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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester Manufacturer/High quality/Best price/In stock

Cas:229625-50-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay 98%min ----------------------------------------------------------------------------------------------

High purity Various Specifications Phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester CAS:229625-50-7

Cas:229625-50-7

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

Phosphoric acid ditert-butyl ester chloromethyl ester

Cas:229625-50-7

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Di-Tert-Butyl Chloromethyl Phosphate CAS 229625-50-7

Cas:229625-50-7

Min.Order:1 Kilogram

FOB Price: $10.0 / 16.0

Type:Trading Company

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 229625-50-7 with best quality

Cas:229625-50-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester

Cas:229625-50-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER CAS:229625-50-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializi

PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER CAS:229625-50-7

Cas:229625-50-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester

Cas:229625-50-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester/ LIDE PHARMA- Factory supply / Best price

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:229625-50-7

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting Phosphoric acid di-t-butyl ester chloromethyl ester CAS:229625-50-7, Please contact us by email freely. We are leading exporter in China.

Phosphoric acid di-t-butyl ester chloromethyl ester CAS:229625-50-7 from fandachem

Cas:229625-50-7

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Triumph International Development Limilted

Appearance:Light yellow transparent solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:Common produ

Phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester

Cas:229625-50-7

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 229625-50-7 CAS 229625-50-7 PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER

Cas:229625-50-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

229625-50-7

Cas:229625-50-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

di-tert-Butyl chloromethyl phosphate

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Di-tert-butyl chloromethyl phosphate

Cas:229625-50-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER Basic information Product Name: PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER Synonyms: Di-tert-butyl Chloromethyl Phosphate;PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROM

TIANFUCHEM-- PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER

Cas:229625-50-7

Min.Order:1 Metric Ton

FOB Price: $20.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Phosphoric acid, chloromethyl bis(1,1-dimethylethyl) ester

Cas:229625-50-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

PHOSPHORICACIDI-T-BUTYLEXTERCHLOROMETHYLESTER

Cas:229625-50-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Di-tert-butyl Chloromethyl Phosphate

Cas:229625-50-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Di-tert-butyl Chloromethyl Phosphate

Cas:229625-50-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Di-tert-butyl Chloromethyl Phosphate

Cas:229625-50-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Nantong Noatic Bio-Pharm Technology Co.,Ltd

We are manufacturer of this product and can supply good quality and competitive price , the purity over 99.0%, this product has been in massive production for years , so its process and quality always keep stable and its price is very competitive .

Di-tert-butyl Chloromethyl Phosphate

Cas:229625-50-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

Di-tert-butyl (chloromethyl) phosphate

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

Phosphoric acid ditert-butyl ester chloromethyl ester

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Di-tert-butyl Chloromethyl Phosphate

Cas:229625-50-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

Hebei Mojin Biotechnology Co.,Ltd

1, High quality with competitive price:2, Fast and safe delivery3.Excellent pre-sales and after-sales service4. Well-trained and professional technologist and sales with rich experience in the field for 5-10 yearsAppearance:see detailed specification

PHOSPHORIC ACI DI-T-BUTYL EXTER CHLOROMETHYL ESTER

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Di-tert-butyl chloromethyl phosphate cas no. 229625-50-7 98%

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

di-tert-Butyl chloromethyl phosphate

Cas:229625-50-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Di-tert-butyl chloromethyl phosphate 100g

Cas:229625-50-7

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

Chloroiodomethane
593-71-5

Chloroiodomethane

di-tert-butyl phosphoric acid tetra-n-butylammonium salt
68695-48-7

di-tert-butyl phosphoric acid tetra-n-butylammonium salt

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
at 20℃; for 4h; Inert atmosphere;97%
In benzene at 20℃; for 20h; Time; Darkness;91%
In benzene at 20℃; for 3h;49%
chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

potassium di-tert-butylphosphate
33494-80-3

potassium di-tert-butylphosphate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Stage #1: potassium di-tert-butylphosphate With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 0℃; for 0.166667h;
Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 20℃; for 20h;
95.3%
With potassium hydrogenphosphate trihydrate; tert-butyl methyl ether; tetra(n-butyl)ammonium hydrogensulfate In water at 0 - 20℃; for 2.41667h;94%
With potassium hydrogenphosphate trihydrate; tetra(n-butyl)ammonium hydrogensulfate In tert-butyl methyl ether; water at 0 - 30℃; for 2.41667h;94%
chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

