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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

4-Fluoro-5-hydroxy-2-methylindole Manufacturer/High quality/Best price/In stock

Cas:288385-88-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Fluoro-5-hydroxy-2-methylindole supplier in China

Cas:288385-88-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

Good quality Good price Promptly delivery Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:intermediate Transportation:A

288385-88-64-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 288385-88-6 4-Fluoro-5-hydroxy-2-methylindole Manufacturer

Cas:288385-88-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/973.html Product Name 4-Fluoro-5-hydroxy-2-methylindole CAS No. 288

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 288385-88-6 with competitive price

Cas:288385-88-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

roducts: 4-fluoro-2-methyl-1H-indol-5-ol Cas No.: 288385-88-6 Molecular Formula: C9H8FNO Molecular Weight: 165.16 Assay: 98% HPLC Molecular Structure: Appearance:Whi

4-fluoro-2-methyl-1H-indol-5-ol

Cas:288385-88-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1H-Indol-5-ol,4-fluoro-2-methyl- 288385-88-6

Cas:288385-88-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-Fluoro-5-hydroxy-2-methylindole CAS:288385-88-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qualit

4-Fluoro-5-hydroxy-2-methylindole CAS:288385-88-6

Cas:288385-88-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1H-Indol-5-ol,4-fluoro-2-methyl-

Cas:288385-88-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1H-Indol-5-ol,4-fluoro-2-methyl-

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-fluoro-2-methyl-1H-indol-5-ol

Cas:288385-88-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 4-Fluoro-5-hydroxy-2-methylindole(288385-88-6)

Cas:288385-88-6

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

4-fluoro-2-methyl-1H-indol-5-olAppearance:Detailed see specifications Storage:Store in dry, dark and ventilated Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect

4-fluoro-2-methyl-1H-indol-5-ol

Cas:288385-88-6

Min.Order:1 Gram

Negotiable

Type:Other

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

4-Fluoro-5-hydroxy-2-methylindole Basic information Product Name: 4-Fluoro-5-hydroxy-2-methylindole Synonyms: 4-FLUORO-5-HYDROXY-2-METHYLINDOLE;4-FLUORO-2-METHYL-1H-INDOL-5-OL;2-Methyl-4-fluoro-5-hydroxyindole;4-Fluoro-5-hydroxy-2-methyl-1H-ind

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

1H-Indol-5-ol,4-fluoro-2-methyl-

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Other

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Wuhu Nuowei Chemistry Technologies Co., Ltd.

Wuhu Nuovo Chemical Technology Co., Ltd. was established in August 2014, mainly engaged in the development, production and sales of ionic liquids, ribose, nucleosides, nucleotides and related chemicals; Products are mainly used in new energy, new ma

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:100 Gram

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Fluoro-5-hydroxy-2-methylindole

Cas:288385-88-6

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

4-fluoro-2-methyl-1H-indol-5-ol

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Fluoro-2-methyl-1H-indol-5-ol cas no. 288385-88-6 98%

Cas:288385-88-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

1-(2-fluoro-3-benzyloxy-6-nitrophenyl)-2-methoxypropene

1-(2-fluoro-3-benzyloxy-6-nitrophenyl)-2-methoxypropene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In methanol at 55 - 60℃; under 1500.15 - 2250.23 Torr; for 4h; Autoclave;91.3%
1-(2-fluoro-3-benzyloxy-6-nitrophenyl)-2-ethoxypropene

1-(2-fluoro-3-benzyloxy-6-nitrophenyl)-2-ethoxypropene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen In methanol at 45 - 50℃; under 2250.23 - 3000.3 Torr; for 6h; Autoclave;91%
1-(2-fluoro-3-(4-methoxybenzyloxy)-6-nitrophenyl)-2-methoxypropene

1-(2-fluoro-3-(4-methoxybenzyloxy)-6-nitrophenyl)-2-methoxypropene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With hydrogen In acetonitrile at 50 - 55℃; under 2250.23 - 3000.3 Torr; for 5h; Autoclave;89.7%
1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one
649736-31-2

