Products

Refine

Country

Business Type

Certificate

Display

Chemvon Biotechnology Co. Ltd.

CAS: 290297-26-6 molecular formula:C30H32F6N4O molecular weight :578.59

Netupitant

Cas:290297-26-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Think Chemical Co. Ltd

Netupitant CAS No.:290297-26-6 Name: Netupitant Synonyms: 2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl]-N-methylisobutyramide Molecular Str

High purity Netupitant CAS No.:290297-26-6

Cas:290297-26-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Other

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Netupitant manufacturer with low price

Cas:290297-26-6

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Netupitant

Cas:290297-26-6

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

Netupitant

Cas:290297-26-6

Min.Order:1 Metric Ton

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Netupitant

Cas:290297-26-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 290297-26-6 with best quality

Cas:290297-26-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best s

99%min Netupitant (CID-6451149)| Tachykinin NK 1 Antagonist CAS 290297-26-6

Cas:290297-26-6

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High Quality Netupitant CAS 290297-26-6 Why choose Beluga chemical 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabil

High Quality Netupitant CAS 290297-26-6

Cas:290297-26-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Netupitant

Cas:290297-26-6

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

NETUPITANT

Cas:290297-26-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Send Pharmaceutical Technology Co., Ltd.

low price high quality high purity good sevice stock Appearance:white Storage:Preserve In Well-Closed, Light-Resistant and Tight Containers. Store In Cool & Dry Place Package:1g,5g,10g...1kg,5kg...more Application:Pharmaceutical intermediat

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Netupitant

Cas:290297-26-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

Netupitant Cas 290297-26-6 in stockAppearance:almost white powder Storage:Packing storage: in tight containers. Package:according to customers' requirements Application:pharmaceutical usage Transportation:By air(EMS or EUB or FedEx or TNT ect...) or

Netupitant Cas 290297-26-6 in stock

Cas:290297-26-6

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hebei Kunsui Technology Co., Ltd.

1. A strong scientific research team . 2. Stable quality (with a complete scientific research center and testing center to ensure the quality stability of each batch of products). 3. Rich export experience (with practical experience in exporting to m

Pharmaceutical Netupitant Powder CAS 290297-26-6

Cas:290297-26-6

Min.Order:1 Kilogram

FOB Price: $8.2 / 8.8

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: Netupitant CAS No.:290297-26-6 Molecule Formula:C30H32F6N4O Molecule Weight:578.59 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS SP

Best Quality Netupitant with good supplier

Cas:290297-26-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Netupitant

Cas:290297-26-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Hangzhou ZeErRui Chemical Co., Ltd.

Product Name: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamideChemicalBook Assay: 99.0% Cas No.: 290297-26-6

Hot sale 290297-26-6Netupitant good supplierNetupitant Stearamide cost

Cas:290297-26-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:Active Pharmaceutical I

Netupitant

Cas:290297-26-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic and fermentation pharmaceutical products. The organizational s

netupitant 290297-26-6 manufacturer/high quality/in stock

Cas:290297-26-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine
290297-25-5

methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride
289686-69-7

2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
With sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine In dichloromethane at 35 - 40℃; for 3h; Cooling with ice;81%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 35 - 40℃; for 3h; Cooling with ice;81%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 10℃; for 2h;74%
1-methyl-piperazine
109-01-3

1-methyl-piperazine

2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide
401891-55-2

2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
With potassium carbonate In dichloromethane at 80℃; for 3h;80%
2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropionyl chloride

2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropionyl chloride

methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine
290297-25-5

methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane Heating;
1-methyl-piperazine
109-01-3

1-methyl-piperazine

Merrifield resin-OC(O)CH2CH2CH(OH)CH2I

Merrifield resin-OC(O)CH2CH2CH(OH)CH2I

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2 h / 100 °C
2: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
3: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
4: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
6-chloro-4-o-tolyl-nicotinoyl chloride

6-chloro-4-o-tolyl-nicotinoyl chloride

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C
2: 2 h / 100 °C
3: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
4: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
5: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
6-chloro-4-(o-tolyl)nicotinamide
342417-00-9

6-chloro-4-(o-tolyl)nicotinamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 2 h / 100 °C
2: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
3: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
4: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1.1: 2 h / 100 °C
2.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C
2.2: 5.33 h / 5 °C
3.1: dichloromethane; toluene / 2 h / 50 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 4 steps
1.1: 2 h / 100 °C
2.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C
2.2: 5.3 h / -5 °C
3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C
4.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
6-chloro-4-o-tolyl-nicotinic acid
342416-99-3

