CAS: 290297-26-6 molecular formula:C30H32F6N4O molecular weight :578.59
Netupitant CAS No.:290297-26-6 Name: Netupitant Synonyms: 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]-N-methylisobutyramide Molecular Str
Cas:290297-26-6
Min.Order:1 Kilogram
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:290297-26-6
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c
Cas:290297-26-6
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryOur Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con
Cas:290297-26-6
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:290297-26-6
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FOB Price: $139.0 / 210.0
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inquiryAdvantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s
Cas:290297-26-6
Min.Order:10 Gram
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inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:290297-26-6
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inquiryBeluga chemical professional supply High Quality Netupitant CAS 290297-26-6 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabil
Cas:290297-26-6
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:290297-26-6
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:290297-26-6
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:290297-26-6
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat
Cas:290297-26-6
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:290297-26-6
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FOB Price: $100.0
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inquiryNetupitant Cas 290297-26-6 in stockAppearance:almost white powder Storage:Packing storage: in tight containers. Package:according to customers' requirements Application:pharmaceutical usage Transportation:By air(EMS or EUB or FedEx or TNT ect...) or
1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m
Cas:290297-26-6
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FOB Price: $8.2 / 8.8
Type:Trading Company
inquiryProduct name: Netupitant CAS No.:290297-26-6 Molecule Formula:C30H32F6N4O Molecule Weight:578.59 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SP
Cas:290297-26-6
Min.Order:1 Kilogram
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inquiryProduct Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,
Cas:290297-26-6
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
Cas:290297-26-6
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FOB Price: $18.0 / 20.0
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inquiryShandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W
Cas:290297-26-6
Min.Order:1 Gram
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inquiry1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer
Cas:290297-26-6
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inquiryProduct Name: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamideChemicalBook Assay: 99.0% Cas No.: 290297-26-6
Cas:290297-26-6
Min.Order:1 Gram
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I
CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic and fermentation pharmaceutical products. The organizational s
Cas:290297-26-6
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquirymethyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine
2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride
netupitant
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine In dichloromethane at 35 - 40℃; for 3h; Cooling with ice; | 81% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 35 - 40℃; for 3h; Cooling with ice; | 81% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 10℃; for 2h; | 74% |
1-methyl-piperazine
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide
netupitant
Conditions | Yield |
---|---|
With potassium carbonate In dichloromethane at 80℃; for 3h; | 80% |
methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine
netupitant
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane Heating; |
1-methyl-piperazine
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2 h / 100 °C 2: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 3: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 4: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme |
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C 2: 2 h / 100 °C 3: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 4: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 5: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme |
6-chloro-4-(o-tolyl)nicotinamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 2 h / 100 °C 2: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 3: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 4: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: 2 h / 100 °C 2.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C 2.2: 5.33 h / 5 °C 3.1: dichloromethane; toluene / 2 h / 50 °C 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme | |
Multi-step reaction with 4 steps 1.1: 2 h / 100 °C 2.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C 2.2: 5.3 h / -5 °C 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C 4.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme |
6-chloro-4-o-tolyl-nicotinic acid
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: SOCl2; DMF / tetrahydrofuran / 2.5 h / 50 °C 2: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C 3: 2 h / 100 °C 4: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 5: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 6: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 50 °C 1.2: 0.5 h / 0 °C 2.1: 2 h / 100 °C 3.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C 3.2: 5.33 h / 5 °C 4.1: dichloromethane; toluene / 2 h / 50 °C 5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme | |
Multi-step reaction with 5 steps 1.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 50 °C 1.2: 0.5 h / 0 °C 2.1: 2 h / 100 °C 3.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C 3.2: 5.3 h / -5 °C 4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C 5.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme |
