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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

2,5-Difluorobenzoic acid Manufacturer/High quality/Best price/In stock

Cas:2991-28-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2,5-Difluoro Benzoic Acids supplier in China

Cas:2991-28-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

chengdu and import and export trade co., LTD., who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do res

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:10 Kilogram

FOB Price: $100.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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COLORCOM LTD.

Colorcom is a global leader in industrial chemical manufacturing and is continuously innovating and transforming to exceed client expectations and industry standards. Colorcom prides itself on superior customer and technical focus, while focusing on

2, 5-Difluorobenzoic Acid

Cas:2991-28-8

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

2,5-Difluorobenzoic acid 2991-28-8 2,5-Difluorobenzoic acid Basic information Product Name: 2,5-Difluorobenzoic acid Synonyms: 2,5-DIFLUOROBENZOIC ACID;RARECHEM AL BO 0019;Benzoic acid

2,5-Difluorobenzoic acid 2991-28-8

Cas:2991-28-8

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

Name: 2,5-Difluorobenzoic acid CAS:2991-28-8 MF: C7H4F2O2 Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25kg Application:APIs Transportation:By sea or by air Port:Qingdao Port

2,5-Difluorobenzoic acid CAS:2991-28-8

Cas:2991-28-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

2,5-Difluorobenzoic acid CAS:2991-28-8

Cas:2991-28-8

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 2991-28-8 with competitive price

Cas:2991-28-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2,5-Difluorobenzoic acid 2991-28-8

Cas:2991-28-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 2,5-Difluorobenzoic acid Synonyms: 2,5-DIFLUOROBENZOIC ACID;RARECHEM AL BO 0019;Benzoic acid, 2,5-difluoro-;2,5-Difluorobenzic acid;2-chloro-6-flurobenzyl cyanide;2,5-Difluorobenzoic;2,5-Difluorobenzoic acid 98%;2,5-Difluorobenzoi

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2,5-Difluorobenzoic acid CAS:2991-28-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

2,5-Difluorobenzoic acid CAS:2991-28-8

Cas:2991-28-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2991-28-8

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2,5-difluoro benzoic acids

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Manufacturers

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2,5-Difluorobenzoic acid CAS NO.2991-28-8

Cas:2991-28-8

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Siwei Development Group Ltd.

Product name: 2,5-Difluorobenzoic Acid CAS No.: 2991-28-8 Molecule Formula:C7H3F2O2 Molecule Weight:157.09 Purity: 99.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TESTING ITEMS

Lower Price 2,5-Difluorobenzoic Acid on stock

Cas:2991-28-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

2,5-difluorobenzoic Acid

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:1 Kilogram

Negotiable

Type:Other

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

5-bromo-2-fluoroaniline

Cas:2991-28-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

2,5-Difluorobenzoic Acid cas no. 2991-28-8 98%

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Vanz Pharm Co.,Ltd

ISO Factory/Good qualityAppearance:off white Storage:dry and cool place Package:10G/BAG; 1KG/BAG ;25KG/DRUM Application:Active pharaceutical ingredients Transportation:BY SEA,AIR,EXPRESS Port:SHANGHAI;BEIJING

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

2,5-Difluorobenzoic acid

Cas:2991-28-8

Min.Order:0

Negotiable

Type:Other

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Synthetic route

2-bromo-1,4-difluorobenzene
399-94-0

2-bromo-1,4-difluorobenzene

carbon dioxide
124-38-9

carbon dioxide

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
With n-butyllithium 1) hexane, Et2O, 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction;
carbon dioxide
124-38-9

carbon dioxide

para-difluorobenzene
540-36-3

para-difluorobenzene

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
With sec.-butyllithium 1.) THF, -78 deg C, 0.5 h, 2.) THF, a) -78 deg C, 15 min, b) from -78 deg C to RT; Yield given. Multistep reaction;
2,3,6-trifluorobenzoic acid
2358-29-4

2,3,6-trifluorobenzoic acid

A

3-fluorobenzoic acid
455-38-9

3-fluorobenzoic acid

B

benzoic acid
65-85-0

benzoic acid

C

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
With ammonia; sodium at -45℃; for 0.25h; Reduction; Hydrodefluorination; Title compound not separated from byproducts;A 9 % Spectr.
B 9 % Spectr.
C 16 % Spectr.
2',5'-difluoroacetophenone
1979-36-8

