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Hangzhou Think Chemical Co. Ltd

Fulvestrant CAS:129453-61-8 EP Name Fulvestrant Synonyms (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol Molecular Structure

Fulvestrant API and intermediates Stock

Cas:129453-61-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Fulvestrant

Cas:129453-61-8

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Fulvestrant 129453-61-8 GMP manufacturer

Cas:129453-61-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways focus on: -Pharmaceutical raw materials -Chemical raw materials -Food additives -Flavors and fragrances -Feed additives -Plant extracts -Veterinary raw materials We could supply you: -Best quality -Competitive price

Fulvestrant 129453-61-8

Cas:129453-61-8

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

inquiry

Hangzhou Hysen Pharma co.,Ltd.

1.Production technique:we has more than 10 years’ experience to produce Fulvestrant,in which improve the technical maturity,make high yield of product and reduce the cost. 2.Impurities:all pharmacopoeia impurities are available.limit of any o

Fulvestrant factory Low price from China

Cas:129453-61-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality Fulvestrant? supplier in China

Cas:129453-61-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Fulvestrant

Cas:129453-61-8

Min.Order:1

Negotiable

Type:Other

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi

Fulvestrant

Cas:129453-61-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Shandong Jiulong Hisince Pharmaceutical Co.,Ltd.

Fulvestrant//CAS No.:129453-61-8 1.Base Date Name:Fulvestrant CAS No.:129453-61-8 Molecular formular:C32H47F5O3S Fulvestrant Chemical structure: 2.

Fulvestrant

Cas:129453-61-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality fulvestrant

Cas:129453-61-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Fulvestrant -- CHemwill

Cas:129453-61-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

inquiry

Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

fulvestrant

Cas:129453-61-8

Min.Order:5 Gram

FOB Price: $80.0 / 150.0

Type:Trading Company

inquiry

Hubei DiBo chemical co., LTD

Name:Fulvestrant The alias:(7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-Chemicalbookdiol;7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL; CAS NO:129453-61-8 EINECS N

Estra-4,9-diene-3,17-dione/CAS:129453-61-8/with favorable price

Cas:129453-61-8

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Fulvestrant Basic information Product Name: Fulvestrant Synonyms: ICI 182,780;FULVESTRANT;FULVESTRANT-13C1-D2;FASLODEX;(7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,

TIANFU-CHEM CAS:129453-61-8 Fulvestrant

Cas:129453-61-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

ProName: Fulvestrant factory Low price from Chi... CasNo: 129453-61-8 Molecular Formula: C32H47F5O3S Appearance: white powder Application: It’s a medication used to treat hormon... DeliveryTime: regular stock PackAge: Special aluminum f

Fulvestrant 129453-61-8

Cas:129453-61-8

Min.Order:1 Kilogram

FOB Price: $15.0 / 50.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Manufacturer supply Fulvestrant

Cas:129453-61-8

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Product Name Fulvestrant Synonyms (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol Molecular Formula C32H47F5O3S Molecu

Fulvestrant

Cas:129453-61-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr

Positive Faslodex Powder , CAS 129453-61-8 Breast Cancer Medical Hormones

Cas:129453-61-8

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2,Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White to Off-white Crystalli

hot sale Fulvestrant

Cas:129453-61-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

About us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.

Fulvestrant

Cas:129453-61-8

Min.Order:1 Gram

FOB Price: $40.0 / 50.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply Fulvestrant CAS 129453-61-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and exported to

Fulvestrant CAS 129453-61-8

Cas:129453-61-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Fulvestrant

Cas:129453-61-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

White pigment Fulvestrant CAS NO.129453-61-8

Cas:129453-61-8

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

inquiry

Wuhan Wonda Pharm Limited

1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers

Treatment of Breast Cancer 98% Fulvestrantly Powder Anti Estrogen API In Stock Fast Delivery

Cas:129453-61-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in lead acetate, diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countrie

Factory Price powder 99% Fulvestrant CAS: 129453-61-8

Cas:129453-61-8

Min.Order:1 Kilogram

FOB Price: $150.0

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

API name:Fulvestrant Certificates: GMP, DMF CAS No.:129453-61-8 Chemical name: (7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol;7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5

