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Luhan Pharmachem Co., Ltd

Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod

Avanafil

Cas:330784-47-9

Min.Order:1 Kilogram

Negotiable

Type:Other

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Avanafil

Cas:330784-47-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White powder Storage:Store in sealed containers at cool & dr

Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

Avanafil

Cas:330784-47-9

Min.Order:1 Gram

Negotiable

Type:Other

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ZHEJIANG JIUZHOU CHEM CO.,LTD

产品描述 优势: 高品质和有竞争力的价格。 1.我们可以提供样品进行测试。 2.全部纯度>99%。 作为制造商,我们可以以出厂价提供高质量的产品。 快速安全的交货。 1. 收到付款追踪号码后,包裹可在 3-5 个工作日内送达。 2.安全、谨慎的运输方式供您选择。 3、海关合格率>99%。 4.我们与DHL、FedEx、TNT、UPS、HK EMS建立了长期稳定的合作关系。如果包裹丢失,我们将免费补发。 我们的客户遍布世界各地。 1、专业的服务和丰富的经验让客户放心,库存充足,交货快捷,满足

Avanafil 330784-47-9

Cas:330784-47-9

Min.Order:10 Gram

FOB Price: $11.0 / 50.0

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-n-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hubei Vanz Pharm Co.,Ltd

Product advantage: Guaranteed quality Good pice Well packed Service advantage: Pre-sale service 1. Technical consultancy, to help customer know about the properties, features, quality, production and supply of the product they wa

Factory bulk supply Avanafil powder purity 99% for men sexual enhancement

Cas:330784-47-9

Min.Order:10 Gram

FOB Price: $3.0 / 10.0

Type:Manufacturers

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------

High purity 330784-47-9 Avanafil

Cas:330784-47-9

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Kono Chem Co.,Ltd

Superiority kono chem is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals. We could give you: 1.Best

Avanafil with best price and top quality

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $800.0

Type:Other

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Hebei yanxi chemical co.,LTD.

Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa

Avanafil Efficient And Safe Sex Enhancers Powder Avanafil CAS NO.330784-47-9

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

inquiry

Xi'an Quanao Biotech Co., Ltd.

We are: Focus on the research, production and sale of Plant and Animal extract, Medical intermediate, complete coverage six industries. Product grade: Medicine, Health care product, Cosmetics, Food,Feed, Biopesticide. Hot selling market: Europe,

Male Sex enhancement Avanafil 99%Powder Price

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $1605.0 / 1613.0

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Avanafil 330784-47-9 GMP Manufacturer

Cas:330784-47-9

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Avanafil

Cas:330784-47-9

Min.Order:10 Milligram

Negotiable

Type:Manufacturers

inquiry

Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Avanafil

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Avanafil

Cas:330784-47-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Avanafil CAS NO: 330784-47-9 Molecular formula:C23H26ClN7O3 Molecular weight:483.9506 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability

Avanafil/CAS:330784-47-9/Raw material supply

Cas:330784-47-9

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Avanafil Basic information Product Name: Avanafil Synonyms: (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Ch

330784-47-9

Cas:330784-47-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Avanafil In stock

Cas:330784-47-9

Min.Order:1 Gram

FOB Price: $1000.0 / 1300.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 330784-47-9 with competitive price

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

High Purity 99% 330784-47-9 Avanafil

Cas:330784-47-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Avanafil/ LIDE PHARMA- Factory supply / Best price

Cas:330784-47-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Sinotech Import&Export Corporation

Product Name Avanafil Synonyms 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide CAS 330784-47-9

Avanafil CAS: 330784-47-9

Cas:330784-47-9

Min.Order:5 Metric Ton

FOB Price: $1.0 / 2.0

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem specialized in APIs, chemical intermediate

High quality Avanafil 330784-47-9 99%

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Avanafil CAS:330784-47-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Avanafil CAS:330784-47-9

Cas:330784-47-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Terui OP New Material Technology Co., Ltd.