2',5'-difluoroacetophenone

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
With potassium permanganate Oxidation;
para-difluorobenzene
540-36-3

para-difluorobenzene

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: KMnO4
View Scheme
1,2,3,5-tetrafluorobenzene
2367-82-0

1,2,3,5-tetrafluorobenzene

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: BuLi / tetrahydrofuran / -70 °C
1.2: tetrahydrofuran
2.1: 9 percent Spectr. / Zn; NH3 / -45 °C
3.1: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C
View Scheme
Multi-step reaction with 3 steps
1.1: BuLi / tetrahydrofuran / -70 °C
1.2: tetrahydrofuran
2.1: 12 percent Spectr. / Na; NH3 / 0.25 h / -45 °C
3.1: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C
View Scheme
1,2,4-trifluorobenzene
367-23-7

1,2,4-trifluorobenzene

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: BuLi / tetrahydrofuran / -70 °C
1.2: tetrahydrofuran
2.1: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C
View Scheme
2,3,4,6-tetrafluorobenzoic acid
32890-92-9

2,3,4,6-tetrafluorobenzoic acid

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 9 percent Spectr. / Zn; NH3 / -45 °C
2: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C
View Scheme
Multi-step reaction with 2 steps
1: 12 percent Spectr. / Na; NH3 / 0.25 h / -45 °C
2: 16 percent Spectr. / Na; NH3 / 0.25 h / -45 °C
View Scheme
2,5-difluoro-α,α-dichloroacetophenone

2,5-difluoro-α,α-dichloroacetophenone

sodium disulfite

sodium disulfite

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
With hydrogenchloride In sodium hypobromide; water
C7H3F2O2(1-)*C25H30N3(1+)

C7H3F2O2(1-)*C25H30N3(1+)

A

crystal violet carbinol base
467-63-0

crystal violet carbinol base

B

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

Conditions
ConditionsYield
With water In chlorobenzene at 28℃; Equilibrium constant; Further Variations:; Temperatures;
2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

2,5-difluorobenzoyl chloride
35730-09-7

2,5-difluorobenzoyl chloride

Conditions
ConditionsYield
Stage #1: 2,5-difluorobenzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h;
Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h;
100%
With thionyl chloride Heating;97%
With sulfuryl dichloride for 4h; Heating;73%
ethanol
64-17-5

ethanol

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

ethyl 2,5-difluorobenzoate
708-25-8

ethyl 2,5-difluorobenzoate

Conditions
ConditionsYield
With sulfuric acid at 100℃; for 12h; Sealed tube;95%
With sulfuric acid Reflux;
With sulfuric acid for 10h; Reflux;
2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

4,7-difluoro-3-hydroxy-1(3H)-isobenzofuranone
111608-81-2

4,7-difluoro-3-hydroxy-1(3H)-isobenzofuranone

Conditions
ConditionsYield
With sec-BuLi In tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide93%
With sec-BuLi In tetrahydrofuran; hydrogenchloride; N,N-dimethyl-formamide93%
Multi-step reaction with 5 steps
1: 73 percent / SO2Cl / 4 h / Heating
2: CH2Cl2 / 6 h / Ambient temperature
3: SOCl2 / 12 h
4: 1.) sec-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 2 h
5: 5 N HCl / Heating
View Scheme
tributyltin acetate
56-36-0

tributyltin acetate

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

tri-n-butyltin 2,5-difluorobenzoate

tri-n-butyltin 2,5-difluorobenzoate

Conditions
ConditionsYield
In ethanol; toluene byproducts: acetic acid; equimolar amts. of Sn-compd. and the benzoic acid are mixed with toluene/EtOH (3:1), mixt. refluxed (4 h); the azeotrope acetic acid/EtOH/toluene followed by the azeotrop toluene/EtOH is distilled off to 50% of the initial vol., evapn. (reduced pressure);92%
t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

C12H14F2N2O3
1079843-62-1

C12H14F2N2O3

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide91%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 3h;
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap In tetrahydrofuran; N,N-dimethyl-formamide for 16h;
2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

