CAS No.27773-65-5,(3alpha,16alpha)-eburnamenine-14-carboxylic acid Suppliers

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1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylicacid, 13a-ethyl-2,3,5,6,13a,13b-hexahydro-, (13aS,13bS)-

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1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylicacid, 13a-ethyl-2,3,5,6,13a,13b-hexahydro-, (13aS,13bS)-

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(3A,16A)-EBURNAMENINE-14-CARBOXYLIC ACIDCASAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

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Vinpocetine Carboxylic Acid (Apovincaminic Acid) Storage:Store in dry and cool condition Package:25kg or according to cutomer's demand Application:Chemical research/Pharmaceutical intermediates Transportation:By Sea,by Air,By courier like DHL or Fedx

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Vinpocetine Carboxylic Acid (Apovincaminic Acid)

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1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylicacid, 13a-ethyl-2,3,5,6,13a,13b-hexahydro-, (13aS,13bS)-

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1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylicacid, 13a-ethyl-2,3,5,6,13a,13b-hexahydro-, (13aS,13bS)-

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Synthetic route

: 42971-09-5
Vinpocetine

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane at 80℃; for 2h;	98%
With sodium hydroxide In ethanol for 5h; Reflux;	92.4%
With sodium hydroxide In methanol at 40℃; for 1h; Kinetics; Further Variations:; Reagents; Solvents; Temperatures; pH-values;

: 4880-92-6
apovincamine

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol for 3h; Reflux;	96%
With sodium hydroxide In ethanol at 20℃; for 2h; Reflux;	96%
With sodium hydroxide In tetrahydrofuran; methanol for 12h;
With hydrogenchloride at 20 - 37℃; for 2h; object of study: degree of hydrolysis;
With sodium hydroxide at 65℃; for 2h;

: 78101-34-5
MR-711

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
With hydrogenchloride at 20 - 37℃; for 2h; object of study: degree of hydrolysis;
With esterases of rat plasma; water at 37℃; object of study: rate of hydrolysis;

: 42971-09-5
Vinpocetine

A: 27773-65-5
Apovincaminic acid

B: 40163-56-2
14,15-dihydro-14β-hydroxy-(3α,16α)-eburnamenine-14-carboxylic acid ethyl ester

C: 3α-epivincaminic acid ethyl ester

D: 14-epivincaminic acid

E: 4880-88-0
vinburnine

F: 28152-73-0
(3α,14β,16α)-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride at 80℃; for 336h; Product distribution; Rate constant; Thermodynamic data; ln A, Ea, ΔS<*>; degradation of vinpocetine in aqueous solutions, degradation products equilibria in solutions, effect of various pH, temperature and ionic strength, buffer catalysis, metal ion catalysis, oxygen effect, mechanism;

...Expand

: 3389-21-7
3-(2-bromoethyl)-1H-indole

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 2: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 3: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 4: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 5: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 6: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 7: Et3N / CH2Cl2 / 0.5 h / 0 °C 8: 55 percent / DBU / 1 h / 100 °C 9: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme
Multi-step reaction with 10 steps 1: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 2: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 3: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 4: 46 percent / TFA / 24 h / Heating 5: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 6: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 7: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 8: Et3N / CH2Cl2 / 0.5 h / 0 °C 9: 55 percent / DBU / 1 h / 100 °C 10: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

Yield

Multi-step reaction with 9 steps
1: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
2: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
3: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
4: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
5: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
6: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
7: Et3N / CH2Cl2 / 0.5 h / 0 °C
8: 55 percent / DBU / 1 h / 100 °C
9: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

Multi-step reaction with 10 steps
1: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
2: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
3: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
4: 46 percent / TFA / 24 h / Heating
5: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
6: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
7: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
8: Et3N / CH2Cl2 / 0.5 h / 0 °C
9: 55 percent / DBU / 1 h / 100 °C
10: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

: 95407-25-3, 95407-56-0
1-phenylpropyl (2S,3R)-3-cyano-3-ethylpipecolate

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 9 steps 1: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 2: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 3: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 4: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 5: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 6: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 7: Et3N / CH2Cl2 / 0.5 h / 0 °C 8: 55 percent / DBU / 1 h / 100 °C 9: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme
Multi-step reaction with 10 steps 1: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 2: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 3: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 4: 46 percent / TFA / 24 h / Heating 5: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 6: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 7: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 8: Et3N / CH2Cl2 / 0.5 h / 0 °C 9: 55 percent / DBU / 1 h / 100 °C 10: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

