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AstaTech ( Chengdu) BioPharmaceutical Corp.

Chengdu AstaTech Chemical Technology Co., Ltd. is a wholly-owned subsidiary of AstaTech (Chengdu) BioPharmaceutical Co., Ltd. It has overall accountability for AstaTech’s product list and sales and promotion of chemical reagents in China. The c

289686-70-0

Cas:289686-70-0

Min.Order:1 Metric Ton

Negotiable

Type:Trading Company

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Chemvon Biotechnology Co. Ltd.

CAS:289686-70-0 molecular formula:C12H10F6O2 molecular weight :300.2

2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propanoic acid

Cas:289686-70-0

Min.Order:0 Metric Ton

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Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White to off-white powder Conforms Identification HPLC

High purity Various Specifications 2-(3,5-Bis-trifluoromethyl-phenyl)-2-methyl-propionic acid CAS:289686-70-0

Cas:289686-70-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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GIHI CHEMICALS CO.,LIMITED

GIHI CHEMICALS exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, GIHI CHEMICALS is your best choice. pls contact with us freely for getting detailed produc

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:1 Kilogram

FOB Price: $5.0

Type:Lab/Research institutions

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Hangzhou Think Chemical Co. Ltd

2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropionic acid CAS No.:289686-70-0 Name: 2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropionic acid Molecular Structure Molecular Formula: C12H10F6O2

High purity 2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropionic acid CAS No.:289686-70-0

Cas:289686-70-0

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

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Henan Allgreen Chemical Co.,Ltd

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid Basic information Product Name: 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid Synonyms: 2-(3

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:1 Gram

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Type:Manufacturers

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem’s R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. Near 20 years DayangChem has provided dif

2-(3,5-bis-(Trifluoromethyl)phenyl)-2-methylpropanoic acid

Cas:289686-70-0

Min.Order:1 Gram

FOB Price: $4.0 / 5.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoic acid CAS NO.289686-70-0

Cas:289686-70-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-(3,5-Bis-trifluoromethyl-phenyl)-2-methyl-propionic acid

Cas:289686-70-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

TIANFU-CHEM 289686-70-0

Cas:289686-70-0

Min.Order:1 Kilogram

FOB Price: $1300.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 289686-70-0 with best quality

Cas:289686-70-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid CAS 289686-70-0 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure tech

2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid CAS 289686-70-0

Cas:289686-70-0

Min.Order:1 Gram

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Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:0

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Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoic acid

Cas:289686-70-0

Min.Order:0

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Type:Manufacturers

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS289686-70-0 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:1 Kilogram

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Type:Lab/Research institutions

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Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

2-【3,5-BIS-TRIFLUOROMETHYL-PHENYL]-2-METHYL-PROPIONIC ACID

Cas:289686-70-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:0

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Type:Lab/Research institutions

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropanoic acid

Cas:289686-70-0

Min.Order:100 Gram

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Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropionic acid

Cas:289686-70-0

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoic acid cas no.:289686-70-0 CAS NO.289686-70-0Appearance:off-white to almost white powder Storage:Store in Cool and dry .place, keep away from incompatible substances Package:according to customers' r

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid Chemical Properties Melting point 105.5-107℃ Boiling point 232.5±35.0 °C(Predicted) density 1.378±0.06 g/cm3(Predicted) storage temp. Sealed in dry,Room Temp

2-(3,5-Bis-trifluoromethyl-phenyl)- 2-methyl-propionic acid

Cas:289686-70-0

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service an

2-(3,5-Bis-trifluoromethyl-phenyl)-2-methyl-propionic acid

Cas:289686-70-0

Min.Order:1 Gram

Negotiable

Type:Other

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SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propanoic acid /Manufacturer in China

Cas:289686-70-0

Min.Order:0 Metric Ton

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Type:Lab/Research institutions

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2-(3,5-Bis(trifluoromethyl)phenyl)-2-methylpropionic acid

Cas:289686-70-0

Min.Order:0

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Type:Lab/Research institutions

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CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic and fermentation pharmaceutical products. The organizational s

2-(3,5-Bis-trifluoromethyl-phenyl)-2-methyl-propionic acid 289686-70-0 manufacturer/high quality/in stock

Cas:289686-70-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Hysen Pharma co.,Ltd.