phosphoric acid di-tert-butyl ester
33494-81-4

phosphoric acid di-tert-butyl ester

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Stage #1: phosphoric acid di-tert-butyl ester With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In water for 0.166667h; Cooling with ice;
Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 20℃; for 24h;
89%
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 0 - 20℃;72%
Stage #1: phosphoric acid di-tert-butyl ester With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water at 0℃; for 0.166667h;
Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 20℃;
72%
chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

tetramethylammonium di-tert-butyl hydrogen phosphate
34075-24-6

tetramethylammonium di-tert-butyl hydrogen phosphate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Stage #1: tetramethylammonium di-tert-butyl hydrogen phsophate With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In water for 0.166667h; Cooling with ice;
Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 20℃; for 24h;
89%
Stage #1: tetramethylammonium di-tert-butyl hydrogen phsophate With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In water for 0.166667h; Cooling with ice;
Stage #2: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 20℃; for 24h;
89%
Chloroiodomethane
593-71-5

Chloroiodomethane

di-tert-butyl phosphate silver salt
18281-42-0

di-tert-butyl phosphate silver salt

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
In benzene at 20℃; for 18h;71%
In toluene at 100℃;1.8 g
In toluene at 100℃;1.8 g
Chloroiodomethane
593-71-5

Chloroiodomethane

phosphoric acid di-tert-butyl ester
33494-81-4

phosphoric acid di-tert-butyl ester

di-tert-butyl phosphite
13086-84-5

di-tert-butyl phosphite

di-tert-butyl phosphate silver salt
18281-42-0

di-tert-butyl phosphate silver salt

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
silver carbonate In acetonitrile; benzene71%
Chloroiodomethane
593-71-5

Chloroiodomethane

tetramethylammonium di-tert-butyl hydrogen phosphate
34075-24-6

tetramethylammonium di-tert-butyl hydrogen phosphate

A

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

B

bis-di-tert-butyl methyl phosphate
427899-56-7

bis-di-tert-butyl methyl phosphate

Conditions
ConditionsYield
In 1,2-dimethoxyethane at 85℃; for 1.5h; Heating / reflux;A 63%
B n/a
In 1,2-dimethoxyethane for 1.5h; Heating;A 35%
B n/a
bis-di-tert-butyl methyl phosphate
427899-56-7

bis-di-tert-butyl methyl phosphate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
With silica gel Chromatography;60%
chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

phosphoric acid dibenzyl ester
1623-08-1

phosphoric acid dibenzyl ester

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate In dichloromethane; water59%
Chloroiodomethane
593-71-5

Chloroiodomethane

di-tert-butyl phosphite
13086-84-5

di-tert-butyl phosphite

pyrographite
7440-44-0

pyrographite

tetramethylammonium di-tert-butyl hydrogen phosphate
34075-24-6

tetramethylammonium di-tert-butyl hydrogen phosphate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
With potassium hydrogencarbonate In potassium permanganate; 1,2-dimethoxyethane; water; acetone
Chloroiodomethane
593-71-5

Chloroiodomethane

tetramethylammonium di-tert-butyl hydrogen phosphate
34075-24-6

tetramethylammonium di-tert-butyl hydrogen phosphate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
In dimethoxymethane, 1,2- Heating / reflux;
In 1,2-dimethoxyethane at 25℃; for 1.5h; Reflux;
In 1,2-dimethoxyethane
Chloroiodomethane
593-71-5

