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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product s

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply 7-Benzyloxy-4-chloro-6-methoxy-quinoline CAS 286371-49-1 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical &

Manufacturer supply 7-Benzyloxy-4-chloro-6-methoxy-quinoline CAS 286371-49-1 with attractive price

Cas:286371-49-1

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% 286371-49-1 7-Benzyloxy-4-chloro-6-methoxy-quinoline Manufacturer

Cas:286371-49-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences,

7-(benzyloxy)-4-chloro-6-methoxyquinoline,Manufacturer/High quality/Best price/In stock

Cas:286371-49-1

Min.Order:1 Gram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 286371-49-1 with competitive price

Cas:286371-49-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be

7-Benzyloxy-4-chloro-6-methoxy-quinoline CAS:286371-49-1

Cas:286371-49-1

Min.Order:1 Kilogram

FOB Price: $30.0 / 40.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

7-Benzyloxy-4-chloro-6-methoxy-quinoline CAS:286371-49-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in hig

7-Benzyloxy-4-chloro-6-methoxy-quinoline CAS:286371-49-1

Cas:286371-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:286371-49-1

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Triumph International Development Limilted

Product name: sodium metabisulfite / sodium metabisulphite Molecular weight: 190.10 Specification: 25Kg woven bag Quality guarantee period: 6 months Appearance:white powder Storage:kept in a cool, dry and ventilated place Package:C

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:10 Gram

FOB Price: $1.0 / 10.0

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 7-Benzyloxy-4-chloro-6-methoxy-quinoline(286371-49-1)

Cas:286371-49-1

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Intermediate 7-(Benzyloxy)-4-chloro-6-methoxyquinoline Powder CAS 286371-49-1

Cas:286371-49-1

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 7-Benzyloxy-4-Chloro-6-Methoxy-Quinoline CAS No.: 286371-49-1 Molecule Formula:C17H14ClNO2 Molecule Weight:299.75 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard T

Lower Price 7-Benzyloxy-4-Chloro-6-Methoxy-Quinoline on stock

Cas:286371-49-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

High purity 7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

7-Benzyloxy-4-chloro-6-methoxy-quinoline Chemical Properties Boiling point 434.8±40.0 °C(Predicted) density 1.262 storage temp. Inert atmosphere,2-8°C pka 3.92±0.30(Predicted)

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

7-Benzyloxy-4-chloro-6-methoxyquinoline

Cas:286371-49-1

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Trading Company

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

286371-49-1 CAS NO.286371-49-1

Cas:286371-49-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

7-(Benzyloxy)-4-chloro-6-methoxyquinoline

Cas:286371-49-1

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Chloro-6-methoxy-7-phenylmethoxyquinoline cas no. 286371-49-1 98%

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Chloro-6-methoxy-7-(phenylmethoxy)-quinoline

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

with high qualityAppearance:white powder Storage:Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Package:25kg/drum Application:as intermediates Transportation:by courier, air or sea Port:At any port from China

7-Benzyloxy-4-chloro-6-methoxy-quinoline 286371-49-1 with best price

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hangzhou Dingyan Chem Co., Ltd

high purity, manufacturer Application:Intermediate

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

Low price and high quality Appearance:White powder Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediates Transportation:shipping,

7-Benzyloxy-4-chloro-6-methoxy-quinoline/manufacturer

Cas:286371-49-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city?in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api,?intermediat

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

7-Benzyloxy-4-chloro-6-methoxy-quinoline

Cas:286371-49-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

4-hydroxy-6-methoxy-7-benzyloxyquinoline
205448-29-9, 849217-23-8

4-hydroxy-6-methoxy-7-benzyloxyquinoline

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Stage #1: 7-benzyloxy-4-hydroxy-6-methoxyquinoline With trichlorophosphate for 2h; Heating / reflux;
Stage #2: With sodium hydrogencarbonate; sodium carbonate In water at 20℃; pH=8;
95%
With trichlorophosphate for 2h; Heating / reflux;95%
With trichlorophosphate In toluene at 120℃; for 1.5h;90%
4-chloro-6-methoxy-7-hydroxyquinoline
205448-31-3

4-chloro-6-methoxy-7-hydroxyquinoline

benzyl bromide
100-39-0

benzyl bromide

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 45℃; for 2h;95%
6-methoxy-7-benzyloxy-4(1H)-quinolinone
205448-29-9, 849217-23-8

