Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye
Cas:1617-90-9
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Cas:1617-90-9
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inquiryUnique advantages for Vincamine Cas 1617-90-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Store at 2-8°C Package:100g,1kg/foil bag
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inquiryName: Vincamine CAS no. :1617-90-9 Molecular formula: C21H26N2O3 Molecular weight:354.44 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability
Cas:1617-90-9
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t
Cas:1617-90-9
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inquiryProduct Name Vincamine CAS 1617-90-9 Appearance white powder Purity 99% min
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inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:1617-90-9
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Type:Lab/Research institutions
inquiryVincamine is a peripheral vasodilator that increases blood flow to the brain. Generic drugs containing vincamine exist in specific regions. Most common drug preparations are in the sustained release forms. Vincamine is a monoterpenoid indole alka
Cas:1617-90-9
Min.Order:1 Gram
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Type:Trading Company
inquiryVincamine CAS:1617-90-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s
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Min.Order:1 Gram
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Min.Order:10 Gram
Negotiable
Type:Trading Company
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Type:Lab/Research institutions
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inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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(+)-15α-Chloro-vincamine
vincamin
Conditions | Yield |
---|---|
With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal In methanol for 6h; Ambient temperature; | 84.7% |
Conditions | Yield |
---|---|
at 250℃; for 0.25h; | A 7% B 83% |
at 20℃; for 0.25h; | A 8% B 75% |
Conditions | Yield |
---|---|
Stage #1: (-)-vincadifformine With monoperoxymaleic acid In methanol at -5 - 0℃; for 6.16667h; Stage #2: With sodium dithionate at 40℃; for 3h; Reagent/catalyst; | 78.3% |
Conditions | Yield |
---|---|
In toluene at 450℃; under 20 Torr; | A 5% B 70% |
Conditions | Yield |
---|---|
With hydrogenchloride In acetone for 72h; Ambient temperature; Yields of byproduct given; | A n/a B 66% |
(-)-methyl 1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine(1β-yl) pyruvate oxime
A
14-epivincamine
B
vincamin
Conditions | Yield |
---|---|
With sodium disulfite; acetic acid In water at 90 - 92℃; for 6h; Yields of byproduct given; | A n/a B 60% |
With sodium disulfite; acetic acid In water at 90 - 92℃; for 6h; Yield given. Title compound not separated from byproducts; | A n/a B 60% |
With sodium disulfite; acetic acid In water at 92 - 95℃; for 5h; | A 20% B 40% |
Conditions | Yield |
---|---|
at 150℃; for 0.25h; | A 35% B 60% |
at 150℃; for 0.25h; other condition; | A 35% B 60% |
In acetic acid at 20℃; for 12h; | A 4 mg B 50 mg |
In acetic acid for 12h; Ambient temperature; | A 4 mg B 50 mg |
Conditions | Yield |
---|---|
With hydrogenchloride; ammonia; sodium chloride In methanol | A n/a B 58% |
Conditions | Yield |
---|---|
In toluene at 400℃; under 20 Torr; | A 9% B 47% C 10% |
Conditions | Yield |
---|---|
With sodium hydroxide; oxygen; sodium acetate; rose bengal; sodium thiosulfate; acetic acid 1.) methanol, irradation, 60 min, 2.) H2O, 70 deg C, 20 min; Yield given. Multistep reaction; | A n/a B 46% |
With sodium hydroxide; oxygen; sodium acetate; rose bengal; sodium thiosulfate; acetic acid 1.) methanol, irradation, 60 min, 2.) H2O; Yield given. Multistep reaction. Yields of byproduct given; | |
With sulfuric acid; ozone In methanol at 60℃; Yield given. Yields of byproduct given; |
Conditions | Yield |
---|---|
With potassium tert-butylate at 20℃; for 2h; | 40% |
With potassium tert-butylate for 2h; Ambient temperature; |