1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With sodium dithionite In water at 0 - 30℃; for 1h;81%
With sodium dithionite In methanol; water at 20 - 25℃; for 5h; Reissert Indole Synthesis; Large scale;69%
With sodium dithionite; potassium carbonate In water at 25℃; for 2h; Product distribution / selectivity; Industry scale;68%
2-methyl-4-fluoro-5-methoxy-1H-indole
288385-93-3

2-methyl-4-fluoro-5-methoxy-1H-indole

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With boron tribromide In dichloromethane70%
With boron tribromide In dichloromethane70%
With boron tribromide In dichloromethane70%
1-(3-benzyloxy-2-fluoro-6-nitro-phenyl)-propan-2-one
288385-98-8

1-(3-benzyloxy-2-fluoro-6-nitro-phenyl)-propan-2-one

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With ammonium formate; palladium 10% on activated carbon In methanol at 20℃;61%
With acetic acid; palladium on charcoal In ethanol; ethyl acetate30%
With acetic acid; palladium on charcoal In ethanol; ethyl acetate30%
2,3,4-trifluoronitrobenzene
771-69-7

2,3,4-trifluoronitrobenzene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / tetrahydrofuran / 7.75 h / 10 °C / Large scale
1.2: 5.5 h / 10 - 22 °C / Large scale
2.1: sulfuric acid / acetic acid / 6.42 h / 70 °C / Large scale
3.1: potassium carbonate / 18.83 h / 9 - 25 °C / Reflux; Large scale
4.1: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale
5.1: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale
View Scheme
Multi-step reaction with 5 steps
1: sodium hydride / tetrahydrofuran / 12 h / 5 - 20 °C
2: hydrogenchloride; acetic acid / 12 h / Reflux
3: N,N-dimethyl-formamide / 10 h / 100 °C
4: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C
5: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C
View Scheme
2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoic acid ethyl ester
1022112-32-8

2-(2,3-difluoro-6-nitrophenyl)-3-oxobutanoic acid ethyl ester

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid / acetic acid / 6.42 h / 70 °C / Large scale
2: potassium carbonate / 18.83 h / 9 - 25 °C / Reflux; Large scale
3: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale
4: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale
View Scheme
Multi-step reaction with 4 steps
1: hydrogenchloride; acetic acid / 12 h / Reflux
2: N,N-dimethyl-formamide / 10 h / 100 °C
3: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C
4: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C
View Scheme
1-(2,3-difluoro-6-nitrophenyl)propan-2-one
121247-16-3

1-(2,3-difluoro-6-nitrophenyl)propan-2-one

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / 18.83 h / 9 - 25 °C / Reflux; Large scale
2: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale
3: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale
View Scheme
Multi-step reaction with 3 steps
1: N,N-dimethyl-formamide / 10 h / 100 °C
2: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C
3: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C
View Scheme
1-(2-fluoro-3-methoxy-6-nitrophenyl)propan-2-one
288385-99-9

1-(2-fluoro-3-methoxy-6-nitrophenyl)propan-2-one

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aluminum (III) chloride; trimethylamine hydrochloride / dichloromethane / 6.75 h / 22 - 42 °C / 2250.23 Torr / Large scale
2: sodium dithionite / methanol; water / 5 h / 20 - 25 °C / Large scale
View Scheme
C11H10FNO5

C11H10FNO5

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogen; palladium on activated charcoal / N,N-dimethyl-formamide; ethanol / 10 h / 40 °C
2: sodium hydrogencarbonate; water / methanol / 10 h / 20 °C
View Scheme
C11H10FNO2

C11H10FNO2

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
With water; sodium hydrogencarbonate In methanol at 20℃; for 10h;
2-fluoro-3-(4-methoxybenzyloxy)-6-nitrotoluene

2-fluoro-3-(4-methoxybenzyloxy)-6-nitrotoluene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) chloride / tetrahydrofuran / 5 h / 65 - 70 °C
2: hydrogen / acetonitrile / 5 h / 50 - 55 °C / 2250.23 - 3000.3 Torr / Autoclave
View Scheme
2-fluoro-3-bromo-6-nitrotoluene