Fulvestrant

Cas:129453-61-8

Min.Order:1 Kilogram

FOB Price: $100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Fulvestrant

Cas:129453-61-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Fulvestrant

Cas:129453-61-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Fulvestrant 129453-61-8

Cas:129453-61-8

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Fulvestrant Synonyms: (7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol;7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL;(7alpha,17beta)-nonyl);estra-1

Fulvestrant 99% Manufactuered in China best quality

Cas:129453-61-8

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

(+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol
153004-31-0

(+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid In water; ethyl acetate at 40℃; for 4h; Inert atmosphere; Schlenk technique;95%
Stage #1: (+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol With β‐cyclodextrin In water; acetone at 20 - 60℃; for 0.5h;
Stage #2: With N-Bromosuccinimide In water; acetone at 40℃; for 10h; Temperature;
87%
With dihydrogen peroxide; acetic acid In water; ethyl acetate for 6 - 8h;85%
7β-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5-trien-3,17β-diol

7β-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5-trien-3,17β-diol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid In ethyl acetate82%
(7R,13S)-3-methoxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol
1221256-46-7

(7R,13S)-3-methoxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
With aluminum (III) chloride; thiourea In dichloromethane at 20 - 55℃; Product distribution / selectivity;32%
ICI 182,780-17β-acetate
261506-24-5

ICI 182,780-17β-acetate

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
With methanol; potassium hydroxide at 20℃; for 3h; Product distribution / selectivity;
7-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5-trien-3,17β-diol

7-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5-trien-3,17β-diol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
With dihydrogen peroxide In water; acetic acid; ethyl acetate at 23℃; for 8h; Large scale reaction;88.4 kg
4,4,5,5,5-pentafluorpentan-1-ol
148043-73-6

4,4,5,5,5-pentafluorpentan-1-ol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
2: isopropyl alcohol / 10 h / Reflux; Inert atmosphere
3: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
4: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 0 - 20 °C
2.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C
3.1: hydrogenchloride / dichloromethane; methanol; water / 1 h
3.2: Reflux
4.1: acetic acid; dihydrogen peroxide / water; ethyl acetate
View Scheme
Multi-step reaction with 4 steps
1: triethylamine; dmap / dichloromethane / 1 h / -10 °C
2: ethanol / 6 h / 65 °C
3: N,N-dimethyl-formamide / 20 °C
4: acetic acid; dihydrogen peroxide / ethyl acetate
View Scheme
1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane
252947-01-6

1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: isopropyl alcohol / 10 h / Reflux; Inert atmosphere
2: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
3: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: ethanol / Reflux
2: sodium hydroxide / water; methanol / 24 h / Inert atmosphere; Reflux
3: sodium periodate / water; methanol / 24 h / 20 °C / Cooling with ice
View Scheme
19-nortestosterone
434-22-0

19-nortestosterone

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium acetate; oxygen / N,N-dimethyl-formamide / 12 h / 20 - 120 °C / 6000.6 Torr / Autoclave
2.1: trichlorophosphate / dichloromethane / 4 h / 35 °C
3.1: potassium tert-butylate / toluene / 1 h / 20 - 50 °C
3.2: 3 h / 10 - 100 °C
4.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C
5.1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
6.1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / 1 h / Reflux
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere
2.2: 2 h / 0 °C / Reflux; Inert atmosphere
3.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
3.2: 0.5 h / -20 - 20 °C
4.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
5.1: water; sodium hydroxide / methanol / 5 h / 20 °C
6.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
7.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / 1 h / Reflux
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere
2.2: 2 h / 0 °C / Reflux; Inert atmosphere
3.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
3.2: 0.5 h / -20 - 20 °C
4.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
5.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
6.1: water; sodium hydroxide / methanol / 5 h / 20 °C
7.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
6-ketoestradiol
571-92-6

6-ketoestradiol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: trichlorophosphate / dichloromethane / 4 h / 35 °C
2.1: potassium tert-butylate / toluene / 1 h / 20 - 50 °C
2.2: 3 h / 10 - 100 °C
3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C
4.1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
5.1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
(8R,9S,13S,14S,17S)-3,17-Bis-(1-methoxy-1-methyl-ethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthren-6-one