Conditions | Yield |
---|---|
With methylene blue In methanol for 4h; Irradiation; | A 2 mg B 10 mg C 40% |
diazomethane
(-)-2-(1α-Ethyl-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizin-1-yl)-2-oxoacetic acid
A
vincamin
B
(-)-14-oxo-15α-oxirano-eburnane
Conditions | Yield |
---|---|
In methanol; dichloromethane at 0℃; for 4h; Product distribution; reactions of vincamones and eburnanes; | A 38% B 27% |
In methanol; dichloromethane at 0℃; for 4h; | A 32% B 27% |
3-((1S,12bS)-1-Ethyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-1-yl)-2-[(E)-hydroxyimino]-propionic acid methyl ester
A
vincamin
B
apovincamine
Conditions | Yield |
---|---|
With sulfuric acid; sodium methylate 1.) AcOH, heating, 2 h; 2.) MeOH, rt, 2 h; Yield given. Multistep reaction; | A n/a B 35% |
(+)-15,15a-didehydro-15-formamido-D-homoeburnamin-14-one
A
14-epivincamine
B
vincamin
Conditions | Yield |
---|---|
With hydrogenchloride; methanol; acetyl chloride for 4h; Heating; Yield given. Yields of byproduct given; |
methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate
(+/-)-16-epi vincamine
B
vincamin
Conditions | Yield |
---|---|
With hydrogenchloride; methanol; iron; sodium nitrite 1.) 50 deg C, 16 h, 2.) room temp., 30 min; Yield given. Multistep reaction. Title compound not separated from byproducts; |
methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate
A
14-epivincamine
B
vincamin
Conditions | Yield |
---|---|
With hydrogenchloride; methanol; iron; sodium nitrite 1.) 50 deg C, 16 h, 2.) room temperature, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; | |
With hydrogenchloride; methanol; iron; sodium nitrite 1.) 50 deg C, 16 h, 2.) room temperature, 30 min; Yield given. Multistep reaction. Yields of byproduct given; |
Conditions | Yield |
---|---|
With ammonium hydroxide In methanol for 4h; Equilibrium constant; Rate constant; Heating; |
14-iodo criocerine
vincamin
Conditions | Yield |
---|---|
With sodium cyanoborohydride In acetic acid at 20℃; for 2.5h; | 8 mg |
(1S,12bS,2'S)-1α-ethyl-1β-(2-hydroxy-2-methoxycarbonylethyl)-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine
vincamin
Conditions | Yield |
---|---|
With sodium methylate 1.) toluene, reflux, 6 h; 2.) MeOH, reflux, 1 h; Yield given. Multistep reaction; |
Δ14-vincamine
vincamin
Conditions | Yield |
---|---|
With hydrogen; platinum(IV) oxide In methanol | 9 mg |
Multi-step reaction with 2 steps 1: 49 mg / acetic acid, iodine, potassium iodate / dioxane / 24 h / 20 °C 2: 8 mg / NaBH3CN / acetic acid / 2.5 h / 20 °C View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 13 steps 1: 83 percent / tetrahydrofuran / 12 h / 20 °C 2: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C 3: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C 4: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating 5: p-TsOH / toluene / 12 h / Heating 6: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h 7: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C 8: 1.) NH2NH2*H2O, 2.) KOH, 3.) conc. HCl / 1.) diethylene glycol, 160 deg C, 1 h, 2.) 220-225 deg C, 4 h, 3.) H2O, 0 deg C, 4.) Et2O, 0 deg C 9: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h 10: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 11: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 12: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 13: 40 percent / t-BuOK / 2 h / 20 °C View Scheme | |
Multi-step reaction with 19 steps 1: 83 percent / tetrahydrofuran / 12 h / 20 °C 2: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C 3: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C 4: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating 5: p-TsOH / toluene / 12 h / Heating 6: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h 7: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C 8: 1.) Et3N, isobutyl chloroformate, 2.) NaBH4 / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, 20 deg C, 3 h 9: 68 percent / imidazole / dimethylformamide / 12 h / 20 °C 10: 1.) NaH, imidazole / 1.) THF, 20 deg C, 30 min, 2.) 30 min, 3.) 15 min 11: 85 percent / AIBN, tri-n-butyl hydride / toluene / 2 h / Heating 12: 69 percent / NaH / tetrahydrofuran / 3 h / 20 °C 13: 77 percent / TBAF / tetrahydrofuran / 4 h / 20 °C 14: 1.) pyridinium dichromate, 3.) formic acid / 1.) DMF, 20 deg C, 12 h, 2.) CH2Cl2, Et2O, 3.) 20 deg C, 12 h 15: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h 16: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 17: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 18: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 19: 40 percent / t-BuOK / 2 h / 20 °C View Scheme |
