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ShangHai Soyoung Biotechnology Inc

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many ye

Vincamine powder 1617-90-9

Cas:1617-90-9

Min.Order:25 Kilogram

FOB Price: $1280.0

Type:Lab/Research institutions

inquiry

Xi'an Yinherb Bio-Tech Co., Ltd.

Xi'an Yinherb Bio-Tech Co., Ltd was founded in 2009, We have more than 10 experienced doctors and scientists and professional managers, specializing in Nootropics, Sarms and Peptides researching and developing, and become the lead

Vincamine 99%

Cas:1617-90-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Vincamine Manufacturer/High quality/Best price/In stock

Cas:1617-90-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Vincamine supplier in China

Cas:1617-90-9

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production 2-phenylacetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carbon environ

Vincamine CAS NO.1617-90-9

Cas:1617-90-9

Min.Order:100 Gram

FOB Price: $2.0

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Vincamine Cas 1617-90-9 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White crystalline powder Storage:Store at 2-8°C Package:100g,1kg/foil bag

Factory supply Vincamine Cas 1617-90-9 with high quality and best price

Cas:1617-90-9

Min.Order:100 Gram

FOB Price: $2.5 / 3.0

Type:Trading Company

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Vincamine

Cas:1617-90-9

Min.Order:1

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Content Natural Extract Vincamine HACCP manufacturer

Cas:1617-90-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Vincamine

Cas:1617-90-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Vincamine (base and/or unspecified salts)

Cas:1617-90-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hubei DiBo chemical co., LTD

Name: Vincamine CAS no. :1617-90-9 Molecular formula: C21H26N2O3 Molecular weight:354.44 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Vincamine /CAS :1617-90-9/raw material/high-quality

Cas:1617-90-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 1617-90-9 Vincamine

Cas:1617-90-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

Vincamine 1617-90-9

Cas:1617-90-9

Min.Order:1 Kilogram

FOB Price: $48.0 / 58.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 1617-90-9 with best quality

Cas:1617-90-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in t

Vincamine Powder USP Standard

Cas:1617-90-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name Vincamine CAS 1617-90-9 Appearance white powder Purity 99% min

Vincamine

Cas:1617-90-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Vincamine 1617-90-9

Cas:1617-90-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Pharmaceutical Nootropics Supplement Vincamine raw Powder Vincamine with Safe Delivery

Cas:1617-90-9

Min.Order:10 Gram

FOB Price: $3.5

Type:Trading Company

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the

Vincamine/ LIDE PHARMA- Factory supply / Best price

Cas:1617-90-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Manufacturer Supply Vincamine CAS 1617-90-9 for Scientific Research use only

Cas:1617-90-9

Min.Order:1 Gram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Vincamine is a peripheral vasodilator that increases blood flow to the brain. Generic drugs containing vincamine exist in specific regions. Most common drug preparations are in the sustained release forms. Vincamine is a monoterpenoid indole alka

(+)-cis-Vincamine,Vincamine,cas:1617-90-9

Cas:1617-90-9

Min.Order:1 Gram

FOB Price: $20.0 / 25.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Vincamine CAS:1617-90-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates, s

Vincamine CAS:1617-90-9

Cas:1617-90-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

Factory Outlet CAS 1617-90-9 Vincamine

Cas:1617-90-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

best price,best quality and fast delivery assurance available in sample product and customization with years of export experience along with excellent quality, advanced services and competitive prices the quality of products conform u

Vincamine 99% CAS NO.1617-90-9

Cas:1617-90-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Sports Nutrition powder Voacanga Africana Extract 99% Vincamine powder

Cas:1617-90-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Vincamine

Cas:1617-90-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Vincamine

Cas:1617-90-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Service 1.Own made fine chemical products 2.Out sourcing and qua

(3alpha,14beta,16alpha)-14,15-Dihydro-14-hydroxyeburnamenine-14-carboxylic acidmethyl ester

Cas:1617-90-9

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Vincamine

Cas:1617-90-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Chengdu Biopurify Phytochemicals Ltd.