Hangzhou Hysen pharma CO.,LTD. is a professional Pharmaceutical company. We are specialized in manufacturing and R&D of API & Intermediates, Contract Manufacturing, Contract Research, and International Trading business as well. *We ow

2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid

Cas:289686-70-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Win-Win chemical Co.Ltd

Stock products, own laboratoryAppearance:White powder Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propanoic acid cas no. 289686-70-0 98%

Cas:289686-70-0

Min.Order:0

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Type:Lab/Research institutions

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Synthetic route

methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate
334477-48-4

methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
Stage #1: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate With lithium hydroxide; water In tetrahydrofuran; methanol at 20℃; for 72h;
Stage #2: With hydrogenchloride In water
100%
With lithium hydroxide; water In tetrahydrofuran; methanol at 20℃; for 72h;100%
With water; sodium hydroxide In methanol at 100℃; for 7h; Time; Temperature; Inert atmosphere;90%
carbon monoxide
201230-82-2

carbon monoxide

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol
67570-38-1

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
With trifluorormethanesulfonic acid In dichloromethane; water at 20℃; under 22501.8 Torr; for 2h;97%
3,5-bistrifluoromethylphenyl acetic acid
85068-33-3

3,5-bistrifluoromethylphenyl acetic acid

methyl iodide
74-88-4

methyl iodide

A

2-methyl-2-(4-methyl-3,5-bis-trifluoromethyl-phenyl)-propionic acid

2-methyl-2-(4-methyl-3,5-bis-trifluoromethyl-phenyl)-propionic acid

B

(RS)-α-Methyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-73-3

(RS)-α-Methyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

C

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
Stage #1: 3,5-bistrifluoromethylphenyl acetic acid With n-butyllithium
Stage #2: methyl iodide
A n/a
B n/a
C 91%
2-(3,5-bis-trifluoromethylphenyl)-2-methyl propionitrile

2-(3,5-bis-trifluoromethylphenyl)-2-methyl propionitrile

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
With sulfuric acid In water for 4h; Time; Reflux;87%
With potassium hydroxide In 5,5-dimethyl-1,3-cyclohexadiene; ethylene glycol at 135℃; for 12h; Autoclave; Large scale;80%
Stage #1: 2-(3,5-bis-trifluoromethylphenyl)-2-methyl propionitrile With sodium hydroxide at 145℃; for 12h; Sealed tube; Large scale;
Stage #2: With hydrogenchloride In water at 20℃; pH=1; Large scale;
2.43 kg
2-bromo-2-methylpropionic acid
2052-01-9

2-bromo-2-methylpropionic acid

3,5-bis-trifluromethylphenylboronic acid
73852-19-4

3,5-bis-trifluromethylphenylboronic acid

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In 1,4-dioxane; water at 60℃; for 3h; Reagent/catalyst; Inert atmosphere;85%
3,5-bistrifluoromethylphenyl acetic acid
85068-33-3

3,5-bistrifluoromethylphenyl acetic acid

methyl iodide
74-88-4

methyl iodide

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -50 - 20℃; for 5h; Inert atmosphere; Large scale;77%
2-(3,5-bistrifluoromethylphenyl)propanenitrile

2-(3,5-bistrifluoromethylphenyl)propanenitrile

ethylene glycol
107-21-1

ethylene glycol

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
With potassium hydroxide at 135℃; for 20h; Reagent/catalyst; Temperature; Reflux;73%
carbon monoxide
201230-82-2

carbon monoxide

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol
67570-38-1

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol

A

C22H16F12

C22H16F12

B

4-methyl-2,4-di[3,5-bis(trifluoromethyl)phenyl]pent-1-ene

4-methyl-2,4-di[3,5-bis(trifluoromethyl)phenyl]pent-1-ene

C

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
With trifluorormethanesulfonic acid at 0℃;A n/a
B n/a
C 56%
3,6-bis(trifluoromethyl)bromobenzene
328-70-1