3-<<2-(1H-indol-3-yl)ethyl>amino>propanoic acid ethyl ester
vincamin
Conditions | Yield |
---|---|
Multi-step reaction with 12 steps 1: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C 2: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C 3: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating 4: p-TsOH / toluene / 12 h / Heating 5: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h 6: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C 7: 1.) NH2NH2*H2O, 2.) KOH, 3.) conc. HCl / 1.) diethylene glycol, 160 deg C, 1 h, 2.) 220-225 deg C, 4 h, 3.) H2O, 0 deg C, 4.) Et2O, 0 deg C 8: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h 9: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 10: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 11: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 12: 40 percent / t-BuOK / 2 h / 20 °C View Scheme | |
Multi-step reaction with 18 steps 1: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C 2: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C 3: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating 4: p-TsOH / toluene / 12 h / Heating 5: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h 6: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C 7: 1.) Et3N, isobutyl chloroformate, 2.) NaBH4 / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, 20 deg C, 3 h 8: 68 percent / imidazole / dimethylformamide / 12 h / 20 °C 9: 1.) NaH, imidazole / 1.) THF, 20 deg C, 30 min, 2.) 30 min, 3.) 15 min 10: 85 percent / AIBN, tri-n-butyl hydride / toluene / 2 h / Heating 11: 69 percent / NaH / tetrahydrofuran / 3 h / 20 °C 12: 77 percent / TBAF / tetrahydrofuran / 4 h / 20 °C 13: 1.) pyridinium dichromate, 3.) formic acid / 1.) DMF, 20 deg C, 12 h, 2.) CH2Cl2, Et2O, 3.) 20 deg C, 12 h 14: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h 15: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 16: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 17: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 18: 40 percent / t-BuOK / 2 h / 20 °C View Scheme |
(-)-1β-methoxycarbonylethyl-1α-ethyl-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine
vincamin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 2: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 3: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 4: 40 percent / t-BuOK / 2 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: tert-butyl nitrite, potassium tert-butoxide / toluene; methanol / 3 h / 40 °C 2: 40 percent / acetic acid, sodium disulfite / H2O / 5 h / 92 - 95 °C View Scheme | |
Multi-step reaction with 5 steps 1: 95 percent / NaOH / aq. ethanol / 1.5 h / Heating 2: 77 percent / phosphoryl chloride / 24 h / Ambient temperature 3: tert-butyl nitrite, t-BuOK / toluene / 1 h / Ambient temperature 4: 60.7 percent / p-TsOH, paraformaldehyde / acetic acid / 5 h / Heating 5: t-BuOK / 2 h / Ambient temperature View Scheme | |
Multi-step reaction with 4 steps 1: 60 percent / NaH / toluene / 5 h / Heating 2: tert-butyl nitrite, t-BuOK / toluene / 1 h / Ambient temperature 3: 60.7 percent / p-TsOH, paraformaldehyde / acetic acid / 5 h / Heating 4: t-BuOK / 2 h / Ambient temperature View Scheme |
(+)-(3S,17S)-14-oxo-E-homo-eburnane
vincamin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 2: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 3: 40 percent / t-BuOK / 2 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: tert-butyl nitrite, t-BuOK / toluene / 1 h / Ambient temperature 2: 60.7 percent / p-TsOH, paraformaldehyde / acetic acid / 5 h / Heating 3: t-BuOK / 2 h / Ambient temperature View Scheme |