Chengdu Biopurify Phytochemicals Ltd. is a leading company in the research, development, manufacture and marketing of High Quality Phytochemicals and Extracts(especially Active Ingredients from Traditional Chinese Medicine,Traditional Chinese Medic

Vincamine

Cas:1617-90-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(+)-15α-Chloro-vincamine
142892-63-5

(+)-15α-Chloro-vincamine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal In methanol for 6h; Ambient temperature;84.7%
14-epivincamine
6835-99-0

14-epivincamine

A

vincamin
1617-90-9

vincamin

B

apovincamine
4880-92-6

apovincamine

Conditions
ConditionsYield
at 250℃; for 0.25h;A 7%
B 83%
at 20℃; for 0.25h;A 8%
B 75%
(-)-vincadifformine
3247-10-7

(-)-vincadifformine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
Stage #1: (-)-vincadifformine With monoperoxymaleic acid In methanol at -5 - 0℃; for 6.16667h;
Stage #2: With sodium dithionate at 40℃; for 3h; Reagent/catalyst;
78.3%
hydroxy-16 dehydro-1 vincadifformine
66113-74-4

hydroxy-16 dehydro-1 vincadifformine

A

vincamin
1617-90-9

vincamin

B

vinburnine
4880-88-0

vinburnine

Conditions
ConditionsYield
In toluene at 450℃; under 20 Torr;A 5%
B 70%
O-methyl vincamine
96861-85-7

O-methyl vincamine

A

14-epivincamine
6835-99-0

14-epivincamine

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With hydrogenchloride In acetone for 72h; Ambient temperature; Yields of byproduct given;A n/a
B 66%
(-)-methyl 1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine(1β-yl) pyruvate oxime
85588-92-7

(-)-methyl 1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine(1β-yl) pyruvate oxime

A

14-epivincamine
6835-99-0

14-epivincamine

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With sodium disulfite; acetic acid In water at 90 - 92℃; for 6h; Yields of byproduct given;A n/a
B 60%
With sodium disulfite; acetic acid In water at 90 - 92℃; for 6h; Yield given. Title compound not separated from byproducts;A n/a
B 60%
With sodium disulfite; acetic acid In water at 92 - 95℃; for 5h;A 20%
B 40%
hydroxy-16 dehydro-1 vincadifformine
66113-74-4

hydroxy-16 dehydro-1 vincadifformine

A

14-epivincamine
6835-99-0

14-epivincamine

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
at 150℃; for 0.25h;A 35%
B 60%
at 150℃; for 0.25h; other condition;A 35%
B 60%
In acetic acid at 20℃; for 12h;A 4 mg
B 50 mg
In acetic acid for 12h; Ambient temperature;A 4 mg
B 50 mg
dichloromethane
75-09-2

dichloromethane

MCPB
94-81-5

MCPB

potassium carbonate
584-08-7

potassium carbonate

A

methyl 3-benzyl-4,4-diethyl-6-hydroxy-2,3,3,a4,5,6-hexahydro-1H-indolo(3,2,1-de)(1,5)naphthyridine-6-carboxylate

methyl 3-benzyl-4,4-diethyl-6-hydroxy-2,3,3,a4,5,6-hexahydro-1H-indolo(3,2,1-de)(1,5)naphthyridine-6-carboxylate

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With hydrogenchloride; ammonia; sodium chloride In methanolA n/a
B 58%
14-epivincamine
6835-99-0

14-epivincamine

A

vincamin
1617-90-9

vincamin

B

vinburnine
4880-88-0

vinburnine

C

apovincamine
4880-92-6

apovincamine

Conditions
ConditionsYield
In toluene at 400℃; under 20 Torr;A 9%
B 47%
C 10%
(-)-vincadifformine
3247-10-7

(-)-vincadifformine

A

14-epivincamine
6835-99-0

14-epivincamine

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With sodium hydroxide; oxygen; sodium acetate; rose bengal; sodium thiosulfate; acetic acid 1.) methanol, irradation, 60 min, 2.) H2O, 70 deg C, 20 min; Yield given. Multistep reaction;A n/a
B 46%
With sodium hydroxide; oxygen; sodium acetate; rose bengal; sodium thiosulfate; acetic acid 1.) methanol, irradation, 60 min, 2.) H2O; Yield given. Multistep reaction. Yields of byproduct given;
With sulfuric acid; ozone In methanol at 60℃; Yield given. Yields of byproduct given;
methanol
67-56-1

methanol

(3α,16α)-D-homoeburnamonine-14,15-dione
35226-43-8

(3α,16α)-D-homoeburnamonine-14,15-dione

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With potassium tert-butylate at 20℃; for 2h;40%
With potassium tert-butylate for 2h; Ambient temperature;
(-)-vincadifformine hydrochloride