We generally use secure shipping methods that do not require you to do any customs clearance. Free shipping to your address without worrying about any customs issues. We have a professional customs clearance team to 100% guarantee the safe delivery o

CAS 330784-47-9330784teruiop Factory Supply Avanafi 330784/47/9 CAS

Cas:330784-47-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Male Enhancement Avanafil CAS NO.330784-47-9

Cas:330784-47-9

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Specification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Package:in aluminum bag and foil bag or as customers' require Application:330784-47-9 Transporta

avanafil

Cas:330784-47-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Lonwin Chemical Group Limited

Avanafil CAS: 330784-47-9 Specification items specifications appearance white or off-white crystalline power identification ir solubility pr

Factory supply Avanafil

Cas:330784-47-9

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

Avanafil

Cas:330784-47-9

Min.Order:1 Kilogram

FOB Price: $8.0 / 10.0

Type:Lab/Research institutions

inquiry

Synthetic route

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
330785-84-7

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid

2-aminomethylpyrimidine
75985-45-4

2-aminomethylpyrimidine

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide; 1-hydroxy-1,2,3-benzotriazine-4(3H)-one In N,N-dimethyl-formamide at 0℃; Temperature;99%
With 5, 10, 15, 20-tetrakis[4-(dihydroxyboryl)phenyl]-21H,23H-porphine In toluene for 16h; Time; Reflux; Green chemistry;91.2%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 4h;90%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) at 20℃; for 8h;
2-chloro-4-((3-chloro-4-methoxybenzyl)amino)-N-[pyrimidin-2ylmethyl]pyrimidine-5-carboxamide

2-chloro-4-((3-chloro-4-methoxybenzyl)amino)-N-[pyrimidin-2ylmethyl]pyrimidine-5-carboxamide

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 20h;97.2%
4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-formamide

4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-formamide

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With 1H-imidazole In toluene at 20℃; for 18h; Solvent; Reagent/catalyst;97%
With triethylamine at 20 - 30℃; for 1h; Solvent;1.1 g
4-[(3-chloro-4-methoxybenzyl)amino]-2-methanesulfonyl-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

4-[(3-chloro-4-methoxybenzyl)amino]-2-methanesulfonyl-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In chloroform at 50℃; Temperature;90.5%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 20℃; for 5h;87.5%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; Temperature; Green chemistry;87%
ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidinecarboxylate

ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidinecarboxylate

2-aminomethylpyrimidine
75985-45-4

2-aminomethylpyrimidine

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidinecarboxylate With dimethyl sulfoxide; citric acid; sodium hydroxide In water for 15h;
Stage #2: 2-aminomethylpyrimidine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 8h;
87%
In dichloromethane at 20℃;44%
6-(3-chloro-4-methoxy-benzylamino)-1,2-dihydropyrimidin-2-one-5-(N-2-methylpyrimidinyl)formamide

6-(3-chloro-4-methoxy-benzylamino)-1,2-dihydropyrimidin-2-one-5-(N-2-methylpyrimidinyl)formamide

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: 6-(3-chloro-4-methoxy-benzylamino)-1,2-dihydropyrimidin-2-one-5-(N-2-methylpyrimidinyl)formamide With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20 - 60℃; for 24h; Inert atmosphere;
Stage #2: (S)-1-Pyrrolidin-2-yl-methanol With sodium hydride In tetrahydrofuran at 65℃; for 5h;
81.3%
4-[(3-chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]pyrimidine

4-[(3-chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]pyrimidine

N-(2-methylpyrimidine)methanamide

N-(2-methylpyrimidine)methanamide

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: 4-[(3-chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]pyrimidine With bromine; sodium hydroxide for 0.0833333h; Microwave irradiation;
Stage #2: N-(2-methylpyrimidine)methanamide With tris(2,4-di-t-butyl)phenoxy phosphazene; sodium methylate; nickel diacetate In 1,2-dimethoxyethane at 120℃; for 10h; Inert atmosphere;
81.1%
4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
330785-84-7

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid

2-aminomethylpyrimidine methanesulfonate

2-aminomethylpyrimidine methanesulfonate

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 25℃;67%
2-aminomethylpyrimidine acetate
1246834-64-9

2-aminomethylpyrimidine acetate

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride
41965-95-1

(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride

2,4-dichloropyrimidine-5-carbonyl chloride
2972-52-3

2,4-dichloropyrimidine-5-carbonyl chloride

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: 2-aminomethylpyrimidine acetate; 2,4-dichloropyrimidine-5-carbonyl chloride With triethylamine In dichloromethane for 1h; Cooling with ice;
Stage #2: (3-chloro-4-methoxyphenyl)methylamine hydrogen chloride With triethylamine In dichloromethane for 2h;
Stage #3: (S)-1-Pyrrolidin-2-yl-methanol In dichloromethane at 20℃;
64%
4-(3-chloro-4-methoxybenzylamino)-2-[(S)-2-hydroxymethylpyrrolidinyl-1-yl]-5-pyrimidinecarboxylic acid chloride