(8R,9S,13S,14S,17S)-3,17-Bis-(1-methoxy-1-methyl-ethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthren-6-one

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: potassium tert-butylate / toluene / 1 h / 20 - 50 °C
1.2: 3 h / 10 - 100 °C
2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C
3.1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
4.1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
C35H55BrO5

C35H55BrO5

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C
2: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
3: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
C35H57BrO4

C35H57BrO4

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
2: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
C40H63F5O4S

C40H63F5O4S

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
carbamimidothioic acid 4,4,5,5,5-pentafluoropentyl mesylate ester

carbamimidothioic acid 4,4,5,5,5-pentafluoropentyl mesylate ester

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C
2: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C
View Scheme
(+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate
875573-66-3

(+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate

4,4,5,5,5-pentafluoro-1-pentanethiol
148757-88-4

4,4,5,5,5-pentafluoro-1-pentanethiol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique
2: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique
View Scheme
1-(acetylsulfanyl)-4,4,5,5,5-pentafluoropentane
160598-75-4

1-(acetylsulfanyl)-4,4,5,5,5-pentafluoropentane

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydroxide / methanol / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique
2: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique
3: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique
View Scheme
9-bromo-1-nonene
89359-54-6

9-bromo-1-nonene

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Schwartz's reagent / dichloromethane / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique
1.2: 0.17 h / 20 °C / Inert atmosphere; Schlenk technique
1.3: 20 °C / Inert atmosphere; Schlenk technique
2.1: lithium bromide; copper(ll) bromide / acetonitrile / 2 h / 20 °C / Inert atmosphere; Schlenk technique
3.1: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique
4.1: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique
View Scheme
6-dehydro-19-nortestosterone acetate
2590-41-2

6-dehydro-19-nortestosterone acetate

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: Schwartz's reagent / dichloromethane / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique
1.2: 0.17 h / 20 °C / Inert atmosphere; Schlenk technique
1.3: 20 °C / Inert atmosphere; Schlenk technique
2.1: lithium bromide; copper(ll) bromide / acetonitrile / 2 h / 20 °C / Inert atmosphere; Schlenk technique
3.1: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique
4.1: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 5 steps
1.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
1.2: 0.5 h / -20 - 20 °C
2.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
3.1: water; sodium hydroxide / methanol / 5 h / 20 °C
4.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
5.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
1.2: 0.5 h / -20 - 20 °C
2.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
3.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
4.1: water; sodium hydroxide / methanol / 5 h / 20 °C
5.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
(+)-3-oxo-(7α)-[9-bromononyl]estr-4-en-17β-ylacetate
875573-63-0

(+)-3-oxo-(7α)-[9-bromononyl]estr-4-en-17β-ylacetate

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium bromide; copper(ll) bromide / acetonitrile / 2 h / 20 °C / Inert atmosphere; Schlenk technique
2: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique
3: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique
View Scheme
Multi-step reaction with 4 steps
1: copper(ll) bromide; lithium bromide / acetonitrile / 3 h / 20 °C / Large scale
2: hydrogen bromide / methanol / 3 h / Reflux; Large scale
3: sodium hydroxide / N,N-dimethyl-formamide; water / 1.5 h / 0 - 15 °C / Large scale
4: acetic acid; dihydrogen peroxide / ethyl acetate / 8 h / 20 - 30 °C / Large scale
View Scheme
C37H55BrO5

C37H55BrO5

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C
2.1: hydrogenchloride / dichloromethane; methanol; water / 1 h
2.2: Reflux
3.1: acetic acid; dihydrogen peroxide / water; ethyl acetate
View Scheme
thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester
862700-61-6

thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C
2.1: hydrogenchloride / dichloromethane; methanol; water / 1 h
2.2: Reflux
3.1: acetic acid; dihydrogen peroxide / water; ethyl acetate
View Scheme
(8R,9S,13S,14S,17S)-13-Methyl-3,17-bis-(tetrahydro-pyran-2-yloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-ol
122566-22-7