(-)-vincadifformine hydrochloride

A

14-epivincamine
6835-99-0

14-epivincamine

B

vincamin
1617-90-9

vincamin

C

C21H26N2O4
78084-15-8

C21H26N2O4

Conditions
ConditionsYield
With methylene blue In methanol for 4h; Irradiation;A 2 mg
B 10 mg
C 40%
(-)-2-(1α-Ethyl-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizin-1-yl)-2-oxoacetic acid
100945-10-6, 100992-96-9, 120201-19-6

(-)-2-(1α-Ethyl-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizin-1-yl)-2-oxoacetic acid

A

vincamin
1617-90-9

vincamin

B

(-)-14-oxo-15α-oxirano-eburnane
120090-43-9

(-)-14-oxo-15α-oxirano-eburnane

Conditions
ConditionsYield
In methanol; dichloromethane at 0℃; for 4h; Product distribution; reactions of vincamones and eburnanes;A 38%
B 27%
In methanol; dichloromethane at 0℃; for 4h;A 32%
B 27%
3-((1S,12bS)-1-Ethyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-1-yl)-2-[(E)-hydroxyimino]-propionic acid methyl ester
89396-77-0

3-((1S,12bS)-1-Ethyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-1-yl)-2-[(E)-hydroxyimino]-propionic acid methyl ester

A

vincamin
1617-90-9

vincamin

B

apovincamine
4880-92-6

apovincamine

Conditions
ConditionsYield
With sulfuric acid; sodium methylate 1.) AcOH, heating, 2 h; 2.) MeOH, rt, 2 h; Yield given. Multistep reaction;A n/a
B 35%
(+)-15,15a-didehydro-15-formamido-D-homoeburnamin-14-one
112965-87-4

(+)-15,15a-didehydro-15-formamido-D-homoeburnamin-14-one

A

14-epivincamine
6835-99-0

14-epivincamine

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With hydrogenchloride; methanol; acetyl chloride for 4h; Heating; Yield given. Yields of byproduct given;
methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate
83289-24-1

methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

(+/-)-16-epi vincamine
18210-81-6

(+/-)-16-epi vincamine

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With hydrogenchloride; methanol; iron; sodium nitrite 1.) 50 deg C, 16 h, 2.) room temp., 30 min; Yield given. Multistep reaction. Title compound not separated from byproducts;
methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate
83289-24-1

methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate

A

14-epivincamine
6835-99-0

14-epivincamine

B

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With hydrogenchloride; methanol; iron; sodium nitrite 1.) 50 deg C, 16 h, 2.) room temperature, 30 min; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With hydrogenchloride; methanol; iron; sodium nitrite 1.) 50 deg C, 16 h, 2.) room temperature, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
14-epivincamine
6835-99-0

14-epivincamine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With ammonium hydroxide In methanol for 4h; Equilibrium constant; Rate constant; Heating;
14-iodo criocerine
74947-45-8

14-iodo criocerine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With sodium cyanoborohydride In acetic acid at 20℃; for 2.5h;8 mg
(1S,12bS,2'S)-1α-ethyl-1β-(2-hydroxy-2-methoxycarbonylethyl)-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine
25328-05-6, 25819-96-9, 34786-67-9, 41173-96-0, 55528-20-6, 64395-18-2, 65634-79-9, 65634-80-2, 95782-87-9

(1S,12bS,2'S)-1α-ethyl-1β-(2-hydroxy-2-methoxycarbonylethyl)-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With sodium methylate 1.) toluene, reflux, 6 h; 2.) MeOH, reflux, 1 h; Yield given. Multistep reaction;
Δ14-vincamine
32790-09-3

Δ14-vincamine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
With hydrogen; platinum(IV) oxide In methanol9 mg
Multi-step reaction with 2 steps
1: 49 mg / acetic acid, iodine, potassium iodate / dioxane / 24 h / 20 °C
2: 8 mg / NaBH3CN / acetic acid / 2.5 h / 20 °C
View Scheme
tryptamine
61-54-1