4-(3-chloro-4-methoxybenzylamino)-2-[(S)-2-hydroxymethylpyrrolidinyl-1-yl]-5-pyrimidinecarboxylic acid chloride

2-aminomethylpyrimidine
75985-45-4

2-aminomethylpyrimidine

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;64%
2-chloro-4-((3-chloro-4-methoxybenzyl)amino)-N-[pyrimidin-2ylmethyl]pyrimidine-5-carboxamide

2-chloro-4-((3-chloro-4-methoxybenzyl)amino)-N-[pyrimidin-2ylmethyl]pyrimidine-5-carboxamide

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; Reagent/catalyst; Solvent; Temperature;61%
4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
330785-84-7

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid

2-aminomethylpyrimidine acetate
1246834-64-9

2-aminomethylpyrimidine acetate

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: 2-aminomethylpyrimidine acetate With triethylamine In N,N-dimethyl-formamide for 0.5h;
Stage #2: 4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 8h;
60%
2,4-dichloro-N-(pyrimidin-2-ylmethyl)-5-pyrimidinecarboxamide

2,4-dichloro-N-(pyrimidin-2-ylmethyl)-5-pyrimidinecarboxamide

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride
41965-95-1

(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: 2,4-dichloro-N-(pyrimidin-2-ylmethyl)-5-pyrimidinecarboxamide; (3-chloro-4-methoxyphenyl)methylamine hydrogen chloride With triethylamine for 2h;
Stage #2: (S)-1-Pyrrolidin-2-yl-methanol at 20℃; for 4h;
32%
4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
330785-84-7

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid

2-aminomethylpyrimidine acetic acid

2-aminomethylpyrimidine acetic acid

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: 4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25 - 35℃; for 0.333333h;
Stage #2: 2-aminomethylpyrimidine acetic acid With triethylamine In N,N-dimethyl-formamide at 25 - 35℃; for 9h;
Stage #3: In methanol at 25 - 35℃; for 0.75h;
68 g
4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylic acid
330786-34-0

4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
2: 3-chloro-benzenecarboperoxoic acid / 0 °C
3: 20 - 120 °C
View Scheme
Multi-step reaction with 3 steps
1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux
1.2: 15 - 30 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C
3.1: triethylamine / dichloromethane
View Scheme
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux
1.2: 15 - 30 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C
3.1: triethylamine / dichloromethane
4.1: sulfuric acid / ethanol / Reflux
4.2: 5 h
View Scheme
4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-formamide

4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-formamide

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / 0 °C
2: 20 - 120 °C
View Scheme
Multi-step reaction with 2 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C
2: triethylamine / dichloromethane
View Scheme
Multi-step reaction with 3 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C
2.1: triethylamine / dichloromethane
3.1: sulfuric acid / ethanol / Reflux
3.2: 5 h
View Scheme
Multi-step reaction with 4 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C
2.1: triethylamine / dichloromethane
3.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux
4.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 5 °C
4.2: 60 - 70 °C
View Scheme
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester
5909-24-0

4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / tetrahydrofuran / 20 °C
2: sodium hydroxide / water; ethanol / 20 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
4: 3-chloro-benzenecarboperoxoic acid / 0 °C
5: 20 - 120 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium carbonate / water / 4 h / 25 - 30 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C
3: triethylamine / dichloromethane / 5 - 10 °C
4: sodium hydroxide / water / 8.17 h / 25 - 100 °C
5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C
3: triethylamine / dichloromethane / 5 - 10 °C
4: sodium hydroxide / water / 8.17 h / 25 - 100 °C
5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate
330785-81-4

ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / water; ethanol / 20 °C
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
3: 3-chloro-benzenecarboperoxoic acid / 0 °C
4: 20 - 120 °C
View Scheme
Multi-step reaction with 4 steps
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C
2: triethylamine / dichloromethane / 5 - 10 °C
3: sodium hydroxide / water / 8.17 h / 25 - 100 °C
4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
Multi-step reaction with 4 steps
1.1: water; sodium hydroxide / methanol / Reflux
2.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux
2.2: 15 - 30 °C
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C
4.1: triethylamine / dichloromethane
View Scheme
(3-chloro-4-methoxyphenyl)methanamine
115514-77-7