Chloroiodomethane

phosphoric acid di-tert-butyl ester
33494-81-4

phosphoric acid di-tert-butyl ester

A

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

B

bis-di-tert-butyl methyl phosphate
427899-56-7

bis-di-tert-butyl methyl phosphate

Conditions
ConditionsYield
Stage #1: phosphoric acid di-tert-butyl ester With tetramethyl ammoniumhydroxide In water; acetone Cooling with ice bath;
Stage #2: Chloroiodomethane In 1,2-dimethoxyethane for 1h; Heating / reflux;
n-butylammonium sulfate

n-butylammonium sulfate

chloromethylchlorosulfonate

chloromethylchlorosulfonate

potassium di-tert-butylphosphate
33494-80-3

potassium di-tert-butylphosphate

A

di-tert-butyl (4-(7-((2-(3-fluoro-5-(trifluoromethyl)phenyl)oxazol-4-yl)methoxy)-4-oxo-4H-chromen-3-yl)phenoxy)methyl phosphate

di-tert-butyl (4-(7-((2-(3-fluoro-5-(trifluoromethyl)phenyl)oxazol-4-yl)methoxy)-4-oxo-4H-chromen-3-yl)phenoxy)methyl phosphate

B

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
With sodium hydrogencarbonate In dichloromethane; water
monochloromethanesulfonyl chloride
3518-65-8

monochloromethanesulfonyl chloride

potassium di-tert-butylphosphate
33494-80-3

potassium di-tert-butylphosphate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Stage #1: potassium di-tert-butylphosphate With tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate In dichloromethane; water at 11.1 - 16.2℃;
Stage #2: monochloromethanesulfonyl chloride In dichloromethane; water at 15 - 23℃;
chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

barium bis(di-tert-butyl phosphate)

barium bis(di-tert-butyl phosphate)

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
With sodium carbonate; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane; water at 0 - 25℃; for 16.5h; Inert atmosphere;
di-tert-butyl phosphite
13086-84-5

di-tert-butyl phosphite

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl phosphite
13086-84-5

di-tert-butyl phosphite

chlorosulfuric acid chloromethyl ester
49715-04-0

chlorosulfuric acid chloromethyl ester

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Stage #1: di-tert-butyl phosphite With potassium permanganate; potassium hydrogencarbonate In water at 0 - 20℃;
Stage #2: chlorosulfuric acid chloromethyl ester With tetra(n-butyl)ammonium hydrogensulfate; potassium hydrogencarbonate In dichloromethane; water at 5 - 20℃; for 71h;
Stage #1: di-tert-butyl phosphite With potassium permanganate; potassium hydrogencarbonate In water at -1 - 20℃;
Stage #2: With tetra(n-butyl)ammonium hydrogensulfate; potassium hydrogencarbonate In water at 20℃; for 0.0833333h;
Stage #3: chlorosulfuric acid chloromethyl ester In dichloromethane; water at 5 - 20℃; for 71h;
di-tert-butyl phosphite
13086-84-5

di-tert-butyl phosphite

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydrogencarbonate; potassium permanganate / water
2.1: water; acetone / 0.5 h
3.1: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / water / 0.17 h / Cooling with ice
3.2: 24 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium permanganate; potassium hydrogencarbonate / water / 1.5 h / 20 °C
2: hydrogenchloride / water; methanol / 0 °C
3: methanol / 0 °C
4: acetone / 40 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium permanganate; potassium hydrogencarbonate / water / 1.5 h / 20 °C
2: hydrogenchloride / water; methanol / 0 °C
3: methanol / Cooling with ice
4: 1,2-dimethoxyethane / Reflux
View Scheme
potassium di-tert-butylphosphate
33494-80-3

potassium di-tert-butylphosphate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / methanol / 0 °C
2: Cooling with ice; Reflux
3: 1,2-dimethoxyethane
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water
2: acetone / pH 7
3: 1,2-dimethoxyethane / 2 h / Reflux
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water
2: acetone / pH 7
3: Dimethyl ether / 2 h / Reflux
View Scheme
phosphoric acid di-tert-butyl ester
33494-81-4

phosphoric acid di-tert-butyl ester

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: water; acetone / 0.5 h
2.1: sodium hydrogencarbonate; tetra(n-butyl)ammonium hydrogensulfate / water / 0.17 h / Cooling with ice
2.2: 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetone / pH 7
2: 1,2-dimethoxyethane / 2 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: acetone / pH 7
2: Dimethyl ether / 2 h / Reflux
View Scheme
4-(3-nitrophenyl)-1H-pyrazole
1190222-97-9