tryptamine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
Multi-step reaction with 13 steps
1: 83 percent / tetrahydrofuran / 12 h / 20 °C
2: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C
3: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C
4: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating
5: p-TsOH / toluene / 12 h / Heating
6: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h
7: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C
8: 1.) NH2NH2*H2O, 2.) KOH, 3.) conc. HCl / 1.) diethylene glycol, 160 deg C, 1 h, 2.) 220-225 deg C, 4 h, 3.) H2O, 0 deg C, 4.) Et2O, 0 deg C
9: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h
10: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C
11: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
12: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
13: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
Multi-step reaction with 19 steps
1: 83 percent / tetrahydrofuran / 12 h / 20 °C
2: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C
3: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C
4: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating
5: p-TsOH / toluene / 12 h / Heating
6: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h
7: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C
8: 1.) Et3N, isobutyl chloroformate, 2.) NaBH4 / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, 20 deg C, 3 h
9: 68 percent / imidazole / dimethylformamide / 12 h / 20 °C
10: 1.) NaH, imidazole / 1.) THF, 20 deg C, 30 min, 2.) 30 min, 3.) 15 min
11: 85 percent / AIBN, tri-n-butyl hydride / toluene / 2 h / Heating
12: 69 percent / NaH / tetrahydrofuran / 3 h / 20 °C
13: 77 percent / TBAF / tetrahydrofuran / 4 h / 20 °C
14: 1.) pyridinium dichromate, 3.) formic acid / 1.) DMF, 20 deg C, 12 h, 2.) CH2Cl2, Et2O, 3.) 20 deg C, 12 h
15: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h
16: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C
17: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
18: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
19: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
3-<<2-(1H-indol-3-yl)ethyl>amino>propanoic acid ethyl ester
14487-98-0

3-<<2-(1H-indol-3-yl)ethyl>amino>propanoic acid ethyl ester

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
Multi-step reaction with 12 steps
1: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C
2: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C
3: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating
4: p-TsOH / toluene / 12 h / Heating
5: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h
6: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C
7: 1.) NH2NH2*H2O, 2.) KOH, 3.) conc. HCl / 1.) diethylene glycol, 160 deg C, 1 h, 2.) 220-225 deg C, 4 h, 3.) H2O, 0 deg C, 4.) Et2O, 0 deg C
8: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h
9: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C
10: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
11: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
12: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
Multi-step reaction with 18 steps
1: 83 percent / 1,4-bis(methylamino)pyridine, DCC / CH2Cl2 / 18 h / 20 °C
2: 79 percent / NaH / tetrahydrofuran / 4 h / 20 °C
3: 79 percent / LiBr, H2O / dimethylformamide / 12 h / Heating
4: p-TsOH / toluene / 12 h / Heating
5: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h
6: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C
7: 1.) Et3N, isobutyl chloroformate, 2.) NaBH4 / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, 20 deg C, 3 h
8: 68 percent / imidazole / dimethylformamide / 12 h / 20 °C
9: 1.) NaH, imidazole / 1.) THF, 20 deg C, 30 min, 2.) 30 min, 3.) 15 min
10: 85 percent / AIBN, tri-n-butyl hydride / toluene / 2 h / Heating
11: 69 percent / NaH / tetrahydrofuran / 3 h / 20 °C
12: 77 percent / TBAF / tetrahydrofuran / 4 h / 20 °C
13: 1.) pyridinium dichromate, 3.) formic acid / 1.) DMF, 20 deg C, 12 h, 2.) CH2Cl2, Et2O, 3.) 20 deg C, 12 h
14: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h
15: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C
16: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
17: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
18: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
(-)-1β-methoxycarbonylethyl-1α-ethyl-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine
23944-42-5

(-)-1β-methoxycarbonylethyl-1α-ethyl-1,2,3,4,6,7,12,12bα-octahydroindolo<2,3-a>quinolizine

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C
2: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
3: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
4: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: tert-butyl nitrite, potassium tert-butoxide / toluene; methanol / 3 h / 40 °C
2: 40 percent / acetic acid, sodium disulfite / H2O / 5 h / 92 - 95 °C
View Scheme
Multi-step reaction with 5 steps
1: 95 percent / NaOH / aq. ethanol / 1.5 h / Heating
2: 77 percent / phosphoryl chloride / 24 h / Ambient temperature
3: tert-butyl nitrite, t-BuOK / toluene / 1 h / Ambient temperature
4: 60.7 percent / p-TsOH, paraformaldehyde / acetic acid / 5 h / Heating
5: t-BuOK / 2 h / Ambient temperature
View Scheme
Multi-step reaction with 4 steps
1: 60 percent / NaH / toluene / 5 h / Heating
2: tert-butyl nitrite, t-BuOK / toluene / 1 h / Ambient temperature
3: 60.7 percent / p-TsOH, paraformaldehyde / acetic acid / 5 h / Heating
4: t-BuOK / 2 h / Ambient temperature
View Scheme
(+)-(3S,17S)-14-oxo-E-homo-eburnane
35226-41-6