6-methoxy-7-benzyloxy-4(1H)-quinolinone

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Stage #1: 6-methoxy-7-benzyloxy-4(1H)-quinolinone With trichlorophosphate at 110℃; for 3h;
Stage #2: With sodium carbonate In chloroform; water Cooling with ice;
94%
With sodium hydroxide; trichlorophosphate In chloroform21%
With trichlorophosphate In acetonitrile for 6h; Reflux;174.8 g
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone
75665-73-5

1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C
1.2: 8 h
2.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere
1.2: Inert atmosphere
2.1: trichlorophosphate / 10 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h
1.2: 15 h / 20 °C
2.1: trichlorophosphate / 4.33 h / Cooling with ice; Reflux
View Scheme
benzyl bromide
100-39-0

benzyl bromide

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C
2.1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8
3.1: ammonium formate; iron / toluene; water / 103 °C
4.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C
4.2: 8 h
5.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2.1: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C
3.1: iron; ammonium acetate / toluene; water / 105 °C
4.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere
4.2: Inert atmosphere
5.1: trichlorophosphate / 10 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 4 h / 20 °C
2.1: nitric acid / dichloromethane / 2 h / -20 - -10 °C
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux
4.1: iron; acetic acid / 2 h / 60 - 90 °C
5.1: trichlorophosphate / acetonitrile / 6 h / Reflux
View Scheme
4-benzyloxy-3-methoxyacetophenone
1835-11-6

4-benzyloxy-3-methoxyacetophenone

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8
2.1: ammonium formate; iron / toluene; water / 103 °C
3.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C
3.2: 8 h
4.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C
2.1: iron; ammonium acetate / toluene; water / 105 °C
3.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere
3.2: Inert atmosphere
4.1: trichlorophosphate / 10 h / Reflux
View Scheme
Multi-step reaction with 4 steps
1: nitric acid / dichloromethane / 2 h / -20 - -10 °C
2: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux
3: iron; acetic acid / 2 h / 60 - 90 °C
4: trichlorophosphate / acetonitrile / 6 h / Reflux
View Scheme
1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone
75665-88-2

1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ammonium formate; iron / toluene; water / 103 °C
2.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C
2.2: 8 h
3.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1.1: iron; ammonium acetate / toluene; water / 105 °C
2.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere
2.2: Inert atmosphere
3.1: trichlorophosphate / 10 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux
2: iron; acetic acid / 2 h / 60 - 90 °C
3: trichlorophosphate / acetonitrile / 6 h / Reflux
View Scheme
1-(3-methoxy-4-hydroxyphenyl)ethanone
498-02-2

1-(3-methoxy-4-hydroxyphenyl)ethanone

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C
2.1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8
3.1: ammonium formate; iron / toluene; water / 103 °C
4.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C
4.2: 8 h
5.1: trichlorophosphate / toluene / 2 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2.1: nitric acid; sulfuric acid / dichloromethane / 2.25 h / 0 °C
3.1: iron; ammonium acetate / toluene; water / 105 °C
4.1: sodium methylate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere
4.2: Inert atmosphere
5.1: trichlorophosphate / 10 h / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 4 h / 20 °C
2.1: nitric acid / dichloromethane / 2 h / -20 - -10 °C
3.1: 5,5-dimethyl-1,3-cyclohexadiene / 15 h / Reflux
4.1: iron; acetic acid / 2 h / 60 - 90 °C
5.1: trichlorophosphate / acetonitrile / 6 h / Reflux
View Scheme
5-{[(3-(benzyloxy)-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6- dione
205448-28-8

5-{[(3-(benzyloxy)-4-methoxyphenyl)amino]methylene}-2,2-dimethyl-1,3-dioxane-4,6- dione

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: biphenyl / diphenylether / 1 h / 220 °C / Inert atmosphere
2: trichlorophosphate / 5 h / Inert atmosphere; Reflux
View Scheme
Multi-step reaction with 2 steps
1: 1,2-dichloro-benzene / 7 h / 180 °C
2: trichlorophosphate / toluene / 1.5 h / 120 °C
View Scheme
Multi-step reaction with 2 steps
1: 1,2-dichloro-benzene / 7 h / 180 °C
2: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 100 °C
View Scheme
1-[2-nitro-4-benzyloxy-5-methoxyphenyl]-3-(dimethylamino)prop-2-en-1-one

1-[2-nitro-4-benzyloxy-5-methoxyphenyl]-3-(dimethylamino)prop-2-en-1-one

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: iron; acetic acid / 2 h / 60 - 90 °C
2: trichlorophosphate / acetonitrile / 6 h / Reflux
View Scheme
2-(benzyloxy)-1-methoxy-4-nitrobenzene
75167-86-1