2-fluoro-3-bromo-6-nitrotoluene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 - 105 °C
2: copper(l) chloride / tetrahydrofuran / 5 h / 65 - 70 °C
3: hydrogen / acetonitrile / 5 h / 50 - 55 °C / 2250.23 - 3000.3 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 105 - 110 °C
2: zinc(II) chloride / tetrahydrofuran / 5 h / 65 - 70 °C
3: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 55 - 60 °C / 1500.15 - 2250.23 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 105 - 110 °C
2: zinc(II) chloride / tetrahydrofuran / 5 h / 75 - 80 °C
3: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 45 - 50 °C / 2250.23 - 3000.3 Torr / Autoclave
View Scheme
2-fluoro-3-benzyloxy-6-nitrotoluene
1229454-43-6

2-fluoro-3-benzyloxy-6-nitrotoluene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: zinc(II) chloride / tetrahydrofuran / 5 h / 65 - 70 °C
2: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 55 - 60 °C / 1500.15 - 2250.23 Torr / Autoclave
View Scheme
2-fluoro-3-iodo-6-nitrotoluene

2-fluoro-3-iodo-6-nitrotoluene

4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 - 95 °C
2: zinc(II) chloride / tetrahydrofuran / 5 h / 65 - 70 °C
3: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 55 - 60 °C / 1500.15 - 2250.23 Torr / Autoclave
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 - 95 °C
2: zinc(II) chloride / tetrahydrofuran / 5 h / 75 - 80 °C
3: 5%-palladium/activated carbon; hydrogen / methanol / 6 h / 45 - 50 °C / 2250.23 - 3000.3 Torr / Autoclave
View Scheme
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

7-benzyloxy-4-chloro-6-methoxyquinazoline
162364-72-9

7-benzyloxy-4-chloro-6-methoxyquinazoline

7-(benzyloxy)-4-[(4-fluoro-2-methyl-1H-indol-5-yl)-oxy]-6-methoxyquinazoline
574745-75-8

7-(benzyloxy)-4-[(4-fluoro-2-methyl-1H-indol-5-yl)-oxy]-6-methoxyquinazoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 85℃; Inert atmosphere;100%
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;75%
With caesium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 16h; Inert atmosphere;53%
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With sodium hydroxide In water; acetonitrile at 0℃; for 0.25h; Industry scale;
Stage #2: 7-benzyloxy-4-chloro-6-methoxyquinazoline In 1-methyl-pyrrolidin-2-one; water; acetonitrile at 80℃; for 4.75h; Industry scale;
With potassium carbonate In N,N-dimethyl acetamide at 90℃; for 2h; Solvent; Temperature; Reagent/catalyst; Inert atmosphere;
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4,6-dichloro-5-cyanopyrimidine
5305-45-3

4,6-dichloro-5-cyanopyrimidine

4-chloro-6-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)pyrimidine-5-carbonitrile

4-chloro-6-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)pyrimidine-5-carbonitrile

Conditions
ConditionsYield
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With potassium carbonate In N,N-dimethyl-formamide; acetonitrile at 20℃; for 1h; Inert atmosphere;
Stage #2: 4,6-dichloro-5-cyanopyrimidine In N,N-dimethyl-formamide; acetonitrile at 20℃; for 1h; Inert atmosphere;
99%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yl pivalate
952490-01-6

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yl pivalate

Conditions
ConditionsYield
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 20 - 29℃; for 1.16667h; Large scale;
Stage #2: 4-chloro-5-methylpyrrolo[1,2-f ][1,2,4]triazin-6-yl pivalate In acetonitrile at 26 - 28℃; for 3h; Large scale;
96.2%
With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 20 - 50℃; for 1.67 - 19h; Product distribution / selectivity;
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine
649736-27-6