6-chloro-4-o-tolyl-nicotinic acid

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: SOCl2; DMF / tetrahydrofuran / 2.5 h / 50 °C
2: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C
3: 2 h / 100 °C
4: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
5: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
6: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 50 °C
1.2: 0.5 h / 0 °C
2.1: 2 h / 100 °C
3.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C
3.2: 5.33 h / 5 °C
4.1: dichloromethane; toluene / 2 h / 50 °C
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 5 steps
1.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 50 °C
1.2: 0.5 h / 0 °C
2.1: 2 h / 100 °C
3.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C
3.2: 5.3 h / -5 °C
4.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C
5.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide
342417-04-3

N-tert-butyl-6-chloro-4-(o-tolyl)nicotinamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 4 h / 100 °C
2: MeSO3H / 5 h / 100 °C
3: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
4: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
5: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 5 steps
1: 100 °C
2: methanesulfonic acid / 100 °C
3: N-Bromosuccinimide / dichloromethane / -5 °C
4: RedAl / toluene / 50 °C
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide
342417-01-0

4-(2-methylphenyl)-6-(4-methylpiperazinyl)-3-pyridinecarboxamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
2: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
3: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / dichloromethane / -5 °C
2: RedAl / toluene / 50 °C
3: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C
1.2: 5.33 h / 5 °C
2.1: dichloromethane; toluene / 2 h / 50 °C
3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C
1.2: 5.3 h / -5 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C
3.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
[6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl]-carbamic acid methyl ester
342417-02-1

[6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl]-carbamic acid methyl ester

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
2: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: RedAl / toluene / 50 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane; toluene / 2 h / 50 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C
2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
N-tert-butyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide
881743-64-2

N-tert-butyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: MeSO3H / 5 h / 100 °C
2: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
3: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
4: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 4 steps
1: methanesulfonic acid / 100 °C
2: N-Bromosuccinimide / dichloromethane / -5 °C
3: RedAl / toluene / 50 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
3,6-bis(trifluoromethyl)bromobenzene
328-70-1

3,6-bis(trifluoromethyl)bromobenzene

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium / diethyl ether / 1 h / 30 °C
1.2: diethyl ether / 0.75 h / 16 - 22 °C
2.1: 97 percent / CF3SO3H / CH2Cl2; H2O / 2 h / 20 °C / 22501.8 Torr
3.1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C
4.1: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol
67570-38-1

α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanol

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / CF3SO3H / CH2Cl2; H2O / 2 h / 20 °C / 22501.8 Torr
2: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C
3: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
o-tolyl magnesium chloride
33872-80-9

o-tolyl magnesium chloride

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: tetrahydrofuran / 19 h / 0 - 20 °C
1.2: acetic acid / tetrahydrofuran / -60 °C
1.3: Mn(OAc)3*2H2O / tetrahydrofuran / 1.5 h / -60 - 20 °C
2.1: SOCl2; DMF / tetrahydrofuran / 2.5 h / 50 °C
3.1: 7.8 g / NH3 / tetrahydrofuran; H2O / 0.5 h / 0 °C
4.1: 2 h / 100 °C
5.1: 99 percent / N-bromosuccinimide / CH2Cl2; methanol / 7 h / -5 °C
6.1: Red-Al / toluene; CH2Cl2 / 1 h / 50 °C
7.1: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 0 - 20 °C
1.2: 1.5 h / -60 - 20 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 50 °C
2.2: 0.5 h / 0 °C
3.1: 2 h / 100 °C
4.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C
4.2: 5.33 h / 5 °C
5.1: dichloromethane; toluene / 2 h / 50 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 6 steps
1.1: acetic acid / tetrahydrofuran / 0 - 20 °C
1.2: 1.5 h / -60 - 20 °C
2.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 50 °C
2.2: 0.5 h / 0 °C
3.1: 2 h / 100 °C
4.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C
4.2: 5.3 h / -5 °C
5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C
6.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid
289686-70-0

α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (COCl)2 / CH2Cl2; dimethylformamide / 17 h / 0 - 20 °C
2: 13.5 g / i-Pr2NEt / CH2Cl2 / 3 h / 0 °C
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4.5 h
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C
View Scheme
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide; dichloromethane / 4.5 h
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 2 steps
1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide; toluene / 4.5 h
2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
6-(4-methyl-1-piperazinyl)-3-pyridinylamine
55403-35-5

6-(4-methyl-1-piperazinyl)-3-pyridinylamine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: Et3N / tetrahydrofuran / 20 °C
2.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C
2.2: I2 / tetrahydrofuran / -78 - 0 °C
3.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C
4.1: aq. HCl / Heating
5.1: TFA / 130 °C
5.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
6.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-propionamide
290297-21-1