N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 4 h / 100 °C 2: MeSO3H / 5 h / 100 °C 3: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 4: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 5: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 5 steps 1: 100 °C 2: methanesulfonic acid / 100 °C 3: N-Bromosuccinimide / dichloromethane / -5 °C 4: RedAl / toluene / 50 °C 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme |
4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 2: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 3: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / dichloromethane / -5 °C 2: RedAl / toluene / 50 °C 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C 1.2: 5.33 h / 5 °C 2.1: dichloromethane; toluene / 2 h / 50 °C 3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme | |
Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C 1.2: 5.3 h / -5 °C 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C 3.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme |
[6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl]-carbamic acid methyl ester
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 2: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: RedAl / toluene / 50 °C 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: dichloromethane; toluene / 2 h / 50 °C 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C 2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme |
N-tert-butyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: MeSO3H / 5 h / 100 °C 2: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 3: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 4: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 4 steps 1: methanesulfonic acid / 100 °C 2: N-Bromosuccinimide / dichloromethane / -5 °C 3: RedAl / toluene / 50 °C 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme |
3,6-bis(trifluoromethyl)bromobenzene
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: magnesium / diethyl ether / 1 h / 30 °C 1.2: diethyl ether / 0.75 h / 16 - 22 °C 2.1: 97 percent / CF3SO3H / CH2Cl2; H2O / 2 h / 20 °C / 22501.8 Torr 3.1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C 4.1: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme |
α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 97 percent / CF3SO3H / CH2Cl2; H2O / 2 h / 20 °C / 22501.8 Torr 2: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C 3: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme |
o-tolyl magnesium chloride
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: tetrahydrofuran / 19 h / 0 - 20 °C 1.2: acetic acid / tetrahydrofuran / -60 °C 1.3: Mn(OAc)3*2H2O / tetrahydrofuran / 1.5 h / -60 - 20 °C 2.1: SOCl2; DMF / tetrahydrofuran / 2.5 h / 50 °C 3.1: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C 4.1: 2 h / 100 °C 5.1: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C 6.1: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C 7.1: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: tetrahydrofuran / 0 - 20 °C 1.2: 1.5 h / -60 - 20 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 50 °C 2.2: 0.5 h / 0 °C 3.1: 2 h / 100 °C 4.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C 4.2: 5.33 h / 5 °C 5.1: dichloromethane; toluene / 2 h / 50 °C 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme | |
Multi-step reaction with 6 steps 1.1: acetic acid / tetrahydrofuran / 0 - 20 °C 1.2: 1.5 h / -60 - 20 °C 2.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 50 °C 2.2: 0.5 h / 0 °C 3.1: 2 h / 100 °C 4.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C 4.2: 5.3 h / -5 °C 5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C 6.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme |
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C 2: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4.5 h 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C View Scheme | |
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide; dichloromethane / 4.5 h 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme | |
Multi-step reaction with 2 steps 1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; toluene / 4.5 h 2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme |
6-(4-methyl-1-piperazinyl)-3-pyridinylamine
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: Et3N / tetrahydrofuran / 20 °C 2.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C 2.2: I2 / tetrahydrofuran / -78 - 0 °C 3.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 4.1: aq. HCl / Heating 5.1: TFA / 130 °C 5.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 6.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme |
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-propionamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C 1.2: I2 / tetrahydrofuran / -78 - 0 °C 2.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 3.1: aq. HCl / Heating 4.1: TFA / 130 °C 4.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 5.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme | |
Multi-step reaction with 5 steps 1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine / tetrahydrofuran; diethyl ether; hexane; water 2: sodium carbonate / tetrakis(triphenylphosphine)palladium (0) / toluene 3: hydrogenchloride 4: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate 5: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme |
1-methyl-piperazine
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: tetrahydrofuran / Heating 2.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr 3.1: Et3N / tetrahydrofuran / 20 °C 4.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C 4.2: I2 / tetrahydrofuran / -78 - 0 °C 5.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 6.1: aq. HCl / Heating 7.1: TFA / 130 °C 7.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 8.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme |
6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl-amine
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: TFA / 130 °C 1.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 2.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme | |
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux 3: N-ethyl-N,N-diisopropylamine / toluene / 1.5 h / 0 - 115 °C View Scheme | |
Multi-step reaction with 2 steps 1: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate 2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme |
N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 2.1: aq. HCl / Heating 3.1: TFA / 130 °C 3.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 4.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme | |
Multi-step reaction with 4 steps 1: sodium carbonate / tetrakis(triphenylphosphine)palladium (0) / toluene 2: hydrogenchloride 3: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate 4: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme |
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: aq. HCl / Heating 2.1: TFA / 130 °C 2.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 3.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride 2: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate 3: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane View Scheme |
2-chloro-5-nitropyridine
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1.1: tetrahydrofuran / Heating 2.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr 3.1: Et3N / tetrahydrofuran / 20 °C 4.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C 4.2: I2 / tetrahydrofuran / -78 - 0 °C 5.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 6.1: aq. HCl / Heating 7.1: TFA / 130 °C 7.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 8.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme |
1-methyl-4-(5-nitropyridin-2-yl)piperazine
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr 2.1: Et3N / tetrahydrofuran / 20 °C 3.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C 3.2: I2 / tetrahydrofuran / -78 - 0 °C 4.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C 5.1: aq. HCl / Heating 6.1: TFA / 130 °C 6.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C 7.1: i-Pr2NEt / CH2Cl2 / Heating View Scheme |
6-Chloro-3-pyridinecarboxylic acid
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: thionyl chloride / toluene / 80 °C 2: toluene / 10 °C 3: tetrahydrofuran 4: 100 °C 5: methanesulfonic acid / 100 °C 6: N-Bromosuccinimide / dichloromethane / -5 °C 7: RedAl / toluene / 50 °C 8: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: tetrahydrofuran / 0 - 20 °C 1.2: 1.5 h / -60 - 20 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 50 °C 2.2: 0.5 h / 0 °C 3.1: 2 h / 100 °C 4.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C 4.2: 5.33 h / 5 °C 5.1: dichloromethane; toluene / 2 h / 50 °C 6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme | |
Multi-step reaction with 6 steps 1.1: acetic acid / tetrahydrofuran / 0 - 20 °C 1.2: 1.5 h / -60 - 20 °C 2.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 50 °C 2.2: 0.5 h / 0 °C 3.1: 2 h / 100 °C 4.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C 4.2: 5.3 h / -5 °C 5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C 6.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice View Scheme |
N-tert-butyl-6-chloro-nicotinamide
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: tetrahydrofuran 2: 100 °C 3: methanesulfonic acid / 100 °C 4: N-Bromosuccinimide / dichloromethane / -5 °C 5: RedAl / toluene / 50 °C 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme |
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: trichlorophosphate / 10 h / 135 °C 2: methanol / 20.25 h / 18 - 25 °C 3: hydrogen; triethylamine; 20% palladium hydroxide-activated charcoal / methanol / 10 h / 25 °C / 2223.8 - 2497.89 Torr 4: sulfuric acid / toluene / 12 h / 70 °C 5: N-Bromosuccinimide / dichloromethane / -5 °C 6: RedAl / toluene / 50 °C 7: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme |
3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: methanol / 20.25 h / 18 - 25 °C 2: hydrogen; triethylamine; 20% palladium hydroxide-activated charcoal / methanol / 10 h / 25 °C / 2223.8 - 2497.89 Torr 3: sulfuric acid / toluene / 12 h / 70 °C 4: N-Bromosuccinimide / dichloromethane / -5 °C 5: RedAl / toluene / 50 °C 6: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme |
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogen; triethylamine; 20% palladium hydroxide-activated charcoal / methanol / 10 h / 25 °C / 2223.8 - 2497.89 Torr 2: sulfuric acid / toluene / 12 h / 70 °C 3: N-Bromosuccinimide / dichloromethane / -5 °C 4: RedAl / toluene / 50 °C 5: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme |
netupitant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sulfuric acid / toluene / 12 h / 70 °C 2: N-Bromosuccinimide / dichloromethane / -5 °C 3: RedAl / toluene / 50 °C 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C View Scheme |
Conditions | Yield |
---|---|
Stage #1: netupitant; di-tert-butyl chloromethyl phosphate With sodium iodide In acetone at 30℃; Stage #2: With hydrogenchloride In water; acetone at 0 - 40℃; for 1.5h; Solvent; Temperature; | 96% |
netupitant
Conditions | Yield |
---|---|
With oxone; sodium hydrogencarbonate In methanol; water at 20℃; for 6.25h; | 80% |
netupitant
1-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-4-methylpiperazine 1,4-dioxide
Conditions | Yield |
---|---|
With Oxone; sodium hydrogencarbonate In methanol; water at 20 - 50℃; for 4h; | 80% |
With oxone||potassium monopersulfate triple salt; sodium hydrogencarbonate In methanol; water at 50℃; for 4h; Inert atmosphere; | 80% |
netupitant
di-tert-butyl chloromethyl phosphate
Conditions | Yield |
---|---|
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dimethoxyethane; acetonitrile at 90℃; for 12h; Reagent/catalyst; Solvent; | 50% |
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dimethoxyethane; acetonitrile at 50 - 90℃; for 12h; |
netupitant
trifluoroacetic acid
Conditions | Yield |
---|---|
Stage #1: netupitant With magnesium; acetic acid In water; dimethyl sulfoxide at 20℃; for 2h; Stage #2: trifluoroacetic acid In methanol; water regioselective reaction; | 45% |
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