4-(3-nitrophenyl)-1H-pyrazole

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

phosphoric acid di-tert-butyl [4-(3-nitrophenyl)-1H-pyrazol-1-yl]methyl ester
1190223-01-8

phosphoric acid di-tert-butyl [4-(3-nitrophenyl)-1H-pyrazol-1-yl]methyl ester

Conditions
ConditionsYield
Stage #1: 4-(3-nitrophenyl)-1H-pyrazole With sodium hydride In N,N-dimethyl-formamide for 1h; Inert atmosphere; Cooling with ice;
Stage #2: di-tert-butyl chloromethyl phosphate In N,N-dimethyl-formamide at 20℃; Cooling with ice; Inert atmosphere;
100%
4-[4-[7-tert-butyl-5-(4,4-dimethylcyclohexyl)furo[3,2-b]pyridine-2-carbonyl]-3,3-dimethylpiperazine-1-carbonyl]-1-methylcyclohexanecarboxylic acid

4-[4-[7-tert-butyl-5-(4,4-dimethylcyclohexyl)furo[3,2-b]pyridine-2-carbonyl]-3,3-dimethylpiperazine-1-carbonyl]-1-methylcyclohexanecarboxylic acid

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butoxyphosphoryloxymethyl 4-[4-[7-tert-butyl-5-(4,4-dimethylcyclohexyl)furo[3,2-b]pyridine-2-carbonyl]-3,3-dimethylpiperazine-1-carbonyl]-1-methylcyclohexanecarboxylate

di-tert-butoxyphosphoryloxymethyl 4-[4-[7-tert-butyl-5-(4,4-dimethylcyclohexyl)furo[3,2-b]pyridine-2-carbonyl]-3,3-dimethylpiperazine-1-carbonyl]-1-methylcyclohexanecarboxylate

Conditions
ConditionsYield
With caesium carbonate; potassium iodide In dimethyl sulfoxide at 40℃; for 3h; Heating;100%
(S)-ethyl 4'-(1H-indazole-7-carboxamido)-6'-methoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxylate

(S)-ethyl 4'-(1H-indazole-7-carboxamido)-6'-methoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxylate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

(S)-ethyl 4'-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H-indazole-7-carboxamido)-6'-methoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxylate

(S)-ethyl 4'-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H-indazole-7-carboxamido)-6'-methoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[3,2-b]pyridine]-1-carboxylate

Conditions
ConditionsYield
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide at 55℃; for 5h;100%
ethyl (S)-6'-bromo-4'-(1H-indazole-7-carboxamido)-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3- c]pyridine]-1-carboxylate

ethyl (S)-6'-bromo-4'-(1H-indazole-7-carboxamido)-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3- c]pyridine]-1-carboxylate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

ethyl (S)-6'-bromo-4'-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H- indazole-7-carboxamido)-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-c]pyridine]-1-carboxylate

ethyl (S)-6'-bromo-4'-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H- indazole-7-carboxamido)-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-c]pyridine]-1-carboxylate

Conditions
ConditionsYield
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide at 55℃; for 5h;100%
methyl (S)-6-bromo-4-(1H-indazole-7-carboxamido)spiro[chromane-2,4'-piperidine]-1'-carboxylate

methyl (S)-6-bromo-4-(1H-indazole-7-carboxamido)spiro[chromane-2,4'-piperidine]-1'-carboxylate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

(S)-methyl 6-bromo-4-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H-indazole-7-carboxamido)spiro[chroman-2,4'-piperidine]-1'-carboxylate

(S)-methyl 6-bromo-4-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H-indazole-7-carboxamido)spiro[chroman-2,4'-piperidine]-1'-carboxylate

Conditions
ConditionsYield
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide at 55℃; for 5h;100%
di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

3,5-dimethyl-4-(4-nitrophenyl)-1H-pyrazole
42418-61-1

3,5-dimethyl-4-(4-nitrophenyl)-1H-pyrazole

di-tert-butyl [3,5-dimethyl-4-(4-nitrophenyl)pyrazol-1-yl]methyl phosphate

di-tert-butyl [3,5-dimethyl-4-(4-nitrophenyl)pyrazol-1-yl]methyl phosphate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 18h;100%
N-(3-(3,6-difluoropyridin-2-yl)-1-((1r,4r)-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)thiazole-4-carboxamide