6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine

Conditions
ConditionsYield
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With sodium hydride In DMF (N,N-dimethyl-formamide) at -20 - 0℃; for 0.5h;
Stage #2: 6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine In DMF (N,N-dimethyl-formamide) at 20℃; for 0.5h;
95%
Stage #1: 4-fluoro-2-methyl-1H-indol-5-ol With sodium hydride In N,N-dimethyl-formamide at -78 - 20℃;
Stage #2: 6-(benzyloxy)-4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine In N,N-dimethyl-formamide at 20℃; for 1h;
4-fluoro-2-methyl-1H-indol-5-ol

4-fluoro-2-methyl-1H-indol-5-ol

4-amino-6-chloro-pyrimidine-5-carbaldehyde
14160-93-1

4-amino-6-chloro-pyrimidine-5-carbaldehyde

4-amino-6-(4-fluoro-2-methyl-1H-indol-5-yloxy)-pyrimidine-5-carbaldehyde
951152-69-5

4-amino-6-(4-fluoro-2-methyl-1H-indol-5-yloxy)-pyrimidine-5-carbaldehyde

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 20℃; for 2h;94%
With caesium carbonate In dimethyl sulfoxide
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine
1609119-39-2

6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine

6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)pyrimidin-4-amine
1609119-41-6

6-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)pyrimidin-4-amine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 50℃;85%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

C9(13)C3H14ClN(15)N2O2
1316667-91-0

C9(13)C3H14ClN(15)N2O2

C18(13)C3H21FN2(15)N2O3
1316667-95-4

C18(13)C3H21FN2(15)N2O3

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In acetonitrile at 48℃; for 1.5h; Inert atmosphere;82%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
199327-69-0

4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline

cediranib

cediranib

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 70 - 75℃; for 5.5h; Inert atmosphere;80%
With potassium carbonate In N,N-dimethyl-formamide Heating;55.2 g
With potassium carbonate In N,N-dimethyl-formamide Heating;30.09 g
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline
398487-42-8

4-chloro-6-cyano-7-(3-(pyrrolidin-1-yl)propoxy)quinoline

6-cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-(3-(pyrrolidin-1-yl)propoxy)quinoline
398487-43-9

6-cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-(3-(pyrrolidin-1-yl)propoxy)quinoline

Conditions
ConditionsYield
With caesium carbonate In methanol; dichloromethane; N,N-dimethyl-formamide79%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4,6-dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3

4,6-dichloro-2-(methylsulfonyl)pyrimidine

5-((4,6-dichloropyrimidin-2-yl)oxy)-4-fluoro-2-methyl-1H-indole
1609119-40-5

5-((4,6-dichloropyrimidin-2-yl)oxy)-4-fluoro-2-methyl-1H-indole

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at -70 - 20℃;79%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

6,7-dimethoxy-4-chloroquinazoline
13790-39-1

6,7-dimethoxy-4-chloroquinazoline

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6,7-dimethoxyquinazoline
1622317-21-8

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6,7-dimethoxyquinazoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 24h;78%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

tert-butyl (3-((4-chloro-3-cyano-6-methoxyquinolin-7-yloxy)methyl)cyclobutyl)carbamate

tert-butyl (3-((4-chloro-3-cyano-6-methoxyquinolin-7-yloxy)methyl)cyclobutyl)carbamate

tert-butyl (3-((3-cyano-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclobutyl)carbamate

tert-butyl (3-((3-cyano-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclobutyl)carbamate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 100℃;76%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

Ethyl 6-(7-(benzyloxy)-4-chloroquinazolin-6-yloxy)hexanoate
1133461-71-8

Ethyl 6-(7-(benzyloxy)-4-chloroquinazolin-6-yloxy)hexanoate

Ethyl 6-(7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)quinazolin-6-yloxy)-hexanoate
1133461-74-1

Ethyl 6-(7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)quinazolin-6-yloxy)-hexanoate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 24h;71%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

trifluoromethylsulfonic anhydride
358-23-6

trifluoromethylsulfonic anhydride

trifluoro-methanesulfonic acid 4-fluoro-2-methyl-1H-indol-5-yl ester
1401727-01-2

trifluoro-methanesulfonic acid 4-fluoro-2-methyl-1H-indol-5-yl ester

Conditions
ConditionsYield
With 2,6-dimethylpyridine In dichloromethane at 20℃;70%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