Yield

: 95407-55-9
(2S,3R)-3-Cyano-3-ethyl-1-[2-(1H-indol-3-yl)-ethyl]-piperidine-2-carboxylic acid

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 2: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 3: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 4: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 5: Et3N / CH2Cl2 / 0.5 h / 0 °C 6: 55 percent / DBU / 1 h / 100 °C 7: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme
Multi-step reaction with 8 steps 1: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 2: 46 percent / TFA / 24 h / Heating 3: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 4: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 5: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 6: Et3N / CH2Cl2 / 0.5 h / 0 °C 7: 55 percent / DBU / 1 h / 100 °C 8: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

Yield

Multi-step reaction with 7 steps
1: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
2: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
3: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
4: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
5: Et3N / CH2Cl2 / 0.5 h / 0 °C
6: 55 percent / DBU / 1 h / 100 °C
7: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

Multi-step reaction with 8 steps
1: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
2: 46 percent / TFA / 24 h / Heating
3: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
4: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
5: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
6: Et3N / CH2Cl2 / 0.5 h / 0 °C
7: 55 percent / DBU / 1 h / 100 °C
8: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

: 95464-02-1
(3R*,4S*,14R*,15R*,16S*)-14,15-dihydro-15-hydroxy-14-methoxycarbonyleburnamenine

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: Et3N / CH2Cl2 / 0.5 h / 0 °C 2: 55 percent / DBU / 1 h / 100 °C 3: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

: 95407-51-5
1-cyano-1-ethyl-12-<(methoxycarbonyl)methyl>-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 2: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 3: Et3N / CH2Cl2 / 0.5 h / 0 °C 4: 55 percent / DBU / 1 h / 100 °C 5: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

: 95407-50-4, 95407-59-3
1-phenylpropyl (2S,3R)-3-cyano-3-ethyl-N-<2-(3-indolyl)ethyl>pipecolate

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 2: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 3: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 4: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 5: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 6: Et3N / CH2Cl2 / 0.5 h / 0 °C 7: 55 percent / DBU / 1 h / 100 °C 8: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme
Multi-step reaction with 9 steps 1: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 2: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 3: 46 percent / TFA / 24 h / Heating 4: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 5: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 6: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 7: Et3N / CH2Cl2 / 0.5 h / 0 °C 8: 55 percent / DBU / 1 h / 100 °C 9: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

Yield

Multi-step reaction with 8 steps
1: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
2: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
3: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
4: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
5: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
6: Et3N / CH2Cl2 / 0.5 h / 0 °C
7: 55 percent / DBU / 1 h / 100 °C
8: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

Multi-step reaction with 9 steps
1: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
2: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
3: 46 percent / TFA / 24 h / Heating
4: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
5: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
6: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
7: Et3N / CH2Cl2 / 0.5 h / 0 °C
8: 55 percent / DBU / 1 h / 100 °C
9: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

: (10S,11S,11aR,11bS)-11a-Ethyl-11-methanesulfonyloxy-2,3,4,5,10,11,11a,11b-octahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid methyl ester

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 55 percent / DBU / 1 h / 100 °C 2: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

: 95407-43-5
N-(3-chloropropyl)-N-(9-phenylfluorenyl)-3-cyanoalanine benzyl ester

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 11 steps 1: NaI / acetonitrile / 22 h / Heating 3: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 4: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 5: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 6: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 7: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 8: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 9: Et3N / CH2Cl2 / 0.5 h / 0 °C 10: 55 percent / DBU / 1 h / 100 °C 11: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme
Multi-step reaction with 12 steps 1: NaI / acetonitrile / 22 h / Heating 3: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 4: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 5: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 6: 46 percent / TFA / 24 h / Heating 7: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 8: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 9: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 10: Et3N / CH2Cl2 / 0.5 h / 0 °C 11: 55 percent / DBU / 1 h / 100 °C 12: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

