Fulvestrant CAS:129453-61-8 EP Name Fulvestrant Synonyms (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol Molecular Structure
Cas:129453-61-8
Min.Order:100 Gram
Negotiable
Type:Other
inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:129453-61-8
Min.Order:1 Gram
FOB Price: $0.1
Type:Manufacturers
inquiryHanways focus on: -Pharmaceutical raw materials -Chemical raw materials -Food additives -Flavors and fragrances -Feed additives -Plant extracts -Veterinary raw materials We could supply you: -Best quality -Competitive price
Cas:129453-61-8
Min.Order:1 Kilogram
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Type:Trading Company
inquiry1.Production technique:we has more than 10 years’ experience to produce Fulvestrant,in which improve the technical maturity,make high yield of product and reduce the cost. 2.Impurities:all pharmacopoeia impurities are available.limit of any o
Cas:129453-61-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWelcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our
Cas:129453-61-8
Min.Order:0 Metric Ton
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Type:Manufacturers
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new api, intermedi
Fulvestrant//CAS No.:129453-61-8 1.Base Date Name:Fulvestrant CAS No.:129453-61-8 Molecular formular:C32H47F5O3S Fulvestrant Chemical structure: 2.
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:129453-61-8
Min.Order:1 Kilogram
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Type:Manufacturers
inquiry
Cas:129453-61-8
Min.Order:1 Metric Ton
FOB Price: $1.0
Type:Manufacturers
inquirychengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res
Name:Fulvestrant The alias:(7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-Chemicalbookdiol;7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL; CAS NO:129453-61-8 EINECS N
Cas:129453-61-8
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryFulvestrant Basic information Product Name: Fulvestrant Synonyms: ICI 182,780;FULVESTRANT;FULVESTRANT-13C1-D2;FASLODEX;(7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,
Cas:129453-61-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryProName: Fulvestrant factory Low price from Chi... CasNo: 129453-61-8 Molecular Formula: C32H47F5O3S Appearance: white powder Application: It’s a medication used to treat hormon... DeliveryTime: regular stock PackAge: Special aluminum f
Cas:129453-61-8
Min.Order:1 Kilogram
FOB Price: $15.0 / 50.0
Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:129453-61-8
Min.Order:10 Kilogram
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Type:Trading Company
inquiryProduct Name Fulvestrant Synonyms (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol Molecular Formula C32H47F5O3S Molecu
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr
Cas:129453-61-8
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1,In No Less five years exporting experience. 2,Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Appearance:White to Off-white Crystalli
Cas:129453-61-8
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryAbout us Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad.
Beluga chemical professional supply Fulvestrant CAS 129453-61-8 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and exported to
Cas:129453-61-8
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,
Cas:129453-61-8
Min.Order:20 Metric Ton
Negotiable
Type:Trading Company
inquiry1.High Quality: Quality is life. Quality is the most important element for all goods. We have a lab doing research in Wuhan China and produce sarms in bulk quantity. We have 8 years experience making all kinds of sarms. And all our old customers
Cas:129453-61-8
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHebei Mojin Biotechnology Co., Ltd, Our company is a professional in lead acetate, diphenyl ethylamine and other chemical raw materials and chemical reagents research and development production enterprises. Our business covers more than 30 countrie
Cas:129453-61-8
Min.Order:1 Kilogram
FOB Price: $150.0
Type:Trading Company