N-t-Butyl-2,5-difluorobenzamide
223444-58-4

N-t-Butyl-2,5-difluorobenzamide

Conditions
ConditionsYield
91%
europium(III) hydroxide

europium(III) hydroxide

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

C21H13EuF6O8

C21H13EuF6O8

Conditions
ConditionsYield
In methanol; acetone at 60℃; for 1h;91%
methanol
67-56-1

methanol

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

methyl 2,5-difluorobenzoate

methyl 2,5-difluorobenzoate

Conditions
ConditionsYield
With thionyl chloride Reflux;90.7%
With sulfuric acid for 12h; Reflux;66%
With thionyl chloride at 60℃; for 3h; Cooling with ice;
2-(3,4-bis(benzyloxy)phenyl)-7-(benzyloxy)-3,5-dihydroxy-4H-chromen-4-one
183067-65-4

2-(3,4-bis(benzyloxy)phenyl)-7-(benzyloxy)-3,5-dihydroxy-4H-chromen-4-one

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

C36H24F2O8

C36H24F2O8

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 50℃; for 5h;84%
2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

(1S,5S,6S,6aR,9S,11aS,11bS,14R)-1,5,6-trihydroxy-4,4-dimethyl-8-methylene-7-oxododecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-14-yl 2,5-difluorobenzoate

(1S,5S,6S,6aR,9S,11aS,11bS,14R)-1,5,6-trihydroxy-4,4-dimethyl-8-methylene-7-oxododecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-14-yl 2,5-difluorobenzoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane83%
tert-butyl alcohol
75-65-0

tert-butyl alcohol

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

N-(tert-Butoxycarbonyl)-2,5-difluoroaniline
129589-71-5

N-(tert-Butoxycarbonyl)-2,5-difluoroaniline

Conditions
ConditionsYield
With diphenylphosphoranyl azide; triethylamine for 2h; Heating;81%
methyl 2-diazohydrocinnamate
51507-18-7

methyl 2-diazohydrocinnamate

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

A

(S)-3-methoxy-3-oxo-2-phenylpropyl 2,5-difluorobenzoate

(S)-3-methoxy-3-oxo-2-phenylpropyl 2,5-difluorobenzoate

B

C17H14F2O4

C17H14F2O4

Conditions
ConditionsYield
With C2HF6NO4S2*C27H30BNO In dichloromethane at -78℃; for 1h; Inert atmosphere; enantioselective reaction;A 75%
B n/a
2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

2,5-difluoro-3-nitro-benzoic acid
741721-49-3

2,5-difluoro-3-nitro-benzoic acid

Conditions
ConditionsYield
With sulfuric acid; nitric acid72%
With sulfuric acid; nitric acid at 0 - 20℃; for 1h;31.3%
With sulfuric acid; nitric acid In water at 0 - 20℃;31.3%
With sulfuric acid; nitric acid at 0 - 20℃;31.3%
With sulfuric acid; nitric acid at 0 - 20℃;31.3%
5-(propylthio)-1H-benzimidazol-2-ylamine
80983-36-4

5-(propylthio)-1H-benzimidazol-2-ylamine

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

2,4-difluoro-N-(5-(propylthio)-1H-benzo[d]imidazol-2-yl)benzamide

2,4-difluoro-N-(5-(propylthio)-1H-benzo[d]imidazol-2-yl)benzamide

Conditions
ConditionsYield
Stage #1: 2,5-difluorobenzoic acid With potassium carbonate; 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.5h;
Stage #2: 5-(propylthio)-1H-benzimidazol-2-ylamine In tetrahydrofuran Reflux;
71%
ethyl acrylate
140-88-5

ethyl acrylate

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

ethyl 2-(4,7-difluoro-3-oxo-1,3-dihydroisobenzofuran-1-yl)acetate

ethyl 2-(4,7-difluoro-3-oxo-1,3-dihydroisobenzofuran-1-yl)acetate

Conditions
ConditionsYield
With silver hexafluoroantimonate; potassium acetate; dichloro[η5-1-(3,5-bis(trifluoromethyl)phenyl)-3-(2-(2,3,4,5-tetramethylcyclopentadienyl)ethyl)urea][(6-oxo-1,6-dihydropyridin-2-yl)diphenylphosphine]rhodium(III); copper(II) trifluoroacetate In toluene at 120℃; for 16h; Reagent/catalyst; Schlenk technique; Inert atmosphere;70%
4-pyridin-2-yl-thiazol-2-ylamine
30235-26-8