Yield

Multi-step reaction with 11 steps
1: NaI / acetonitrile / 22 h / Heating
3: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
4: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
5: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
6: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
7: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
8: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
9: Et3N / CH2Cl2 / 0.5 h / 0 °C
10: 55 percent / DBU / 1 h / 100 °C
11: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

Multi-step reaction with 12 steps
1: NaI / acetonitrile / 22 h / Heating
3: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
4: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
5: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
6: 46 percent / TFA / 24 h / Heating
7: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
8: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
9: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
10: Et3N / CH2Cl2 / 0.5 h / 0 °C
11: 55 percent / DBU / 1 h / 100 °C
12: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

: (S)-3-Cyano-2-[(3-iodo-propyl)-(9-phenyl-9H-fluoren-9-yl)-amino]-propionic acid benzyl ester

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 10 steps 2: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 3: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 4: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 5: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 6: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 7: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 8: Et3N / CH2Cl2 / 0.5 h / 0 °C 9: 55 percent / DBU / 1 h / 100 °C 10: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme
Multi-step reaction with 11 steps 2: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 3: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 4: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 5: 46 percent / TFA / 24 h / Heating 6: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 7: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 8: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 9: Et3N / CH2Cl2 / 0.5 h / 0 °C 10: 55 percent / DBU / 1 h / 100 °C 11: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

Yield

Multi-step reaction with 10 steps
2: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
3: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
4: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
5: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
6: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
7: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
8: Et3N / CH2Cl2 / 0.5 h / 0 °C
9: 55 percent / DBU / 1 h / 100 °C
10: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

Multi-step reaction with 11 steps
2: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
3: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
4: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
5: 46 percent / TFA / 24 h / Heating
6: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
7: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
8: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
9: Et3N / CH2Cl2 / 0.5 h / 0 °C
10: 55 percent / DBU / 1 h / 100 °C
11: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

: 95407-42-4
N-(3-chloropropyl)-3-cyanoalanine benzyl ester

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 12 steps 1: K3PO4, Pb(NO3)2 / acetonitrile / 24 h 2: NaI / acetonitrile / 22 h / Heating 4: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 5: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 6: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 7: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 8: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 9: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 10: Et3N / CH2Cl2 / 0.5 h / 0 °C 11: 55 percent / DBU / 1 h / 100 °C 12: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme
Multi-step reaction with 13 steps 1: K3PO4, Pb(NO3)2 / acetonitrile / 24 h 2: NaI / acetonitrile / 22 h / Heating 4: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating 5: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr 6: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h 7: 46 percent / TFA / 24 h / Heating 8: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 9: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 10: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 11: Et3N / CH2Cl2 / 0.5 h / 0 °C 12: 55 percent / DBU / 1 h / 100 °C 13: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

Yield

Multi-step reaction with 12 steps
1: K3PO4, Pb(NO3)2 / acetonitrile / 24 h
2: NaI / acetonitrile / 22 h / Heating
4: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
5: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
6: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
7: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
8: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
9: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
10: Et3N / CH2Cl2 / 0.5 h / 0 °C
11: 55 percent / DBU / 1 h / 100 °C
12: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

Multi-step reaction with 13 steps
1: K3PO4, Pb(NO3)2 / acetonitrile / 24 h
2: NaI / acetonitrile / 22 h / Heating
4: 80 percent / NaHCO3 / acetonitrile / 24 h / Heating
5: H2 / 10percent Pd/C / methanol; ethyl acetate / 4 h / 2585.7 Torr
6: 1.) pyridine, TsCl, 2.) NaHCO3 / 1.) CH2Cl2, 1 h, 2.) 1 h
7: 46 percent / TFA / 24 h / Heating
8: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h
9: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h
10: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C
11: Et3N / CH2Cl2 / 0.5 h / 0 °C
12: 55 percent / DBU / 1 h / 100 °C
13: aq. NaOH / methanol; tetrahydrofuran / 12 h
View Scheme

: 70672-30-9, 70702-10-2, 95463-99-3, 95464-00-9
1-cyano-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 2: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 3: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 4: Et3N / CH2Cl2 / 0.5 h / 0 °C 5: 55 percent / DBU / 1 h / 100 °C 6: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