2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-propionamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C
1.2: I2 / tetrahydrofuran / -78 - 0 °C
2.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C
3.1: aq. HCl / Heating
4.1: TFA / 130 °C
4.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
5.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
Multi-step reaction with 5 steps
1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine / tetrahydrofuran; diethyl ether; hexane; water
2: sodium carbonate / tetrakis(triphenylphosphine)palladium (0) / toluene
3: hydrogenchloride
4: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate
5: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane
View Scheme
1-methyl-piperazine
109-01-3

1-methyl-piperazine

phloroglucinol dihydrate

phloroglucinol dihydrate

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / Heating
2.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr
3.1: Et3N / tetrahydrofuran / 20 °C
4.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C
4.2: I2 / tetrahydrofuran / -78 - 0 °C
5.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C
6.1: aq. HCl / Heating
7.1: TFA / 130 °C
7.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
8.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl-amine
290297-24-4

6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl-amine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: TFA / 130 °C
1.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
2.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Reflux
3: N-ethyl-N,N-diisopropylamine / toluene / 1.5 h / 0 - 115 °C
View Scheme
Multi-step reaction with 2 steps
1: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate
2: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane
View Scheme
N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide
290297-22-2

N-[4-iodo-6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-2,2-dimethyl-propionamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C
2.1: aq. HCl / Heating
3.1: TFA / 130 °C
3.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
4.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
Multi-step reaction with 4 steps
1: sodium carbonate / tetrakis(triphenylphosphine)palladium (0) / toluene
2: hydrogenchloride
3: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate
4: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane
View Scheme
2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide
290297-23-3

2,2-dimethyl-N-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-propionamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: aq. HCl / Heating
2.1: TFA / 130 °C
2.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
3.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride
2: hydrogenchloride; sodium hydroxide; trifluoroacetic acid / tetrahydrofuran; trimethyl orthoformate
3: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane
View Scheme
2-chloro-5-nitropyridine
4548-45-2

2-chloro-5-nitropyridine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1.1: tetrahydrofuran / Heating
2.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr
3.1: Et3N / tetrahydrofuran / 20 °C
4.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C
4.2: I2 / tetrahydrofuran / -78 - 0 °C
5.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C
6.1: aq. HCl / Heating
7.1: TFA / 130 °C
7.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
8.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
1-methyl-4-(5-nitropyridin-2-yl)piperazine
55403-34-4

1-methyl-4-(5-nitropyridin-2-yl)piperazine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: hydrogen / Pd/C / methanol / 45 °C / 760 Torr
2.1: Et3N / tetrahydrofuran / 20 °C
3.1: n-BuLi; TMEDA; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran / -78 - -30 °C
3.2: I2 / tetrahydrofuran / -78 - 0 °C
4.1: Pd(PPh3)4; Na2CO3 / toluene / 80 °C
5.1: aq. HCl / Heating
6.1: TFA / 130 °C
6.2: LiAlH4 / tetrahydrofuran / 0 - 20 °C
7.1: i-Pr2NEt / CH2Cl2 / Heating
View Scheme
6-Chloro-3-pyridinecarboxylic acid
5326-23-8

6-Chloro-3-pyridinecarboxylic acid

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: thionyl chloride / toluene / 80 °C
2: toluene / 10 °C
3: tetrahydrofuran
4: 100 °C
5: methanesulfonic acid / 100 °C
6: N-Bromosuccinimide / dichloromethane / -5 °C
7: RedAl / toluene / 50 °C
8: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 0 - 20 °C
1.2: 1.5 h / -60 - 20 °C
2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 50 °C
2.2: 0.5 h / 0 °C
3.1: 2 h / 100 °C
4.1: N-Bromosuccinimide / methanol; dichloromethane / 6 h / -5 °C
4.2: 5.33 h / 5 °C
5.1: dichloromethane; toluene / 2 h / 50 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
Multi-step reaction with 6 steps
1.1: acetic acid / tetrahydrofuran / 0 - 20 °C
1.2: 1.5 h / -60 - 20 °C
2.1: thionyl chloride / tetrahydrofuran; N,N-dimethyl-formamide / 2 h / 50 °C
2.2: 0.5 h / 0 °C
3.1: 2 h / 100 °C
4.1: N-Bromosuccinimide / methanol; dichloromethane / 16 h / -5 °C
4.2: 5.3 h / -5 °C
5.1: sodium bis(2-methoxyethoxy)aluminium dihydride / dichloromethane; toluene / 2 h / 50 °C
6.1: sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 35 - 40 °C / Cooling with ice
View Scheme
N-tert-butyl-6-chloro-nicotinamide
115309-58-5