4-pyridin-2-yl-thiazol-2-ylamine

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

2-[(2,5-difluorobenzoyl)amino]-4-(pyridin-2-yl)thiazole

2-[(2,5-difluorobenzoyl)amino]-4-(pyridin-2-yl)thiazole

Conditions
ConditionsYield
Stage #1: 2,5-difluorobenzoic acid With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 23℃; for 0.5h; Inert atmosphere;
Stage #2: 4-pyridin-2-yl-thiazol-2-ylamine In N,N-dimethyl-formamide at 23℃; for 16h; Inert atmosphere;
69%
tetrahydrofuran
109-99-9

tetrahydrofuran

[Ru2II,III(CH3CO2)4(THF)2]BF4

[Ru2II,III(CH3CO2)4(THF)2]BF4

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

[Ru2II,II(2,5-F2PhCO2)4(THF)2]*0.5THF

[Ru2II,II(2,5-F2PhCO2)4(THF)2]*0.5THF

Conditions
ConditionsYield
Stage #1: [Ru2II,III(CH3CO2)4(THF)2]BF4; 2,5-difluorobenzoic acid In N,N-dimethyl-aniline for 12h; Schlenk technique; Glovebox; Reflux;
Stage #2: tetrahydrofuran
67%
{2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine

{2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

N‐({2‐benzyl‐2‐azabicyclo[2.1.1]hexan‐1‐yl}methyl)‐2,5‐difluorobenzamide

N‐({2‐benzyl‐2‐azabicyclo[2.1.1]hexan‐1‐yl}methyl)‐2,5‐difluorobenzamide

Conditions
ConditionsYield
Stage #1: 2,5-difluorobenzoic acid With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: {2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine In dichloromethane at 20℃; for 1h;
65%
4-(6-(4-amino-4-methylpiperidin-1-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

4-(6-(4-amino-4-methylpiperidin-1-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

N-(1-(5-(3-cyano-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-methylpiperidin-4-yl)-2,5-difluorobenzamide

N-(1-(5-(3-cyano-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridin-4-yl)pyridin-2-yl)-4-methylpiperidin-4-yl)-2,5-difluorobenzamide

Conditions
ConditionsYield
With N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridine-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h;64%
5-chloro-2-benzoxazolinone
95-25-0

5-chloro-2-benzoxazolinone

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

5-chloro-6-(2,5-difluoro-benzoyl)-3H-benzooxazol-2-one
230628-47-4

5-chloro-6-(2,5-difluoro-benzoyl)-3H-benzooxazol-2-one

Conditions
ConditionsYield
With PPA Acylation;62%
N-(2-methylbenzoyl)-8-aminoquinoline
1182669-71-1

N-(2-methylbenzoyl)-8-aminoquinoline

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

2-fluoro-7-methyl-5-(quinolin-8-yl)-5,6-dihydrophenanthridin-6-one

2-fluoro-7-methyl-5-(quinolin-8-yl)-5,6-dihydrophenanthridin-6-one

Conditions
ConditionsYield
Stage #1: 2,5-difluorobenzoic acid With sodium carbonate In N,N-dimethyl acetamide at 110℃; for 0.5h; Schlenk technique; Inert atmosphere;
Stage #2: N-(2-methylbenzoyl)-8-aminoquinoline With nickel(II) acetate tetrahydrate; silver nitrate In N,N-dimethyl acetamide at 170℃; for 24h; Schlenk technique; Inert atmosphere;
62%
2-bromo-4-(methylsulfonyl)phenol
20951-43-3