3,6-bis(trifluoromethyl)bromobenzene

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: magnesium / diethyl ether / 1 h / 30 °C
1.2: diethyl ether / 0.75 h / 16 - 22 °C
2.1: 97 percent / CF3SO3H / CH2Cl2; H2O / 2 h / 20 °C / 22501.8 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
1.2: 10 h / 90 °C
2.1: sodium hydroxide / methanol / 5 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / -5 °C
3.2: 10 h / 50 °C
View Scheme
Multi-step reaction with 2 steps
1: bis(η3-allyl-μ-chloropalladium(II)); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; 1,3,5-trimethyl-benzene / 20 h / 140 °C / Schlenk technique; Inert atmosphere; Reflux
2: potassium hydroxide / 20 h / 135 °C / Reflux
View Scheme
3,5-(bistrifluoromethyl)chlorobenzene
328-72-3

3,5-(bistrifluoromethyl)chlorobenzene

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: bis(η3-allyl-μ-chloropalladium(II)); dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,3,5-trimethyl-benzene / 20.25 h / 0 - 145 °C / Inert atmosphere; Large scale
2.1: sodium hydride / mineral oil; 1,4-dioxane / 10.25 h / 15 - 45 °C / Inert atmosphere; Large scale
3.1: sodium hydroxide / 12 h / 145 °C / Sealed tube; Large scale
3.2: 20 °C / pH 1 / Large scale
View Scheme
dimethyl sulfate
77-78-1

dimethyl sulfate

3,5-bistrifluoromethylphenyl acetic acid
85068-33-3

3,5-bistrifluoromethylphenyl acetic acid

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
Stage #1: 3,5-bistrifluoromethylphenyl acetic acid With sodium hydride In N,N-dimethyl-formamide at -5℃; for 1h;
Stage #2: dimethyl sulfate In N,N-dimethyl-formamide at 50℃; for 10h;
325.1 g
2-(3,5-bistrifluoromethylphenyl)propanenitrile

2-(3,5-bistrifluoromethylphenyl)propanenitrile

glycerol
56-81-5

glycerol

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

Conditions
ConditionsYield
With barium(II) hydroxide Reagent/catalyst; Concentration;
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride
289686-69-7

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

Conditions
ConditionsYield
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide; toluene for 4.5h;100%
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 17h;
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 24h;
oxalyl dichloride
79-37-8

oxalyl dichloride

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride
289686-69-7

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

Conditions
ConditionsYield
In dichloromethane; N,N-dimethyl-formamide for 4.5h;100%
In dichloromethane; N,N-dimethyl-formamide; toluene
4-(3,5-dichlorophenoxy)-2-(piperazin-1-yl)pyrimidine

4-(3,5-dichlorophenoxy)-2-(piperazin-1-yl)pyrimidine

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis(trifluoromethyl)phenyl)-1-(4-(4-(3,5-dichlorophenoxy)pyrimidin-2-yl)piperazin-1-yl)-2-methylpropan-1-one

2-(3,5-bis(trifluoromethyl)phenyl)-1-(4-(4-(3,5-dichlorophenoxy)pyrimidin-2-yl)piperazin-1-yl)-2-methylpropan-1-one

Conditions
ConditionsYield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 10h;83%
C18H21ClN2O2

C18H21ClN2O2

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide
401891-55-2

2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide

Conditions
ConditionsYield
Stage #1: C18H21ClN2O2 With trifluoroacetic acid In dichloromethane at 20℃; for 2h;
Stage #2: α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In N,N-dimethyl-formamide at 100℃; for 4h;
75%
2-Amino-5-chlorobenzophenone
719-59-5