2-(benzyloxy)-1-methoxy-4-nitrobenzene

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ammonium chloride; iron / ethanol; water / 1 h / 20 °C / Reflux
2: ethanol / 1 h / Reflux
3: 1,2-dichloro-benzene / 7 h / 180 °C
4: trichlorophosphate / toluene / 1.5 h / 120 °C
View Scheme
Multi-step reaction with 4 steps
1: iron / ethanol; water / Reflux
2: ethanol / 1 h / 80 °C
3: 1,2-dichloro-benzene / 7 h / 180 °C
4: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 100 °C
View Scheme
3-benzyloxy-4-methoxybenzeneamine
61324-40-1

3-benzyloxy-4-methoxybenzeneamine

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 1 h / Reflux
2: 1,2-dichloro-benzene / 7 h / 180 °C
3: trichlorophosphate / toluene / 1.5 h / 120 °C
View Scheme
Multi-step reaction with 3 steps
1: ethanol / 1 h / 80 °C
2: 1,2-dichloro-benzene / 7 h / 180 °C
3: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 100 °C
View Scheme
5-nitroguaiacol
636-93-1

5-nitroguaiacol

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 40 °C
2: ammonium chloride; iron / ethanol; water / 1 h / 20 °C / Reflux
3: ethanol / 1 h / Reflux
4: 1,2-dichloro-benzene / 7 h / 180 °C
5: trichlorophosphate / toluene / 1.5 h / 120 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C
2: iron / ethanol; water / Reflux
3: ethanol / 1 h / 80 °C
4: 1,2-dichloro-benzene / 7 h / 180 °C
5: trichlorophosphate / N,N-dimethyl-formamide / 1 h / 100 °C
View Scheme
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

4-chloro-6-methoxy-7-hydroxyquinoline
205448-31-3

4-chloro-6-methoxy-7-hydroxyquinoline

Conditions
ConditionsYield
With methanesulfonic acid; trifluoroacetic acid for 3h; Reflux; Inert atmosphere;100%
Stage #1: 7-(benzyloxy)-4-chloro-6-methoxyquinoline With methanesulfonic acid; trifluoroacetic acid for 3h; Reflux;
Stage #2: With sodium hydroxide for 2h; pH=7;
100%
With trifluoroacetic acid at 75℃; for 6h;95.4%
With hydrogen bromide; acetic acid In water at 80℃; for 3h;80%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

4-Amino-3-chlorophenol hydrochloride
52671-64-4

4-Amino-3-chlorophenol hydrochloride

4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-chloroaniline
286371-53-7

4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2-chloroaniline

Conditions
ConditionsYield
With sodium hydride; potassium carbonate In N,N-dimethyl-formamide; mineral oil at 100℃; for 2h; Inert atmosphere;98%
With dimethyl sulfoxide In methanol; water66%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline
516526-32-2

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline

Conditions
ConditionsYield
Stage #1: 4-amino-phenol With sodium methylate In methanol; ISOPROPYLAMIDE at 20℃; for 1h;
Stage #2: 7-(benzyloxy)-4-chloro-6-methoxyquinoline In ISOPROPYLAMIDE at 120℃; for 22h;
96%
Multi-step reaction with 2 steps
1.1: 1-methyl-pyrrolidin-2-one / 2 h / 150 °C
2.1: hydrogenchloride; methanol; water / 6 h / Heating / reflux
2.2: pH 12
View Scheme
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / 5,5-dimethyl-1,3-cyclohexadiene / 140 °C / Inert atmosphere
2: iron; ammonium chloride / ethanol; water / 2 h / 90 °C / Inert atmosphere
View Scheme
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

2-fluoro-4-nitrophenol
403-19-0

2-fluoro-4-nitrophenol

7-benzyloxy-4-(2-fluoro-4-nitro-phenoxy)-6-methyloxyquinoline
479690-03-4

7-benzyloxy-4-(2-fluoro-4-nitro-phenoxy)-6-methyloxyquinoline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In chlorobenzene at 140℃; for 18h;92%
With N-ethyl-N,N-diisopropylamine In chlorobenzene for 48h; Reflux;82%
With N-ethyl-N,N-diisopropylamine In 5,5-dimethyl-1,3-cyclohexadiene at 140℃;81%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

ethyl 1-[(3-fluoro-4-hydroxyphenyl)carbamoyl]cyclopropane-1-carboxylate

ethyl 1-[(3-fluoro-4-hydroxyphenyl)carbamoyl]cyclopropane-1-carboxylate

ethyl 1-[[3-fluoro-4-[[6-methoxy-7-benzyloxyquinolin-4-yl]oxy]phenyl]carbamoyl]cyclopropane-1-carboxylate

ethyl 1-[[3-fluoro-4-[[6-methoxy-7-benzyloxyquinolin-4-yl]oxy]phenyl]carbamoyl]cyclopropane-1-carboxylate