2-bromo-4-(methylsulfonyl)phenol

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

C14H10BrFO5S

C14H10BrFO5S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 3h;62%
tetraacetyl thioglucose
19879-84-6

tetraacetyl thioglucose

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

2,3,4,6-tetraacetate-1-(2,5-difluorobenzoate) β-D-glucopyranose

2,3,4,6-tetraacetate-1-(2,5-difluorobenzoate) β-D-glucopyranose

Conditions
ConditionsYield
With copper acetylacetonate; silver carbonate at 130℃; for 0.25h; Microwave irradiation; Inert atmosphere; Sealed tube; stereoselective reaction;62%
tert-butyl alcohol
75-65-0

tert-butyl alcohol

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

C11H12F2O2

C11H12F2O2

Conditions
ConditionsYield
With sulfuric acid; magnesium sulfate In toluene at 20℃; Sealed tube;62%
(R)-2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(4-cyanophenyl)-N-(cyclopropylmethyl)acetamide

(R)-2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-2-(4-cyanophenyl)-N-(cyclopropylmethyl)acetamide

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

(R)-2-(4-cyanophenyl)-N-(cyclopropylmethyl)-2-(8-(2,5-difluorobenzoyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)acetamide

(R)-2-(4-cyanophenyl)-N-(cyclopropylmethyl)-2-(8-(2,5-difluorobenzoyl)-3,8-diazabicyclo[3.2.1]octan-3-yl)acetamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 18h;59%
2-Benzoxazolinone
59-49-4

2-Benzoxazolinone

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

6-(2,5-difluoro-benzoyl)-3H-benzooxazol-2-one
230628-46-3

6-(2,5-difluoro-benzoyl)-3H-benzooxazol-2-one

Conditions
ConditionsYield
With PPA Acylation;58%
With PPA
With PPA at 140 - 160℃;
2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

2,5-difluorobenzohydrazide
265644-03-9

2,5-difluorobenzohydrazide

Conditions
ConditionsYield
Stage #1: 2,5-difluorobenzoic acid With thionyl chloride In dichloromethane at 20℃; Reflux;
Stage #2: With hydrazine In dichloromethane for 4h; Reflux;
56%
Multi-step reaction with 2 steps
1: sulfuric acid / Reflux
2: hydrazine hydrate / ethanol / Reflux
View Scheme
Multi-step reaction with 2 steps
1: sulfuric acid / 10 h / Reflux
2: hydrazine hydrate / ethanol / 8 h / Reflux
View Scheme
(Z)-N′-hydroxy-1H-benzo[d]imidazole-5-carboximidamide

(Z)-N′-hydroxy-1H-benzo[d]imidazole-5-carboximidamide

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

3-(1H-benzo[d]imidazol-6-yl)-5-(2,5-difluorophenyl)-1,2,4-oxadiazol

3-(1H-benzo[d]imidazol-6-yl)-5-(2,5-difluorophenyl)-1,2,4-oxadiazol

Conditions
ConditionsYield
Stage #1: 2,5-difluorobenzoic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: (Z)-N′-hydroxy-1H-benzo[d]imidazole-5-carboximidamide In N,N-dimethyl-formamide at 110℃;
47.6%
(R)-3-amino-N-(3-(cyclopropylmethyl)-7-fluoro-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)piperidine-1-carboxamide

(R)-3-amino-N-(3-(cyclopropylmethyl)-7-fluoro-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)piperidine-1-carboxamide

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

(3R)-N-(3-(cyclopropylmethyl)-7-fluoro-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3-((2,5-difluorobenzoyl)amino)-piperidine-1-carboxamide

(3R)-N-(3-(cyclopropylmethyl)-7-fluoro-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3-((2,5-difluorobenzoyl)amino)-piperidine-1-carboxamide

Conditions
ConditionsYield
With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 70℃; for 6h;39.5%
N-biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride
1187890-09-0

N-biphenyl-4-yl-3-oxo-3-piperazin-1-yl-propionamide hydrochloride

2,5-difluorobenzoic acid
2991-28-8

2,5-difluorobenzoic acid

N-Biphenyl-4-yl-3-[4-(2,5-difluoro-benzoyl)-piperazin-1-yl]-3-oxo-propionamide
1187889-55-9

N-Biphenyl-4-yl-3-[4-(2,5-difluoro-benzoyl)-piperazin-1-yl]-3-oxo-propionamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 10 - 20℃;37%

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