6-chloro-N-(5-propenyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine
1609119-44-9

6-chloro-N-(5-propenyl-1H-pyrazol-3-yl)-2-(methylsulfonyl)pyrimidin-4-amine

(E)-6-chloro-2-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-N-(5-(prop-1-en-1-yl)-1H-pyrazol-3-yl)pyrimidin-4-amine
1609119-45-0

(E)-6-chloro-2-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-N-(5-(prop-1-en-1-yl)-1H-pyrazol-3-yl)pyrimidin-4-amine

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 55℃; for 16h;64%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

1-(3-azidobut-1-yn-1-yl)-4-fluorobenzene

1-(3-azidobut-1-yn-1-yl)-4-fluorobenzene

C19H16F2N4O

C19H16F2N4O

Conditions
ConditionsYield
With silver trifluoromethanesulfonate In acetonitrile at 60℃; for 24h;64%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate
832113-96-9

methyl 4-chloro-5-methylthieno[2,3-d]pyrimidine-6-carboxylate

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 95℃; for 0.75h;45%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4-chloro-5-((3,3-difluoro-1-methylpiperidin-4-yl)oxy)-7-methoxyquinazoline

4-chloro-5-((3,3-difluoro-1-methylpiperidin-4-yl)oxy)-7-methoxyquinazoline

5-((3,3-difluoro-1-methylpiperidin-4-yl)oxy)-4-((4-fluoro-2-methyl-1H-indole- 5-yl)oxy)-7-methoxyquinazoline

5-((3,3-difluoro-1-methylpiperidin-4-yl)oxy)-4-((4-fluoro-2-methyl-1H-indole- 5-yl)oxy)-7-methoxyquinazoline

Conditions
ConditionsYield
With caesium carbonate In acetonitrile at 70℃; for 1h; Inert atmosphere;45%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

1-chloro-4-(pyridin-4-yl-methyl)-phthalazine
101094-85-3

1-chloro-4-(pyridin-4-yl-methyl)-phthalazine

1-(4-fluoro-2-methylindol-5-yloxy)-4-(pyridin-4-ylmethyl)phthalazine
397842-88-5

1-(4-fluoro-2-methylindol-5-yloxy)-4-(pyridin-4-ylmethyl)phthalazine

Conditions
ConditionsYield
With caesium carbonate In dichloromethane; ethyl acetate; N,N-dimethyl-formamide41%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

7-(benzyloxy)-4-chloro-6-methoxycinnoline
398127-72-5

7-(benzyloxy)-4-chloro-6-methoxycinnoline

7-benzyloxy-4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxycinnoline
398127-73-6

7-benzyloxy-4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxycinnoline

Conditions
ConditionsYield
With caesium carbonate In dichloromethane; ethyl acetate; N,N-dimethyl-formamide39%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline
398127-69-0

4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline

4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline
398127-70-3

4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)cinnoline

Conditions
ConditionsYield
With caesium carbonate In methanol; 2,4-dichlorophenoxyacetic acid dimethylamine; pentane38%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

7-methoxy-6-cyano-4-chloro-quinoline
398487-31-5

7-methoxy-6-cyano-4-chloro-quinoline

6-cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-methoxyquinoline
398487-52-0

6-cyano-4-(4-fluoro-2-methylindol-5-yloxy)-7-methoxyquinoline

Conditions
ConditionsYield
With caesium carbonate In methanol; ethyl acetate; N,N-dimethyl-formamide35%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinoline
1210828-43-5

7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 16h; Inert atmosphere;27%
With dmap In 1,4-dioxane for 72h; Reflux;
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

4-(4-fluoro-2-methylindol-5-yloxy)thieno[3,2-d]pyrimidine
397842-86-3

4-(4-fluoro-2-methylindol-5-yloxy)thieno[3,2-d]pyrimidine

Conditions
ConditionsYield
7%

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