inquiryAPI name:Fulvestrant Certificates: GMP, DMF CAS No.:129453-61-8 Chemical name: (7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol;7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
Cas:129453-61-8
Min.Order:100 Metric Ton
Negotiable
Type:Lab/Research institutions
inquiryProduct Name: Fulvestrant Synonyms: (7a,17b)-7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol;7A,17B-[9[(4,4,5,5,5-PENTAFLUOROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL;(7alpha,17beta)-nonyl);estra-1
Cas:129453-61-8
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiry(+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol
fulvestrant
Conditions | Yield |
---|---|
With dihydrogen peroxide; acetic acid In water; ethyl acetate at 40℃; for 4h; Inert atmosphere; Schlenk technique; | 95% |
Stage #1: (+)-(7α)-[9-(4,4,5,5,5-pentafluoropentylsulfanyl)nonyl]estra-1,3,5(10)-triene-3,17β-diol With β‐cyclodextrin In water; acetone at 20 - 60℃; for 0.5h; Stage #2: With N-Bromosuccinimide In water; acetone at 40℃; for 10h; Temperature; | 87% |
With dihydrogen peroxide; acetic acid In water; ethyl acetate for 6 - 8h; | 85% |
fulvestrant
Conditions | Yield |
---|---|
With dihydrogen peroxide; acetic acid In ethyl acetate | 82% |
(7R,13S)-3-methoxy-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-ol
fulvestrant
Conditions | Yield |
---|---|
With aluminum (III) chloride; thiourea In dichloromethane at 20 - 55℃; Product distribution / selectivity; | 32% |
ICI 182,780-17β-acetate
fulvestrant
Conditions | Yield |
---|---|
With methanol; potassium hydroxide at 20℃; for 3h; Product distribution / selectivity; |
fulvestrant
Conditions | Yield |
---|---|
With dihydrogen peroxide In water; acetic acid; ethyl acetate at 23℃; for 8h; Large scale reaction; | 88.4 kg |
4,4,5,5,5-pentafluorpentan-1-ol
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2: isopropyl alcohol / 10 h / Reflux; Inert atmosphere 3: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 4: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 0 - 20 °C 2.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C 3.1: hydrogenchloride / dichloromethane; methanol; water / 1 h 3.2: Reflux 4.1: acetic acid; dihydrogen peroxide / water; ethyl acetate View Scheme | |
Multi-step reaction with 4 steps 1: triethylamine; dmap / dichloromethane / 1 h / -10 °C 2: ethanol / 6 h / 65 °C 3: N,N-dimethyl-formamide / 20 °C 4: acetic acid; dihydrogen peroxide / ethyl acetate View Scheme |
1-methanesulfonyloxy-4,4,5,5,5-pentafluoropentane
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: isopropyl alcohol / 10 h / Reflux; Inert atmosphere 2: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 3: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: ethanol / Reflux 2: sodium hydroxide / water; methanol / 24 h / Inert atmosphere; Reflux 3: sodium periodate / water; methanol / 24 h / 20 °C / Cooling with ice View Scheme |
19-nortestosterone
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium acetate; oxygen / N,N-dimethyl-formamide / 12 h / 20 - 120 °C / 6000.6 Torr / Autoclave 2.1: trichlorophosphate / dichloromethane / 4 h / 35 °C 3.1: potassium tert-butylate / toluene / 1 h / 20 - 50 °C 3.2: 3 h / 10 - 100 °C 4.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C 5.1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 6.1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: toluene-4-sulfonic acid / 1 h / Reflux 2.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere 2.2: 2 h / 0 °C / Reflux; Inert atmosphere 3.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere 3.2: 0.5 h / -20 - 20 °C 4.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 5.1: water; sodium hydroxide / methanol / 5 h / 20 °C 6.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 7.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme | |
Multi-step reaction with 7 steps 1.1: toluene-4-sulfonic acid / 1 h / Reflux 2.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere 2.2: 2 h / 0 °C / Reflux; Inert atmosphere 3.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere 3.2: 0.5 h / -20 - 20 °C 4.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 5.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 6.1: water; sodium hydroxide / methanol / 5 h / 20 °C 7.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme |
