Luhan Pharmachem Co., Ltd. owns strong elite professional quality sales force, has the customer base from the US, Europe, Japan, Southeast Asia, Korea, Hong Kong, Taiwan and other countries and regions, the company operates in accordance with the mod
Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
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Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
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Name:Avanafil CAS NO: 330784-47-9 Molecular formula:C23H26ClN7O3 Molecular weight:483.9506 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability
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inquiryAvanafil Basic information Product Name: Avanafil Synonyms: (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Ch
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inquiryProduct Name Avanafil Synonyms 4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide CAS 330784-47-9
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:330784-47-9
Min.Order:10 Gram
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inquirySpecification:USP/EP Month production ablity:50kg/Month Low price& High quality Manufacturer Appearance:white powder Storage:Room Temperature Package:in aluminum bag and foil bag or as customers' require Application:330784-47-9 Transporta
Avanafil CAS: 330784-47-9 Specification items specifications appearance white or off-white crystalline power identification ir solubility pr
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4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
2-aminomethylpyrimidine
avanafil
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide; 1-hydroxy-1,2,3-benzotriazine-4(3H)-one In N,N-dimethyl-formamide at 0℃; Temperature; | 99% |
With 5, 10, 15, 20-tetrakis[4-(dihydroxyboryl)phenyl]-21H,23H-porphine In toluene for 16h; Time; Reflux; Green chemistry; | 91.2% |
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dimethyl sulfoxide at 20℃; for 4h; | 90% |
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In DMF (N,N-dimethyl-formamide) at 20℃; for 8h; |
(S)-1-Pyrrolidin-2-yl-methanol
avanafil
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 20h; | 97.2% |
(S)-1-Pyrrolidin-2-yl-methanol
avanafil
Conditions | Yield |
---|---|
With 1H-imidazole In toluene at 20℃; for 18h; Solvent; Reagent/catalyst; | 97% |
With triethylamine at 20 - 30℃; for 1h; Solvent; | 1.1 g |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In chloroform at 50℃; Temperature; | 90.5% |
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 20℃; for 5h; | 87.5% |
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; Temperature; Green chemistry; | 87% |
Conditions | Yield |
---|---|
Stage #1: ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)tetrahydropyrrole-1-yl)-5-pyrimidinecarboxylate With dimethyl sulfoxide; citric acid; sodium hydroxide In water for 15h; Stage #2: 2-aminomethylpyrimidine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 8h; | 87% |
In dichloromethane at 20℃; | 44% |
(S)-1-Pyrrolidin-2-yl-methanol
avanafil
Conditions | Yield |
---|---|
Stage #1: 6-(3-chloro-4-methoxy-benzylamino)-1,2-dihydropyrimidin-2-one-5-(N-2-methylpyrimidinyl)formamide With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 20 - 60℃; for 24h; Inert atmosphere; Stage #2: (S)-1-Pyrrolidin-2-yl-methanol With sodium hydride In tetrahydrofuran at 65℃; for 5h; | 81.3% |
avanafil
Conditions | Yield |
---|---|
Stage #1: 4-[(3-chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]pyrimidine With bromine; sodium hydroxide for 0.0833333h; Microwave irradiation; Stage #2: N-(2-methylpyrimidine)methanamide With tris(2,4-di-t-butyl)phenoxy phosphazene; sodium methylate; nickel diacetate In 1,2-dimethoxyethane at 120℃; for 10h; Inert atmosphere; | 81.1% |
4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
avanafil
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 15 - 25℃; | 67% |
2-aminomethylpyrimidine acetate
(S)-1-Pyrrolidin-2-yl-methanol
(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride
2,4-dichloropyrimidine-5-carbonyl chloride
avanafil
Conditions | Yield |
---|---|
Stage #1: 2-aminomethylpyrimidine acetate; 2,4-dichloropyrimidine-5-carbonyl chloride With triethylamine In dichloromethane for 1h; Cooling with ice; Stage #2: (3-chloro-4-methoxyphenyl)methylamine hydrogen chloride With triethylamine In dichloromethane for 2h; Stage #3: (S)-1-Pyrrolidin-2-yl-methanol In dichloromethane at 20℃; | 64% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; | 64% |
avanafil
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 100℃; Reagent/catalyst; Solvent; Temperature; | 61% |
4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