: 70672-30-9, 70702-10-2, 95463-99-3, 95464-00-9
1-cyano-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1: 46 percent / TFA / 24 h / Heating 2: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) - 30 deg C, 1 h 3: 56 percent / LDA / tetrahydrofuran; hexane / 1.0 -78 deg C, 15 min, 2.) 0 deg C, 9 h 4: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 5: Et3N / CH2Cl2 / 0.5 h / 0 °C 6: 55 percent / DBU / 1 h / 100 °C 7: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

: 95464-01-0
(3S,16R)-14-(methoxycarbonyl)-15-oxoeburnane

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 90 percent / NaBH4 / methanol / 0.05 h / -25 °C 2: Et3N / CH2Cl2 / 0.5 h / 0 °C 3: 55 percent / DBU / 1 h / 100 °C 4: aq. NaOH / methanol; tetrahydrofuran / 12 h View Scheme

: 1617-90-9
vincamin

: 27773-65-5
Apovincaminic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene; water / 2 h 2: sodium hydroxide / 2 h / 65 °C View Scheme
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / 2 h / Reflux 2: sodium hydroxide / ethanol / 3 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: toluene-4-sulfonic acid / toluene / 2 h / Reflux 2: sodium hydroxide / ethanol / 2 h / 20 °C / Reflux View Scheme

: 27773-65-5
Apovincaminic acid

: (S)-aminopropan-1-ol

: (41S,13aS)-13a-ethyl-N-((S)-1-hydroxypropan-2-yl)-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With 2-(7-azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Stage #2: (S)-aminopropan-1-ol In dichloromethane for 4h;	96%

: 27773-65-5
Apovincaminic acid

: 27773-67-7
(41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With thionyl chloride In chloroform; N,N-dimethyl-formamide for 3h; Reflux; Stage #2: With ammonium hydroxide In chloroform; N,N-dimethyl-formamide at 20℃; for 2h;	95%
Stage #1: Apovincaminic acid With toluene-4-sulfonic acid In dichloromethane at 20℃; for 4h; Stage #2: With ammonia In dichloromethane at 20℃; for 3h;	83%
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: With ammonia In dichloromethane at 20℃; for 3h;	83%
Stage #1: Apovincaminic acid With thionyl chloride; N,N-dimethyl-formamide In chloroform for 4h; Reflux; Stage #2: With ammonium hydroxide In chloroform; water for 2h; Cooling with ice;

: 2491-20-5
L-alanine methyl ester hydrochloride

: 27773-65-5
Apovincaminic acid

: ethyl (S)-methyl-2-((4S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-formylamino)propionate

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With 2-(7-azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Stage #2: L-alanine methyl ester hydrochloride In dichloromethane for 4h;	95%

: 75-04-7
ethylamine

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-N,13a-diethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: ethylamine In dichloromethane at 20℃; for 3h;	92%

: 27773-65-5
Apovincaminic acid

: (S)-2-amino-N-methoxy-N-methylpropanamide hydrochloride

: (41S,13aS)-13a-ethyl-N-((S)-1-(methoxyl(methyl)amino)-1-oxopropan-2-yl)-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With 2-(7-azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Stage #2: (S)-2-amino-N-methoxy-N-methylpropanamide hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane for 14h;	90.58%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-13a-ethyl-N-methoxy-N-methyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-carboxamide

Conditions

Conditions	Yield
With 2-(7-azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃;	90%

: 27773-65-5
Apovincaminic acid

: 109-89-7
diethylamine

: (41S,13aS)-N,N,13a-triethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: diethylamine In dichloromethane at 20℃; for 3h;	90%

: 7737-17-9
1-aminopropan-2-one hydrochloride

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-13a-ethyl-N-(2-oxopropyl)-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrid o[3,2,1-ij][1,5]naphthyridin-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With 2-(7-azobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Stage #2: 1-aminopropan-2-one hydrochloride In dichloromethane for 4h;	89%

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-hydrazide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With thionyl chloride In chloroform; N,N-dimethyl-formamide at 0℃; for 3h; Reflux; Stage #2: With hydrazine hydrate In chloroform; N,N-dimethyl-formamide at 20℃; for 2h;	89%

: 107-10-8
propylamine

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-13a-ethyl-N-propyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: propylamine In dichloromethane at 20℃; for 3h;	89%