(8R,9S,13S,14S,17S)-13-Methyl-3,17-bis-(tetrahydro-pyran-2-yloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-ol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: pyridine; Dess-Martin periodane / dichloromethane / 1 h / 20 °C
2.1: triethyl borane; potassium tert-butylate / toluene; tetrahydrofuran / 0.17 h / 110 °C
2.2: Reflux
3.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C
4.1: hydrogenchloride / dichloromethane; methanol; water / 1 h
4.2: Reflux
5.1: acetic acid; dihydrogen peroxide / water; ethyl acetate
View Scheme
3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene-6-one
53573-82-3

3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene-6-one

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triethyl borane; potassium tert-butylate / toluene; tetrahydrofuran / 0.17 h / 110 °C
1.2: Reflux
2.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C
3.1: hydrogenchloride / dichloromethane; methanol; water / 1 h
3.2: Reflux
4.1: acetic acid; dihydrogen peroxide / water; ethyl acetate
View Scheme
C29H44O3

C29H44O3

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
2: water; sodium hydroxide / methanol / 5 h / 20 °C
3: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
4: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
2: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
3: water; sodium hydroxide / methanol / 5 h / 20 °C
4: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
C31H44O4

C31H44O4

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water; sodium hydroxide / methanol / 5 h / 20 °C
2: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
3: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
2: water; sodium hydroxide / methanol / 5 h / 20 °C
3: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
C27H40O2

C27H40O2

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
2: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
C36H51F5O4S

C36H51F5O4S

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; sodium hydroxide / methanol / 5 h / 20 °C
2: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: acetic acid; dihydrogen peroxide / ethyl acetate / 0 - 25 °C
2: sodium hydroxide / methanol / 25 °C
View Scheme
4,4,5,5,5-pentafluoro-1-pentanethiol
148757-88-4

4,4,5,5,5-pentafluoro-1-pentanethiol

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
2: water; sodium hydroxide / methanol / 5 h / 20 °C
3: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
3,17β-diacetoxy-estra-3,5-diene
4999-76-2

3,17β-diacetoxy-estra-3,5-diene

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere
1.2: 2 h / 0 °C / Reflux; Inert atmosphere
2.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
2.2: 0.5 h / -20 - 20 °C
3.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
4.1: water; sodium hydroxide / methanol / 5 h / 20 °C
5.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
6.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere
1.2: 2 h / 0 °C / Reflux; Inert atmosphere
2.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere
2.2: 0.5 h / -20 - 20 °C
3.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C
4.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation
5.1: water; sodium hydroxide / methanol / 5 h / 20 °C
6.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C
View Scheme
C11H10F5NO5S

C11H10F5NO5S

fulvestrant
129453-61-8

fulvestrant

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethanol / 6 h / 65 °C
2: N,N-dimethyl-formamide / 20 °C
3: acetic acid; dihydrogen peroxide / ethyl acetate
View Scheme
fulvestrant
129453-61-8

fulvestrant

formic acid ethyl ester
109-94-4

formic acid ethyl ester

ICI 182,780-17β-formate
403656-82-6

ICI 182,780-17β-formate

Conditions
ConditionsYield
With toluene-4-sulfonic acid Heating;100%
benzoyl chloride
98-88-4

benzoyl chloride

fulvestrant
129453-61-8

fulvestrant

ICI 182,780-3-benzoate
261506-25-6

ICI 182,780-3-benzoate

Conditions
ConditionsYield
With potassium hydroxide In dichloromethane at 0 - 20℃; for 2.5h; Schotten-Baumann reaction;99%
With potassium hydroxide In dichloromethane Esterification;
ethyl acetate
141-78-6

ethyl acetate

fulvestrant
129453-61-8

fulvestrant

ICI 182,780-17β-acetate
261506-24-5

ICI 182,780-17β-acetate

Conditions
ConditionsYield
With toluene-4-sulfonic acid for 6h; Heating;97%
fulvestrant
129453-61-8

fulvestrant

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentyl sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yloxy)methyl phosphate

di-tert-butyl ((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentyl sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yloxy)methyl phosphate

Conditions
ConditionsYield
Stage #1: fulvestrant With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.0833333h; Inert atmosphere;
Stage #2: di-tert-butyl chloromethyl phosphate In tetrahydrofuran at 70℃;
95.38%
fulvestrant
129453-61-8

fulvestrant

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-deca hydro-6H-cyclopenta[a]phenanthren-3-yl sulfurofluoridate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-deca hydro-6H-cyclopenta[a]phenanthren-3-yl sulfurofluoridate

