioselective reaction;
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

(3)H3C15H12NO3

(3)H3C15H12NO3

Conditions
ConditionsYield
With tritium; polystyrene-bound PPh3-[(COD)Ir(PCy3)(Py)]PF6 complex In dichloromethane at 20℃; for 3h;
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid 2-[(1-methyl-1,4-dihydro-pyridine-3-carbonyl)-amino]-ethyl ester

[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetic acid 2-[(1-methyl-1,4-dihydro-pyridine-3-carbonyl)-amino]-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 68 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / acetonitrile
2: 79 percent / CH2Cl2; acetonitrile / 144 h / 20 °C
3: 100 percent / NaHCO3; Na2S2O4 / H2O; ethyl acetate / 0.25 h / 0 °C / pH 7
View Scheme
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
26171-23-3

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid

1-methyl-3-(2-{[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetoxy}-ethylcarbamoyl)-pyridinium; iodide

1-methyl-3-(2-{[1-methyl-5-(4-methyl-benzoyl)-1H-pyrrol-2-yl]-acetoxy}-ethylcarbamoyl)-pyridinium; iodide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / acetonitrile
2: 79 percent / CH2Cl2; acetonitrile / 144 h / 20 °C
View Scheme

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