: 110-58-7
1-pentanamine

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-13a-ethyl-N-pentyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: n-Pentylamine In dichloromethane at 20℃; for 3h;	88%

: 27773-65-5
Apovincaminic acid

: 109-73-9
N-butylamine

: (41S,13aS)-N-butyl-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: N-butylamine In dichloromethane at 20℃; for 3h;	86%

: 142-84-7
di-n-propylamine

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-13a-ethyl-N,N-dipropyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5] naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: di-n-propylamine In dichloromethane at 20℃; for 3h;	86%

: 27773-65-5
Apovincaminic acid

: 75-31-0
isopropylamine

: (41S,13aS)-13a-ethyl-N-isopropyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]-naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: isopropylamine In dichloromethane at 20℃; for 3h;	85%

: 27773-65-5
Apovincaminic acid

: 124-40-3
dimethyl amine

: (41S,13aS)-13a-ethyl-N,N-dimethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5] naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: dimethyl amine In dichloromethane at 20℃; for 3h;	85%

: 111-92-2
dibutylamine

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-N,N-dibutyl-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5] naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: dibutylamine In dichloromethane at 20℃; for 3h;	85%

: 110-89-4
piperidine

: 27773-65-5
Apovincaminic acid

: ((41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-yl)(piperidin-1-yl)methanone

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: piperidine In dichloromethane at 20℃; for 3h;	85%

: 27773-65-5
Apovincaminic acid

: 74-89-5
methylamine

: (41S,13aS)-13a-ethyl-N-methyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With toluene-4-sulfonic acid In dichloromethane at 20℃; for 4h; Stage #2: methylamine With triethylamine In dichloromethane at 20℃; for 3h;	83%
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: methylamine In dichloromethane at 20℃; for 3h;	82%

: 27773-65-5
Apovincaminic acid

: 1003-03-8
Cyclopentamine

: (41S,13aS)-N-cyclopentyl-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]-naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: Cyclopentamine In dichloromethane at 20℃; for 3h;	81%

: 104-94-9
4-methoxy-aniline

: 27773-65-5
Apovincaminic acid

: C27H29N3O2

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: 4-methoxy-aniline In dichloromethane at 20℃; for 3h;	81%

: 123-75-1
pyrrolidine

: 27773-65-5
Apovincaminic acid

: ((41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-yl)(pyrrolidin-1-yl)methanone

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: pyrrolidine In dichloromethane at 20℃; for 3h;	81%

: 141-43-5
ethanolamine

: 27773-65-5
Apovincaminic acid

: (41S,13aS)-13a-ethyl-N-(2-hydroxyethyl)-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]-naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: ethanolamine In dichloromethane at 20℃; for 3h;	79%

: 110-91-8
morpholine

: 27773-65-5
Apovincaminic acid

: ((41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-yl)(morpholino)methanone

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: morpholine In dichloromethane at 20℃; for 3h;	78%

: 27773-65-5
Apovincaminic acid

: 156-87-6
propan-1-ol-3-amine

: (41S,13aS)-13a-ethyl-N-(3-hydroxypropyl)-2,3,41,5,6,13ahexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: propan-1-ol-3-amine In dichloromethane at 20℃; for 3h;	75%

: 27773-65-5
Apovincaminic acid

: 62-53-3
aniline

: (41S,13aS)-13a-ethyl-N-phenyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxamide

Conditions

Conditions	Yield
Stage #1: Apovincaminic acid With p-toluenesulfonyl chloride In dichloromethane at 20℃; for 4h; Stage #2: aniline In dichloromethane at 20℃; for 3h;	72%

: 27773-65-5
Apovincaminic acid

: 146563-40-8
4-(nitrooxy)butyl bromide

: (11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid 4-nitrooxy-butyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 3h; Ambient temperature;	46.9%

: 27773-65-5
Apovincaminic acid

: 10-(nitrooxy)decyl bromide

: (11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid 10-nitrooxy-decyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 3h; Ambient temperature;	44.8%

: 27773-65-5
Apovincaminic acid

: 7-(nitrooxy)heptyl bromide

: (11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid 7-nitrooxy-heptyl ester

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 3h; Ambient temperature;	43%

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