N-(3-(3,6-difluoropyridin-2-yl)-1-((1r,4r)-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)thiazole-4-carboxamide

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((4-(4-((3-(3,6-difluoropyridin-2-yl)-1-(trans-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)carbamoyl)thiazol-2-yl)-1H-pyrazol-1-yl)methyl) phosphate

di-tert-butyl ((4-(4-((3-(3,6-difluoropyridin-2-yl)-1-(trans-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)carbamoyl)thiazol-2-yl)-1H-pyrazol-1-yl)methyl) phosphate

Conditions
ConditionsYield
Stage #1: N-(3-(3,6-difluoropyridin-2-yl)-1-((trans)-4-ethoxycyclohexyl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)thiazole-4-carboxamide With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: di-tert-butyl chloromethyl phosphate In N,N-dimethyl-formamide at 20℃; for 38h;
100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 38h;
N-(1-((1r,4r)-4-ethoxycyclohexyl)-3-(pyrazin-2-yl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)oxazole-4-carboxamide

N-(1-((1r,4r)-4-ethoxycyclohexyl)-3-(pyrazin-2-yl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)oxazole-4-carboxamide

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((4-(4-((1-((1r,4r)-4-ethoxycyclohexyl)-3-(pyrazin-2-yl)-1H-pyrazol-4-yl)carbamoyl)oxazol-2-yl)-1H-pyrazol-1-yl)methyl) phosphate

di-tert-butyl ((4-(4-((1-((1r,4r)-4-ethoxycyclohexyl)-3-(pyrazin-2-yl)-1H-pyrazol-4-yl)carbamoyl)oxazol-2-yl)-1H-pyrazol-1-yl)methyl) phosphate

Conditions
ConditionsYield
Stage #1: N-(1-((1r,4r)-4-ethoxycyclohexyl)-3-(pyrazin-2-yl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)oxazole-4-carboxamide With caesium carbonate In N,N-dimethyl-formamide at 20℃;
Stage #2: di-tert-butyl chloromethyl phosphate In N,N-dimethyl-formamide
99%
5-bromopyridin-3-yl 4,6-O-benzyliden-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-α-D-galactopyranoside

5-bromopyridin-3-yl 4,6-O-benzyliden-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-α-D-galactopyranoside

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

5-bromopyridin-3-yl 4,6-O-benzylidene-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-2-O-[(di-tert-butylphosphonooxy)methyl]-1-thio-α-D-galactopyranoside

5-bromopyridin-3-yl 4,6-O-benzylidene-3-deoxy-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-2-O-[(di-tert-butylphosphonooxy)methyl]-1-thio-α-D-galactopyranoside

Conditions
ConditionsYield
With sodium iodide; silver(l) oxide In N,N-dimethyl-formamide at 20℃; Inert atmosphere; Molecular sieve;96%
netupitant
290297-26-6

netupitant

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

C31H36F6N4O5P(1+)*Cl(1-)

C31H36F6N4O5P(1+)*Cl(1-)

Conditions
ConditionsYield
Stage #1: netupitant; di-tert-butyl chloromethyl phosphate With sodium iodide In acetone at 30℃;
Stage #2: With hydrogenchloride In water; acetone at 0 - 40℃; for 1.5h; Solvent; Temperature;
96%
fulvestrant
129453-61-8

fulvestrant

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentyl sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yloxy)methyl phosphate

di-tert-butyl ((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentyl sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yloxy)methyl phosphate

Conditions
ConditionsYield
Stage #1: fulvestrant With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.0833333h; Inert atmosphere;
Stage #2: di-tert-butyl chloromethyl phosphate In tetrahydrofuran at 70℃;
95.38%
N-(1-((1,3-cis)-3-ethoxycyclobutyl)-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)thiazole-4-carboxamide

N-(1-((1,3-cis)-3-ethoxycyclobutyl)-3-(pyridin-2-yl)-1H-pyrazol-4-yl)-2-(1H-pyrazol-4-yl)thiazole-4-carboxamide