Conditions
ConditionsYield
With dmap at 160℃; for 4h;90.5%
4-nitro-phenol
100-02-7

4-nitro-phenol

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

7-(benzyloxy)-6-methoxy-4-(4-nitrophenoxy)quinoline
417725-03-2

7-(benzyloxy)-6-methoxy-4-(4-nitrophenoxy)quinoline

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In xylene for 12h; Reflux;84.3%
In chlorobenzene for 16h; Reflux;62.4%
In chlorobenzene for 20h; Reflux;201.8 g
1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one
649736-31-2

1-(2-fluoro-3-hydroxy-6-nitrophenyl)propan-2-one

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one
1210828-42-4

1-(3-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-2-fluoro-6-nitrophenyl)propan-2-one

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In 1-methyl-pyrrolidin-2-one at 100℃;84%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

3-fluoro-4-nitrophenol
394-41-2

3-fluoro-4-nitrophenol

7-(benzyloxy)-4-(3-fluoro-4-nitrophenoxy)-6-methoxyquinoline
286371-58-2

7-(benzyloxy)-4-(3-fluoro-4-nitrophenoxy)-6-methoxyquinoline

Conditions
ConditionsYield
In chlorobenzene at 120℃; for 21h;82%
Stage #1: 7-(benzyloxy)-4-chloro-6-methoxyquinoline; 3-fluoro-4-nitrophenol In chlorobenzene at 120℃; for 21h;
Stage #2: With sodium hydroxide In chloroform; water; chlorobenzene at 20℃;
82%
With N-ethyl-N,N-diisopropylamine In chlorobenzene at 140℃; for 15h;50%
With sodium hydroxide In chloroform; chlorobenzene47%
In chlorobenzene for 16h; Reflux;
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

methyl-phenyl-thioether
100-68-5

methyl-phenyl-thioether

4-chloro-6-methoxy-7-hydroxyquinoline
205448-31-3

4-chloro-6-methoxy-7-hydroxyquinoline

Conditions
ConditionsYield
With sodium hydroxide; methanesulfonic acid In hexane; trifluorormethanesulfonic acid75%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

4-amino-2-fluorophenol
399-96-2

4-amino-2-fluorophenol

4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorobenzenamine
479690-04-5

4-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorobenzenamine

Conditions
ConditionsYield
Stage #1: 4-amino-2-fluorophenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 7-(benzyloxy)-4-chloro-6-methoxyquinoline In N,N-dimethyl-formamide; mineral oil at 100℃; for 30h;
73%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

N-(3-fluoro-4-hydroxyphenyl)-N'-(2-phenylethyl)ethanediamide
849217-56-7

N-(3-fluoro-4-hydroxyphenyl)-N'-(2-phenylethyl)ethanediamide

N-{4-[(7-benzyloxy-6-methoxyquinolin-4-yl)oxy]-3-fluorophenyl}-N'-(2-phenylethyl)ethanediamide

N-{4-[(7-benzyloxy-6-methoxyquinolin-4-yl)oxy]-3-fluorophenyl}-N'-(2-phenylethyl)ethanediamide

Conditions
ConditionsYield
With dmap; bromobenzene for 6h; Heating / reflux;61%
With dmap In bromobenzene for 6h; Heating / reflux;61%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

7-(benzyloxy)-6-methoxy-4-((4-nitrophenyl)thio)quinoline

7-(benzyloxy)-6-methoxy-4-((4-nitrophenyl)thio)quinoline

Conditions
ConditionsYield
In chlorobenzene for 16h; Reflux;60.1%
6-hydroxy-N-methyl-1-naphthalenecarboxamide
847802-91-9

6-hydroxy-N-methyl-1-naphthalenecarboxamide

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

6-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide
1058137-70-4

6-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide

Conditions
ConditionsYield
With copper(l) iodide; caesium carbonate In N,N-dimethyl-formamide; acetylacetone at 120℃; for 24h; Reagent/catalyst; Solvent; Temperature; Time; Concentration;58%
With dmap In 1,4-dioxane for 72h; Product distribution / selectivity; Heating / reflux;
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

meta-nitrophenol
554-84-7

meta-nitrophenol

C23H18N2O5

C23H18N2O5

Conditions
ConditionsYield
In chlorobenzene for 16h; Reflux;52.4%
In chlorobenzene for 18h; Reflux;
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