6-ketoestradiol
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: trichlorophosphate / dichloromethane / 4 h / 35 °C 2.1: potassium tert-butylate / toluene / 1 h / 20 - 50 °C 2.2: 3 h / 10 - 100 °C 3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C 4.1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 5.1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: potassium tert-butylate / toluene / 1 h / 20 - 50 °C 1.2: 3 h / 10 - 100 °C 2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C 3.1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 4.1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 4 h / 0 - 25 °C 2: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 3: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 2: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / acetonitrile; triethylamine; water / 3 h / 70 °C 2: sodium hydrogensulfate monohydrate / dichloromethane; water / 3 h / Reflux 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 - 5 °C View Scheme |
(+)-(7α)-[9-bromononyl]estra-1,3,5(10)-triene-3-ol-17β-yl acetate
4,4,5,5,5-pentafluoro-1-pentanethiol
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique 2: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique View Scheme |
1-(acetylsulfanyl)-4,4,5,5,5-pentafluoropentane
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium hydroxide / methanol / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique 2: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique 3: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique View Scheme |
9-bromo-1-nonene
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Schwartz's reagent / dichloromethane / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique 1.2: 0.17 h / 20 °C / Inert atmosphere; Schlenk technique 1.3: 20 °C / Inert atmosphere; Schlenk technique 2.1: lithium bromide; copper(ll) bromide / acetonitrile / 2 h / 20 °C / Inert atmosphere; Schlenk technique 3.1: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique 4.1: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique View Scheme |
6-dehydro-19-nortestosterone acetate
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: Schwartz's reagent / dichloromethane / 0.33 h / 20 °C / Inert atmosphere; Schlenk technique 1.2: 0.17 h / 20 °C / Inert atmosphere; Schlenk technique 1.3: 20 °C / Inert atmosphere; Schlenk technique 2.1: lithium bromide; copper(ll) bromide / acetonitrile / 2 h / 20 °C / Inert atmosphere; Schlenk technique 3.1: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique 4.1: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique View Scheme | |
Multi-step reaction with 5 steps 1.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere 1.2: 0.5 h / -20 - 20 °C 2.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 3.1: water; sodium hydroxide / methanol / 5 h / 20 °C 4.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 5.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere 1.2: 0.5 h / -20 - 20 °C 2.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 3.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 4.1: water; sodium hydroxide / methanol / 5 h / 20 °C 5.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme |
(+)-3-oxo-(7α)-[9-bromononyl]estr-4-en-17β-ylacetate
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium bromide; copper(ll) bromide / acetonitrile / 2 h / 20 °C / Inert atmosphere; Schlenk technique 2: methanol / 2 h / 40 °C / Inert atmosphere; Schlenk technique 3: dihydrogen peroxide; acetic acid / water; ethyl acetate / 4 h / 40 °C / Inert atmosphere; Schlenk technique View Scheme | |
Multi-step reaction with 4 steps 1: copper(ll) bromide; lithium bromide / acetonitrile / 3 h / 20 °C / Large scale 2: hydrogen bromide / methanol / 3 h / Reflux; Large scale 3: sodium hydroxide / N,N-dimethyl-formamide; water / 1.5 h / 0 - 15 °C / Large scale 4: acetic acid; dihydrogen peroxide / ethyl acetate / 8 h / 20 - 30 °C / Large scale View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C 2.1: hydrogenchloride / dichloromethane; methanol; water / 1 h 2.2: Reflux 3.1: acetic acid; dihydrogen peroxide / water; ethyl acetate View Scheme |