Conditions
ConditionsYield
With fluorosulfonyl fluoride; triethylamine In acetonitrile at 20℃; for 1h; chemoselective reaction;90%
With fluorosulfonyl fluoride; triethylamine In dichloromethane at 20℃; for 12h; Sealed tube;72%
2,3,4,6-Tetra-O-pivaloyl-α-D-glucopyranosyl trichloroacetimidate
103366-74-1

2,3,4,6-Tetra-O-pivaloyl-α-D-glucopyranosyl trichloroacetimidate

fulvestrant
129453-61-8

fulvestrant

C84H131F5O21S

C84H131F5O21S

Conditions
ConditionsYield
Stage #1: fulvestrant With boron trifluoride diethyl etherate In 1,2-dichloro-ethane at -20℃;
Stage #2: 2,3,4,6-Tetra-O-pivaloyl-α-D-glucopyranosyl trichloroacetimidate In 1,2-dichloro-ethane Further stages.;
80%
fulvestrant
129453-61-8

fulvestrant

ICI 182,780-17-ketone

ICI 182,780-17-ketone

Conditions
ConditionsYield
With oxalyl dichloride; dimethyl sulfoxide; diisopropylamine In 1,2-dichloro-ethane at -70 - 20℃; Swern oxidation;65%
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
990-91-0

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

fulvestrant
129453-61-8

fulvestrant

dibenzyl ((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl) phosphate

dibenzyl ((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl) phosphate

Conditions
ConditionsYield
Stage #1: fulvestrant With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.0833333h;
Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at 70℃; for 18h;
62.99%
all cis-5,8,11,14,17-eicosapentaenoic acid
10417-94-4

all cis-5,8,11,14,17-eicosapentaenoic acid

fulvestrant
129453-61-8

fulvestrant

C52H75F5O4S

C52H75F5O4S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;58%
succinic acid anhydride
108-30-5

succinic acid anhydride

fulvestrant
129453-61-8

fulvestrant

4-(((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)-4-oxobutanoic acid

4-(((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)-4-oxobutanoic acid

Conditions
ConditionsYield
With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 16h;54.08%
bis-(p-nitrophenyl) carbonate
5070-13-3

bis-(p-nitrophenyl) carbonate

L-valine tert-butylester hydrochloride
13518-40-6

L-valine tert-butylester hydrochloride

fulvestrant
129453-61-8

fulvestrant

(2S)-tert-butyl 2-(((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H cyclopenta[a]phenanthren-3-yloxy)carbonylamino)-3-methylbutanoate

(2S)-tert-butyl 2-(((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H cyclopenta[a]phenanthren-3-yloxy)carbonylamino)-3-methylbutanoate

Conditions
ConditionsYield
Stage #1: bis-(p-nitrophenyl) carbonate; L-valine tert-butylester hydrochloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: fulvestrant With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;
48.8%
dimethylaminoacetic acid
1118-68-9

dimethylaminoacetic acid

fulvestrant
129453-61-8

fulvestrant

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl dimethylglycinate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl dimethylglycinate

Conditions
ConditionsYield
Stage #1: dimethylaminoacetic acid; fulvestrant With dmap In dichloromethane at 0℃; for 0.166667h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h;
46.77%
bis-(p-nitrophenyl) carbonate
5070-13-3

bis-(p-nitrophenyl) carbonate

L-phenylalanine tert-butyl ester
16874-17-2

L-phenylalanine tert-butyl ester

fulvestrant
129453-61-8

fulvestrant

(2S)-tert-butyl 2-(((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoro pentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yloxy)carbonylamino)-3-phenylpropanoate

(2S)-tert-butyl 2-(((7R,8R,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoro pentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yloxy)carbonylamino)-3-phenylpropanoate

Conditions
ConditionsYield
Stage #1: bis-(p-nitrophenyl) carbonate; L-phenylalanine tert-butyl ester With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: fulvestrant With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Inert atmosphere;
33.96%
morpholin-4-ylacetic acid
3235-69-6

morpholin-4-ylacetic acid

fulvestrant
129453-61-8

fulvestrant

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-morpholinoacetate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-morpholinoacetate