2-Amino-5-chlorobenzophenone

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide
289686-54-0

N-(2-benzoyl-4-chloro-phenyl)-2-(3,5-bis-trifluoromethyl-phenyl)-isobutyramide

Conditions
ConditionsYield
Stage #1: 5-chloro-2-aminobenzophenone; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid In 1,2-dichloro-ethane at 80℃; for 1h;
Stage #2: With dicyclohexyl-carbodiimide In 1,2-dichloro-ethane at 80℃;
58%
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine hydrochloride
374822-30-7

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine hydrochloride

Conditions
ConditionsYield
Stage #1: α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With diphenyl phosphoryl azide; triethylamine In toluene at 90℃; for 18h;
Stage #2: With hydrogenchloride; water for 18h; Heating / reflux;
Stage #3: With hydrogenchloride In diethyl ether
20%
4-amino-4-phenylcyclohexan-1-one
95261-39-5

4-amino-4-phenylcyclohexan-1-one

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide
374791-63-6

α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine In N,N-dimethyl-formamide at 20℃;
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine
488098-44-8

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine

Conditions
ConditionsYield
Stage #1: α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With diphenyl phosphoryl azide; triethylamine In toluene at 90℃;
Stage #2: With hydrogenchloride In diethyl ether at 20℃;
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

C12H11F6NO

C12H11F6NO

Conditions
ConditionsYield
With ammonium chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methyl-morpholine
C17H25N3O3

C17H25N3O3

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

C29H31F6N3O3

C29H31F6N3O3

Conditions
ConditionsYield
Stage #1: C17H25N3O3; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In toluene at 110℃;
Stage #2: In toluene at 110℃; Further stages.;
C17H24FN3O3

C17H24FN3O3

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

C29H30F7N3O3

C29H30F7N3O3

Conditions
ConditionsYield
Stage #1: C17H24FN3O3; α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide
Stage #2: In toluene at 110℃; Further stages.;
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide
290296-68-3

2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C
2: 17.3 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C
2: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4.5 h
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; dichloromethane / 4.5 h
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; toluene / 4.5 h
2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

4-oxo-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

4-oxo-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: (PhO)2PON3; Et3N / toluene / 90 °C
1.2: HCl / diethyl ether / 20 °C
2.1: Et3N; EDC; HOBt / dimethylformamide / 20 °C
View Scheme
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexyl}-isobutyramide

2-(3,5-bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexyl}-isobutyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N; EDC; HOBt / dimethylformamide / 20 °C
View Scheme
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexyl}-isobutyramide

2-(3,5-bis-trifluoromethyl-phenyl)-N-{4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexyl}-isobutyramide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N; EDC; HOBt / dimethylformamide / 20 °C
View Scheme
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: (PhO)2PON3; Et3N / toluene / 90 °C
1.2: HCl / diethyl ether / 20 °C
2.1: Et3N; EDC; HOBt / dimethylformamide / 20 °C
View Scheme
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

4-[4-(4-fluoro-phenyl)-piperidin-1-yl]-1-phenyl-cyclohexanecarboxylic acid [1-(3,5-bis-trifluoromethyl-phenyl)-1-methyl-ethyl]-amide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: (PhO)2PON3; Et3N / toluene / 90 °C
1.2: HCl / diethyl ether / 20 °C
2.1: Et3N; EDC; HOBt / dimethylformamide / 20 °C
View Scheme
5-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine
889650-17-3

5-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-amine

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-N-[5-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-yl]propanamide

2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-N-[5-(2-methylphenyl)-2-morpholin-4-ylquinolin-6-yl]propanamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide
401891-55-2

2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4.5 h
2: dmap / toluene / 23 h / 120 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / 20 °C / Inert atmosphere; Cooling with ice
2.2: 1 h / 20 °C / Inert atmosphere; Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; dichloromethane / 4.5 h
2: dmap / toluene / 23 h / 120 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; toluene / 4.5 h
2: dmap / toluene / 23 h / 120 °C / Inert atmosphere
View Scheme

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