15a-homo-eburnamenine-14,15-dione 15-oxime
vincamin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 2: 40 percent / t-BuOK / 2 h / 20 °C View Scheme |
3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-2,4-piperidinedione
vincamin
Conditions | Yield |
---|---|
Multi-step reaction with 9 steps 1: p-TsOH / toluene / 12 h / Heating 2: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h 3: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C 4: 1.) NH2NH2*H2O, 2.) KOH, 3.) conc. HCl / 1.) diethylene glycol, 160 deg C, 1 h, 2.) 220-225 deg C, 4 h, 3.) H2O, 0 deg C, 4.) Et2O, 0 deg C 5: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h 6: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 7: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 8: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 9: 40 percent / t-BuOK / 2 h / 20 °C View Scheme | |
Multi-step reaction with 15 steps 1: p-TsOH / toluene / 12 h / Heating 2: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h 3: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C 4: 1.) Et3N, isobutyl chloroformate, 2.) NaBH4 / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, 20 deg C, 3 h 5: 68 percent / imidazole / dimethylformamide / 12 h / 20 °C 6: 1.) NaH, imidazole / 1.) THF, 20 deg C, 30 min, 2.) 30 min, 3.) 15 min 7: 85 percent / AIBN, tri-n-butyl hydride / toluene / 2 h / Heating 8: 69 percent / NaH / tetrahydrofuran / 3 h / 20 °C 9: 77 percent / TBAF / tetrahydrofuran / 4 h / 20 °C 10: 1.) pyridinium dichromate, 3.) formic acid / 1.) DMF, 20 deg C, 12 h, 2.) CH2Cl2, Et2O, 3.) 20 deg C, 12 h 11: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h 12: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C 13: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C 14: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C 15: 40 percent / t-BuOK / 2 h / 20 °C View Scheme |
vincamin
(15S,17S,19S)-15-ethyl-17-(hydroxymethyl)-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-ol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 66℃; for 1.5h; Inert atmosphere; | 99% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 66℃; for 1.5h; Inert atmosphere; | 99% |
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 0℃; for 2.5h; | 51% |
vincamin
2,7-seco 14-epivincamine
Conditions | Yield |
---|---|
With 3,7-bis(dimethylamino)phenothiazin-5-ium chloride trihydrate; oxygen In methanol Irradiation; | 99% |
With oxygen; methylene blue for 24h; Irradiation; | 35% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 2h; Dean-Stark; Reflux; Inert atmosphere; | 95% |
With toluene-4-sulfonic acid In toluene for 2h; Reflux; | 92% |
With toluene-4-sulfonic acid In toluene for 2h; Reflux; | 92% |
ethanol
vincamin
14,15-dihydro-14β-hydroxy-(3α,16α)-eburnamenine-14-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
With titanium(IV) tetraethanolate In various solvent(s) for 8h; Heating; | 90% |
vincamin
(-)-vincamine N-oxide
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid In chloroform | 84.8% |
Conditions | Yield |
---|---|
With sulfuric acid for 8h; Reflux; | 81% |
With sulfuric acid for 8h; Reflux; | 81% |
Conditions | Yield |
---|---|
Reflux; | 78% |
Conditions | Yield |
---|---|
In tetrahydrofuran at 66℃; for 3.5h; Inert atmosphere; | A 78% B 15% |
Conditions | Yield |
---|---|
In chloroform at 62℃; for 4h; Inert atmosphere; diastereoselective reaction; | A 15% B 78% |
vincamin
(-)-18-iodo-criocerine
Conditions | Yield |
---|---|
With iodine; sodium hydrogencarbonate In chloroform for 2h; Ambient temperature; | 77% |
With iodine; sodium hydrogencarbonate In chloroform at 20℃; | 77% |
With iodine; sodium hydrogencarbonate In chloroform; water for 6h; Inert atmosphere; | 77% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 80℃; for 4h; | 75% |
Conditions | Yield |
---|---|
With sulfuric acid for 8h; Reflux; | 74% |
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