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((4-(4-((1-((1,3-cis)-3-ethoxycyclobutyl)-3-(pyridin-2-yl)-1H-pyrazol-4-yl)carbamoyl)thiazol-2-yl)-1H-pyrazol-1-yl)methyl) phosphate

di-tert-butyl ((4-(4-((1-((1,3-cis)-3-ethoxycyclobutyl)-3-(pyridin-2-yl)-1H-pyrazol-4-yl)carbamoyl)thiazol-2-yl)-1H-pyrazol-1-yl)methyl) phosphate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 20℃;95%
With caesium carbonate In N,N-dimethyl-formamide at 20℃;95%
ethyl (S)-4-(1H-indazole-7-carboxamido)spiro[chromane-2,4'-piperidine]-1'-carboxylate

ethyl (S)-4-(1H-indazole-7-carboxamido)spiro[chromane-2,4'-piperidine]-1'-carboxylate

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

(S)-ethyl 4-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H-indazole-7-carboxamido)spiro[chroman-2,4'-piperidine]-1'-carboxylate

(S)-ethyl 4-(2-(((di-tert-butoxyphosphoryl)oxy)methyl)-2H-indazole-7-carboxamido)spiro[chroman-2,4'-piperidine]-1'-carboxylate

Conditions
ConditionsYield
With caesium carbonate; sodium iodide In N,N-dimethyl-formamide at 55℃; for 5h;94%
3-{(13S,15R)-3-hydroxy-17-[(E)-methoxyimino]-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-15-yl}-N-(5-methylthiazol-2-yl)propanamide

3-{(13S,15R)-3-hydroxy-17-[(E)-methoxyimino]-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-15-yl}-N-(5-methylthiazol-2-yl)propanamide

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((((13S,15R,E)-17-(methoxyimino)-13-methyl-15-(3-((5-methylthiazol-2-yl)amino)-3-oxopropyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)-methyl)phosphate

di-tert-butyl ((((13S,15R,E)-17-(methoxyimino)-13-methyl-15-(3-((5-methylthiazol-2-yl)amino)-3-oxopropyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)-methyl)phosphate

Conditions
ConditionsYield
With tetra-(n-butyl)ammonium iodide; sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃;91%
6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzo[d]imidazole
68786-66-3

6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzo[d]imidazole

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

A

[6-chloro-2-(methylthio)-5-(2,3-dichlorophenoxy)-1H-benzimidazol-1-yl]methyl dihydrogen phosphate

[6-chloro-2-(methylthio)-5-(2,3-dichlorophenoxy)-1H-benzimidazol-1-yl]methyl dihydrogen phosphate

B

[5-chloro-2-(methylthio)-6-(2,3-dichlorophenoxy)-1H-benzimidazol-1-yl]methyl dihydrogen phosphate

[5-chloro-2-(methylthio)-6-(2,3-dichlorophenoxy)-1H-benzimidazol-1-yl]methyl dihydrogen phosphate

Conditions
ConditionsYield
Stage #1: 6-chloro-5-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzo[d]imidazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;
Stage #2: di-tert-butyl chloromethyl phosphate In N,N-dimethyl-formamide; mineral oil for 24h;
Stage #3: With hydrogenchloride In 1,4-dioxane for 0.5h;
A n/a
B 90%
N-(((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)-5-phenylfuran-2-carboxamide

N-(((R)-2-((R)-1-(N-hydroxyformamido)propyl)heptanamido)methyl)-5-phenylfuran-2-carboxamide

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((4R,5R)-4-ethyl-3-formyl-6,10-dioxo-5-pentyl-10-(5-phenylfuran-2-yl)-2-oxa-3,7,9-triazadecyl) phosphate

di-tert-butyl ((4R,5R)-4-ethyl-3-formyl-6,10-dioxo-5-pentyl-10-(5-phenylfuran-2-yl)-2-oxa-3,7,9-triazadecyl) phosphate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran for 24h;84%
2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine
1443732-64-6

2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate
1612288-98-8

di-tert-butyl {2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridin-1-yl}methyl phosphate

Conditions
ConditionsYield
Stage #1: 2-(2-chloro-6-fluorophenyl)-5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-1H-pyrrolo[3,2-b]pyridine With sodium hydride In N,N-dimethyl-formamide at 20℃; for 0.333333h;
Stage #2: di-tert-butyl chloromethyl phosphate With sodium iodide In N,N-dimethyl-formamide at 60℃; for 2.5h;
82%

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