(3-chloro-4-methoxyphenyl)methanamine

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: triethylamine / tetrahydrofuran / 20 °C
2: sodium hydroxide / water; ethanol / 20 °C
3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
4: 3-chloro-benzenecarboperoxoic acid / 0 °C
5: 20 - 120 °C
View Scheme
Multi-step reaction with 6 steps
1: methanol / 0.25 h / 60 - 65 °C
2: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C
4: triethylamine / dichloromethane / 5 - 10 °C
5: sodium hydroxide / water / 8.17 h / 25 - 100 °C
6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
Multi-step reaction with 5 steps
1.1: tetrabutylammomium bromide; sodium carbonate / dichloromethane; water / 25 - 30 °C
2.1: water; sodium hydroxide / methanol / Reflux
3.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux
3.2: 15 - 30 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C
5.1: triethylamine / dichloromethane
View Scheme
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate
53554-29-3

ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: trichlorophosphate / toluene / 4 h / 55 - 105 °C
2: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C
4: triethylamine / dichloromethane / 5 - 10 °C
5: sodium hydroxide / water / 8.17 h / 25 - 100 °C
6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
Multi-step reaction with 6 steps
1: trichlorophosphate / toluene / 4 h / 55 - 105 °C
2: sodium carbonate / water / 4 h / 25 - 30 °C
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C
4: triethylamine / dichloromethane / 5 - 10 °C
5: sodium hydroxide / water / 8.17 h / 25 - 100 °C
6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
Multi-step reaction with 6 steps
1: trichlorophosphate / acetonitrile / 6 h / Reflux
2: triethylamine / acetone / 3 h / 20 °C
3: methanol; sodium hydroxide / 4.5 h / 20 - 30 °C
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide; N,N-dimethyl-aniline / 7 h / 60 °C
5: acetic acid; dihydrogen peroxide / 4 h / 65 - 80 °C
6: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 5 h / 20 °C
View Scheme
4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonyl-2-methylsulfinylpyrimidine
330785-82-5

4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonyl-2-methylsulfinylpyrimidine

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 5 - 10 °C
2: sodium hydroxide / water / 8.17 h / 25 - 100 °C
3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / -5 - 30 °C / Large scale
2: sodium hydroxide / dimethyl sulfoxide; water / 25 - 35 °C / Large scale
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 - 25 °C
View Scheme
ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidinecarboxylate

ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidinecarboxylate

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydroxide / water / 8.17 h / 25 - 100 °C
2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
Multi-step reaction with 2 steps
1.1: sodium hydroxide / water; dimethyl sulfoxide / 20 °C / Cooling with ice
2.1: triethylamine / N,N-dimethyl-formamide / 0.5 h
2.2: 8 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: sodium hydroxide / water; dimethyl sulfoxide / 20 °C / Cooling with ice
2: thionyl chloride / 4 h / 80 °C
3: triethylamine / dichloromethane / 20 °C
View Scheme
1-(pyrimidin-2-yl)methanamine hydrochloride
372118-67-7

1-(pyrimidin-2-yl)methanamine hydrochloride

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
330785-84-7

4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0 - 5℃; for 14h; Time;145 g
(3-chloro-4-methoxyphenyl)methanamine malate

(3-chloro-4-methoxyphenyl)methanamine malate

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C
3: triethylamine / dichloromethane / 5 - 10 °C
4: sodium hydroxide / water / 8.17 h / 25 - 100 °C
5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C
View Scheme
4-[(3-chloro-4-methoxybenzyl)amino]-2-(methyl sulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

4-[(3-chloro-4-methoxybenzyl)amino]-2-(methyl sulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane
2.1: sulfuric acid / ethanol / Reflux
2.2: 5 h
View Scheme
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane
2.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux
3.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 5 °C
3.2: 60 - 70 °C
View Scheme
4-[(3-chloro-4-methoxybenzyl)amino]-2-(methyl sulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

4-[(3-chloro-4-methoxybenzyl)amino]-2-(methyl sulfinyl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide

(S)-1-Pyrrolidin-2-yl-methanol
23356-96-9

(S)-1-Pyrrolidin-2-yl-methanol

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
With triethylamine In dichloromethane8 g
C23H24ClN7O4

C23H24ClN7O4

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: C23H24ClN7O4 With sulfuric acid In ethanol Reflux;
Stage #2: With sodium tetrahydroborate; lithium bromide In ethanol for 5h;
7.5 g
C23H23Cl2N7O3

C23H23Cl2N7O3

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Stage #1: C23H23Cl2N7O3 With sodium tetrahydroborate In tetrahydrofuran at 0 - 5℃;
Stage #2: With potassium hydroxide In water at 60 - 70℃;
40 g
4-(bromomethyl)-2-chloro-1-methoxybenzene
320407-92-9