thiobenzoic acid S-(4,4,5,5,5-pentafluoro-pentyl)ester
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C 2.1: hydrogenchloride / dichloromethane; methanol; water / 1 h 2.2: Reflux 3.1: acetic acid; dihydrogen peroxide / water; ethyl acetate View Scheme |
(8R,9S,13S,14S,17S)-13-Methyl-3,17-bis-(tetrahydro-pyran-2-yloxy)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-ol
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: pyridine; Dess-Martin periodane / dichloromethane / 1 h / 20 °C 2.1: triethyl borane; potassium tert-butylate / toluene; tetrahydrofuran / 0.17 h / 110 °C 2.2: Reflux 3.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C 4.1: hydrogenchloride / dichloromethane; methanol; water / 1 h 4.2: Reflux 5.1: acetic acid; dihydrogen peroxide / water; ethyl acetate View Scheme |
3,17β-bis(2-tetrahydropyranyloxy)estra-1,3,5(10)-triene-6-one
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: triethyl borane; potassium tert-butylate / toluene; tetrahydrofuran / 0.17 h / 110 °C 1.2: Reflux 2.1: potassium tert-butylate / tetrahydrofuran; methanol / 70 °C 3.1: hydrogenchloride / dichloromethane; methanol; water / 1 h 3.2: Reflux 4.1: acetic acid; dihydrogen peroxide / water; ethyl acetate View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 2: water; sodium hydroxide / methanol / 5 h / 20 °C 3: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 4: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 2: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 3: water; sodium hydroxide / methanol / 5 h / 20 °C 4: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water; sodium hydroxide / methanol / 5 h / 20 °C 2: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 3: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 2: water; sodium hydroxide / methanol / 5 h / 20 °C 3: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 2: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water; sodium hydroxide / methanol / 5 h / 20 °C 2: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: acetic acid; dihydrogen peroxide / ethyl acetate / 0 - 25 °C 2: sodium hydroxide / methanol / 25 °C View Scheme |
4,4,5,5,5-pentafluoro-1-pentanethiol
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 2: water; sodium hydroxide / methanol / 5 h / 20 °C 3: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme |
3,17β-diacetoxy-estra-3,5-diene
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere 1.2: 2 h / 0 °C / Reflux; Inert atmosphere 2.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere 2.2: 0.5 h / -20 - 20 °C 3.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 4.1: water; sodium hydroxide / methanol / 5 h / 20 °C 5.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 6.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: N-Bromosuccinimide / N,N-dimethyl-formamide; water / 1.25 h / 0 - 7 °C / Inert atmosphere 1.2: 2 h / 0 °C / Reflux; Inert atmosphere 2.1: copper(I) bromide / tetrahydrofuran / 0.75 h / -20 °C / Inert atmosphere 2.2: 0.5 h / -20 - 20 °C 3.1: copper(I) bromide; lithium bromide / acetonitrile / 24 h / 20 °C 4.1: 2,2-dimethoxy-2-phenylacetophenone / chloroform / 5 h / 20 °C / Inert atmosphere; UV-irradiation 5.1: water; sodium hydroxide / methanol / 5 h / 20 °C 6.1: acetic acid; dihydrogen peroxide / ethyl acetate / 16 h / 20 °C View Scheme |
fulvestrant
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethanol / 6 h / 65 °C 2: N,N-dimethyl-formamide / 20 °C 3: acetic acid; dihydrogen peroxide / ethyl acetate View Scheme |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid Heating; | 100% |
Conditions | Yield |
---|---|
With potassium hydroxide In dichloromethane at 0 - 20℃; for 2.5h; Schotten-Baumann reaction; | 99% |
With potassium hydroxide In dichloromethane Esterification; |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid for 6h; Heating; | 97% |
fulvestrant
di-tert-butyl chloromethyl phosphate
Conditions | Yield |
---|---|
Stage #1: fulvestrant With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.0833333h; Inert atmosphere; Stage #2: di-tert-butyl chloromethyl phosphate In tetrahydrofuran at 70℃; | 95.38% |
fulvestrant