N-tert-butyl-6-chloro-nicotinamide

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: tetrahydrofuran
2: 100 °C
3: methanesulfonic acid / 100 °C
4: N-Bromosuccinimide / dichloromethane / -5 °C
5: RedAl / toluene / 50 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
5'-cyano-1',2',3',4'-tetrahydro-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium inner salt

5'-cyano-1',2',3',4'-tetrahydro-6'-hydroxy-4'-(2-methylphenyl)-2'-oxo-1,3'-bipyridinium inner salt

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: trichlorophosphate / 10 h / 135 °C
2: methanol / 20.25 h / 18 - 25 °C
3: hydrogen; triethylamine; 20% palladium hydroxide-activated charcoal / methanol / 10 h / 25 °C / 2223.8 - 2497.89 Torr
4: sulfuric acid / toluene / 12 h / 70 °C
5: N-Bromosuccinimide / dichloromethane / -5 °C
6: RedAl / toluene / 50 °C
7: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine
873443-66-4

3-cyano-2,6-dichloro-4-(2-methylphenyl)pyridine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: methanol / 20.25 h / 18 - 25 °C
2: hydrogen; triethylamine; 20% palladium hydroxide-activated charcoal / methanol / 10 h / 25 °C / 2223.8 - 2497.89 Torr
3: sulfuric acid / toluene / 12 h / 70 °C
4: N-Bromosuccinimide / dichloromethane / -5 °C
5: RedAl / toluene / 50 °C
6: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-methylpiperazinyl)pyridine

2-chloro-3-cyano-4-(2-methylphenyl)-6-(4-methylpiperazinyl)pyridine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogen; triethylamine; 20% palladium hydroxide-activated charcoal / methanol / 10 h / 25 °C / 2223.8 - 2497.89 Torr
2: sulfuric acid / toluene / 12 h / 70 °C
3: N-Bromosuccinimide / dichloromethane / -5 °C
4: RedAl / toluene / 50 °C
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
5-cyano-4-(2-methylphenyl)-2-(4-methylpiperazinyl)pyridine

5-cyano-4-(2-methylphenyl)-2-(4-methylpiperazinyl)pyridine

netupitant
290297-26-6

netupitant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sulfuric acid / toluene / 12 h / 70 °C
2: N-Bromosuccinimide / dichloromethane / -5 °C
3: RedAl / toluene / 50 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 40 °C
View Scheme
netupitant
290297-26-6

netupitant

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

C31H36F6N4O5P(1+)*Cl(1-)

C31H36F6N4O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: netupitant; di-tert-butyl chloromethyl phosphate With sodium iodide In acetone at 30℃;
Stage #2: With hydrogenchloride In water; acetone at 0 - 40℃; for 1.5h; Solvent; Temperature;
96%
netupitant
290297-26-6

netupitant

2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-[6-(4-methyl-4-oxy-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-isobutyramide

2-(3,5-bis-trifluoromethyl-phenyl)-N-methyl-N-[6-(4-methyl-4-oxy-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-isobutyramide

Conditions
ConditionsYield
With oxone; sodium hydrogencarbonate In methanol; water at 20℃; for 6.25h;80%
netupitant
290297-26-6

netupitant

1-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-4-methylpiperazine 1,4-dioxide
1431216-61-3

1-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-4-methylpiperazine 1,4-dioxide

Conditions
ConditionsYield
With Oxone; sodium hydrogencarbonate In methanol; water at 20 - 50℃; for 4h;80%
With oxone||potassium monopersulfate triple salt; sodium hydrogencarbonate In methanol; water at 50℃; for 4h; Inert atmosphere;80%
netupitant
290297-26-6

netupitant

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-{[(tert-butoxy)phosphoryl]oxymethyl}piperazin-1-ium

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dimethoxyethane; acetonitrile at 90℃; for 12h; Reagent/catalyst; Solvent;50%
With N,N,N',N'-tetramethyl-1,8-diaminonaphthalene In 1,2-dimethoxyethane; acetonitrile at 50 - 90℃; for 12h;
netupitant
290297-26-6

netupitant

trifluoroacetic acid
76-05-1

trifluoroacetic acid

2-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide trifluoroacetic acid salt

2-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)-N,2-dimethyl-N-(6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)propanamide trifluoroacetic acid salt

Conditions
ConditionsYield
Stage #1: netupitant With magnesium; acetic acid In water; dimethyl sulfoxide at 20℃; for 2h;
Stage #2: trifluoroacetic acid In methanol; water regioselective reaction;
45%

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View