4-(bromomethyl)-2-chloro-1-methoxybenzene

avanafil
330784-47-9

avanafil

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: potassium iodide; triethylamine / ethanol / 3 h / 50 - 80 °C
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / acetonitrile / 24 h / 20 - 60 °C / Inert atmosphere
2.2: 5 h / 55 °C
3.1: bromine; sodium hydroxide / 0.08 h / Microwave irradiation
3.2: 10 h / 120 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1.1: potassium iodide; triethylamine / ethanol / 3 h / 50 - 80 °C
2.1: sodium hydroxide; iodine / 0.08 h / Microwave irradiation
2.2: 10 h / 110 °C / Inert atmosphere
3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / acetonitrile / 24 h / 20 - 60 °C / Inert atmosphere
3.2: 5 h / 65 °C
View Scheme
avanafil
330784-47-9

avanafil

citric acid
77-92-9

citric acid

avanafil-citric acid

avanafil-citric acid

Conditions
ConditionsYield
In acetone at 25℃; for 8h; Solvent; Sealed tube;96.5%
avanafil
330784-47-9

avanafil

4-nitrophenyl 3-[(25)-2,3-bis(nitrooxy)propoxy] propanoate

4-nitrophenyl 3-[(25)-2,3-bis(nitrooxy)propoxy] propanoate

[(2S)-1-(4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-5-{[(pyrimidin-2-yl)methyl]carbamoyl}pyrimidin-2-yl)pyrrolidin-2-yl]methyl 3-[(2S)-2,3-bis(nitrooxy)propoxy]propanoate

[(2S)-1-(4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-5-{[(pyrimidin-2-yl)methyl]carbamoyl}pyrimidin-2-yl)pyrrolidin-2-yl]methyl 3-[(2S)-2,3-bis(nitrooxy)propoxy]propanoate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃;95%
avanafil
330784-47-9

avanafil

(5S)-5,6-bis(nitrooxy)hexanoic acid
1178531-55-9

(5S)-5,6-bis(nitrooxy)hexanoic acid

[(2S)-1-(4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-5-{[(pyrimidin-2-yl)methyl]carbamoyl}pyrimidin-2-yl)pyrrolidin-2-yl]methyl (5S)-5,6-bis(nitrooxy)hexanoate

[(2S)-1-(4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-5-{[(pyrimidin-2-yl)methyl]carbamoyl}pyrimidin-2-yl)pyrrolidin-2-yl]methyl (5S)-5,6-bis(nitrooxy)hexanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;94.5%
avanafil
330784-47-9

avanafil

6-(nitrooxy)hexanoic acid
74754-55-5

6-(nitrooxy)hexanoic acid

(S)-(1-(4-(3-chloro-4-methoxybenzylamino)-5-(pyrimidin-2-ylmethylcarbamoyl)pyrimidin-2-yl)pyrrolidin-2-yl)methyl 6-(nitrooxy)hexanoate

(S)-(1-(4-(3-chloro-4-methoxybenzylamino)-5-(pyrimidin-2-ylmethylcarbamoyl)pyrimidin-2-yl)pyrrolidin-2-yl)methyl 6-(nitrooxy)hexanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;93%
avanafil
330784-47-9

avanafil

2-(2-(nitrooxy)ethoxy)acetic acid
1321458-84-7

2-(2-(nitrooxy)ethoxy)acetic acid

(S)-(1-(4-(3-chloro-4-methoxybenzylamino)-5-(pyrimidin-2-ylmethylcarbamoyl)pyrimidin-2-yl)pyrrolidin-2-yl)methyl 2-(2-(nitrooxy)ethoxy)acetate

(S)-(1-(4-(3-chloro-4-methoxybenzylamino)-5-(pyrimidin-2-ylmethylcarbamoyl)pyrimidin-2-yl)pyrrolidin-2-yl)methyl 2-(2-(nitrooxy)ethoxy)acetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;52%
avanafil
330784-47-9

avanafil

boron monobromide
19961-29-6

boron monobromide

sodium hydrogencarbonate
144-55-8

sodium hydrogencarbonate

(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-hydroxybenzylamino)-5-[N-(2-pyrimidylmethyl)carbamoyl]pyrimidine
330785-05-2

(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-hydroxybenzylamino)-5-[N-(2-pyrimidylmethyl)carbamoyl]pyrimidine

Conditions
ConditionsYield
In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate

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