(+)-(3S,17S)-14-oxo-E-homo-eburnane

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
2: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
3: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: tert-butyl nitrite, t-BuOK / toluene / 1 h / Ambient temperature
2: 60.7 percent / p-TsOH, paraformaldehyde / acetic acid / 5 h / Heating
3: t-BuOK / 2 h / Ambient temperature
View Scheme
15a-homo-eburnamenine-14,15-dione 15-oxime
35226-42-7

15a-homo-eburnamenine-14,15-dione 15-oxime

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
2: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-2,4-piperidinedione
190378-04-2

3-ethyl-1-[2-(1H-indol-3-yl)ethyl]-2,4-piperidinedione

vincamin
1617-90-9

vincamin

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: p-TsOH / toluene / 12 h / Heating
2: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h
3: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C
4: 1.) NH2NH2*H2O, 2.) KOH, 3.) conc. HCl / 1.) diethylene glycol, 160 deg C, 1 h, 2.) 220-225 deg C, 4 h, 3.) H2O, 0 deg C, 4.) Et2O, 0 deg C
5: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h
6: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C
7: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
8: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
9: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
Multi-step reaction with 15 steps
1: p-TsOH / toluene / 12 h / Heating
2: 1.) hydroquinone, 2.) 20percent AcOH / 1.) THF, 60 deg C, 2 d,2.) H2O, THF, 40 deg C, 72 h
3: 76 percent / LiOH, 30percent H2O2 / methanol / 5 h / 20 °C
4: 1.) Et3N, isobutyl chloroformate, 2.) NaBH4 / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, 20 deg C, 3 h
5: 68 percent / imidazole / dimethylformamide / 12 h / 20 °C
6: 1.) NaH, imidazole / 1.) THF, 20 deg C, 30 min, 2.) 30 min, 3.) 15 min
7: 85 percent / AIBN, tri-n-butyl hydride / toluene / 2 h / Heating
8: 69 percent / NaH / tetrahydrofuran / 3 h / 20 °C
9: 77 percent / TBAF / tetrahydrofuran / 4 h / 20 °C
10: 1.) pyridinium dichromate, 3.) formic acid / 1.) DMF, 20 deg C, 12 h, 2.) CH2Cl2, Et2O, 3.) 20 deg C, 12 h
11: 1.) POCl3, 2.) 1M LiClO4, 3.) H2, 4.) 30percent ammonia / 3.) 10percent Pd/C / 1.) CH3CN, 100 deg C, 4 h, 2.) CH2Cl2, 10 min, 3.) DMF, 1 bar, 5 h
12: 70 percent / sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 2 h / 20 °C
13: 65 percent / tert-butyl nitrite, sodium bis(trimethylsilyl)amide / toluene; tetrahydrofuran / 1.5 h / 50 °C
14: p-TsOH, paraformaldehyde / acetic acid / 5 h / 100 - 105 °C
15: 40 percent / t-BuOK / 2 h / 20 °C
View Scheme
vincamin
1617-90-9

vincamin

(15S,17S,19S)-15-ethyl-17-(hydroxymethyl)-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-ol
3382-95-4

(15S,17S,19S)-15-ethyl-17-(hydroxymethyl)-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-ol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 66℃; for 1.5h; Inert atmosphere;99%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 66℃; for 1.5h; Inert atmosphere;99%
With sodium tetrahydroborate; boron trifluoride diethyl etherate In tetrahydrofuran at 0℃; for 2.5h;51%
vincamin
1617-90-9

vincamin

2,7-seco 14-epivincamine
59373-44-3

2,7-seco 14-epivincamine

Conditions
ConditionsYield
With 3,7-bis(dimethylamino)phenothiazin-5-ium chloride trihydrate; oxygen In methanol Irradiation;99%
With oxygen; methylene blue for 24h; Irradiation;35%
vincamin
1617-90-9

vincamin

apovincamine
4880-92-6

apovincamine

Conditions
ConditionsYield
With toluene-4-sulfonic acid In toluene for 2h; Dean-Stark; Reflux; Inert atmosphere;95%
With toluene-4-sulfonic acid In toluene for 2h; Reflux;92%
With toluene-4-sulfonic acid In toluene for 2h; Reflux;92%
ethanol
64-17-5

ethanol

vincamin
1617-90-9

vincamin

14,15-dihydro-14β-hydroxy-(3α,16α)-eburnamenine-14-carboxylic acid ethyl ester
40163-56-2