2-aminomethylpyrimidine acetate
avanafil
Conditions | Yield |
---|---|
Stage #1: 2-aminomethylpyrimidine acetate With triethylamine In N,N-dimethyl-formamide for 0.5h; Stage #2: 4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 8h; | 60% |
(S)-1-Pyrrolidin-2-yl-methanol
(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride
avanafil
Conditions | Yield |
---|---|
Stage #1: 2,4-dichloro-N-(pyrimidin-2-ylmethyl)-5-pyrimidinecarboxamide; (3-chloro-4-methoxyphenyl)methylamine hydrogen chloride With triethylamine for 2h; Stage #2: (S)-1-Pyrrolidin-2-yl-methanol at 20℃; for 4h; | 32% |
4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
avanafil
Conditions | Yield |
---|---|
Stage #1: 4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25 - 35℃; for 0.333333h; Stage #2: 2-aminomethylpyrimidine acetic acid With triethylamine In N,N-dimethyl-formamide at 25 - 35℃; for 9h; Stage #3: In methanol at 25 - 35℃; for 0.75h; | 68 g |
4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylic acid
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C 2: 3-chloro-benzenecarboperoxoic acid / 0 °C 3: 20 - 120 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux 1.2: 15 - 30 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C 3.1: triethylamine / dichloromethane View Scheme | |
Multi-step reaction with 4 steps 1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux 1.2: 15 - 30 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C 3.1: triethylamine / dichloromethane 4.1: sulfuric acid / ethanol / Reflux 4.2: 5 h View Scheme |
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / 0 °C 2: 20 - 120 °C View Scheme | |
Multi-step reaction with 2 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C 2: triethylamine / dichloromethane View Scheme | |
Multi-step reaction with 3 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C 2.1: triethylamine / dichloromethane 3.1: sulfuric acid / ethanol / Reflux 3.2: 5 h View Scheme | |
Multi-step reaction with 4 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C 2.1: triethylamine / dichloromethane 3.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux 4.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 5 °C 4.2: 60 - 70 °C View Scheme |
4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine / tetrahydrofuran / 20 °C 2: sodium hydroxide / water; ethanol / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C 4: 3-chloro-benzenecarboperoxoic acid / 0 °C 5: 20 - 120 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium carbonate / water / 4 h / 25 - 30 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C 3: triethylamine / dichloromethane / 5 - 10 °C 4: sodium hydroxide / water / 8.17 h / 25 - 100 °C 5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 5 steps 1: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C 3: triethylamine / dichloromethane / 5 - 10 °C 4: sodium hydroxide / water / 8.17 h / 25 - 100 °C 5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme |
ethyl 4-[(3-chloro-4-methoxybenzyl)amino]-2-(methylsulfanyl)pyrimidine-5-carboxylate
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / water; ethanol / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C 3: 3-chloro-benzenecarboperoxoic acid / 0 °C 4: 20 - 120 °C View Scheme | |
Multi-step reaction with 4 steps 1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C 2: triethylamine / dichloromethane / 5 - 10 °C 3: sodium hydroxide / water / 8.17 h / 25 - 100 °C 4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: water; sodium hydroxide / methanol / Reflux 2.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux 2.2: 15 - 30 °C 3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C 4.1: triethylamine / dichloromethane View Scheme |
(3-chloro-4-methoxyphenyl)methanamine
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: triethylamine / tetrahydrofuran / 20 °C 2: sodium hydroxide / water; ethanol / 20 °C 3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C 4: 3-chloro-benzenecarboperoxoic acid / 0 °C 5: 20 - 120 °C View Scheme | |
Multi-step reaction with 6 steps 1: methanol / 0.25 h / 60 - 65 °C 2: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C 4: triethylamine / dichloromethane / 5 - 10 °C 5: sodium hydroxide / water / 8.17 h / 25 - 100 °C 6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: tetrabutylammomium bromide; sodium carbonate / dichloromethane; water / 25 - 30 °C 2.1: water; sodium hydroxide / methanol / Reflux 3.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux 3.2: 15 - 30 °C 4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 - 30 °C 5.1: triethylamine / dichloromethane View Scheme |
ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: trichlorophosphate / toluene / 4 h / 55 - 105 °C 2: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C 4: triethylamine / dichloromethane / 5 - 10 °C 5: sodium hydroxide / water / 8.17 h / 25 - 100 °C 6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1: trichlorophosphate / toluene / 4 h / 55 - 105 °C 2: sodium carbonate / water / 4 h / 25 - 30 °C 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C 4: triethylamine / dichloromethane / 5 - 10 °C 5: sodium hydroxide / water / 8.17 h / 25 - 100 °C 6: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 6 steps 1: trichlorophosphate / acetonitrile / 6 h / Reflux 2: triethylamine / acetone / 3 h / 20 °C 3: methanol; sodium hydroxide / 4.5 h / 20 - 30 °C 4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide; N,N-dimethyl-aniline / 7 h / 60 °C 5: acetic acid; dihydrogen peroxide / 4 h / 65 - 80 °C 6: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 5 h / 20 °C View Scheme |
4-(3-chloro-4-methoxybenzylamino)-5-ethoxycarbonyl-2-methylsulfinylpyrimidine
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 5 - 10 °C 2: sodium hydroxide / water / 8.17 h / 25 - 100 °C 3: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / -5 - 30 °C / Large scale 2: sodium hydroxide / dimethyl sulfoxide; water / 25 - 35 °C / Large scale 3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 - 25 °C View Scheme |
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium hydroxide / water / 8.17 h / 25 - 100 °C 2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: sodium hydroxide / water; dimethyl sulfoxide / 20 °C / Cooling with ice 2.1: triethylamine / N,N-dimethyl-formamide / 0.5 h 2.2: 8 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium hydroxide / water; dimethyl sulfoxide / 20 °C / Cooling with ice 2: thionyl chloride / 4 h / 80 °C 3: triethylamine / dichloromethane / 20 °C View Scheme |
1-(pyrimidin-2-yl)methanamine hydrochloride
4-{[(3-chloro-4-methoxyphenyl)methyl]amino}-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid
avanafil
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 0 - 5℃; for 14h; Time; | 145 g |
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: sodium carbonate; tetrabutylammomium bromide / water / 8 h / 25 - 30 °C 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C 3: triethylamine / dichloromethane / 5 - 10 °C 4: sodium hydroxide / water / 8.17 h / 25 - 100 °C 5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 14 h / 0 - 5 °C View Scheme |
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane 2.1: sulfuric acid / ethanol / Reflux 2.2: 5 h View Scheme | |
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane 2.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2.5 h / Reflux 3.1: sodium tetrahydroborate / tetrahydrofuran / 0 - 5 °C 3.2: 60 - 70 °C View Scheme |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 8 g |
avanafil
Conditions | Yield |
---|---|
Stage #1: C23H24ClN7O4 With sulfuric acid In ethanol Reflux; Stage #2: With sodium tetrahydroborate; lithium bromide In ethanol for 5h; | 7.5 g |
avanafil
Conditions | Yield |
---|---|
Stage #1: C23H23Cl2N7O3 With sodium tetrahydroborate In tetrahydrofuran at 0 - 5℃; Stage #2: With potassium hydroxide In water at 60 - 70℃; | 40 g |
4-(bromomethyl)-2-chloro-1-methoxybenzene
avanafil
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: potassium iodide; triethylamine / ethanol / 3 h / 50 - 80 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / acetonitrile / 24 h / 20 - 60 °C / Inert atmosphere 2.2: 5 h / 55 °C 3.1: bromine; sodium hydroxide / 0.08 h / Microwave irradiation 3.2: 10 h / 120 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium iodide; triethylamine / ethanol / 3 h / 50 - 80 °C 2.1: sodium hydroxide; iodine / 0.08 h / Microwave irradiation 2.2: 10 h / 110 °C / Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / acetonitrile / 24 h / 20 - 60 °C / Inert atmosphere 3.2: 5 h / 65 °C View Scheme |
Conditions | Yield |
---|---|
In acetone at 25℃; for 8h; Solvent; Sealed tube; | 96.5% |
avanafil
Conditions | Yield |
---|---|
With dmap In dichloromethane at 20℃; | 95% |
avanafil
(5S)-5,6-bis(nitrooxy)hexanoic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 94.5% |
avanafil
6-(nitrooxy)hexanoic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 93% |
avanafil
2-(2-(nitrooxy)ethoxy)acetic acid
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 52% |
avanafil
boron monobromide
sodium hydrogencarbonate
(S)-2-(2-hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-hydroxybenzylamino)-5-[N-(2-pyrimidylmethyl)carbamoyl]pyrimidine
Conditions | Yield |
---|---|
In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate |
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