Conditions | Yield |
---|---|
With fluorosulfonyl fluoride; triethylamine In acetonitrile at 20℃; for 1h; chemoselective reaction; | 90% |
With fluorosulfonyl fluoride; triethylamine In dichloromethane at 20℃; for 12h; Sealed tube; | 72% |
2,3,4,6-Tetra-O-pivaloyl-α-D-glucopyranosyl trichloroacetimidate
fulvestrant
Conditions | Yield |
---|---|
Stage #1: fulvestrant With boron trifluoride diethyl etherate In 1,2-dichloro-ethane at -20℃; Stage #2: 2,3,4,6-Tetra-O-pivaloyl-α-D-glucopyranosyl trichloroacetimidate In 1,2-dichloro-ethane Further stages.; | 80% |
fulvestrant
Conditions | Yield |
---|---|
With oxalyl dichloride; dimethyl sulfoxide; diisopropylamine In 1,2-dichloro-ethane at -70 - 20℃; Swern oxidation; | 65% |
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate
fulvestrant
Conditions | Yield |
---|---|
Stage #1: fulvestrant With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.0833333h; Stage #2: dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate In tetrahydrofuran at 70℃; for 18h; | 62.99% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h; | 58% |
succinic acid anhydride
fulvestrant
Conditions | Yield |
---|---|
With dmap; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 50℃; for 16h; | 54.08% |
bis-(p-nitrophenyl) carbonate
L-valine tert-butylester hydrochloride
fulvestrant
Conditions | Yield |
---|---|
Stage #1: bis-(p-nitrophenyl) carbonate; L-valine tert-butylester hydrochloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: fulvestrant With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; | 48.8% |
dimethylaminoacetic acid
fulvestrant
Conditions | Yield |
---|---|
Stage #1: dimethylaminoacetic acid; fulvestrant With dmap In dichloromethane at 0℃; for 0.166667h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; | 46.77% |
bis-(p-nitrophenyl) carbonate
L-phenylalanine tert-butyl ester
fulvestrant
Conditions | Yield |
---|---|
Stage #1: bis-(p-nitrophenyl) carbonate; L-phenylalanine tert-butyl ester With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: fulvestrant With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Inert atmosphere; | 33.96% |
morpholin-4-ylacetic acid
fulvestrant
Conditions | Yield |
---|---|
Stage #1: morpholin-4-ylacetic acid; fulvestrant With dmap In dichloromethane at 0℃; for 0.0833333h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 0℃; for 2h; | 33.07% |
4-methyl-piperazine-1-carbonyl chloride
fulvestrant
Conditions | Yield |
---|---|
Stage #1: fulvestrant With dmap; potassium carbonate In acetonitrile at 20℃; for 0.5h; Stage #2: 4-methyl-piperazine-1-carbonyl chloride at 0 - 20℃; for 18h; | 31.46% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h; | 27.7% |
3-morpholin-4-ylpropionic acid
fulvestrant
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 6h; | 26.37% |
fulvestrant
di-tert-butyl chloromethyl phosphate
Conditions | Yield |
---|---|
Stage #1: fulvestrant With potassium tert-butylate In tetrahydrofuran at 70℃; for 0.25h; Stage #2: di-tert-butyl chloromethyl phosphate In tetrahydrofuran at 70℃; for 7h; | 26.14% |
diethyl chlorophosphate
fulvestrant
Conditions | Yield |
---|---|
Stage #1: fulvestrant With tetrabutylammomium bromide; sodium hydroxide In chloroform; water at 20℃; for 0.5h; Stage #2: diethyl chlorophosphate In chloroform; water at 20℃; for 16h; | 24.5% |
fulvestrant
(4-Methyl-piperazin-1-yl)-acetic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 16h; | 24.37% |
2-(pyrrolidin-1-yl)acetic acid
fulvestrant
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 6h; | 23.24% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h; | 23.2% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h; | 22% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h; | 21.5% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 48h; | 21.1% |
fulvestrant
salicylic acid
Conditions | Yield |
---|---|
Stage #1: fulvestrant; salicylic acid With dmap In dichloromethane at 0℃; for 0.0833333h; Stage #2: With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; | 18.92% |
3-dimethylaminopropionic acid
fulvestrant
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 12h; | 18.62% |
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