Conditions
ConditionsYield
Stage #1: morpholin-4-ylacetic acid; fulvestrant With dmap In dichloromethane at 0℃; for 0.0833333h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 2h;
33.07%
4-methyl-piperazine-1-carbonyl chloride
39539-66-7

4-methyl-piperazine-1-carbonyl chloride

fulvestrant
129453-61-8

fulvestrant

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 4-methylpiperazine-1-carboxylate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 4-methylpiperazine-1-carboxylate

Conditions
ConditionsYield
Stage #1: fulvestrant With dmap; potassium carbonate In acetonitrile at 20℃; for 0.5h;
Stage #2: 4-methyl-piperazine-1-carbonyl chloride at 0 - 20℃; for 18h;
31.46%
undecylenic acid
112-37-8

undecylenic acid

fulvestrant
129453-61-8

fulvestrant

C43H67F5O4S

C43H67F5O4S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;27.7%
3-morpholin-4-ylpropionic acid
4497-04-5

3-morpholin-4-ylpropionic acid

fulvestrant
129453-61-8

fulvestrant

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 3-morpholinopropanoate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 3-morpholinopropanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 6h;26.37%
fulvestrant
129453-61-8

fulvestrant

di-tert-butyl chloromethyl phosphate
229625-50-7

di-tert-butyl chloromethyl phosphate

di-tert-butyl ((((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl- 7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)methyl) phosphate

di-tert-butyl ((((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl- 7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)methyl) phosphate

Conditions
ConditionsYield
Stage #1: fulvestrant With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.25h;
Stage #2: di-tert-butyl chloromethyl phosphate In tetrahydrofuran at 70℃; for 7h;
26.14%
diethyl chlorophosphate
814-49-3

diethyl chlorophosphate

fulvestrant
129453-61-8

fulvestrant

diethyl ((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl) phosphate

diethyl ((7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl) phosphate

Conditions
ConditionsYield
Stage #1: fulvestrant With tetrabutylammomium bromide; sodium hydroxide In chloroform; water at 20℃; for 0.5h;
Stage #2: diethyl chlorophosphate In chloroform; water at 20℃; for 16h;
24.5%
fulvestrant
129453-61-8

fulvestrant

(4-Methyl-piperazin-1-yl)-acetic acid
54699-92-2

(4-Methyl-piperazin-1-yl)-acetic acid

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-(4-methylpiperazin-1-yl)acetate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-(4-methylpiperazin-1-yl)acetate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h;24.37%
2-(pyrrolidin-1-yl)acetic acid
37386-15-5

2-(pyrrolidin-1-yl)acetic acid

fulvestrant
129453-61-8

fulvestrant

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-(pyrrolidin-1-yl)acetate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-(pyrrolidin-1-yl)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 6h;23.24%
5,7,7-trimethyl-2-(1,3,3-trimethylbutyl)-octanoic acid

5,7,7-trimethyl-2-(1,3,3-trimethylbutyl)-octanoic acid

fulvestrant
129453-61-8

fulvestrant

C50H81F5O4S

C50H81F5O4S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;23.2%
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

fulvestrant
129453-61-8

fulvestrant

C48H77F5O4S

C48H77F5O4S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;22%
fulvestrant
129453-61-8

fulvestrant

C43H65F5O4S

C43H65F5O4S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;21.5%
fulvestrant
129453-61-8

fulvestrant

docosahexa-4,7,10,13,16,19-enoic acid

docosahexa-4,7,10,13,16,19-enoic acid

C54H77F5O4S

C54H77F5O4S

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h;21.1%
fulvestrant
129453-61-8

fulvestrant

salicylic acid
69-72-7

salicylic acid

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-hydroxybenzoate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 2-hydroxybenzoate

Conditions
ConditionsYield
Stage #1: fulvestrant; salicylic acid With dmap In dichloromethane at 0℃; for 0.0833333h;
Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h;
18.92%
3-dimethylaminopropionic acid
6300-04-5

3-dimethylaminopropionic acid

fulvestrant
129453-61-8

fulvestrant

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 3-(dimethylamino)propanoate

(7R,8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl 3-(dimethylamino)propanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 12h;18.62%

Raw Materials

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