14,15-dihydro-14β-hydroxy-(3α,16α)-eburnamenine-14-carboxylic acid ethyl ester

Conditions
ConditionsYield
With titanium(IV) tetraethanolate In various solvent(s) for 8h; Heating;90%
vincamin
1617-90-9

vincamin

(-)-vincamine N-oxide
51442-60-5, 1239866-77-3

(-)-vincamine N-oxide

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid In chloroform84.8%
propan-1-ol
71-23-8

propan-1-ol

vincamin
1617-90-9

vincamin

(41S,13aS)-propyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

(41S,13aS)-propyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

Conditions
ConditionsYield
With sulfuric acid for 8h; Reflux;81%
With sulfuric acid for 8h; Reflux;81%
methanol
67-56-1

methanol

vincamin
1617-90-9

vincamin

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

methyl 7-ethyl-14-hydroxy-8-methoxy-3-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-1,2,3,4,5,6,7,8-octahydro-7,9-ethanoazecino[5,4-b]indole-14-carboxylate

methyl 7-ethyl-14-hydroxy-8-methoxy-3-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-1,2,3,4,5,6,7,8-octahydro-7,9-ethanoazecino[5,4-b]indole-14-carboxylate

Conditions
ConditionsYield
Reflux;78%
ethanol
64-17-5

ethanol

vincamin
1617-90-9

vincamin

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

A

C27H36N2O6

C27H36N2O6

B

C27H36N2O6

C27H36N2O6

Conditions
ConditionsYield
In tetrahydrofuran at 66℃; for 3.5h; Inert atmosphere;A 78%
B 15%
ethanol
64-17-5

ethanol

vincamin
1617-90-9

vincamin

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

A

methyl (9R,11S,19R)-19-ethoxy-11-ethyl-9-hydroxy-15-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-8,15-diazatetracyclo[9.6.2.02,7.08,18]nonadeca-1(18),2,4,6-tetraene-9-carboxylate

methyl (9R,11S,19R)-19-ethoxy-11-ethyl-9-hydroxy-15-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-8,15-diazatetracyclo[9.6.2.02,7.08,18]nonadeca-1(18),2,4,6-tetraene-9-carboxylate

B

methyl (9S,11S,19R)-19-ethoxy-11-ethyl-9-hydroxy-15-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-8,15-diazatetracyclo[9.6.2.02,7.08,18]nonadeca-1(18),2,4,6-tetraene-9-carboxylate

methyl (9S,11S,19R)-19-ethoxy-11-ethyl-9-hydroxy-15-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-8,15-diazatetracyclo[9.6.2.02,7.08,18]nonadeca-1(18),2,4,6-tetraene-9-carboxylate

Conditions
ConditionsYield
In chloroform at 62℃; for 4h; Inert atmosphere; diastereoselective reaction;A 15%
B 78%
vincamin
1617-90-9

vincamin

(-)-18-iodo-criocerine
74947-45-8

(-)-18-iodo-criocerine

Conditions
ConditionsYield
With iodine; sodium hydrogencarbonate In chloroform for 2h; Ambient temperature;77%
With iodine; sodium hydrogencarbonate In chloroform at 20℃;77%
With iodine; sodium hydrogencarbonate In chloroform; water for 6h; Inert atmosphere;77%
vincamin
1617-90-9

vincamin

n-butyl isocyanide
111-36-4

n-butyl isocyanide

(3S,14S,16S)-eburnane-14-spiro-5'-(3'-butyloxazolidine-2',4'-dione)

(3S,14S,16S)-eburnane-14-spiro-5'-(3'-butyloxazolidine-2',4'-dione)

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 80℃; for 4h;75%
vincamin
1617-90-9

vincamin

isopropyl alcohol
67-63-0

isopropyl alcohol

(41S,13aS)-isopropyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

(41S,13aS)-isopropyl 13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate

Conditions
ConditionsYield
With sulfuric acid for 8h; Reflux;74%

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