2,5-dimethyl-4-amino phenol
3096-71-7

2,5-dimethyl-4-amino phenol

4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2,5-dimethylaniline
286371-50-4

4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2,5-dimethylaniline

Conditions
ConditionsYield
With dimethyl sulfoxide In methanol; water52%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

4-amino-2,3-dimethylphenol
3096-69-3

4-amino-2,3-dimethylphenol

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2,3-dimethylaniline
286371-56-0

4-{[7-(Benzyloxy)-6-methoxy-4-quinolyl]oxy}-2,3-dimethylaniline

Conditions
ConditionsYield
With dimethyl sulfoxide49%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

2-phenyl-[1,8]naphthyridin-3-ol
666735-37-1

2-phenyl-[1,8]naphthyridin-3-ol

3-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-2-phenyl-[1,8]naphthyridine

3-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-2-phenyl-[1,8]naphthyridine

Conditions
ConditionsYield
With dmap In 1,2-dichloro-benzene at 140℃; for 20h;42%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ol hydrochloride
1149370-96-6

3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ol hydrochloride

7-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3,4-dihydro-2H-benzo[b][1,4]oxazine
1149370-97-7

7-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-3,4-dihydro-2H-benzo[b][1,4]oxazine

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 109h;40.5%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

thiophene-2-carboxylic acid (4-hydroxy-phenyl)-amide
98902-53-5

thiophene-2-carboxylic acid (4-hydroxy-phenyl)-amide

thiophene-2-carboxylic acid [4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-amide
914490-48-5

thiophene-2-carboxylic acid [4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-amide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 140℃; for 5h;36%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

p-benzoylaminophenol
15457-50-8

p-benzoylaminophenol

N-[4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-benzamide
914200-89-8

N-[4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-benzamide

Conditions
ConditionsYield
at 140℃; for 3h;32%
at 140℃; for 3h; Product distribution / selectivity;32%
at 140℃; for 3h;32%
In N,N-dimethyl-formamide at 145℃; for 7h; Product distribution / selectivity;28%
4-fluoro-2-methyl-1H-indol-5-ol
288385-88-6

4-fluoro-2-methyl-1H-indol-5-ol

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinoline
1210828-43-5

7-(benzyloxy)-4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 20 - 100℃; for 16h; Inert atmosphere;27%
With dmap In 1,4-dioxane for 72h; Reflux;
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

2-(4-hydroxyphenyl)-1-phenylethan-1-one
6420-90-2

2-(4-hydroxyphenyl)-1-phenylethan-1-one

2-[4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-1-phenyl-ethanone
914490-65-6

2-[4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-1-phenyl-ethanone

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 145℃; for 5h;21%
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

sodium 4-aminophenolate
15267-98-8

sodium 4-aminophenolate

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline
516526-32-2

4-(7-benzyloxy-6-methoxyquinolin-4-yloxy)aniline

Conditions
ConditionsYield
In ISOPROPYLAMIDE at 120℃; for 22h;
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

4-acetaminophenol
103-90-2

4-acetaminophenol

N-[4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-acetamide
914490-52-1

N-[4-(7-benzyloxy-6-methoxy-quinolin-4-yloxy)-phenyl]-acetamide

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 150℃; for 2h;
7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

6-hydroxy-1-naphthoic acid
2437-17-4

6-hydroxy-1-naphthoic acid

6-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-1-naphthoic acid
1044676-75-6

6-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-1-naphthoic acid

Conditions
ConditionsYield
With potassium hydroxide In dimethyl sulfoxide at 130℃; for 5h;
indol-5-ol
1953-54-4

indol-5-ol

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

C25H20N2O3
1058157-84-8

C25H20N2O3

Conditions
ConditionsYield
With dmap In 1,4-dioxane for 72h; Heating / reflux;
5-amino-1H-indole
5192-03-0

5-amino-1H-indole

7-(benzyloxy)-4-chloro-6-methoxyquinoline
286371-49-1

7-(benzyloxy)-4-chloro-6-methoxyquinoline

4-(1H-indol-5-ylamino)-7-benzyloxy-6-methoxy-quinoline
1058157-22-4

4-(1H-indol-5-ylamino)-7-benzyloxy-6-methoxy-quinoline

Conditions
ConditionsYield
In isopropyl alcohol for 1h; Heating / reflux;

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